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| 1 | Progress towards onchocerciasis elimination in the participating countries of the African Programme for Onchocerciasis Control: epidemiological evaluation results显示文摘Background:The African Programme for Onchocerciasis Control(APOC)was created in 1995 to establish community-directed treatment with ivermectin(CDTi)in order to control onchocerciasis as a public health problem in 20 African countries that had 80%of the global disease burden.When research showed that CDTi may ultimately eliminate onchocerciasis infection,APOC was given in 2008 the additional objective to determine when and where treatment can be safely stopped.We report the results of epidemiological evaluations undertaken from 2008 to 2014 to assess progress towards elimination in CDTi areas with≥6 years treatment.Methods:Skin snip surveys were undertaken in samples of first-line villages to determine the prevalence of O.volvulus microfilariae.There were two evaluation phases.The decline in prevalence was evaluated in phase 1A.Observed and model-predicted prevalences were compared after correcting for endemicity level and treatment coverage.Bayesian statistics and Monte Carlo simulation were used to classify the decline in prevalence as faster than predicted,on track or delayed.Where the prevalence approached elimination levels,phase 1B was launched to determine if treatment could be safely stopped.Village sampling was extended to the whole CDTi area.Survey data were analysed within a Bayesian framework to determine if stopping criteria(overall prevalence<1.4%and maximum stratum prevalence<5%)were met.Results:In phase 1A 127665 people from 639 villages in 54 areas were examined.The prevalence had fallen dramatically.The decline in prevalence was faster than predicted in 23 areas,on track in another 23 and delayed in eight areas.In phase 1B 108636 people in 392 villages were examined in 22 areas of which 13 met the epidemiological criteria for stopping treatment.Overall,32 areas(25.4 million people)had reached or were close to elimination,18 areas(17.4 million)were on track but required more years treatment,and in eight areas(10.4 million)progress was unsatisfactory.Conclusions:Onchocerciasis has been largely controlled as a public health problem.Great progress has been made towards elimination which already appears to have been achieved for millions of people.For most APOC countries,nationwide onchocerciasis elimination is within reach. | Afework H.Tekle Honorath G.M.Zouré Mounkaila Noma Michel Boussinesq Luc E.Coffeng Wilma A.Stolk Jan H.F.Remme | 2016 | Infectious Diseases of Poverty2016，5，1： | 6 |
| 2 | Post-Mortem MRI and Histopathology in Neurologic Disease:A Translational Approach显示文摘In this review, combined post-mortem brain magnetic resonance imaging(MRI) and histology studies are highlighted, illustrating the relevance of translational approaches to de?ne novel MRI signatures of neuropathological lesions in neuroin?ammatory and neurodegenerative disorders. Initial studies combining post-mortem MRI and histology have validated various MRI sequences,assessing their sensitivity and speci?city as diagnostic biomarkers in neurologic disease. More recent studies have focused on de?ning new radiological(bio)markers and implementing them in the clinical(research) setting. By combining neurological and neuroanatomical expertise with radiological development and pathological validation,a cycle emerges that allows for the discovery of novel MRI biomarkers to be implemented in vivo. Examples of this cycle are presented for multiple sclerosis, Alzheimer's disease, Parkinson's disease, and traumatic brain injury.Some applications have been shown to be successful, while others require further validation. In conclusion, there is much to explore with post-mortem MRI and histology studies, which can eventually be of high relevance for clinical practice. | Laura E.Jonkman Boyd Kenkhuis Jeroen J.G.Geurts Wilma D.J.van de Berg | 2019 | Neuroscience Bulletin2019，35，2： | 4 |
| 3 | Burden of onchocerciasis-associated epilepsy:first estimates and research priorities显示文摘Background:Since the 1990s,evidence has accumulated of an increased prevalence of epilepsy in onchocerciasisendemic areas in Africa as compared to onchocerciasis-free areas.Although the causal relationship between onchocerciasis and epilepsy has yet to be proven,there is likely an association.Here we discuss the need for disease burden estimates of onchocerciasis-associated epilepsy(OAE),provide them,detail how such estimates should be refined,and discuss the socioeconomic impact of OAE,including a cost-estimate for anti-epileptic drugs.Main body:Providing OAE burden estimates may aid prevention of epilepsy in onchocerciasis-endemic areas by inciting and informing collaboration between onchocerciasis control programmes and mental health services.Epilepsy not only massively impacts the health of those affected,but it also carries a high socioeconomic burden for the households and communities involved.We used previously published geospatial estimates of onchocerciasis in Africa and a separately published logistic regression model quantifying the association between onchocerciasis and epilepsy to estimate the number of OAE cases.We then applied disability weights for epilepsy to quantify the burden in terms of years of life lived with disability(YLD)and estimate the cost of treatment.We estimate that in 2015 roughly 117000 people were affected by OAE across onchocerciasis-endemic areas previously under the African Programme for Onchocerciases control(APOC)mandate where OAE has ever been reported or suspected,and another 264000 persons in onchocerciasis-endemic areas where OAE has never been investigated before.The total number of YLDs due to OAE was 39300 and 88700 in these areas respectively,based on a weighted mean disability weight of 0.336.The burden of OAE is approximately 13%of the total YLDs attributable to onchocerciasis and 10%of total YLDs attributable to epilepsy.We estimated that by 2015 the total costs of treatment with antiepileptic drug for OAE cases would have been a minimum of 12.4 million US$.Conclusions:These estimates suggest a considerable health,social and economic burden of OAE in Africa.The treatment and care for people with epilepsy,especially in hyperendemic onchocerciasis areas with high epilepsy prevalence thus requires more financial and human resources. | Natalie V.S.Vinkeles Melchers Sarah Mollenkopf Robert Colebunders Michael Edlinger Luc E.Coffeng Julia Irani Tresor Zola Joseph N.Siewe Sake Jde Vlas Andrea S.Winkler Wilma A.Stolk | 2018 | Infectious Diseases of Poverty2018，7，1： | 3 |
| 4 | Magnetic Resonance Imaging Surveillance Detects Early-Stage Pancreatic Cancer in Carriers of a p16-Leiden Mutation显示文摘 | Hans F.A. Vasen Martin Wasser Anneke van Mil Rob A. Tollenaar Marja Konstantinovski Nelleke A. Gruis Wilma Bergman Frederik J. Hes Daniel W. Hommes G. Johan A. Offerhaus Hans Morreau Bert A. Bonsing Wouter H. de Vos tot Nederveen Cappel | 2011 | Gastroenterology2011，，3： | 3 |
| 5 | Presence of a high amount of stroma and downregulation of SMAD4 predict for worse survival for stage I–II colon cancer patients显示文摘 | Wilma E. Mesker Gerrit-Jan Liefers Jan M.C. Junggeburt Gabi W. van Pelt Paola Alberici Peter J.K. Kuppen Noel F. Miranda Karin A.M. van Leeuwen Hans Morreau Karoly Szuhai Rob A.E.M. Tollenaar Hans J. Tanke | 2009 | Cellular Oncology2009，，3： | 2 |
| 6 | CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson’s disease: a study in LRRK2 mutation carriers显示文摘Background Asymptomatic carriers of leucine-rich repeat kinase 2(LRRK2)gene mutations constitute an ideal population for discovering prodromal biomarkers of Parkinson’s disease(PD).In this study,we aim to identify CSF candidate risk biomarkers of PD in individuals with LRRK2 mutation carriers.Methods We measured the levels of CSF total-(t-),oligomeric(o-)and phosphorylated S129(pS129-)α-syn,total-tau(tTau),phosphorylated threonine 181 tau(pTau),amyloid-beta 40(Aβ-40),amyloid-beta-42(Aβ-42)and 40 inflammatory chemokines in symptomatic(n=23)and asymptomatic(n=51)LRRK2 mutation carriers,subjects with a clinical diagnosis of PD(n=60)and age-matched healthy controls(n=34).General linear models corrected for age and gender were performed to assess differences in CSF biomarkers between the groups.Markers that varied significantly between the groups were then analyzed using backward-elimination logistic regression analysis to identify an ideal biomarkers panel of prodromal PD.Results Discriminant function analysis revealed low levels of CSF t-α-syn,high levels of CSF o-α-syn and TNF-αbest discriminated asymptomatic LRRK2 mutation carriers from both symptomatic PD and healthy controls.Assessing the discriminative power using receiver operating curve analysis,an area under the curve>0.80 was generated.Conclusions The current study suggests that CSF t-,o-α-syn and TNF-αare candidate risk biomarkers for the detection of PD at the prodromal stage.Our findings also highlight the dynamic interrelationships between CSF proteins and the importance of using a biomarkers’panel approach for an accurate and timely diagnosis of PD. | Nour K.Majbour Jan O.Aasly Eldbjørg Hustad Mercy A.Thomas Nishant N.Vaikath Naser Elkum Wilma D.Jvan de Berg Takahiko Tokuda Brit Mollenhauer Henk W.Berendse Omar M.A.El-Agnaf | 2020 | Translational Neurodegeneration2020，9，2： | 2 |
| 7 | Functional conservation of the grapevine candidate gene INNER NO OUTER for ovule development and seed formation显示文摘Seedlessness represents a highly appreciated trait in table grapes.Based on an interesting case of seedless fruit production described in the crop species Annona squamosa,we focused on the Vitis vinifera INNER NO OUTER(INO)gene as a candidate.This gene encodes a transcription factor belonging to the YABBY family involved in the determination of abaxial identity in several organs.In Arabidopsis thaliana,this gene was shown to be essential for the formation and asymmetric growth of the ovule outer integument and its mutation leads to a phenotypic defect of ovules and failure in seed formation.In this study,we identified in silico the V.vinifera orthologue and investigated its phylogenetic relationship to INO genes from other species and its expression in different organs in seeded and seedless varieties.Applying cross-species complementation,we have tested its functionality in the Arabidopsis ino-1 mutant.We show that the V.vinifera INO successfully rescues the ovule outer integument growth and seeds set and also partially complements the outer integument asymmetric growth in the Arabidopsis mutant,differently from orthologues from other species.These data demonstrate that VviINO retains similar activity and protein targets in grapevine as in Arabidopsis.Potential implications for grapevine breeding are discussed. | Valentina di Rienzo Zahra Imanifard Isabella Mascio Charles SGasser Debra JSkinner Ciro Leonardo Pierri Martina Marini Valentina Fanelli Wilma Sabetta Cinzia Montemurro Diana Bellin | 2021 | Horticulture Research2021，8，1： | 2 |
| 8 | Extrahepatic aneurysm of the portal venous system and portal hypertension显示文摘Portal venous aneurysm (PVA) is a rare condition characterized by dilatation of the portal venous system. PVA manifestation of symptoms is varied and depends on the aneurysm size, location and related-complications, such as thrombosis. While the majority of reported cases of PVA are attributed to portal hypertension, very little is known about the condition's pathophysiology and clinical management remains a challenge. Here, we describe a 67-year-old woman who presented with complaint of dyspepsia and without a significant medical history, for whom PVA was incidentally diagnosed. The initial upper abdominal ultrasound revealed marked dilatation of the main portal vein, and subsequent contrast-enhanced computed tomography with angiography revealed a large aneurysm arising from the extrahepatic troncus portion of the portal vein, as well as gastroesophageal varices. A conservative approach using beta-blocker therapy was chosen. The patient was followed-up for 60 mo, during which time the asymptomatic status was unaltered and the PVA remained stable. | Wilma Debernardi-Venon Davide Stradella Greta Ferruzzi Filippo Marchisio Chiara Elia Mario Rizzetto | 2013 | World Journal of Hepatology2013，5，3： | 2 |
| 9 | 再生IIR在轮胎气密层中的应用显示文摘再生IIR是轮胎工业中广泛应用的一种重要配合剂。用再生IIR部分替代IIR或BIIR可改善胶料工艺性能 ,并对胶料的某些非常重要的性能 (包括胶料成本 )有着积极的影响。 对气密层来说 ,最有意义的工艺性能改进是提高了轮胎成型和硫化过程中的气密性。含有再生IIR的气密层胶料具有较低的透气率 ,使制造商能够减薄气密层 ,同时不降低其气密性。胶料的耐老化性能也提高了 ,特别是老化后的屈挠疲劳寿命大大提高。 | HenkJan Manuel Wilma Dierkes 赵敏 涂学忠 | 2001 | 轮胎工业2001，21，6： | 2 |
| 10 | The role of gelatinases in colorectal cancer progression and metastasis显示文摘 | Olaf R.F. Mook Wilma M. Frederiks Cornelis J.F. Van Noorden | 2004 | BBA - Reviews on Cancer2004，，2： | 2 |
| 11 | Global equilibrium configurations of supercoiled DNA 显示文摘 | Hao Ming-Hong Olson Wilma K | 1989 | Macromolecules1989，22，： | 1 |
| 12 | Enhancing a Competitive Intelligence Culture in South Africa显示文摘 | Wilma Viviers andrea Saayman Mari6-Luce Muller | 2005 | International Journal of Social Economics2005，32，7： | 1 |
| 13 | Non-cooperation:The Dark Side of Strategic Alliances显示文摘 | WILMA W SUEN | 2006 | Journal of Product Innovation Management2006，2，1： | 1 |
| 14 | Centrosome Amplification and the Origin of Chromosomal Instability in Breast Cancer显示文摘 | Jeffrey L. Salisbury Antonino B. D’Assoro Wilma L. Lingle | 2004 | Journal of Mammary Gland Biology and Neoplasia2004，，3： | 1 |
| 15 | Physical activity,screentime and self-rated health and mental health in canadianadolescents显示文摘 | KATYA M HERMAN WILMA M HOPMAN CATHERINE M SABISTON | 2015 | Preventive Medicine2015，，11： | 1 |
| 16 | Cold plasma treatment of polypropylene surface:a study on wettability and adhesion显示文摘 | LUIGI Garrino GIOVANNI Moroni WILMA Polini | 2002 | Journal of Materials Processing Technology2002，121，： | 1 |
| 17 | Warfarin and aortic valve calcifica- tionin hemodialysis patients 显示文摘 | Rachel M Holden Anthony S Sanfilippo Wilma M Hopman | 2007 | ephrol2007，20，： | 1 |
| 18 | Sponta- neous switch to PIA-independent biofilm formation in an ica-positive Staphylococcus epidermidis isolate 显示文摘 | Susanne Hermiga Sun Nyunt Waib Wilma Ziebuhra | 2007 | International Journal of Medi- cal Microbiology2007，297，： | 1 |
| 19 | Species differences in the localization of cGMP-producing and NO-responsive elements in the mouse and rat hippocampus using cGMP immunocytochemistry显示文摘 | WILMA C HARRY W MARJANNE M | 2004 | EurJ N eurosci2004，19，8： | 1 |
| 20 | Angioneurotic edema attributed to the use of losartan显示文摘 | 10,Van Rijinsoever rea,Wilma J Kwee zuiderwijk M | 1998 | Arch Intern Med1998，158，12： | 1 |
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