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| 1 | Secretion of melatonin and 6-sulfatoxymelatonin urinary excretion in functional dyspepsia显示文摘AIM:To evaluate blood concentration of melatonin and urinary excretion of its metabolite,6-sulfatoxymelatonin(6-OHMS),in functional dyspepsia(FD).METHODS:Ninety individuals were enrolled in the study:30 in each study group:patients with postprandial distress syndrome(PDS),epigastric pain syndrome(EPS),and controls.Blood samples were drawn at 02:00 and 09:00 h and 24-h urine collection was performed.Serum melatonin and urinary 6-OHMS concentrations were measured by enzyme-linked immunosorbent assay.RESULTS:Serum melatonin concentration at night and in the morning was significantly(P < 0.001) higher in PDS patients [at 02:00 h-93.3 pg/mL,quartile range(QR):79.8-116.2;at 09.00 h-14.3 pg/mL,QR:7.06-19.0] than in EPS(57.2 pg/mL,QR:42.6-73.1;8.1 pg/mL,QR:4.1-9.3) and control patients(57.7 pg/mL,QR:51.2-62.5;8.1 pg/mL,QR:5.4-10.3).A similar relationship was observed for urinary 6-OHMS excretion.Patients with severe PDS symptoms had a higher melatonin concentration than these with moderate syndromes,whereas patients with severe EPS had a lower urinary 6-OHMS excretion than patients with moderate symptoms.CONCLUSION:Evaluation of melatonin serum concentrations and 24-h urinary 6-OHMS excretion are useful methods for differential diagnosis of various clinical forms of FD. | Cezary Chojnacki Tomasz Poplawski Grazyna Klupinska Janusz Blasiak Jan Chojnacki Russel J Reiter | 2011 | World Journal of Gastroenterology2011，17，21： | 8 |
| 2 | Evaluation of enterochromaffin cells and melatonin secretion exponents in ulcerative colitis显示文摘AIM: To study an assessment of the number of enterochromaffin cells and expression of hydroxyindole-Omethyltransferase in colonic mucosa and urine excretion of 6-sulfatoxymelatonin in patients with ulcerative colitis. METHODS: The study included 30 healthy subjects (groupⅠ-C), 30 patients with ulcerative proctitis [group Ⅱ-ulcerative proctitis (UP)] and 30 patients with ulcerative colitis [group Ⅲ-ulcerative colitis (UC)] in acute phases of these diseases. The number of enterochromaffin cells (EC) was estimated in rectal and colonic mucosa. Bioptates were assembled from many different parts of the large intestine. Immunorective cells collected from various parts of the colon were counted according to the Eurovision DAKO (Dako A/S, Copenhagen, Denmark) System in the range of 10 fields in each bioptate at × 200 magnification. The level of mRNA expression of hydroxyindole-O-methyltransferase (HIOMT) in colonic mucosa was estimated with RT-PCR. Urine 6-sulfatoxymelatonin (6-HMS) excretion was determined immunoenzymatically using an IBL (IBL International GmbH, Hamburg, Germany) kit (RE 54031). RESULTS: The number of EC cells in healthy subjects (C) was 132.40 ± 31.26. In patients of group Ⅱ (UP) and group Ⅲ (UC) the number of these cells was higher 225.40 ± 37.35 (P < 0.001) and 225.24 ± 40.50 (P < 0.001) respectively. Similar differences were related to HIOMT expression, which was 1.04 ± 0.36 in group C, 1.56 ± 0.56 (P < 0.01) in group UP and 2.00 ± 0.35 (P < 0.001) in group UC. Twenty-four hour 6-HMS urinary excretion was as follows: C 16.32 ± 4.95 μg/24 h, UP 26.30 ± 7.29 μg/24 h (P < 0.01), UC 42.30 ± 12.56 μg/24h (P < 0.001). A correlation between number of EC cells and 6-HMS excretion was noted in all groups: r = 0.766 in patients with UP, r = 0.703 with UC and r = 0.8551 in the control group; the correlation between the results is statistically significant. CONCLUSION: In the acute phases of both UP and UC, proliferation of EC cells and high expression of HIOMT and urine excretion of 6-HMS is noted. These changes may represent a beneficial response in the anti-inflammatory and defense mechanism. | Cezary Chojnacki Maria Wisniewska-Jarosińska Grazyna Kulig Ireneusz Majsterek Russel J Reiter Jan Chojnacki | 2013 | World Journal of Gastroenterology2013，19，23： | 5 |
| 3 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet . 2011 (9807)2011，，9807： | 2 |
| 4 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet2011，，9807： | 2 |
| 5 | Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial显示文摘 | Bernard Escudier Anna Pluzanska Piotr Koralewski Alain Ravaud Sergio Bracarda Cezary Szczylik Christine Chevreau Marek Filipek Bohuslav Melichar Emilio Bajetta Vera Gorbunova Jacques-Olivier Bay Istvan Bodrogi Agnieszka Jagiello-Gruszfeld Nicola Moore | 2007 | The Lancet . 2007 (9605)2007，，： | 2 |
| 6 | Building Transcription Factor Binding Site Models to Understand Gene Regulation in Plants显示文摘Transcription factors (TFs) are key cellular components that control gene expression. They recognize specific DNA sequences, the TF binding sites (TFBSs), and thus are targeted to specific regions of the genome where they can recruit transcriptional co-factors and/or chromatin regulators to fine-tune spatiotemporal gene regulation. Therefore, the identification of TFBSs in genomic sequences and their subsequent quantitative modeling is of crucial importance for understanding and predicting gene expression. Here, we review how TFBSs can be determined experimentally, how the TFBS models can be constructed in silico, and how they can be optimized by taking into account features such as position interdependence within TFBSs, DNA shape, and/or by introducing state-of-the-art computational algorithms such as deep learning methods. In addition, we discuss the integration of context variables into the TFBS modeling, including nucleosome positioning, chromatin states, methylation patterns, 3D genome architectures, and TF cooperative binding, in order to better predict TF binding under cellular contexts. Finally, we explore the possibilities of combining the optimized TFBS model with technological advances, such as targeted TFBS perturbation by CRISPR, to better understand gene regulation, evolution, and plant diversity. | Xuelei Lai Arnaud Stigliani Gilles Vachon Cristel Carles Cezary Smaczniak Chloe Zubieta Kerstin Kaufmann Francois Parcy | 2019 | Molecular Plant2019，12，6： | 2 |
| 7 | Improving duplicate elimination in storage systems显示文摘 | Deepak R. Bobbarjung Suresh Jagannathan Cezary Dubnicki | 2006 | ACM Transactions on Storage (TOS)2006，，4： | 2 |
| 8 | Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2R[gamma]c-deficient mice显示文摘 | Sarry Jean-Emmanuel Murphy Kathleen Perry Robin Sanchez Patricia V Secreto Anthony Keefer Cathy Swider Cezary R Strzelecki Anne-Claire Cavelier Cindy Récher Christian Mansat-De Mas Véronique Delabesse Eric Danet-Desnoyers G Carroll Martin | 2011 | Journal of Clinical Investigation2011，，1： | 2 |
| 9 | Resistance to first line platinum paclitaxel chemotherapy in serousepithelial ovarian cancer: The prediction value of ERCC1 and Tau expression显示文摘 | Karina Steffensen Marta Smoter Marianne Waldstr?m Bart?omiej Grala Lubomir Bodnar Rafa? Stec Cezary Szczylik Anders Jakobsen | 2014 | International Journal of Oncology2014，，5： | 2 |
| 10 | Catching-up and inflation differentials in a heterogeneous monetary union:Some implications for the euro area and new EU member states显示文摘 | RONALD M CEZARY W | 2008 | Economic Systems2008，32，1： | 1 |
| 11 | A repre- senatative ex-situ fretting wear investigation of orthodontic arch-wire/bracket contacts显示文摘 | Cezary Rapiejko Siegfried Fouvry Brigitte Grosgogeat | 2009 | Wear2009，266，78： | 1 |
| 12 | Composition of milk and blood metabolites in high productivity dairy cows on pasture显示文摘 | Cezary P Barbara P Dariusz M | 2005 | VETERINARIJA IR ZOOTECHNIKA2005，32，54： | 1 |
| 13 | The role of erythropoietin and its receptor in growth, survival and therapeutic response of human tumor cells显示文摘 | Jolanta Szenajch Gabriel Wcislo Jee-Yeong Jeong Cezary Szczylik Laurie Feldman | 2010 | BBA - Reviews on Cancer2010，，1： | 1 |
| 14 | Credit Booms,Monetary Integration and the New Neoclassical Synthesis显示文摘 | Peter Backe Cezary Wojcik | | 0，，32： | 1 |
| 15 | Fruit cuticular waxes as 压 source of biologically active triterpenoids显示文摘 | ANNA S CEZARY P FLORA P | 2012 | Phytochemistry Reviews2012，11，23： | 1 |
| 16 | Microelectrona cladara gen.et sp.nov.:A New Protodikraneurini from the Eocene Baltic Amber(Hemiptera:Cicadomorpha:Cicadellidae:Typhlocybinae)显示文摘一张新类 Microelectrona 情报。nov。并且种类 Microelectrona cladara sp。nov。叶蝉的绝灭的部落 Protodikraneurini (Cicadellidae:Typhlocybinae ) 从始新世波罗的语琥珀被描述。包含叶蝉包括的琥珀的片被打破,揭开一些词法结构,并且用扫描电子显微镜学启用他们的研究。 | Jacek SZWEDO Cezary GEBICKI Magdalena KOWALEWSKA | 2010 | Acta Geologica Sinica(English Edition)2010，84，4： | 1 |
| 17 | Fuzzy decision trees:Issues and methods显示文摘 | Cezary Z Janikow | 1998 | IEEE Trans on Systems Man and Cybernetics1998，28，1： | 1 |
| 18 | Coherent generation and detection of continuous terahertz waves using two photomixers driven by laser diodes显示文摘 | Rajind Mendis Cezary Sydlo Jochen Sigmund | 2005 | International Journal of Infrared and Millimeter Waves2005，26，2： | 1 |
| 19 | Renal protection with magnesium subcarbonate and magnesium sulphate in patients with epithelial ovarian cancer after cisplatin and paclitaxel chemotherapy: A randomised phase II study显示文摘 | Lubomir Bodnar Gabriel Wcislo Agnieszka Gasowska-Bodnar Agnieszka Synowiec Katarzyna Szarlej-Wcis?o Cezary Szczylik | 2008 | European Journal of Cancer2008，，17： | 1 |
| 20 | Highly selective synthesis of 1 - (silyl) -1 -(boryl) ethenes via a ruthenium-catalyzed silylative coupling reaction 显示文摘 | Magdalena J Bogdan M Cezary P Joanna C | 2004 | Tetrahedron Lett2004，45，25： | 1 |
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