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| 1 | Paracrine Receptor Activation by Microenvironment Triggers Bypass Survival Signals and ALK Inhibitor Resistance in EML4-ALK Lung Cancer Cells显示文摘 | Tadaaki Yamada Shinji Takeuchi Junya Nakade Kenji Kita Takayuki Nakagawa Shigeki Nanjo Takahiro Nakamura Kunio Matsumoto Manabu Soda Hiroyuki Mano Toshimitsu Uenaka Seiji Yano | 2012 | Clinical Cancer Research2012，，13： | 1 |
| 2 | Hepatocyte Growth Factor Induces Resistance to Anti-Epidermal Growth Factor Receptor Antibody in Lung Cancer显示文摘 | Tadaaki Yamada Shinji Takeuchi Kenji Kita Hideaki Bando Takahiro Nakamura Kunio Matsumoto Seiji Yano | 2012 | Journal of Thoracic Oncology2012，，2： | 1 |
| 3 | The origin of fluoride-rich groundwater in Mizunami area,Japan:mineralogy and geochemistry implica- tions显示文摘 | Abdelrahman M Abdelgawad Kunio Watanabe Shinji Takeuchi | 2009 | Engineering Geology2009，108，： | 1 |
| 4 | Back-analysis for tunnel engineering as a modern observational method显示文摘 | Sakurai S Akutagawa S Takeuchi R Shinji M Shimizu N | | 0，，2： | 1 |
| 5 | Rheoloical Properties of Reversible Thermo-setting in Situ Delling Solution with the Methylce Llulose-polyethylene Glycol-citric Acid Ternary System 显示文摘 | Masanobu Takeuchi Shinji Kageyama Hidekazu Suzukietal | 2002 | Colloid & Polymer Science2002，281，12： | 1 |
| 6 | Development of electric power steering system with H∞ control 显示文摘 | Toshio Kohno Shinji Takeuchi Minekazu Moniyama | 2000 | SAE paper2000，，： | 1 |
| 7 | Phase II trial of carboplatin, S-1, and gefitinib as first-line triplet chemotherapy for advanced non-small cell lung cancer patients with activating epidermal growth factor receptor mutations显示文摘 | Akihiro Tamiya Motohiro Tamiya Takayuki Shiroyama Nobuhiko Saijo Takeshi Nakatani Shojiro Minomo Taisuke Tsuji Naoko Takeuchi Naoki Omachi Kanako Kurata Hidekazu. Suzuki Norio Okamoto Kyoichi Okishio Tomonori Hirashima Shinji Atagi | 2015 | Medical Oncology2015，，3： | 1 |
| 8 | Severe degenerative change of multiple organs mediated by chronic active Epstein–Barr virus infection with infected T-cell expansion显示文摘 | Michihide Tokuhira Atsushi Iizuka Reiko Watanabe Naoya Sekiguchi Norihide Sato Chen-Kang Chien Yasunobu Sekiguchi Tomoe Nemoto Kyoko Hanzawa Jun-ichi Tamaru Shinji Itoyama Hiroshi Suzuki Tsutomu Takeuchi Shigehisa Mori Masahiro Kizaki | 2008 | International Journal of Hematology2008，，5： | 1 |
| 9 | Hepatocyte Growth Factor Expression in EGFR Mutant Lung Cancer with Intrinsic and Acquired Resistance to Tyrosine Kinase Inhibitors in a Japanese Cohort显示文摘 | Seiji Yano Tadaaki Yamada Shinji Takeuchi Keisei Tachibana Yuko Minami Yasushi Yatabe Tetsuya Mitsudomi Hidenori Tanaka Tatsuo Kimura Shinzoh Kudoh Hiroshi Nokihara Yuichiro Ohe Jun Yokota Hidetaka Uramoto Kosei Yasumoto Katsuyuki Kiura Masahiko Higashiya | 2011 | Journal of Thoracic Oncology2011，，12： | 1 |
| 10 | Screening for Estrogen and Androgen Receptor Activities in 200Pesticides by In Vitro Reporter Gene Assays Using Chinese Hamster Ovary Cells 显示文摘 | Hiroyuki Kojima Eiji Katsura Shinji Takeuchi | 2004 | Environmental Health Perspectives2004，112，5： | 1 |
| 11 | Photocatalytic degradation of gaseous sulfur compounds by silver-deposited titanium dioxide显示文摘 | Shinji Kato Yuji Hirano Misao Iwata Taizo Sano Koji Takeuchi Sadao Matsuzawa | 2004 | Applied Catalysis B, Environmental2004，，2： | 1 |
| 12 | Rheological properties of reversible thermo-setting in situ gelling solutions with the methylcellulose-polyethylene glycol-citric acid ternary system 显示文摘 | MASANOBU Takeuchi SHINJI Kageyama HIDEKAZU Suzuki | 2003 | Colloid and Polymer Science2003，281，12： | 1 |
| 13 | Methotrexate/iatrogenic lymphoproliferative disorders in rheumatoid arthritis: histology, E pstein– B arr virus, and clonality are important predictors of disease progression and regression显示文摘 | Ayako Ichikawa Fumiko Arakawa Junichi Kiyasu Kensaku Sato Hiroaki Miyoshi Daisuke Niino Yoshizo Kimura Masanori Takeuchi Maki Yoshida Yukinao Ishibashi Shinji Nakashima Yasuo Sugita Osamu Miura Koichi Ohshima | 2013 | Eur J Haematol2013，，1： | 1 |
| 14 | Graft polymerization of vinyl monomers initiated by peroxycarbonate groups introduced onto silica surface by Michael addition 显示文摘 | SHINJI HAYASHI YOSHIHIRO TAKEUCHI MASUMI EGUCHI | 1999 | J Appl Polym Sci1999，71，9： | 1 |
| 15 | Back analysis for tunnel engineering as a modern observational method显示文摘 | Shunsuke Sakurai Shinichi Akutagawa Kunifumi Takeuchi Masato Shinji Norikazu Shimizu | 2003 | Tunnelling and Underground Space Technology incorporating Trenchless Technology Research2003，，2： | 1 |
| 16 | Recent Progress in Plasma Control Studies on the Improvement of Plasma Performance in Heliotron J显示文摘Recent progress in plasma control studies on the improvement of plasma performancein Heliotron J is reviewed.The supersonic molecular beam injection (SMBI)fueling issuccessfully applied to Heliotron J plasma.A supersonic H2-beam is effectively injected to increasefueling efficiency and generate a peaked density profile.Local fueling with a short-pulsedSMBI can increase the core plasma density and avoid the degradation arising from edge cooling.Second harmonic electron cyclotron current drive (ECCD)experiments were conducted by launchinga focused Gaussian beam with a parallel refractive index of-0.05≤N||≤ 0.6.Results showthat the electron cyclotron (EC)driven current is determined not only by N|| but also by localmagnetic field (B)structure where the EC power is deposited.Detailed analysis of the observedN|| and B dependences is in progress with a ray-tracing simulation using the TRAVIS code.Fastion velocity distribution was investigated using fast protons generated by ion cyclotron resonantfrequency (ICRF)minority heating.For the standard configuration in Heliotron J.charge exchangeneutral particle analysis (CX-NPA)measurements show higher effective temperature offast minority protons in the on-axis resonance case compared to that in the HFS (high field side)off-axis resonance case.However,the increase in bulk ion temperature in the HFS resonance caseis larger than that in the on-axis resonance. | Tohru MIZUUCHI Kazunobu NAGASAKI Hiroyuki OKADA Shinji KOBAYASHI Satoshi YAMAMOTO Takashi MINAMI Shinsuke OHSHIMA Masaki TAKEUCHI Kiyofumi MUKAI Hyunyong LEE Linge ZANG Kohta NOMURA Masashige SUWA Kento YAMAMOTO Hiroaki YASHIRO Hayao YOSHINO Shouhei ARAI Tasuku KAGAWA Takayuki MINAMI Kouji MIZUNO Yoshinobu WADA Hiroto WATADA Nobuhiro NISHINO Yosuke NAKASHIMA Kiyoshi HANATANI Yuji NAKAMURA Shigeru KONOSHIMA Fumimichi SANO | 2011 | Plasma Science and Technology2011，13，1： | 0 |
| 17 | Dedifferentiated chondrosarcoma of the middle finger arising from a solitary enchondroma:A case report显示文摘BACKGROUND Dedifferentiated chondrosarcoma(DDCS)accounts for 10%of all chondrosarcomas and has the poorest outcome,with a 5-year survival rate of 7%-25%.DDCS commonly occurs in the femur and pelvis,whereas DDCS of the finger is extremely rare.Furthermore,the histological findings of preexisting solitary enchondroma samples are important and valuable for diagnosing malignant transformations.CASE SUMMARY We report our experience with DDCS in the proximal phalanx of the left middle finger of an 87-year-old woman.She had undergone surgery for enchondroma,with curettage and artificial bone grafting,11 years ago,in the same location.Several years after the primary surgery,the left middle finger gradually started to enlarge,and the growth speed increased in the past year.Plain radiographs showed an expansive osteolytic lesion with calcifications and residual grafting material.Owing to the suspicion of malignancy,we performed ray amputation.Histological findings revealed an abrupt transition between the low-grade chondrosarcoma and dedifferentiated sarcoma components.The dedifferentiated components showed the features of a high-grade undifferentiated pleomorphic sarcoma.The patient was diagnosed with DDCS arising from a preexisting enchondroma.She had no local recurrence or distant metastasis and died of pneumonia 6 years and 10 months after the second surgery.CONCLUSION The histological findings of a precursor lesion showed a typical enchondroma,suggesting that DDCS can arise from enchondroma. | Hirotaka Yonezawa Norio Yamamoto Katsuhiro Hayashi Akihiko Takeuchi Shinji Miwa Kentaro Igarashi Sei Morinaga Yohei Asano Shiro Saito Yasunori Tome Hiroko Ikeda Takayuki Nojima Hiroyuki Tsuchiya | 2022 | World Journal of Clinical Cases2022，10，10： | 0 |
| 18 | Long-term survival in a patient with Hutchinson-Gilford progeria syndrome and osteosarcoma:A case report显示文摘BACKGROUND Hutchinson-Gilford progeria syndrome(HGPS)is an extremely rare disease characterized by the rapid appearance of aging with an onset in childhood.Serious cardiovascular complications can be life-threatening events for affected patients and the cause of early death.Herein we report a HGPS patient with osteosarcoma hat was successfully managed and is alive 13 years after the diagnosis.This is the first report describing the detailed surgical procedure and long-term follow-up of osteosarcoma in a patient with HGPS.CASE SUMMARY The patient was diagnosed with HGPS at 5 years of age with typical features and was referred to our department with a suspected bone tumor of the left proximal tibia at the age of 18.Open biopsy of the tibial bone tumor revealed a conventional fibroblastic osteosarcoma.We have developed and performed a freezing technique using liquid nitrogen for tumor reconstruction.This technique overcame the small size of the tibia for megaprosthesis and avoided amputation and limb salvage was achieved 13 years post-operatively.Although the patient had a number of surgical site complications,such as wound dehiscence,and superficial and deep infections due to vulnerable skin in HGPS,no recurrence or metastases were detected for 13 years,and she walks assisted by crutches.Her general health was good at the latest follow-up at 31 years of age.CONCLUSION A HGPS patient with osteosarcoma was successfully managed and she was alive 13 years after the diagnosis. | Katsuhiro Hayashi Norio Yamamoto Akihiko Takeuchi Shinji Miwa Kentaro Igarashi Yoshihiro Araki Hirotaka Yonezawa Sei Morinaga Yohei Asano Hiroyuki Tsuchiya | 2021 | World Journal of Clinical Cases2021，9，4： | 0 |
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