|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Influences of Ivabradine treatment on serum levels of cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in patients with chronic heart failure显示文摘长期的心失败(CHF ) 代表住院和死亡的一个主要原因。最近的证据表演那新奇 biomarkers 象 tumorigenicity (sST2 ) 的可溶的抑制那样,生长区别 factor-15 (GDF-15 ) ,可溶的尿激 plasminogen 使活跃之物受体(suPAR ) 和心类型丰满的酸绑定蛋白质(H-FABP ) 被相关与煽动性并且在 CHF 病人的 ischemic 回答。在这研究,我们检验了禁止了 激活hyperpolarization 的周期的核苷酸门隧道的 Ivabradine 的效果( HCN 隧道,也叫的滑稽电流我 从而导致选择心率减小的 f ),和改进的心肌的氧在心脏的 biomarkers sST2 上供应, GDF-15 ,在在 Jena 的大学医院的 50 个 CHF 病人的 suPAR 和 H-FABP 。病人们基于 CHF 的病原学被划分成三个组:扩大心肌症(DCM, n=20 ) , ischemic 心肌症(ICM, n=20 ) 并且高血压的心肌症(HCM, n=10 ) 。病人是管理 Ivabradine (5 mg,为 3 个月的出价,和 7.5 mg 期望推进 3 个月) 。心血管的 biomarkers 的分析在基线以及在 3 月、 6 月的后续被执行。在 6 月的后续, GDF-15 层次显著地与基线层次(P=0.0215 ) 相比被减少,显示在心脏的改变的进步的减小。H-FABP 集中在与 ICM (1.89 对 3.24 g/mL ) 和 HCM 病人(1.89 对 3.80 g/mL ) 相比的 DCM 病人是显著地更低的,并且在 6 月的后续(P=0.0151 ) 上减少了。中部的层次仍然是的 suPAR 提高了,暗示主要进行中的煽动性的过程。是在 GDF-15 和 H-FABP 由重要减少证明层次,在室的改变的减小和无临床症状的局部缺血能被假定。然而,血液动力学的应力(sST2 ) 的标记和发炎(suPAR ) 没在 CHF 病人在 6 月 Ivabradine 治疗以后显示出变化或前进。进一步的研究是必要的验证这些新奇心血管的 biomarkers 的临床的适用性。 | Peter JIRAK Dzeneta FEJZIC Vera PAAR Bernhard WERNLY Rudin PISTULLI Ilonka ROHM Christian JUNG Uta C HOPPE P Christian SCHULZE Michael LICHTENAUER Atilla YILMAZ Daniel KRETZSCHMAR | 2018 | Acta Pharmacologica Sinica2018，39，7： | 31 |
| 2 | Comparison of high-resolution ultrasound and MR-enterography in patients with inflammatory bowel disease显示文摘AIM:To compare the results of high-resolution ultrasound(HR-US) and magnetic resonance enterography(MRE) examinations in patients with inflammatory bowel disease(IBD).METHODS:The reports of 250 consecutive cases with known IBD,who had an MRE and HR-US examination,were retrospectively analyzed.Using a patient-based approach we evaluated morphological disease features such as affected bowel wall,stenosis,abscess and fistula.The comparison between the two modalities was based on the hypothesis,that any pathological change described in any imaging modality was a true finding,as no further standard of reference was available for complete assessment.RESULTS:Two hundred and fifty examinations representing 207 different patients were evaluated.Both modalities assessed similar bowel wall changes in 65% of the examinations,with more US findings in 11% and more MRE findings in 15%.When the reports were analyzed with regard to 'bowel wall inflammation',US reported more findings in 2%,while MRE reported more findings in 53%.Stenoses were assessed to be identical in 8%,while US found more in 3% and MRE in 29%(P < 0.01).For abscess detection,US showed more findings in 2%(n = 4) while MRE detected more in 6%(n = 16).US detected more fistulas in 1%(n = 2),while MRE detected more in 13%(n = 32)(P < 0.001).The most common reason for no detected pathology by US was a difficult to assess anatomical region(lesser pelvis,n = 72).CONCLUSION:US can miss clinically relevant pathological changes in patients with IBD mostly due to difficulty in assessing certain anatomical regions. | Andreas G Schreyer Cynthia Menzel Chris Friedrich Florian Poschenrieder Lukas Egger Christian Dornia Gabriela Schill Lena M Dendl Doris Schacherer Christl Girlich Ernst-Michael Jung | 2011 | World Journal of Gastroenterology2011，17，8： | 7 |
| 3 | AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南显示文摘脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grades of Recommendation Assessment,Development and Evaluation,GRADE),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。 | Zhongheng Zhang Nathan J.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis Jordi Rello Patrick M.Honore Win Sen Kuan Juliet June Ray Jiancang Zhou You Shang Yuetian Yu Christian Jung Chiara Robba Fabio Silvio Taccone Pietro Caironi David Grimaldi Stefan Hofer George Dimopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud Won Young Kim Herbert D.Spapen Jose Rodolfo Rocco 张建成(译) 尚游(译) 钟鸣(校) | 2016 | 临床与病理杂志2016，36，10： | 5 |
| 4 | National Forest Inventories capture the multifunctionality of managed forests in Germany显示文摘Background:Forests perform various important ecosystem functions that contribute to ecosystem services.In many parts of the world,forest management has shifted from a focus on timber production to multi-purpose forestry,combining timber production with the supply of other forest ecosystem services.However,it is unclear which forest types provide which ecosystem services and to what extent forests primarily managed for timber already supply multiple ecosystem services.Based on a comprehensive dataset collected across 150 forest plots in three regions differing in management intensity and species composition,we develop models to predict the potential supply of 13 ecosystem services.We use those models to assess the level of multifunctionality of managed forests at the national level using national forest inventory data.Results:Looking at the potential supply of ecosystem services,we found trade-offs(e.g.between both bark beetle control or dung decomposition and both productivity or soil carbon stocks)as well as synergies(e.g.for temperature regulation,carbon storage and culturally interesting plants)across the 53 most dominant forest types in Germany.No single forest type provided all ecosystem services equally.Some ecosystem services showed comparable levels across forest types(e.g.decomposition or richness of saprotrophs),while others varied strongly,depending on forest structural attributes(e.g.phosphorous availability or cover of edible plants)or tree species composition(e.g.potential nitrification activity).Variability in potential supply of ecosystem services was only to a lesser extent driven by environmental conditions.However,the geographic variation in ecosystem function supply across Germany was closely linked with the distribution of main tree species.Conclusions:Our results show that forest multifunctionality is limited to subsets of ecosystem services.The importance of tree species composition highlights that a lack of multifunctionality at the stand level can be compensated by managing forests at the landscape level,when stands of complementary forest types are combined.These results imply that multi-purpose forestry should be based on a variety of forest types requiring coordinated planning across larger spatial scales. | Nadja K.Simons María R.Felipe-Lucia Peter Schall Christian Ammer Jürgen Bauhus Nico Blüthgen Steffen Boch François Buscot Markus Fischer Kezia Goldmann Martin M.Gossner Falk Hänsel Kirsten Jung Peter Manning Thomas Nauss Yvonne Oelmann Rodica Pena Andrea Polle Swen C.Renner Michael Schloter Ingo Schöning Ernst-Detlef Schulze Emily F.Solly Elisabeth Sorkau Barbara Stempfhuber Tesfaye Wubet Jörg Müller Sebastian Seibold Wolfgang W.Weisser | 2021 | Forest Ecosystems2021，8，1： | 2 |
| 5 | Cardiotrophin-1 induces intercellular adhesion molecule-1 expression by nuclear factor κB activation in human umbilical vein endothelial cells显示文摘 | Michael Fritzenwanger Martin Foerster Katharina Meusel Christian Jung Hans R. Figulla | 2008 | Chinese Medical Journal2008，，24： | 2 |
| 6 | Heterotic patterns in rapeseed (Brassica napus L.) using exotic germplasm for Chinese semi-winter hybrid breeding显示文摘Chinese semi-winter rapeseed,genetically differing from winter and spring rapeseed,has been considered to possess strong potential as parent in winter and spring rapeseed hybrid breeding programs. However,no detailed researches have been documented whether winter and spring rapeseed lines have potential for Chinese semiwinter rapeseed hybrid breeding. The objectives of this study are to estimate the potential of winter and spring rapeseed for semi-winter rapeseed hybrid breeding,and to investigate the association of general combining ability(GCA) with adaptation of parental lines by combining with the data in our previous studies. Four winter and four spring male sterile lines were crossed with 14 Chinese semi-winter rapeseed lines to develop 112 hybrids,which were evaluated together with their parents for seed yield under three environments in China. The exotic parental lines were not adapted to local environment as demonstrated by late flowering,low seed weight and poor seed yield per se. However,the hybrids,especially derived from winter rapeseed exhibited strong heterosis for seed yield,indicating that winter rapeseed germplasm has a great potential for rapeseed hybrid breeding in China. Our data suggested a strong association of GCA with their adaptation ability of parental lines,since high to middle correlations were found for local parental lines and low correlations for exotic parental lines under spring,winter and semi-winter eco-growth environments. The hybrid breeding program using exotic germplasm in rapeseed was discussed. | Qian Lunwen Chen Lunlin Mei Jiaqin Li Maoteng Martin Frauen Christian Jung Qian Wei Meng Jinling | 2013 | Engineering Sciences2013，11，5： | 2 |
| 7 | Lane following and lane departure using a linear-parabolic model 显示文摘 | Clatudio Rosito Jung Christian Roberto Kelber | 2005 | Image and VisionComputing(S0262-8856)2005，23，13： | 1 |
| 8 | Sporamin-mediated resistance to beet cyst nematodes (Heterodera schachtii Schm.) is dependent on trypsin inhibitory activity in sugar beet (Beta vulgaris L.) hairy roots显示文摘 | Daguang Cai Tim Thurau Yanyan Tian Tina Lange Kai-Wun Yeh Christian Jung | 2003 | Plant Molecular Biology2003，，6： | 1 |
| 9 | Impact of diabetes mellitus and its complications: survival and quality-of-life in critically ill patients显示文摘 | Katharina Bannier Michael Lichtenauer Marcus Franz Michael Fritzenwanger Bjoern Kabisch Hans-Reiner Figulla Ruediger Pfeifer Christian Jung | 2015 | Journal of Diabetes and Its Complications2015，，8： | 1 |
| 10 | Lane following and lane departure using a linear-parabolic model显示文摘 | Claudio Rosito Jung Christian Roberto Kelber | 2005 | Image and Vision Computing2005，23，13： | 1 |
| 11 | Late onset oral treatment with tranilast following large myocardialinfarction has no beneficial effects on cardiac remodeling and mortality in rats显示文摘 | Stefan Betge Christian Kunz Hans Figulla Christian Jung | 2014 | Experimental and Therapeutic Medicine2014，，6： | 1 |
| 12 | Superselective arterial embolisation with a liquid polyvinyl alcohol copolymer in patients with acute gastrointestinal haemorrhage显示文摘 | Markus Lenhart Christian Paetzel Michael Sackmann Hans Schneider Ernst Michael Jung Andreas G. Schreyer Stefan Feuerbach Niels Zorger | 2010 | European Radiology2010，，8： | 1 |
| 13 | Engineering nematode resistance in crop species显示文摘 | Christian Jung Daguang Cai Michael Kleine | 1998 | Trends in Plant Science1998，，7： | 1 |
| 14 | The promoter of the nematode resistance gene Hs1 pro?1 activates a nematode-responsive and feeding site-specific gene expression in sugar beet ( Beta vulgaris L.) and Arabidopsis thaliana显示文摘 | Tim Thurau Sirak Kifle Christian Jung Daguang Cai | 2003 | Plant Molecular Biology2003，，3： | 1 |
| 15 | Heat shock protein 27 as a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma显示文摘 | Claus Sch?fer Hendrik Seeliger Dominik C. Bader Gerald Assmann Denise Buchner Yang Guo Andreas Ziesch Andreas Palagyi Stephanie Ochs Rüdiger P. Laubender Andreas Jung Enrico N. De Toni Thomas Kirchner Burkhard G?ke Christiane Bruns Eike Gallmeier | 2012 | Journal of Cellular and Molecular Medicine2012，，8： | 1 |
| 16 | High-resolution mapping of YACs and the single-copy gene Hs1pro?1 on Beta vulgaris chromosomes by multi-colour fluorescence in situ hybridization显示文摘 | Christine Desel Christian Jung Daguang Cai Michael Kleine Thomas Schmidt | 2001 | Plant Molecular Biology2001，，1： | 1 |
| 17 | Selection, Characterization and X-ray Structure of Anti-ampicillin Single-chain Fv Fragments from Phage-displayed Murine Antibody Libraries显示文摘 | J?rg Burmester Silvia Spinelli Luisa Pugliese Anke Krebber Annemarie Honegger Sabine Jung Bernhard Schimmele Christian Cambillau Andreas Plückthun | 2001 | Journal of Molecular Biology2001，，3： | 1 |
| 18 | AFLP markers tightly linked to sex locua in Aspcoragus officinalis L显示文摘 | Stella Marie Remon Butter Jorg Schondel Marie Christian Jung | 1998 | Morlecular Breeding1998，4，： | 1 |
| 19 | Lane Following and Lane Departure Using s Linear-parabolic Model显示文摘 | Cláudio Rosito Jung Christian Roberto Kelber | 2005 | Image and Vision Computing2005，23，13： | 1 |
| 20 | Superselective arterial embolisation with a liquid polyvinyl alcohol copolymer in patients with acute gastrointestinal haemorrhage显示文摘 | Markus Lenhart Christian Paetzel Michael Sackmann Hans Schneider Ernst Michael Jung Andreas G. Schreyer Stefan Feuerbach Niels Zorger | 2010 | European Radiology2010，，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员