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| 1 | Science and prediction of monsoon heavy rainfall显示文摘With the increasing incidence of heavy rainfall events,particularly over the monsoon regions,the highly dense populations are more vulnerable[1].Research initiatives on observation,modeling,and prediction of monsoon heavy rainfall have been promoted actively by World Weather Research Programme's(WWRP)Working Group on Tropical Meteorology Research(WGTMR)of the World Meteorological Organization(WMO)since 2010.Series of monsoon-heavy-rainfall workshops were held in Beijing(2011),Petaling Jaya(2012),and New Delhi(2015)to benefit scientists worldwide and forecasters from the National Meteorological and Hydrological Services.An international Research and Development Project,namely,the Southern China Monsoon Rainfall Experiment(SCMREX)[2]was established in 2013 to coordinate field campaign experiments and to conduct scientific research on presummer(April-June)heavy rainfall processes in southern China. | Yali Luo Liye Li Richard HJohnson Chih-Pei Chang Lianshou Chen Wai-Kin Wong Jing Chen Kalli Furtado John LMcBride Ajit Tyagi Nanette Lomarda Thierry Lefort Esperanza O.Cayanan | 2019 | Science Bulletin2019，64，21： | 4 |
| 2 | 辅助生殖的妊娠结局显示文摘研究目的研究人类辅助生殖(AHR)的围生期结局,明确出生结局和AHR需要进一步研究的领域,为优化产科处理和辅助生殖技术的咨询工作提供指南。研究结果文章比较了各种AHR技术的围生期结局,并与自然受孕者进行比较,有助于临床医师更好理解AHR相关的产科并发症、不良围生期结局、多胎妊娠、先天性结构畸形、染色体异常、基因印记疾病。证据来源使用合适的词汇和关键字(辅助生殖、辅助生殖技术、促排卵、胞浆内单精子显微注射、胚胎移植、体外授精)检索MEDLINE和Cochrane图书馆2005年1月至2012年12月的文献。研究结果并不只限系统综述、随机对照试验/对照临床试验和观察性研究,所有的2005年1月至2012年12月英语研究都包括在内,还包括根据书目查找的文章。定期更新检索,纳入了2013年8月之前的指南。灰色(未发表)的文献是通过查询卫生技术评估和卫生技术评估相关机构、临床实践指南的集合,临床试验登记处,以及国家和国际医疗专业团体而获得的。价值本文的的证据等级根据加拿大预防保健专责小组报告的标准评定(表1)。 | Nanette Okun Sony Sierra 李炎燚 | 2014 | 中国产前诊断杂志(电子版)2014，，2： | 3 |
| 3 | What do the recent American Heart Association/American College of Cardiology Foundation Clinical Practice Guidelines tell us about the evolving management of coronary heart disease in older adults?显示文摘Biological aging predisposes older adults to increased cardiovascular disease (CHD) and greater disease complexity. Given the high age-related prevalence of CHDand age-related compounding factors, the recently updatedAmerican HeartAssociation/American College of Cardiology Foundation CHD-related guidelines increased their focus on older patients. These guidelines are predominately evidence-based (using data from quality randomized clinical trials) and are organized to delineate medications and procedures that best treat particular cardiovascular diseases.While such rationale and thought work well in young and middle aged adults, they become problematic in patientswho are very old. Data pertaining to adults aged ≥80 are virtually absent from most randomized clinical trials, and even in the instances when very old patients were included, eligibility criteria typically excluded candidates with co-morbidities and complexities of customary CHD patients. While medications and interventions yielding benefit in clinical trials should theoretically produce the greatest benefits for patients with high intrinsic risk, age-related cardiovascular complexities also increase iatrogenic risks. Navigating between the potential for high benefit and high risk in “evidence-based”cardiovascular management remains a key Geriatric Cardiology challenge. In this review we consider the expanded Geriatric Cardiology content of current guidelines, acknowledging both the progress that has been made, as well as the work that still needs to be accomplished to truly address the patient-centered priorities of older CHDpatients. | Daniel Forman Nanette K Wenger | 2013 | Journal of Geriatric Cardiology2013，10，2： | 3 |
| 4 | 2012 ACCF/AHA Focused Update Incorporated Into the ACCF/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction显示文摘 | Jeffrey L. Anderson Cynthia D. Adams Elliott M. Antman Charles R. Bridges Robert M. Califf Donald E. Casey William E. Chavey Francis M. Fesmire Judith S. Hochman Thomas N. Levin A. Michael Lincoff Eric D. Peterson Pierre Theroux Nanette K. Wenger R. Scott | 2013 | Journal of the American College of Cardiology2013，，23： | 2 |
| 5 | 转录辅激活因子和乙酰基转移酶p300在心脏成纤维细胞衰老相关纤维化中的作用显示文摘目的:探讨转录辅激活因子和乙酰基转移酶p300在心脏成纤维细胞(CFs)衰老相关纤维化中的作用。方法:不同月龄的C57BL/6小鼠处死后取左心房组织或原代分离的CFs,Western blot检测p300蛋白,纤维化相关因子I型胶原蛋白α1链(Col1A1)、基质金属蛋白酶2(MMP-2)和转化生长因子β(TGF-β),以及衰老相关蛋白p53和p21的表达。将Cre酶转染来自p300+/+和p300 flox/+小鼠的原代培养CFs,筛选建立稳定敲除p300的CFs,PCR检测细胞基因型,Western blot检测沉默效率;衰老相关β-半乳糖苷酶(SA-β-Gal)染色观察敲除p300对CFs衰老率的影响,细胞计数观察细胞增殖能力。结果:随着月龄增加,小鼠左心房组织p300、Col1A1、MMP-2、TGF-β、p53和p21表达增加(P<0.05)。随着小鼠CFs传代代数增加,SA-β-G染色显示细胞衰老率增加,同时p300、Col1A1、MMP-2、TGF-β、p53和p21蛋白表达明显增加(P<0.05)。与野生型组相比,敲除p300的CFs随着代数的增加,未见衰老细胞,且细胞增殖能力明显强于对照组(P<0.05)。结论:心房组织中,p300可能参与CFs衰老相关纤维化。 | 高小燕 李昕 韦鉴钦 Nanette Hahr BISHOPRIC 王钊煜 周慧珊 饶芳 邓春玉 | 2019 | 中国病理生理杂志2019，35，12： | 2 |
| 6 | The comparative efficacy of ezetimibe added to atorvastatin 10 mg versus uptitration to atorvastatin 40 mg in subgroups of patients aged 65 to 74 years or greater than or equal to 75 years显示文摘有年龄的背景冠的心疾病(CHD ) 风险增加;然而类脂化合物阴沉的治疗是显著地在病人的 under-utilized > 65 年。目的是评估安全,在更老的病人的类脂化合物阴沉的治疗的功效与 atorvastatin 对待 10 mg + ezetimibe 10 mg (EZ/Atorva ) 对增加 atorvastatin 剂量到 40 mg。方法病人有动脉粥样硬化患者的 65 年脉管的疾病(LDL-C 1.81 mmol/L ) 或在为冠的心的高风险,疾病(LDL-C 2.59 mmol/L ) 为 12 wk 对 uptitration 被使随机化到 EZ/Atorva 到为 6 wk 的 20 mg 由 atorvastatin 跟随了的 atorvastatin 为 6 wk 的 40 mg。在完成 prespecified LDL-C 层次的 LDL-C 和另外的类脂化合物参数和百分比病人的百分比变化在 12 wk 以后被估计。结果 EZ/Atorva 在病人在大多数类脂化合物参数对 atorvastatin 的 uptitration 生产了更大的减小 75 年(n = 228 ) ,与病人通常一致 6574 年(n = 812 ) 。更多的病人在 6 wk 并且在病人在两个年龄组与联合治疗对 monotherapy 完成了 LDL-C 目标在 12 wk 的 75 年。在 12 wk,更多的病人 75 年与 monotherapy 对联合治疗完成了 LDL-C 目标。EZ/Atorva 在大多数类脂化合物生产了更有利的改进对加倍或 quadrupling 在病人的 atorvastatin 剂量 75 年,与在病人的调查结果通常一致 6574 年。我们的结果扩大了证明 ezetimibe 增加了 statin 的以前的调查结果的结论为在病人改进类脂化合物侧面提供了一种通常容忍得好的治疗学的选择 65 ~ 74 年和 75 岁。 | Ori Ben-Yehuda Nanette K. Wenger Christian Constance Franklin Zieve Mary E. Hanson Jian-Xin Lin Arvind K. Shah Charlotte Jones-Burton Andrew M. Tershakovec | 2011 | Journal of Geriatric Cardiology2011，8，1： | 2 |
| 7 | 指导性集体锻炼对治疗中的早期乳腺癌妇女的益处:实用性随机对照试验显示文摘目的确定12周指导性集体锻炼对治疗中的早期乳腺癌患者在机体功能和心理上的获益,并随访6个月。设计实用性、前瞻性、随机对照、开放性试验。地点苏格兰3家国家医疗卫生服务体系肿瘤门诊和社区运动设施。参加者共203位妇女参加研究;其中177位完成6个月随访。干预与常规护理相对照,干预组予12周指导性集体锻炼加常规护理。主要结果评价癌症治疗功能评价(FACT)问卷、贝克抑郁问卷、正性和负性情绪量表、体重指数、7日体力活动回忆问卷、12分钟步行实验和肩关节活动度评估。结果对基线值、研究中心、基线治疗和参加干预试验时的年龄进行校正后,综合效应模型的评估结果(干预组减对照组)显示第12周时:12分钟步行距离为129米(95%可信区间83~176),1周的中等强度活动时间182分钟(75~289),肩关节活动度2.6(1.6~3.7),乳腺癌特定的生活质量量表2.5(1.0~3.9),正性情绪4.0(1.8~6.3)。初步结果未发现干预锻炼对生活质量综合量表(FACT-G)有影响。随访6个月后,大多数效果维持不变,并且在乳腺癌特定的生活质量上得到改善。尚未有不良反应的报道。结论在12周干预锻炼结束时以及6个月后,指导性集体锻炼均显示出机体功能和心理上的获益。因此临床医生应该鼓励患者活动,决策者们应该考虑把体育锻炼纳入到癌症康复服务中来。试验注册号当前对照试验 ISRCTN12587864[controlled-trial.com]。 | Nanette Mutrie Anna M Campbell Fiona Whyte Alex McConnachie Carol Emslie Laura Lee Nora Kearney Andrew Walker Diana Ritchie 方桦(译) 王燕(校) | 2007 | 英国医学杂志中文版2007，10，4： | 2 |
| 8 | Treating to New Targets (TNT) Study: does lowering low-density lipoprotein cholesterol levels below currently recommended guidelines yield incremental clinical benefit?显示文摘 | David D Waters John R Guyton David M Herrington Mary P McGowan Nanette K Wenger Charles Shear | 2004 | The American Journal of Cardiology2004，，2： | 2 |
| 9 | Resistance exercise decreases the need for insulin in overweight women with gestational diabetes mellitus显示文摘 | Gabrielle N Brankston B.F Mitchell Edmond A Ryan Nanette B Okun | 2004 | American Journal of Obstetrics and Gynecology2004，，1： | 2 |
| 10 | Innate Immune Tolerance and the Role of Kupffer Cells in Differential Responses to Interferon Therapy Among Patients with HCV Genotype 1 Infection显示文摘 | Daryl T.-Y. Lau Amina Negash Jie Chen Nanette Crochet Mala Sinha Yuhong Zhang Jeremie Guedj Sharon Holder Takeshi Saito Stanley M. Lemon Bruce A. Luxon Alan S. Perelson Michael Gale | 2012 | Gastroenterology2012，，： | 2 |
| 11 | Silicon breast i mplant rupture in an animal model: comparision of Mammography, MRI,US and CT显示文摘 | David PG Nanette DD Christina AM | 1994 | Radiology1994，190，1： | 1 |
| 12 | 2012 ACCF/AHA Focused Update of the Guideline for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction (Updating the 2007 Guideline and Replacing the 2011 Focused Update)显示文摘 | Hani Jneid Jeffrey L. Anderson R. Scott Wright Cynthia D. Adams Charles R. Bridges Donald E. Casey Steven M. Ettinger Francis M. Fesmire Theodore G. Ganiats A. Michael Lincoff Eric D. Peterson George J. Philippides Pierre Theroux Nanette K. Wenger James P | 2012 | Journal of the American College of Cardiology2012，，7： | 1 |
| 13 | Mesenchymal stem cells for the treatment of neurodegenerative disease显示文摘 | Nanette Joyce Geralyn Annett Louisa Wirthlin Scott Olson Gerhard Bauer Jan A Nolta | 2010 | Regen Med2010，，6： | 1 |
| 14 | 老年人急性心肌梗死的循证治疗方案:目前的观点 | Nanette Kass Wenger Tarek Helmy Bobby Varkey Khan Amar D.Patel | 2005 | 世界核心医学期刊文摘(心脏病学分册)2005，0，9： | 1 |
| 15 | 2011 ACCF/AHA Focused Update Incorporated Into the ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction显示文摘 | R. Scott Wright Jeffrey L. Anderson Cynthia D. Adams Charles R. Bridges Donald E. Casey Steven M. Ettinger Francis M. Fesmire Theodore G. Ganiats Hani Jneid A. Michael Lincoff Eric D. Peterson George J. Philippides Pierre Theroux Nanette K. Wenger James P | 2011 | Journal of the American College of Cardiology2011，，19： | 1 |
| 16 | The sacred spark of academic research 显示文摘 | RODGERS ROBERT RODGERS NANETTE | 1999 | Journal of Public Administration Research and Theory: J-PART1999，9，3： | 1 |
| 17 | Intensive Lipid Lowering With Atorvastatin in Patients With Coronary Heart Disease and Chronic Kidney Disease显示文摘 | James Shepherd John J.P. Kastelein Vera Bittner Prakash Deedwania Andrei Breazna Stephen Dobson Daniel J. Wilson Andrea Zuckerman Nanette K. Wenger | 2008 | Journal of the American College of Cardiology2008，，15： | 1 |
| 18 | Crohn’s disease, pregnancy, and birth weight显示文摘 | Michael A.J Moser Nanette B Okun Damon C Mayes Robert J Bailey | 2000 | The American Journal of Gastroenterology2000，，4： | 1 |
| 19 | Development of the Scottish Walkability Assessment Tool (SWAT)显示文摘 | Catherine Millington Catharine Ward Thompson David Rowe Peter Aspinall Claire Fitzsimons Norah Nelson Nanette Mutrie | | 0，，： | 1 |
| 20 | Altered cell differentiation and proliferation in mice lacking p57^KIP2 indicates a role in Beckwith-Wiedemenn syndrome显示文摘 | Pumin Zhang Nanette J Liegeois | 1997 | Nature1997，387，6629： | 1 |
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