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| 1 | The HuangZaoSi Maize Genome Provides Insights into Genomic Variation and Improvement History of Maize显示文摘Maize is a globally important crop that was a classic model plant for genetic studies. Here, we report a 2.2 Gb draft genome sequence of an elite maize line, HuangZaoSi (HZS). Hybrids bred from HZS-improved lines (HILs) are planted in more than 60% of maize fields in China. Proteome clustering of six completed sequeneed maize genomes show that 638 proteins fall into 264 HZS-specific gene families with the majority of contributions from tandem duplication events. Resequencing and comparative analysis of 40 HZSrelated lines reveals the breeding history of HILs. More than 60% of identified selective sweeps were clustered in identity.by.descent conserved regions, and yield-related genes/QTLs were enriched in HZS characteristic selected regions. Furthermore, we dem on strated that HZS-specific family genes were not uniformly distributed in the genome but enriched in improvement/function.related genomic regions. This study provides an important and novel resource for maize genome research and expands our knowledge on the breadth of genomic variation and improvement history of maize. | Chunhui Li Wei Song Yingfeng Luo Shenghan Gao Ruyang Zhang Zi Shi Xiaqing Wang Ronghuan Wang Fengge Wang Jidong Wang Yanxin Zhao Aiguo Su Shuai Wang Xin Li Meijie Luo Shuaishuai Wang Yunxia Zhang Jianrong Ge Xinyu Tan Ye Yuan Xiaochun Bi Hang He Jianbing Yan Yuandong Wang Songnian Hu Jiuran Zhao | 2019 | Molecular Plant2019，12，3： | 15 |
| 2 | Nodeless superconductivity in the kagome metal CsV_(3)Sb_(5)显示文摘The recently discovered kagome metal series AV3Sb5(A=K, Rb, Cs) exhibits topologically nontrivial band structures, chiral charge order and superconductivity, presenting a unique platform for realizing exotic electronic states. The nature of the superconducting state and the corresponding pairing symmetry are key questions that demand experimental clarification. Here, using a technique based on the tunneling diode oscillator, the magnetic penetration depth ?λ(T) of CsV3Sb5 was measured down to 0.07 K. A clear exponential behavior in ?λ(T) with marked deviations from a T or T2 temperature dependence was observed at low temperatures, indicating an absence of nodal quasiparticles. Temperature dependence of the superfiuid density and electronic specific heat can be described by two-gap s-wave superconductivity, consistent with the presence of multiple Fermi surfaces in CsV3Sb5. These results evidence nodeless superconductivity in CsV3Sb5 under ambient pressure, and constrain the allowed pairing symmetry. | Weiyin Duan Zhiyong Nie Shuaishuai Luo Fanghang Yu Brenden R.Ortiz Lichang Yin Hang Su Feng Du An Wang Ye Chen Xin Lu Jianjun Ying Stephen DWilson Xianhui Chen Yu Song Huiqiu Yuan | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，10： | 3 |
| 3 | Comparative study of big data of global adakites and mineralization-related granite in the Geza arc metallogenic belt, northwest Yunnan, Southwest China显示文摘The Geza arc is an important part of the Sanjiang tectono-magmatic belt and is a newly discovered copper polymetallic ore concentration area in northwest Yunnan province,Southwest China.The area comprises numerous metal ore deposits,including one super-largedeposit,three large deposits,etc.The formation of these deposits was closely related to intermediate–acidic magmatic intrusions.Based on previous studies,the“big data”analysis technique was used for a comparative study of large geochemical datasets of granite related to ore-formation in the Geza porphyry copper deposit and global adakites.As a result,1313 element combinations and 127,765 overlap ratios were obtained.The results show that the Geza porphyry has similar geochemical characteristics to global adakites(the ratios of REE and Ga to major elements are in the range of global adakites).However,theCu,Mo,and Zn contents of the porphyry are significantly higher than those of global adakites,and the porphyry may,therefore,represent an end-member of the global range of adakite composition.In addition,the geochemistry of adakites associated with the porphyry copper deposits overlaps in part with that of global adakites,although most of the data lie outside of the range of global adakites(i.e.lowMn/Cu,Sr/Cu,Na/Cu,and Zr/Cu values,and high Th/Cu,Ba/Cu,Na/Mo,Rb/Mo,Th/Mo,Ta/Mo,Ba/Mo,Mn/Zn,and Ba/Znvalues).The samples with characteristics that deviate significantly from the geochemistry of global adakites show more advanced mineralization and alteration,and a stronger relationship with Cu and Momineralization.The results of geochemical data mining can be used as a prospecting indicator,and provide a new scientific basis for geological prospecting of the deep levels and per-iphery of the Geza Cu polymetallic ore belt. | Liu Xuelong Li Wenchang Zhang Qi Zhang Na Zhang Changzhen Luo Ying Wang Shuaishuai Yang Fucheng Chen Jianhang Li Zhenhuan | 2018 | Big Earth Data2018，2，3： | 1 |
| 4 | Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1显示文摘Macrophages in tumors(tumor-associated macrophages,TAMs),a major population within most tumors,play key homeostatic functions by stimulating angiogenesis,enhancing tumor cell growth,and suppressing antitumor immunity.Resetting TAMs by simple,efficacious and safe approach(s)is highly desirable to enhance antitumor immunity and attenuate tumor cell malignancy.Previously,we used tumor cell-derived microparticles to package chemotherapeutic drugs(drug-MPs),which resulted in a significant treatment outcome in human malignant pleural effusions via neutrophil recruitments,implicating that drug-MPs might reset TAMs,considering the inhibitory effects of M2 macrophages on neutrophil recruitment and activation.Here,we show that drug-MPs can function as an antitumor immunomodulator by resetting TAMs with M1 phenotype and IFN-βrelease.Mechanistically,drug molecules in tumor MPs activate macrophage lysosomal P450 monooxygenases,resulting in superoxide anion formation,which further amplifies lysosomal ROS production and pH value by activating lysosomal NOX2.Consequently,lysosomal Ca^(2+)signaling is activated,thus polarizing macrophages towards M1.Meanwhile,the drug molecules are delivered from lysosomes into the nucleus where they activate DNA sensor hnRNPA2B1 for IFN-βproduction.This lysosomal-nuclear machinery fully arouses the antitumor activity of macrophages by targeting both lysosomal pH and the nuclear innate immunity.These findings highlight that drug-MPs can act as a new immunotherapeutic approach by revitalizing antitumor activity of macrophages.This mechanistic elucidation can be translated to treat malignant ascites by drug-MPs combined with PD-1 blockade. | Keke Wei Huafeng Zhang Shuaishuai Yang Yuxiao Cui Bingxia Zhang Jincheng Liu Liang Tang Yaoyao Tan Simin Liu Shiqi Chen Wu Yuan Xiao Luo Chen Chen Fei Li Junwei Liu Jie Chen Pingwei Xu Jiadi Lv Ke Tang Yi Zhang Jingwei Ma Bo Huang | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 5 | Configuring topologically optimum vapor recompressed dividing-wall distillation columns to maximize operating efficiency显示文摘For dividing-wall distillation columns(DWDCs) separating a heavy-component dominated and wide boiling-point ternary(HCDWBT) mixture, a significant amount of excessive heat exists inevitably in stripping the heavy-component from the intermediate-component and it can be employed to initiate the development of vapor recompression heat pump(VRHP) assisted DWDC(VRHP-DWDC). Despite dividing wall may locate in the top, middle, and bottom, the optimum VRHP-DWDC is found to involve uniformlytwo VRHP circles. While the first one serves to compress and transform the excessive heat resulted from the separation of the heavy-component from the intermediate-component, the second one to compress and transform the overhead vapor stream of the light-component pre-heated sequentially with the condensate from the first one and the bottom product stream of the heavy-component, both releasing the temperature-elevated latent heat to the pre-fractionator's or common stripping section. The processing of two HCDWBT mixtures of benzene/toluene/o-xylene and n-pentane/n-hexane/n-heptane are selected to assess the derived optimum topological configurations of the VRHP-DWDC and their optimality is confirmed through detailed comparisons with the DWDC and two VRHP-DWDCs involving only one VRHP circle. The proposed strategy helps to tap the full potential of the VRHP-DWDC with considerably alleviated complication in process development. | Kejin Huang Shuaishuai Han Lijing Zang Haisheng Chen Yihang Luo Liang Zhang Yang Yuan Xing Qian Shaofeng Wang | 2023 | Chinese Journal of Chemical Engineering2023，57，5： | 0 |
| 6 | Development of UAV-based shot seeding device for rice planting显示文摘In order to realize the high-quality row seeding operation with unmanned aerial vehicle(UAV)in paddy field,a shot seeding device that can sow five rows of pelleted rice seeds at the same time was designed.The shot seeding device mainly consists of an external grooved wheel seed metering device and five shot seeding modules.The designed external grooved wheel seed metering device can take the seeds out of the seed box and divide the seeds into five parts.The shot seeding module can accelerate the pelleted rice seeds to reduce the impact of the UAV wind on the direction of seed movement.Furthermore,an angle adjustment mechanism for the shot seeding module was used to change the row spacing.The seed metering device test verified that when the speed of the seed metering wheel was 15 r/min,the coefficient of variation of the discharge rate of each row(C.V1)and total seed discharge rate stability(C.V2)were 1.70%and 1.04%,respectively.Image processing technique was used to test the UAV seeding performance.The distribution characteristics of seeds on the ground showed that the number of seeds in each row gradually increased from both sides to the middle in the width direction.According to the statistics,there were 60%-70%of the seeds in each row in the 100 mm width range.The field test showed that when the working height was 1.5 m and the seeding quantity was 38.56 kg/hm^(2),the performance of sowing in rows was obvious,the deviation rate of seeding quantity was 1.89%.After 16 d of sowing,the seeds’emergence rate was stable,and the average emergence rate was 82.63%and the yield was 6775.50 kg/hm^(2). | Wei Liu Shuaishuai Zou Xuelang Xu Qingyu Gu Weizhuo He Jun Huang Junhao Huang Zichen Lyu Jianqin Lin Zhiyan Zhou Rui Jiang Xiwen Luo | 2022 | International Journal of Agricultural and Biological Engineering2022，15，6： | 0 |
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