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| 1 | 为表面的食道的有鳞的房间瘤的内视镜的 submucosal 解剖显示文摘 Endoscopic resection is an effective treatment for noninvasive esophageal squamous cell neoplasms(ESCNs).Endoscopic mucosal resection(EMR)has been developed for small localized ESCNs as an alternative to surgical therapy because it shows similar effectiveness and is less invasive than esophagectomy.However,EMR is limited in resection size and therefore piecemeal resection is performed for large lesions,resulting in an imprecise histological evaluation and a high frequency of local recurrence.Endoscopic submucosal dissection(ESD)has been developed in Japan as one of the standard endoscopic resection techniques for ESCNs.ESD enables esophageal lesions,regardless of their size,to be removed en bloc and thus has a lower local recurrence rate than EMR.The development of new devices and the establishment of optimal strategies for esophageal ESD have resulted in fewer complications such as perforation than expected.However,esophageal stricture after ESD may occur when the resected area is larger than three-quarters of the esophageal lumen or particularly when it encompasses the entire circumference;such a stricture requires multiple sessions of endoscopic balloon dilatation.Recently,oral prednisolone has been reported to be useful in preventing post-ESD stricture.In addition,a combination of chemoradiotherapy(CRT)and ESD might be an alternative therapy for submucosal esophageal cancer that has a risk of lymph node metastasis because esophagectomy is extremely invasive;CRT has a higher local recurrence rate than esophagectomy but is less invasive.ESD is likely to play a central role in the treatment of superficial esophageal squamous cell neoplasms in the future. | Kuniomi Honda Hirotada Akiho | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，2： | 18 |
| 2 | Novel strategies for the treatment of inflammatory bowel disease: Selective inhibition of cytokines and adhesion molecules显示文摘煽动性的肠疾病(IBD ) 的病原学还没被澄清了,非明确地减少发炎和免疫的抑制免疫力的代理人为 IBD 在常规治疗被使用了。证据显示在 IBD 的内脏的粘膜免疫的 dysregulation 引起煽动性的 cytokines 和受动器白血球的交通国王的生产过剩进肠,因此导致不受管束的肠的发炎。在 IBD 的致病的理解的如此的最近的进展创造了明确地禁止涉及煽动性的串联的分子的新奇生物制品疗法的一个最近的趋势。为如此的处理的主要目标是煽动性的 cytokines 和他们的受体,和粘附分子。妄想的 anti-TNF-alpha 单音的同种细胞的抗体, infliximab,为 CD 成为了标准治疗,它也是可能的为 UC 有益。几 anti-TNF 试剂被开发了,但是他们中的大多数似乎不象 infliximab 一样有效。人性化的 anti-TNF 单音的同种细胞的抗体, adalimumab 可能为输了的病人的治疗是有用的应答的海角或发达不耐到 infliximab。对 IL-12 p40 和 IL-6 受体的抗体能是为 IBD 的其他的新 anti-cytokine 治疗。Anti-interferon-gamma 和 anti-CD25 治疗被开发,但是这些代理人的利益还没被建立了。进肠的白细胞移行的选择堵住似乎是一条好途径。对 alpha4 integrin 和 alpha4beta7 integrin 的抗体为 IBD 显示出利益。细胞间的粘附分子 1 的 Antisense oligonucleotide (ICAM-1 ) 可能为 IBD 是有效的。如此的混合物的临床的试用最近也被报导了或当前是在进行之中的。在这篇文章,我们为 IBD 考察如此的新奇生物制品疗法的功效和安全。 | Kazuhiko Nakamura Kuniomi Honda Takahiro Mizutani Hirotada Akiho Naohiko Harada | 2006 | World Journal of Gastroenterology2006，12，29： | 18 |
| 3 | Low-grade inflammation plays a pivotal role in gastrointestinal dysfunction in irritable bowel syndrome显示文摘The pathogenesis of irritable bowel syndrome (IBS) is considered to be multifactorial and includes psychosocial factors, visceral hypersensitivity, infection, microbiota and immune activation. It is becoming increasingly clear that low-grade inflammation is present in IBS patients and a number of biomarkers have emerged. This review describes the evidence for low-grade inflammation in IBS and explores its mechanism with particular focus on gastrointestinal motor dysfunction. Understanding of the immunological basis of the altered gastrointestinal motor function in IBS may lead to new therapeutic stra- tegies for IBS. | Hirotada Akiho Eikichi Ihara Kazuhiko Nakamura | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，3： | 13 |
| 4 | Acute pancreatitis associated with peroral double-balloon enteroscopy: A case report显示文摘人有的一个 58 岁的日本人逗留凳子和严重贫血症。既不上面也不更低胃肠(官方补给) 内视镜检查法显示出任何局部性的损害。因此,他的官方补给的流血的来源被怀疑在小肠,并且他用 EN-450T5 每口头的双汽球肠寄生物(DBE ) 经历了(Fujinon 东芝 ES 系统公司,东京,日本) 。没有损害,考虑是官方补给的流血的来源。在过程以后,病人开始经历了腹的疼痛。实验室测试揭示了血淀粉酶过多,腹的计算断层摄影术揭示了胰和仙子胰的发炎。他因此被诊断有尖锐胰腺炎。保守疗法导致了临床并且实验室改善。他没有白酒摄取,胆石疾病或胰腺炎的历史。磁性的回声 cholangiopancreatography 没在 pancreatobiliary 管的系统表明结构的改变和没有石头。当他的腹的疼痛在过程以后开始了,他的尖锐胰腺炎因此被认为与 per 有关是口头的 DBE。这是可能与联系的尖锐胰腺炎的首先报导的案例每口头的 DBE。 | Kuniomi Honda Takahiro Mizutani Kazuhiko Nakamura Naomi Higuchi Kenji Kanayama Yorinobu Sumida Shigetaka Yoshinaga Soichi Itaba Hirotada Akiho Ken Kawabe Yoshiyuki Arita Tetsuhide Ito | 2006 | World Journal of Gastroenterology2006，12，11： | 11 |
| 5 | Promising biological therapies for ulcerative colitis: A review of the literature显示文摘Ulcerative colitis(UC) is a chronic lifelong condition characterized by alternating flare-ups and remission. There is no single known unifying cause, and the pathogenesis is multifactorial, with genetics, environmental factors, microbiota, and the immune system all playing roles. Current treatment modalities for UC include 5-aminosalicylates, corticosteroids, immunosuppressants(including purine antimetabolites, cyclosporine, and tacrolimus), and surgery. Therapeutic goals for UC are evolving. Medical treatment aims to induce remission and prevent relapse of disease activity. Infliximab, an anti-tumor necrosis factor(TNF)-α monoclonal antibody, is the first biological agent for the treatment of UC. Over the last decade, infliximab and adalimumab(anti-TNF-α agents) have been used for moderate to severe UC, and have been shown to be effective in inducing and maintaining remission. Recent studies have indicated that golimumab(another anti-TNF-α agent), tofacitinib(a Janus kinase inhibitor), and vedolizumab and etrolizumab(integrin antagonists), achieved good clinical remission and response rates in UC. Recently, golimumab and vedolizumab have been approved for UC by the United States Food and Drug Administration. Vedolizumab may be used as a first-line alternative to anti-TNF-α therapy in patients with an inadequate response to corticosteroids and/or immunosuppressants. Here, we provide updated information on various biological agents in the treatment of UC. | Hirotada Akiho Azusa Yokoyama Shuichi Abe Yuichi Nakazono Masatoshi Murakami Yoshihiro Otsuka Kyoko Fukawa Mitsuru Esaki Yusuke Niina Haruei Ogino | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 8 |
| 6 | Cytokine-induced alterations of gastrointestinal motility in gastrointestinal disorders显示文摘Inflammation and immune activation in the gut are usually accompanied by alteration of gastrointestinal(GI) motility.In infection,changes in motor function have been linked to host defense by enhancing the expulsion of the infectious agents.In this review,we describe the evidence for inflammation and immune activation in GI infection,inflammatory bowel disease,ileus,achalasia,eosinophilic esophagitis,microscopic colitis,celiac disease,pseudo-obstruction and functional GI disorders. We also describe the possible mechanisms by which inflammation and immune activation in the gut affect GI motility.GI motility disorder is a broad spectrum disturbance of GI physiology.Although several systems including central nerves,enteric nerves,interstitial cells of Cajal and smooth muscles contribute to a coordinated regulation of GI motility,smooth muscle probably plays the most important role.Thus,we focus on the relationship between activation of cytokines induced by adaptive immune response and alteration of GI smooth muscle contractility.Accumulated evidence has shownthat Th1 and Th2 cytokines cause hypocontractility and hypercontractility of inflamed intestinal smooth muscle. Th1 cytokines downregulate CPI-17 and L-type Ca 2+ channels and upregulate regulators of G protein signaling 4,which contributes to hypocontractility of inflamed intestinal smooth muscle.Conversely,Th2 cytokines cause hypercontractilty via signal transducer and activator of transcription 6 or mitogen-activated protein kinase signaling pathways.Th1 and Th2 cytokines have opposing effects on intestinal smooth muscle contraction via 5-hydroxytryptamine signaling.Understanding the immunological basis of altered GI motor function could lead to new therapeutic strategies for GI functional and inflammatory disorders. | Hirotada Akiho Eikichi Ihara Yasuaki Motomura Kazuhiko Nakamura | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，5： | 8 |
| 7 | Improved techniques for double-balloon-enteroscopy-assisted endoscopic retrograde cholangiopancreatography显示文摘AIM: To investigate the clinical outcome of double balloon enteroscopy (DBE)-assisted endoscopic retrograde cholangiopancreatography (DB-ERCP) in patients with altered gastrointestinal anatomy. METHODS: Between September 2006 and April 2011, 47 procedures of DB-ERCP were performed in 28 patients with a Roux-en-Y total gastrectomy (n = 11), Billroth Ⅱ gastrectomy (n = 15), or Roux-en-Y anastomosis with hepaticojejunostomy (n = 2). DB-ERCP was performed using a short-type DBE combined with several technical innovations such as using an endoscope attachment, marking by submucosal tattooing,selectively applying contrast medium, and CO2 insufflations. RESULTS: The papilla of Vater or hepaticojejunostomy site was reached in its entirety with a 96% success rate (45/47 procedures). There were no significant differences in the success rate of reaching the blind end with a DBE among Roux-en-Y total gastrectomy (96%), Billroth Ⅱ reconstruction (94%), or pancreatoduodenectomy (100%), respectively (P = 0.91). The total successful rate of cannulation and contrast enhancement of the target bile duct in patients whom the blind end was reached with a DBE was 40/45 procedures (89%). Again, there were no significant differences in the success rate of cannulation and contrast enhancement of the target bile duct with a DBE among Roux-en-Y total gastrectomy (88 %), Billroth Ⅱ reconstruction (89%), or pancreatoduodenectomy (100%), respectively (P = 0.67). Treatment was achieved in all 40 procedures (100%) in patients whom the contrast enhancement of the bile duct was successful. Common endoscopic treatments were endoscopic biliary drainage (24 procedures) and extraction of stones (14 procedures). Biliary drainage was done by placement of plastic stents. Stones extraction was done by lithotomy with the mechanical lithotripter followed by extraction with a basket or by the balloon pull-through method. Endoscopic sphincterotomy was performed in 14 procedures with a needle precutting knife using a guidewire. The mean total duration of the procedure was 93.6 ± 6.8 min and the mean time required to reach the papilla was 30.5 ± 3.7 min. The mean time required to reach the papilla tended to be shorter in Billroth Ⅱ reconstruction (20.9 ± 5.8 min) than that in Roux-en-Y total gastrectomy (37.1 ± 4.9 min) but there was no significant difference (P = 0.09). A major complication occurred in one patient (3.5%); perforation of the long limb in a patient with Billroth Ⅱ anastomosis.CONCLUSION: Short-type DBE combined with several technical innovations enabled us to perform ERCP in most patients with altered gastrointestinal anatomy. | Takashi Osoegawa Yasuaki Motomura Kazuya Akahoshi Naomi Higuchi Yoshimasa Tanaka Terumasa Hisano Souichi Itaba Junya Gibo Mariko Yamada Masaru Kubokawa Yorinobu Sumida Hirotada Akiho Eikichi Ihara Kazuhiko Nakamura | 2012 | World Journal of Gastroenterology2012，18，46： | 7 |
| 8 | Safety advantage of endocut mode over endoscopic sphincterotomy for choledocholithiasis显示文摘瞄准:评估一个自动地控制的切割系统(endocut 模式) 是否能与常规混合切割模式相比在 EST 以后减少内视镜的括约肌切开术(EST ) 和浆液血淀粉酶过多的复杂并发症率。方法:从 2001 年 1 月到 2003 年 10 月,有胆总管石病的 134 个病人在括约肌切开术的时候被分到任何一个 endocut 模式组或常规混合切割模式组。二个组回顾地在 EST 和浆液淀粉酶以后为复杂并发症被比较水平在前和在过程以后的 24 h。结果:对待的 134 个病人, 79 被分到常规混合切割模式组, 55 组织到 endocut 模式。在年龄,性别,和在在二个组之间的 EST 前的浆液淀粉酶水平没有有效差量。复杂并发症在 endocut 模式组(9%) 的 5 个病人被发现:血淀粉酶过多(比正常高 5 倍) 在 4 并且在 1 的中等胰腺炎。复杂并发症在常规混合切割模式组(16%) 的 13 个病人被发现:在 12 的血淀粉酶过多和在 1 的中等胰腺炎。浆液淀粉酶层次在两个组被提高在 EST (P<0.02 ) 以后的 24 h。在在常规混合切割模式的 EST 以后的 24 h 组织的平均浆液淀粉酶水平在 endocut 模式组(P<0.05 ) 比那显著地高。结论:Endocut 模式由减少血淀粉酶过多在 EST 以后为胰腺炎在常规混合切割模式上提供一个安全优点。 | Hirotada Akiho Yorinobu Sumida Kazuya Akahoshi Atsuhiko Murata Jiro Ouchi Yasuaki Motomura Taisuke Toyomasu Mitsuhide Kimura Masaru Kubokawa Masahiro Matsumoto Shingo Endo Kazuhiko Nakamura | 2006 | World Journal of Gastroenterology2006，12，13： | 6 |
| 9 | Mucosal-incision assisted biopsy for suspected gastric gastrointestinal stromal tumors显示文摘To evaluate the diagnostic yield of the procedure, mucosal-incision assisted biopsy (MIAB), for the histological diagnosis of gastric gastrointestinal stromal tumor (GIST), we performed a retrospective review of the 27 patients with suspected gastric GIST who underwent MIAB in our hospitals. Tissue samples obtained by MIAB were sufficient to make a histological diagnosis (diagnostic MIAB) in 23 out of the 27 patients, where the lesions had intraluminal growth patterns. Alternatively, the samples were insufficient (non-diagnosticMIAB) in remaining 4 patients, three of whom had gastric submucosal tumor with extraluminal growth patterns. Although endoscopic ultrasound and fine needle aspiration is the gold standard for obtaining tissue specimens for histological and cytological analysis of suspected gastric GISTs, MIAB can be used as an alternative method for obtaining biopsy specimens of lesions with an intraluminal growth pattern. | Eikichi Ihara Hiroshi Matsuzaka Kuniomi Honda Yoshitaka Hata Yorinobu Sumida Hirotada Akiho Tadashi Misawa Satoshi Toyoshima Yoshiharu Chijiiwa Kazuhiko Nakamura Ryoichi Takayanagi | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，4： | 3 |
| 10 | An increase in the serum amylase level in patients after peroral double-balloon enteroscopy: an association with the development of pancreatitis显示文摘 | K. Honda S. Itaba T. Mizutani Y. Sumida K. Kanayama N. Higuchi S. Yoshinaga H. Akiho K. Kawabe Y. Arita T. Ito K. Nakamura R. Takayanagi | 2006 | Endoscopy2006，，10： | 2 |
| 11 | Modulation of intestinal muscle contraction by interleukin-9 (IL-9) or IL-9 neutralization: correlation with worm expulsion in murine nematode infections 显示文摘 | Khan WI Richard M Akiho H | 2003 | Infect Immun2003，71，5： | 1 |
| 12 | High pressure hydropyrolysis of coals by using a continuous free-fall reactor显示文摘 | XU W C MATSUOKA K AKIHO H | 2003 | Fuel2003，82，： | 1 |
| 13 | Randomized controlled trial: roxatidine vs omeprazole for non-erosive reflux disease显示文摘 | NAKAMURA K AKIHO H OCHIAI T | 2010 | Hepatogastroenterology2010，57，99100： | 1 |
| 14 | Mechanisms underlying the maintenance of muscle hypercontractility in a model of postinfective gut dysfunction显示文摘 | Akiho H Deng Y Blennerhassett P | 2005 | Gastroentemlogy2005，129，1： | 1 |
| 15 | The Physical Character of Coal Char Formed During Rapid Pyrolysis at High Pressure显示文摘 | MATSUOKA K AKIHO H XU Weichun | 2005 | Fuel2005，84，： | 1 |
| 16 | Mechanisms underlying the maintenance of muscle hypercontractility in a model of postinfective gut dysfunction显示文摘 | Akiho H Deng Y Blennerhassett P | 2005 | Gastroenterology2005，129，1： | 1 |
| 17 | High Pressure Hydropyrolysis of Coals by Using a Continuous Free-fall Reactor显示文摘 | Xu W C Matsuoka K Akiho H | 2003 | Fuel2003，82，： | 1 |
| 18 | Role of IL-4,IL-13,and STAT6 in inflammation-induced hypercontractility of murine smooth muscle cells显示文摘 | Akiho H Blennerhassett P Deng Y | 2002 | Am J Physiol Gastrointest Liver Physiol2002，282，2： | 1 |
| 19 | High pressure hydropyrolysis of coals by using a continuous free-fall reactor 显示文摘 | XU W C MATSUOKA K AKIHO H | 2003 | Fuel2003，82，6： | 1 |
| 20 | Machanisms underlying the maintenance of muscle hypercontractility in a model of postinfective gut dysfunction 显示文摘 | Akiho H Deng Y Blennerhassett P | 2005 | Gastroenterology2005，129，1： | 1 |
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