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| 1 | Endoscopic submucosal dissection for superficial esophageal neoplasms显示文摘Endoscopic submucosal dissection(ESD) is currently accepted as the major treatment modality for superficial neoplasms in the gastrointestinal tract including the esophagus.An important advantage of ESD is its effectiveness in resecting lesions regardless of their size and severity of fibrosis.Based on excellent outcomes for esophageal neoplasms with a small likelihood of lymph node metastasis,the number of ESD candidates has increased.On the other hand,ESD still requires highly skilled endoscopists due to technical difficulties.To avoid unnecessary complications including perforation and postoperative stricture,the indications for ESD require careful consideration and a full understanding of this modality.This article,in the highlight topic series,provides detailed information on the indication,procedure,outcome,complications and their prevention in ESD of superficial esophageal neoplasms. | Satoshi Ono Mitsuhiro Fujishiro Kazuhiko Koike | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，5： | 32 |
| 2 | Bleeding after endoscopic submucosal dissection: Risk factors and preventive methods显示文摘Endoscopic submucosal dissection(ESD) has become widely accepted as a standard method of treatment for superficial gastrointestinal neoplasms because it enables en block resection even for large lesions or fibrotic lesions with minimal invasiveness, and decreases the local recurrence rate. Moreover, specimens resected in an en block fashion enable accurate histological assessment. Taking these factors into consideration, ESD seems to be more advantageous than conventional endoscopic mucosal resection(EMR), but the associated risks of perioperative adverse events are higher than in EMR. Bleeding after ESD is the most frequent among these adverse events. Although post-ESD bleeding can be controlled by endoscopic hemostasis in most cases, it may lead to serious conditions including hemorrhagic shock. Even with preventive methods including administration of acid secretion inhibitors and preventive hemostasis, post-ESD bleeding cannot be completely prevented. In addition high-risk cases for post-ESD bleeding, which include cases with the use of antithrombotic agents or which require large resection, are increasing. Although there have been many reports about associated risk factors and methods of preventing post-ESD bleeding, many issues remain unsolved. Therefore, in this review, we have overviewed risk factors and methods of preventing post-ESD bleeding from previous studies. Endoscopists should have sufficient knowledge of these risk factors and preventive methods when performing ESD. | Yosuke Kataoka Yosuke Tsuji Yoshiki Sakaguchi Chihiro Minatsuki Itsuko Asada-Hirayama Keiko Niimi Satoshi Ono Shinya Kodashima Nobutake Yamamichi Mitsuhiro Fujishiro Kazuhiko Koike | 2016 | World Journal of Gastroenterology2016，22，26： | 16 |
| 3 | Gastric cancer treated in 2002 in Japan: 2009 annual report of the JGCA nationwide registry显示文摘 | Atsushi Nashimoto Kohei Akazawa Yoh Isobe Isao Miyashiro Hitoshi Katai Yasuhiro Kodera Shunichi Tsujitani Yasuyuki Seto Hiroshi Furukawa Ichiro Oda Hiroyuki Ono Satoshi Tanabe Michio Kaminishi | 2013 | Gastric Cancer2013，，1： | 6 |
| 4 | Survival of geriatric patients after percutaneous endoscopic gastrostomy in Japan显示文摘AIM: To examine the long term survival of geriatric patients treated with percutaneous endoscopic gastrostomy (PEG) in Japan. METHODS: We retrospectively included 46 Japanese community and tertiary hospitals to investigate 931 consecutive geriatric patients (≥ 65 years old) with swallowing difficulty and newly performed PEG between Jan 1st 2005 and Dec 31st 2008. We set death as an outcome and explored the associations among patient’s characteristics at PEG using log-rank tests and Cox proportional hazard models. RESULTS: Nine hundred and thirty one patients were followed up for a median of 468 d. A total of 502 deaths were observed (mortality 53%). However, 99%, 95%, 88%, 75% and 66% of 931 patients survived more than 7, 30, 60 d, a half year and one year, respectively. In addition, 50% and 25% of the patients survived 753 and 1647 d, respectively. Eight deaths were considered as PEG-related, and were associated with lower serum albumin levels (P = 0.002). On the other hand, among 28 surviving patients (6.5%), PEG was removed. In a multivariate hazard model, older age [hazard ratio (HR), 1.02; 95% confidence interval (CI), 1.00-1.03; P = 0.009], higher C-reactive protein (HR, 1.04; 95% CI: 1.01-1.07; P = 0.005), and higher blood urea nitrogen (HR, 1.01; 95% CI: 1.00-1.02; P = 0.003) were significant poor prognostic factors, whereas higher albumin (HR, 0.67; 95% CI: 0.52-0.85; P = 0.001), female gender (HR, 0.60; 95% CI: 0.48-0.75; P < 0.001) and no previous history of ischemic heart disease (HR, 0.69; 95% CI: 0.54-0.88, P = 0.003) were markedly better prognostic factors. CONCLUSION: These results suggest that more than half of geriatric patients with PEG may survive longer than 2 years. The analysis elucidated prognostic factors. | Yutaka Suzuki Seryna Tamez Akihiko Murakami Akihiko Taira Akihiro Mizuhara Akira Horiuchi Chie Mihara Eiji Ako Hirohito Muramatsu Hitoshi Okano Hitoshi Suenaga Kazuaki Jomoto Junya Kobayashi Katsunari Takifuji Kazuhiro Akiyama Koh Tahara Koji Onishi Makoto Shimazaki Masami Matsumoto Masashi Ijima Masato Murakami Masato Nakahori Michiaki Kudo Michio Maruyama Mikako Takahashi Naohiro Washizawa Shigeru Onozawa Satoshi Goshi Satoyoshi Yamashita Shigeki Ono Shin Imazato Shinji Nishiwaki Shuichirou Kitahara Takao Endo Takao Iiri Takeshi Nagahama Takuto Hikichi Tatsuya Mikami Tetsuo Yamamoto Tetsushi Ogawa Tomoko Ogawa Tomoyuki Ohta Toshifumi Matsumoto Toshiroh Kura Tsutomu Kikuchi Tsuyoshi Iwase Tsuyotoshi Tsuji Yukio Nishiguchi Mitsuyoshi Urashima | 2010 | World Journal of Gastroenterology2010，16，40： | 4 |
| 5 | Long-term continuous entecavir therapy in nucleos(t)ide-na?ve chronic hepatitis B patients显示文摘 | Atsushi Ono Fumitaka Suzuki Yusuke Kawamura Hitomi Sezaki Tetsuya Hosaka Norio Akuta Masahiro Kobayashi Yoshiyuki Suzuki Satoshi Saitou Yasuji Arase Kenji Ikeda Mariko Kobayashi Sachiyo Watahiki Rie Mineta Hiromitsu Kumada | 2012 | Journal of Hepatology2012，，3： | 3 |
| 6 | Curative ESD for intraepithelial esophageal carcinoma with leiomyoma mimicking submucosal invasive carcinoma显示文摘This case report presents a 65-year-old man who developed early esophageal cancer with leiomyoma treated by endoscopic submucosal dissection(ESD).There have been several reports of co-existing superficial esophageal cancer and leiomyoma treated by endoscopic mucosal resection.However,there is no previous report describing the co-existing lesion treated by ESD.In order to determine treatment strategies for esophageal cancer,accurate endoscopic evaluation of the cancerous depth is essential.In the present case,the combination of endoscopic ultrasonography and narrow-band imaging system with magnifying endoscopy was extremely useful to evaluate the superficial esophageal cancer with leiomyoma,which lead to the appropriate treatment,ESD. | Keiko Niimi Shinya Kodashima Satoshi Ono Osamu Goto Nobutake Yamamichi Mitsuhiro Fujishiro | 2009 | World Journal of Gastrointestinal Endoscopy2009，1，1： | 3 |
| 7 | Endoscopic Submucosal Dissection of Esophageal Squamous Cell Neoplasms显示文摘 | Mitsuhiro Fujishiro Naohisa Yahagi Naomi Kakushima Shinya Kodashima Yosuke Muraki Satoshi Ono Nobutake Yamamichi Ayako Tateishi Yasuhito Shimizu Masashi Oka Keiji Ogura Takao Kawabe Masao Ichinose Masao Omata | 2006 | Clinical Gastroenterology and Hepatology2006，，6： | 2 |
| 8 | Outcomes of Endoscopic Submucosal Dissection for Colorectal Epithelial Neoplasms in 200 Consecutive Cases显示文摘 | Mitsuhiro Fujishiro Naohisa Yahagi Naomi Kakushima Shinya Kodashima Yosuke Muraki Satoshi Ono Nobutake Yamamichi Ayako Tateishi Masashi Oka Keiji Ogura Takao Kawabe Masao Ichinose Masao Omata | 2007 | Clinical Gastroenterology and Hepatology2007，，6： | 2 |
| 9 | Image-based autonomous navigation of Hayabusa2 using artificial landmarks: The design and brief in-flight results of the first landing on asteroid Ryugu显示文摘Hayabusa2 is an asteroid sample return mission carried out by the Japan Aerospace Exploration Agency.The spacecraft was launched in 2014 and arrived at the target asteroid Ryugu on June 27,2018.During the 1.5-year proximity phase,several critical operations(including two landing/sampling operations)were successfully performed.They were based on autonomous image-based descent and landing techniques.This paper describes an imagebased autonomous navigation scheme of the Hayabusa2 mission using artificial landmarks named target markers(TMs).Its basic algorithm,and the in-flight results of the first touchdown and its rehearsal,are shown. | Naoko Ogawa Fuyuto Terui Yuya Mimasu Kent Yoshikawa Go Ono Seiji Yasuda Kota Matsushima Tetsuya Masuda Hiroki Hihara Junpei Sano Takashi Matsuhisa Satoshi Danno Manabu Yamada Yasuhiro Yokota Yuto Takei Takanao Saiki Yuichi Tsuda | 2020 | Astrodynamics2020，4，2： | 2 |
| 10 | Minimally invasive surgery for resection of duodenal carcinoid tumors: endoscopic full-thickness resection under laparoscopic observation显示文摘 | Hironori Tsujimoto Takashi Ichikura Shigeaki Nagao Tomoki Sato Satoshi Ono Satoshi Aiko Shuichi Hiraki Yoshihisa Yaguchi Naoko Sakamoto Takemaru Tanimizu Junji Yamamoto Kazuo Hase | 2010 | Surgical Endoscopy2010，，2： | 2 |
| 11 | Multicenter study of the long-term outcomes of endoscopic submucosal dissection for early gastric cancer in patients 80 years of age or older显示文摘 | Nobutsugu Abe Takuji Gotoda Toshiaki Hirasawa Shu Hoteya Kenji Ishido Yosuke Ida Hiroyuki Imaeda Eiji Ishii Atsushi Kokawa Chika Kusano Tadateru Maehata Satoshi Ono Hirohisa Takeuchi Masanori Sugiyama Shinichi Takahashi | 2012 | Gastric Cancer2012，，1： | 2 |
| 12 | Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients With Cardiovascular Disease Indicate Myocardial Damage显示文摘 | Yasuhide Kuwabara Koh Ono Takahiro Horie Hitoo Nishi Kazuya Nagao Minako Kinoshita Shin Watanabe Osamu Baba Yoji Kojima Satoshi Shizuta Masao Imai Toshihiro Tamura Toru Kita Takeshi Kimura | 2011 | Circulation: Cardiovascular Genetics2011，，： | 2 |
| 13 | Relationships of early esophageal cancer with human papillomavirus and alcohol metabolism显示文摘BACKGROUND It is well known that an alcohol consumption habit together with inactive heterozygous aldehyde dehydrogenase-2(ALDH2)is an important risk factor for the development of esophageal squamous cell carcinoma(ESCC).It remains controversial whether human papillomavirus(HPV)infection contributes to the occurrence/development of ESCC.There has been no study in which the relationship between ESCC and HPV in addition to alcohol dehydrogenase-1B(ADH1B)and ALDH2 genotypes was evaluated.AIM To evaluate relationships between HPV infection and development of esophageal cancer,particularly early esophageal cancer,based on ADH1B/ALDH2 polymorphisms.METHODS We conducted an exploratory retrospective study using new specimens,and we enrolled 145 patients who underwent endoscopic resection for superficial ESCC and had been observed for more than two years by both physical examination and endoscopic examination in Hokkaido University Hospital.Saliva was collected to analyze genetic polymorphisms of ADH1B/ALDH2.We performed in situ hybridization for resected specimens to detect HPV by using an HPV type 16/18 probe.RESULTS HPV was detected in 15(10.3%)of the 145 patients with ESCC.HPV-positive rates in inactive ALDH2*1/*2 and ALDH2*1/*1+*2/*2 were 10.8%and 9.8%,respectively(P=1.00).HPV-positive rates in slow-metabolizing ADH1B*1/*1 and ADH1B*1/*2+*2/*2 were 12.0%and 10.0%,respectively(P=0.72).HPV-positive rates in the heavy or moderate alcohol consumption group and the light or rare consumption group were 11.1%and 8.7%,respectively(P=0.68).HPV-positive rates in the heavy smoking group and the light or no smoking group were 11.8%and 8.3%,respectively(P=0.59).The 3-year incidence rates of secondary ESCC or head and neck cancer after initial treatment in the HPV-positive and HPVnegative groups were 14.4%and 21.4%(P=0.22),respectively.CONCLUSION In the present situation,HPV status is considered to be less important than other risk factors,such as alcohol consumption,smoking habit,ADH1B/ALDH2 polymorphisms,and HPV status would therefore have no effect on ESCC risk management. | Masaki Inoue Yuichi Shimizu Marin Ishikawa Satoshi Abiko Yoshihiko Shimoda Ikko Tanaka Sayoko Kinowaki Masayoshi Ono Keiko Yamamoto Shoko Ono Naoya Sakamoto | 2020 | World Journal of Gastroenterology2020，26，39： | 2 |
| 14 | Polyglycolic acid sheets and fibrin glue decrease the risk of bleeding after endoscopic submucosal dissection of gastric neoplasms (with video)显示文摘 | Yosuke Tsuji Mitsuhiro Fujishiro Shinya Kodashima Satoshi Ono Keiko Niimi Satoshi Mochizuki Itsuko Asada-Hirayama Rie Matsuda Chihiro Minatsuki Chiemi Nakayama Yu Takahashi Yoshiki Sakaguchi Nobutake Yamamichi Kazuhiko Koike | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 15 | Omentum-preserving gastrectomy for advanced gastric cancer: a propensity-matched retrospective cohort study显示文摘 | Shinichi Hasegawa Chikara Kunisaki Hidetaka Ono Takashi Oshima Shoichi Fujii Masataka Taguri Satoshi Morita Tsutomu Sato Roppei Yamada Norio Yukawa Yasushi Rino Munetaka Masuda | 2013 | Gastric Cancer2013，，3： | 2 |
| 16 | Sessile serrated adenoma detection rate is correlated with adenoma detection rate显示文摘AIM To investigated the association between adenoma detection rate(ADR) and sessile serrated ADR(SSADR) and significant predictors for sessile serrated adenomas(SSA) detection.METHODS This study is a retrospective, single-center analysis. Total colonoscopies performed by the gastroenterologists at the University of Tokyo Hospital between January and December 2014 were retrospectively identified. Polyps were classified as low-grade or high-grade adenoma, cancer, SSA, or SSA with cytological dysplasia, and the prevalence of each type of polyp was investigated. Predictors of adenoma and SSA detection were examined using logistic generalized estimating equation models. The association between ADR and SSADR for each gastroenterologist was investigated by calculating a correlation coefficient weighted by the number of each gastroenterologist's examination.RESULTS A total of 3691 colonoscopies performed by 35 gastroenterologists were assessed. Overall, 978 (26.5%) low-and 84 (2.2%) high-grade adenomas, 81 (2.2%) cancers, 66 (1.8%) SSAs, and 2 (0.1%) SSAs with cytological dysplasia were detected. Overall ADR was 29.5%(men 33.2%, women 23.8%) and overall SSADR was 1.8%(men 1.7%, women 2.1%). In addition, 672 low-grade adenomas (68.8% of all the detected lowgrade adenomas), 58 (69.9%) high-grade adenomas, 29 (34.5%) cancers, 52 (78.8%) SSAs, and 2 (100%) SSAs with cytological dysplasia were found in the proximal colon. Adenoma detection was the only significant predictor of SSA detection (adjusted OR: 2.53, 95%CI: 1.53-4.20; P < 0.001). The correlation coefficient between ADR and SSADR weighted by the number of each gastroenterologist's examinations was 0.606(P < 0.001).CONCLUSION Our results demonstrated that ADR is correlated to SSADR. In addition, patients with adenomas had a higher prevalence of SSAs than those without adenomas. | Daisuke Ohki Yosuke Tsuji Tomohiro Shinozaki Yoshiki Sakaguchi Chihiro Minatsuki Hiroto Kinoshita Keiko Niimi Satoshi Ono Yoku Hayakawa Shuntaro Yoshida Atsuo Yamada Shinya Kodashima Nobutake Yamamichi Yoshihiro Hirata Tetsuo Ushiku Mitsuhiro Fujishiro Masashi Fukayama Kazuhiko Koike | 2018 | World Journal of Gastrointestinal Oncology2018，10，3： | 2 |
| 17 | Video-assisted thoracoscopic surgery for esophageal cancer attenuates postoperative systemic responses and pulmonary complications显示文摘 | Hironori Tsujimoto Risa Takahata Shinsuke Nomura Yoshihisa Yaguchi Isao Kumano Yusuke Matsumoto Kazumichi Yoshida Hiroyuki Horiguchi Shuichi Hiraki Satoshi Ono Junji Yamamoto Kazuo Hase | 2012 | Surgery2012，，5： | 1 |
| 18 | Oral delivery of insulin by using surface coating liposomes: Improvement of stability of insulin in GI tract 显示文摘 | Kazunori I Satoshi Ono Kohji Narioka | 1997 | Int J Pharm1997，157，： | 1 |
| 19 | Fabrication of Bulk Nanocrystalline A1 Electrodeposited From a Dimethylsulfone Bath显示文摘 | Matsui Isao Matsui Ono Satoshi Ono Takigawa Yorinobu Takigawa | 2012 | Sci Eng A2012，550，： | 1 |
| 20 | Pooled analysis of the reports of erlotinib after failure of gefitinib for non-small cell lung cancer显示文摘 | Kyoichi Kaira Tateaki Naito Toshiaki Takahashi Eriko Ayabe Rai Shimoyama Rieko Kaira Akira Ono Satoshi Igawa Takehito Shukuya Haruyasu Murakami Asuka Tsuya Yukiko Nakamura Masahiro Endo Nobuyuki Yamamoto | 2009 | Lung Cancer2009，，1： | 1 |
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