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| 1 | Dehiscence following successful endoscopic closure of gastric perforation during endoscopic submucosal dissection显示文摘Gastric perforation is one of the most serious complications that can occur during endoscopic submucosal dissection(ESD).In terms of the treatment of such perforations,we previously reported that perforations immediately observed and successfully closed with endoclips during endoscopic resection could be managed conservatively.We now report the first case in our medical facility of a gastric perforation during ESD that was ineffectively treated conservatively even after successful endoscopic closure.In December 2006,we performed ESD on a recurrent early gastric cancer in an 81-year-old man with a medical history of laparotomy for cholelithiasis.A perforation occurred during ESD that was immediately observed and successfully closed with endoclips so that ESD could be continued resulting in an en-bloc resection.Intensive conservative management was conducted following ESD,however,an endoscopic examination five days after ESD revealed dehiscence of the perforation requiring an emergency laparotomy. | Masau Sekiguchi Haruhisa Suzuki Ichiro Oda Shigetaka Yoshinaga Satoru Nonaka Makoto Saka Hitoshi Katai Hirokazu Taniguchi Ryoji Kushima Yutaka Saito | 2012 | World Journal of Gastroenterology2012，18，31： | 7 |
| 2 | ARID1A expression in gastric adenocarcinoma:Clinicopathological significance and correlation with DNA mismatch repair status显示文摘AIM:To analyze the mismatch repair(MMR)status and the ARID1A expression as well as their clinicopathological significance in gastric adenocarcinomas.METHODS:We examined the expressions of MMR proteins and ARID1A by immunohistochemistry in consecutive 489 primary gastric adenocarcinomas.The results were further correlated with clinicopathological variables.RESULTS:The loss of any MMR protein expression,indicative of MMR deficiency,was observed in 38cases(7.8%)and was significantly associated with an older age(68.6±9.2 vs 60.4±11.7,P<0.001),a female sex(55.3%vs 31.3%,P=0.004),an antral location(44.7%vs 25.7%,P=0.021),and a differentiated histology(57.9%vs 39.7%,P=0.023).Abnormal ARID1A expression,including reduced or loss of ARID1A expression,was observed in 109 cases(22.3%)and was significantly correlated with lymphatic invasion(80.7%vs 69.5%,P=0.022)and lymph node metastasis(83.5%vs 73.7%,P=0.042).The tumors with abnormal ARID1A expression more frequently indicated MMR deficiency(47.4%vs 20.2%,P<0.001).A multivariate analysis identified abnormal ARID1A expression as an independent poor prognostic factor(HR=1.36,95%CI:1.01-1.84;P=0.040).CONCLUSION:Our observations suggest that the AIRD1A inactivation is associated with lymphatic invasion,lymph node metastasis,poor prognosis,and MMR deficiency in gastric adenocarcinomas. | Ryo Inada Shigeki Sekine Hirokazu Taniguchi Hitoshi Tsuda Hitoshi Katai Toshiyoshi Fujiwara Ryoji Kushima | 2015 | World Journal of Gastroenterology2015，21，7： | 7 |
| 3 | Gastric cancer treated in 2002 in Japan: 2009 annual report of the JGCA nationwide registry显示文摘 | Atsushi Nashimoto Kohei Akazawa Yoh Isobe Isao Miyashiro Hitoshi Katai Yasuhiro Kodera Shunichi Tsujitani Yasuyuki Seto Hiroshi Furukawa Ichiro Oda Hiroyuki Ono Satoshi Tanabe Michio Kaminishi | 2013 | Gastric Cancer2013，，1： | 6 |
| 4 | Safety and feasibility of laparoscopy-assisted distal gastrectomy with suprapancreatic nodal dissection for clinical stage I gastric cancer: a multicenter phase II trial (JCOG 0703)显示文摘 | Hitoshi Katai Mitsuru Sasako Haruhiko Fukuda Kenichi Nakamura Naoki Hiki Makoto Saka Hiroki Yamaue Takaki Yoshikawa Kazuyuki Kojima | 2010 | Gastric Cancer2010，，4： | 4 |
| 5 | Phase II trial of S-1 for neoadjuvant chemotherapy against scirrhous gastric cancer (JCOG 0002)显示文摘 | Taira Kinoshita Mitsuru Sasako Takeshi Sano Hitoshi Katai Hiroshi Furukawa Akira Tsuburaya Isao Miyashiro Masahide Kaji Motoki Ninomiya | 2009 | Gastric Cancer2009，，1： | 3 |
| 6 | Questionnaire survey regarding the current status of superextended lymph node dissection in Japan显示文摘AIM To verify the current status of super-extended lymph node dissection for advanced gastric cancer according to a questionnaire survey.METHODS One-hundred and five institutions responded to the questionnaire.The survey included the following items: Number of experiences,whether performed prophylactically and/or therapeutically,whether preoperative chemotherapy was provided,number of preoperative chemotherapy rounds,and therapeutic options after chemotherapy.RESULTS Eighty-seven of the 105 institutions(83%) had performed D3 gastrectomy in the past or continued to perform D3 gastrectomy at present.However,D3 gastrectomy was rarely performed prophylactically in clinical practice.Seventy-eight institutions(74%) indicated that preoperative chemotherapy with curative intent was required for patients suspected of having para-aortic node(PAN) metastases.After chemotherapy,a D3 gastrectomy was scheduled for patients with a complete or partial response,stable disease,and progressive disease at 36(46%),28(36%),and 13(17%) of the institutions,respectively.CONCLUSION For patients with apparent PAN metastasis,a D3 gastrectomy is typically planned if a few courses of preoperative chemotherapy yield at least a stable disease condition. | Shinji Morita Takeo Fukagawa Hisataka Fujiwara Hitoshi Katai | 2016 | World Journal of Gastrointestinal Oncology2016，8，9： | 3 |
| 7 | Gastric cancer treated in 1991 in Japan: data analysis of nationwide registry显示文摘 | Keiichi Maruyama Michio Kaminishi Ken-ichi Hayashi Yoh Isobe Ichiro Honda Hitoshi Katai Kuniyoshi Arai Yasuhiro Kodera Atsushi Nashimoto | 2006 | Gastric Cancer2006，，2： | 2 |
| 8 | Multicenter study evaluating the clinical performance of the OSNA assay for the molecular detection of lymph node metastases in gastric cancer patients显示文摘 | Koshi Kumagai Noriko Yamamoto Isao Miyashiro Yasuhiko Tomita Hitoshi Katai Ryoji Kushima Hitoshi Tsuda Yuko Kitagawa Hiroya Takeuchi Makio Mukai Masayuki Mano Hidetaka Mochizuki Yo Kato Nariaki Matsuura Takeshi Sano | 2014 | Gastric Cancer2014，，2： | 2 |
| 9 | Billroth 1 versus Roux-en-Y reconstructions: a quality-of-life survey at 5 years显示文摘 | Souya Nunobe Abuchi Okaro Mitsuru Sasako Makoto Saka Takeo Fukagawa Hitoshi Katai Takeshi Sano | 2007 | International Journal of Clinical Oncology2007，，6： | 2 |
| 10 | Identification of Risk Factors for Esophagojejunal Anastomotic Leakage after Gastric Surgery显示文摘 | Yasunori Deguchi Takeo Fukagawa Shinji Morita Masaki Ohashi Makoto Saka Hitoshi Katai | 2012 | World Journal of Surgery2012，，7： | 2 |
| 11 | Correlation between the length of the pyloric cuff and postoperative evaluation after pylorus-preserving gastrectomy显示文摘 | Shinji Morita Mitsuru Sasako Makoto Saka Takeo Fukagawa Takeshi Sano Hitoshi Katai | 2010 | Gastric Cancer2010，，2： | 2 |
| 12 | Function-preserving surgery for gastric cancer显示文摘 | Hitoshi Katai | 2006 | International Journal of Clinical Oncology2006，，5： | 2 |
| 13 | Bone metastasis from early gastric cancer following non-curative endoscopic submucosal dissection显示文摘A 67-year-old male underwent endoscopic submucosal dissection(ESD)to treat early gastric cancer(EGC)in 2001.The lesion(50 mm × 25 mm diameter)was histologically diagnosed as poorly differentiated adenocarcinoma,with an ulcer finding.Although the tumor was confined to the mucosa with no evidence of lymphovascular involvement,the ESD was regarded as a noncurative resection due to the histological type,tumor size,and existence of an ulcer finding(as indicated by the 2010 Japanese gastric cancer treatment guidelines,ver.3).Despite strong recommendation for subsequent gastrectomy,the patient refused surgery.An alternative follow-up routine was designed,which included five years of biannual clinical examinations to detect and measure serum tumor markers and perform visual assessment of recurrence by endoscopy and computed tomography scan after which the examinations were performed annually.The patient's condition remained stable for eight years,until a complaint of back pain in 2010 prompted further clinical investigation.Bone scintigraphy indicated increased uptake.Histological examination of biopsy specimens taken from the lumbar spine revealed adenocarcinoma resembling the carcinoma cells from the EGC that had been treated previously by ESD,and which was consistent with immunohistochemical findings of gastrointestinal tract cancer.Thus,the diagnosis of bone metastasis from EGC was made.The reported rates of EGC recurrence in surgically resected cases range 1.4%-3.4%,but among these bone metastasis is very rare.To our knowledge,this is the first reported case of bone metastasis from EGC following a non-curative ESD and occurring after an eight-year disease-free interval. | Hiroyuki Kawabata Ichiro Oda Haruhisa Suzuki Satoru Nonaka Shigetaka Yoshinaga Hitoshi Katai Hirokazu Taniguchi Ryoji Kushima Yutaka Saito | 2013 | World Journal of Gastroenterology2013，19，30： | 2 |
| 14 | Cancer of the gastric stump following distal gastrectomy for cancer显示文摘 | Ohashi M Katai H Fukagawa T | | 0，，01： | 2 |
| 15 | Amylase concentration of drainage fluid after total gastrectomy 显示文摘 | Sano T Sasako M Katai H | 1997 | Br J Surg1997，84，9： | 1 |
| 16 | Outcome of pylorus-preserving gastrectomy for early gastric cancer 显示文摘 | Morita S Katai H Saka M | 2008 | Br J Surg2008，95，9： | 1 |
| 17 | BDNF diminishes caspase-2 but not c-jun immunoreactivity of neurons in retinal ganglion cell layer after transient ischemia显示文摘 | Katai N Shibuki H Kuroiwa S Kurimoto Y Nakayama C | 1999 | Invest Ophthalmol Vis Sci1999，40，12： | 1 |
| 18 | A novel adaptive morphological approach for degraded character image segmentation 显示文摘 | Nomura S Yamanaka K Katai O | 2005 | Pattern Rec- ognition2005，38，11： | 1 |
| 19 | Lioid peroxidation and peroxynitrite in retinal ischemia-reperfusion injury显示文摘 | Katai N Yodi J | 2000 | I Invest Ophthalmol Vis Sci2000，41，11： | 1 |
| 20 | Regulation of intestinal Na^+-dependen phosphate co-transporters by a low-phosphate diet and 1, 25-dihydroxyvitamin D3显示文摘 | Katai K Miyamoto K Kishida S | 1999 | Biochem1999，343，： | 1 |
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