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| 1 | Grain size records reveal variability of the East Asian Winter Monsoon since the Middle Holocene in the Central Yellow Sea mud area,China显示文摘Three cores(ZY-1,ZY-2 and ZY-3) retrieved from the Central Yellow Sea mud(CYSM) were analyzed in sensitive grain size and AMS 14 C dating to reconstruct the history of the East Asian Winter Monsoon(EAWM) since the Middle Holocene in the study area.The results show that these data provide a continuous history of the EAWM over the past 7.2 ka and that the EAWM can be divided into three periods:strong and highly fluctuating during 7.2-4.2 ka BP;moderate and relatively stable during 4.2-1.8 ka BP;and weakened during 1.8-0 ka BP.Compared with the East Asian Summer Monsoon(EASM) recorded in the previous studies,the evolutionary history of the EAWM broadly follows the orbital-derived winter insolation with a similar long-term step-decreased trend as the EASM.At the centennial scale,however,the EAWM intensified events correlate well with the EASM weakened events and the North Atlantic climatic variations(Bond events 0 to 5) within the dating error,most likely forced by the reduction of solar irradiance through changes in the oceanic-atmospheric circulation patterns. | HU BangQi YANG ZuoSheng ZHAO MeiXun Yoshiki SAITO FAN DeJiang WANG LiBo | 2012 | Science China Earth Sciences2012，55，10： | 39 |
| 2 | East Asia Winter Monsoon changes inferred from environmentally sensitive grain-size component records during the last 2300 years in mud area southwest off Cheju Island,ECS显示文摘Environmentally sensitive grain-size component (ESGSC) extracted from grain-size data of a sediment core B2, which were retrieved from mud area southwest off Cheju Island (MACI), East China Sea (ECS), can be used to indicate the variations of East Asia Winter Monsoon (EAWM), with high (low) content/mean-size of ESGCS denote to strong (weak) EAWM. Combined with AMS14C datings core B2 provides a continuous high-resolution record of EAWM changes over the past 2300 years, with an average resolution of 13 years. The results show that the variations of EAWM are con-sistent with temperature changes inferred from historical documents in eastern China over the past 2300 years, from which four climate stages may be identified. In stages before 1900 aBP (50 AD) and 1450―780 aBP (50―1170 AD) the EAWM were comparatively weak, corresponding to warm climate periods in eastern China, respectively. And in stages of 1900―1450 aBP (50―500 AD) and 780―219 aBP (1170―1731 AD) the EAWM were strongly developed, which correspond well to climate changes of two cold periods in eastern China. It is also shown from this study that the stage at 780―219 aBP (1170―1731 AD) was the coldest climate period during the last 2300 years and could be, therefore, related to the Little Ice Age (LIA). Climatic fluctuations appeared obviously in all the four stages, and two climate events of abrupt changes from warm to cold occurred at around 1900 aBP (50 AD) and 780 aBP (1170 AD), of which the latter is probably related to globe-scale changes of atmospheric circulation at that time. | Yoshiki Saito | 2006 | Science China Earth Sciences2006，49，6： | 28 |
| 3 | 南黄海中部泥质区YE-2孔8.4kaBP来的沉积特征显示文摘对取自南黄海中部泥质区YE-2钻孔的6.1m岩心进行了年代学、沉积学、微体古生物学和U3K7′海表温度分析,结果显示,该孔沉积物基本类型为黏土质粉砂,8400aBP来的沉积环境可分为3段:8.4~6.9kaBP为砂含量达13%的滨岸浅水环境;6.9~6.1kaBP为砂含量8%的滨岸浅水向稳定浅海过渡的环境;6.1~0kaBP为基本不含砂的黏土质粉砂稳定浅海环境。表层海水温度(SST)在滨岸浅水阶段较低,平均约14.2℃;在第2阶段从6.9kaBP开始增加,最高达18.1℃,指示了黄海暖流的入侵;6.4kaBP增温结束后,浅海阶段SST稳定在15~16℃之间,同时有3个SST平均为13.9℃的短暂低温期,大致为5.7~5.2、3.7~3.2和2.3~1.8kaBP。在稳定浅海环境的黏土质粉砂地层中发现了罕见的3个砂质粉砂质粗粒级夹层,大致形成于6.0、3.9和2.5kaBP,其粒度具有风暴沉积特征,重矿物表现出变质岩特点,U3K7′-SST和黏土矿物指示其沉积环境的温度偏高。上述特征与岩心其他所有层位差异较大,显示了异地搬运的特征,可能为风暴沉积。根据AMS14C测年,不考虑风暴沉积,YE-2岩心的沉积速率在50.7~75.6cm/ka之间。 | 王利波 杨作升 赵晓辉 邢磊 赵美训 Yoshiki Saito 范德江 | 2009 | 海洋地质与第四纪地质2009，29，5： | 26 |
| 4 | Transarterial chemoembolization for hepatocellular carcinoma: A review of techniques显示文摘Hepatocellular carcinoma(HCC)is one of the most common malignant diseases worldwide.While curative therapies,including resection,liver transplantation,and percutaneous ablation(percutaneous ethanol injection and radiofrequency ablation),are applicable for only a portion of the HCC population,transcatheter arterial chemoembolization(TACE)has been recognized as an effective palliative treatment option for patients with advanced HCC.TACE is also used even for single HCCs in which it is difficult to perform surgical resection or locoregional treatment due to systemic co-morbidities or anatomical problems.TACE has become widely adopted in the treatment of HCC.By using computed tomography-angiography,TACE is capable of performing diagnosis and treatment at the same time.Furthermore,TACE plays an important role in the multidisciplinary treatment for HCC when combined with other treatment.In this review,we first discuss the history of TACE,and then review the previous findings about techniques of achieving a locoregional treatment effect(liver infarction treatment,e.g.,ultra-selective TACE,balloon-occluded TACE),and the use of TACE as a drugdelivery system for anti-cancer agents(palliative,e.g.,platinum complex agents,drug-eluting beads)for multiple lesions. | Norihiro Imai Masatoshi Ishigami Yoji Ishizu Teiji Kuzuya Takashi Honda Kazuhiko Hayashi Yoshiki Hirooka Hidemi Goto | 2014 | World Journal of Hepatology2014，6，12： | 24 |
| 5 | 南黄海中部泥质区7200年以来东亚冬季风变化的沉积记录显示文摘对南黄海中部泥质区的三个柱样(ZY-1,ZY-2和ZY-3孔)进行了AMS14C测年、沉积层序以及沉积物敏感粒级的分析.结果表明此三孔的岩性上下均一且沉积连续,均为黏土质粉沙,是全新世高海平面以来的沉积产物.ZY-1,ZY-2和ZY-3孔的粒度垂向变化特征基本一致,主要受控于现代黄海环流体系中冬季风驱动的黄海近岸海流的强弱,间接反映了东亚冬季风强弱变化.利用ZY-1,ZY-2和ZY-3孔的沉积物敏感粒级获得了近7200年来高分辨率的东亚冬季风替代指标,发现在7.2~4.2ka期间东亚冬季风强盛且波动大,4.2~1.8ka期间东亚冬季风表现为中等强度且比较稳定,东亚冬季风强度在1.8~0ka期间虽较弱,但在此阶段后期略有上升.中全新世以来,南黄海中部泥质区所记录的东亚冬季风变化趋势在千年尺度上与已报道的东亚夏季风强度变化趋势基本一致,主要受控于轨道驱动的太阳辐射量冬、夏季季节性变化差异;但在百年尺度上东亚冬季风增强事件则与夏季风减弱事件相对应,呈现反向变化,可能是对太阳活动减弱的敏感响应. | 胡邦琦 杨作升 赵美训 Yoshiki SAITO 范德江 王利波 | 2012 | 中国科学:地球科学2012，42，10： | 19 |
| 6 | Sedimentary Evolution of the Holocene Subaqueous Clinoform off the Southern Shandong Peninsula in the Western South Yellow Sea显示文摘Based on the stratigraphic sequence formed since the last glaciation and revealed by 3000 km long high-resolution shallow seismic profiles and the core QDZ03 acquired recently off the southern Shandong Peninsula, we addressed the sedimentary characteristics of a Holocene subaqueous clinoform in this paper. Integrated analyses were made on the core QDZ03, including sedimentary facies, sediment grain sizes, clay minerals, geochemistry, micro paleontology, and AMS 14 C dating. The result indicates that there exists a Holocene subaqueous clinoform, whose bottom boundary generally lies at 15–40 m below the present sea level with its depth contours roughly parallel to the coast and getting deeper seawards. The maximum thickness of the clinoform is up to 22.5 m on the coast side, and the thickness contours generally spread in a banded way along the coastline and becomes thinner towards the sea. At the mouths of some bays along the coast, the clinoform stretches in the shape of a fan and its thickness is evidently larger than that of the surrounding sediments. This clinoform came into being in the early Holocene(about 11.2 cal kyr BP) and can be divided into the lower and upper depositional units(DU 2 and DU 1, respectively). The unit DU 2, being usually less than 3 m in thickness and formed under a low sedimentation rate, is located between the bottom boundary and the Holocene maximum flooding surface(MFS), and represents the sediment of a post-glacial transgressive systems tract; whereas the unit DU 1, the main body of the clinoform, sits on the MFS, belonging to the sediment of a highstand systems tract from middle Holocene(about 7–6 cal kyr BP) to the present. The provenance of the clinoform differs from that of the typical sediments of the Yellow River and can be considered as the results of the joint contribution from both the Yellow River and the proximal coastal sediments of the Shandong Peninsula, as evidenced by the sediment geochemistry of the core. As is controlled mainly by coactions of multiple factors such as the Holocene sea-level changes, sediment supplies and coastal dynamic conditions, the development of the clinoform is genetically related with the synchronous clinoform or subaqueous deltas around the northeastern Shandong Peninsula and in the northern South Yellow Sea in the spatial distribution and sediment provenance, as previously reported, with all of them being formed from the initial stage of the Holocene up to the present. | QIU Jiandong LIU Jian SAITO Yoshiki YANG Zigeng YUE Baojing WANG Hong KONG Xianghuai | 2014 | Journal of Ocean University of China2014，13，5： | 17 |
| 7 | Asymmetric dimethylarginine, a biomarker of cardiovascular complications in diabetes mellitus显示文摘Cardiovascular(CV) complications are an essential causal element of prospect in diabetes mellitus(DM), with carotid atherosclerosis being a common risk factor for prospective crisis of coronary artery diseases and/or cerebral infarction in DM subjects. From another point of view, asymmetric dimethylarginine(ADMA) has been established as an inhibitor of endogenous nitric oxide synthesis and the relationship between ADMA and arteriosclerosis has been reported. In our study with 87 type 2 DM(T2DM) patients, we have examined whether ADMA and other CV risk factors are the useful predictors of DMCV complications. After the measurement of the respective CV risk factors, we have followed the enrolled T2 DM patients for 5 years. We have finally analyzed 77 patients. DMCV complications developed in 15 cases newly within 5 years, and 4 cases recurred. The concentrations of ADMA in plasma were markedly more elevated in 19 DM patients with CV complications than in 58 DM patients without CV complications. Urinary albumin(U-Alb), mean intimal-medial thickness(IMT) and ankle brachial index(ABI) were also higher in patients with CV complications. Multiple regression analyses showed that U-Alb had an influence on the high level of ADMA(standardized β = 6.59, P = 0.00014) independently of age, systolic BP, fibrinogen, mean IMT, plaque score, and ABI. The review indicates what is presently known regarding plasma ADMA that might be a new and meaningful biomarker of CV complications in DM subjects. | Hiroyuki Konya Masayuki Miuchi Kahori Satani Satoshi Matsutani Yuzo Yano Taku Tsunoda Takashi Ikawa Toshihiro Matsuo Fumihiro Ochi Yoshiki Kusunoki Masaru Tokuda Tomoyuki Katsuno Tomoya Hamaguchi Jun-ichiro Miyagawa Mitsuyoshi Namba | 2015 | World Journal of Experimental Medicine2015，5，2： | 16 |
| 8 | Bleeding after endoscopic submucosal dissection: Risk factors and preventive methods显示文摘Endoscopic submucosal dissection(ESD) has become widely accepted as a standard method of treatment for superficial gastrointestinal neoplasms because it enables en block resection even for large lesions or fibrotic lesions with minimal invasiveness, and decreases the local recurrence rate. Moreover, specimens resected in an en block fashion enable accurate histological assessment. Taking these factors into consideration, ESD seems to be more advantageous than conventional endoscopic mucosal resection(EMR), but the associated risks of perioperative adverse events are higher than in EMR. Bleeding after ESD is the most frequent among these adverse events. Although post-ESD bleeding can be controlled by endoscopic hemostasis in most cases, it may lead to serious conditions including hemorrhagic shock. Even with preventive methods including administration of acid secretion inhibitors and preventive hemostasis, post-ESD bleeding cannot be completely prevented. In addition high-risk cases for post-ESD bleeding, which include cases with the use of antithrombotic agents or which require large resection, are increasing. Although there have been many reports about associated risk factors and methods of preventing post-ESD bleeding, many issues remain unsolved. Therefore, in this review, we have overviewed risk factors and methods of preventing post-ESD bleeding from previous studies. Endoscopists should have sufficient knowledge of these risk factors and preventive methods when performing ESD. | Yosuke Kataoka Yosuke Tsuji Yoshiki Sakaguchi Chihiro Minatsuki Itsuko Asada-Hirayama Keiko Niimi Satoshi Ono Shinya Kodashima Nobutake Yamamichi Mitsuhiro Fujishiro Kazuhiko Koike | 2016 | World Journal of Gastroenterology2016，22，26： | 16 |
| 9 | Intraductal neoplasm of the intrahepatic bile duct: Clinicopathological study of 24 cases显示文摘AIM: To investigate the clinicopathological features of intraductal neoplasm of the intrahepatic bile duct (INihB). METHODS: Clinicopathological features of 24 cases of INihB, which were previously diagnosed as biliary papillomatosis or intraductal growth of intrahepatic biliary neoplasm, were reviewed. Mucin immunohistochemistry was performed for mucin (MUC)1, MUC2, MUC5AC and MUC6. Ki-67, P53 and β-catenin immunoreactivity were also examined. We categorized each tumor as adenoma (low grade), borderline (intermediate grade), and malignant (carcinoma in situ , high grade including tumors with microinvasion). RESULTS: Among 24 cases of INihB, we identified 24 tumors. Twenty of 24 tumors (83%) were composed of a papillary structure; the same feature observed in intraductal papillary neoplasm of the bile duct (IPNB). In contrast, the remaining four tumors (17%) showed both tubular and papillary structures. In three of the four tumors (75%), macroscopic mucin secretion was limited but microscopic intracellular mucin was evident. Histologically, 16 tumors (67%) were malignant, three (12%) were borderline, and five (21%) were adenoma. Microinvasion was found in four cases (17%). Immunohistochemical analysis revealed that MUC1 was not expressed in the borderline/adenoma group but was expressed only in malignant lesions (P = 0.0095). Ki-67 labeling index (LI) was significantly higher in the malignant group than in the borderline/adenoma group (22.2 ± 15.5 vs 7.5 ± 6.3, P < 0.01). In the 16 malignant cases, expression of MUC5AC showed borderline significant association with high Ki-67 LI (P = 0.0622). Nuclear expression of β-catenin was observed in two (8%) of the 24 tumors, and these two tumors also showed MUC1 expression. P53 was negative in all tumors. CONCLUSION: Some cases of INihB have a tubular structure, and are subcategorized as IPNB with tubular structure. MUC1 expression in INihB correlates positively with degree of malignancy. | Yoshiki Naito Hironori Kusano Osamu Nakashima Eiji Sadashima Satoshi Hattori Tomoki Taira Akihiko Kawahara Yoshinobu Okabe Kazuhide Shimamatsu Jun Taguchi Seiya Momosaki Koji Irie Rin Yamaguchi Hiroshi Yokomizo Michiko Nagamine Seiji Fukuda Shinichi Sugiyama Naoyo Nishida Koichi Higaki Munehiro Yoshitomi Masafumi Yasunaga Koji Okuda Hisafumi Kinoshita Masayoshi Kage Masamichi Nakayama Makiko Yasumoto Jun Akiba Hirohisa Yano | 2012 | World Journal of Gastroenterology2012，18，28： | 16 |
| 10 | 东亚东倾地形格局的形成与季风系统演化历史寻踪--综合大洋钻探计划683号航次建议书简介显示文摘围绕IODP 683号建议书,介绍东亚东倾地形格局与季风系统演化历史的相关研究。新生代全球宏观环境格局发生了一系列重大变化,表现为岩石圈活动强烈,板块漂移导致海陆格局和地貌格局的变化,并引发洋流和大气环流的改组,最终导致全球气候的重大变化。新生代岩石圈运动和气候变化表现最为典型的地区是亚洲,其中最具标志性和全球意义的地质事件是喜马拉雅山和青藏高原的隆升及亚洲季风系统的形成与演化。青藏高原隆升最直接的结果是亚洲地区现代地貌格局的形成,大江大河的发育,并在很大程度上影响了亚洲季风系统的形成与演化。综合大洋钻探计划683号航次建议书,计划在长江中下游盆地和东海陆架盆地实施钻探,以获得长江历史演化和东亚季风演化的地质记录,并为研究青藏高原的演化提供新的证据。 | 郑洪波 汪品先 刘志飞 杨守业 王家林 李前裕 周祖翼 贾军涛 李上卿 贾健宜 John Chappell Yoshiki Saito Takahiro Inoue | 2008 | 地球科学进展2008，23，11： | 14 |
| 11 | Arterial steroid injection therapy can inhibit the progression of severe acute hepatic failure toward fulminant liver failure显示文摘AIM: To utilize transcatheter arterial steroid injection therapy (TASIT) via the hepatic artery to reduce hepatic macrophage activity in patients with severe acute hepatic failure.METHODS: Thirty-four patients with severe acute hepatic failure were admitted to our hospital between June 2002 to June 2006 providing for the possibility of liver transplantation (LT). Seventeen patients were treated using traditional liver supportive procedures, and the other 17 patients additionally underwent TASIT with 1000 mg methylprednisolone per day for 3 continuous days. RESULTS: Of the 17 patients who received TASIT, 13 were cured without any complications, 2 died, and 2 underwent LT. Of the 17 patients who did not receive TASIT, 4 were self-limiting, 7 died, and 6 underwent LT. Univariate logistic analysis revealed that ascites, serum albumin, prothrombin time, platelet count, and TASIT were significant variables for predicating the prognosis. Multivariate logistic regression analysis using stepwise variable selection showed that prothrombin time, platelet count, and TASIT were independent predictive factors. CONCLUSION: TASIT might effectively prevent the progression of severe acute hepatic failure to a fatal stage of fulminant liver failure. | Kazuhiro Kotoh Munechika Enjoji Makoto Nakamuta Tsuyoshi Yoshimoto Motoyuki Kohjima Shusuke Morizono Shinsaku Yamashita Yuki Horikawa Kengo Yoshimitsu Tsuyoshi Tajima Yoshiki Asayama Kousei Ishigami Masakazu Hirakawa | 2006 | World Journal of Gastroenterology2006，12，41： | 13 |
| 12 | Utility of linked color imaging for endoscopic diagnosis of early gastric cancer显示文摘BACKGROUND Linked color imaging(LCI) is a method of endoscopic imaging that emphasizes slight differences in red mucosal color.AIM To evaluate LCI in diagnostic endoscopy of early gastric cancer and to compare LCI and pathological findings.METHODS Endoscopic images were obtained for 39 patients(43 lesions) with early gastric cancer. Three endoscopists evaluated lesion recognition with white light imaging(WLI) and LCI. Color values in Commission Internationale de l'Eclairage(CIE)1976 L*a*b* color space were used to calculate the color difference(ΔE) between cancer lesions and non-cancer areas. After endoscopic submucosal dissection,blood vessel density in the surface layer of the gastric epithelium was evaluated pathologically. The identical region of interest was selected for analyses of endoscopic images(WLI and LCI) and pathological analyses.RESULTS LCI was superior for lesion recognition(P < 0.0001), and ΔE between cancer and non-cancer areas was significantly greater with LCI than WLI(29.4 vs 18.6, P <0.0001). Blood vessel density was significantly higher in cancer lesions(5.96% vs4.15%, P = 0.0004). An a* cut-off of ≥ 24 in CIE 1976 L*a*b* color space identified a cancer lesion using LCI with sensitivity of 76.7%, specificity of 93.0%, and accuracy of 84.9%.CONCLUSION LCI is more effective for recognition of early gastric cancer compared to WLI as a result of improved visualization of changes in redness. Surface blood vessel density was significantly higher in cancer lesions, and this result is consistent with LCI image analysis. | Toshihisa Fujiyoshi Ryoji Miyahara Kohei Funasaka Kazuhiro Furukawa Tsunaki Sawada Keiko Maeda Takeshi Yamamura Takuya Ishikawa Eizaburo Ohno Masanao Nakamura Hiroki Kawashima Masato Nakaguro Masahiro Nakatochi Yoshiki Hirooka | 2019 | World Journal of Gastroenterology2019，25，10： | 12 |
| 13 | Analysis of the risk factors for severity in post endoscopic retrograde cholangiopancreatography pancreatitis: The indication of prophylactic treatments显示文摘AIM To determine the risk factors of severe post endoscopic retrograde cholangiopancreatography pancreatitis(s PEP) and clarify the indication of prophylactic treatments.METHODS At our hospital, endoscopic retrograde cholangiopancreatography(ERCP) was performed on 1507 patients from May 2012 to December 2015. Of these patients, we enrolled all 121 patients that were diagnosed with post endoscopic retrograde PEP. Fourteen of 121 patients diagnosed as s PEP were analyzed.RESULTS Forty-one patients had contrast media remaining in the pancreatic duct after completion of ERCP. Seventy-one patients had abdominal pain within three hours after ERCP. These were significant differences for s PEP(P < 0.05). The median of Body mass index, the median time for ERCP, the median serum amylase level of the next day, past histories including drinking and smoking, past history of pancreatitis, sphincter of Oddi dysfunction, whether emergency or not, expertise of ERCP procedure, diverticulum nearby Vater papilla, whether there was sphincterotomy or papillary balloon dilation, pancreatic duct cannulation, use of intraductal ultrasonography enforcement, and transpapillary biopsies had no significant differences with s PEP.CONCLUSION Contrast media remaining in the pancreatic duct and the appearance of abdominal pain within three hours after ERCP were risk factors of s PEP. | Hiroshi Matsubara Fumihiro Urano Yuki Kinoshita Shozo Okamura Hiroki Kawashima Hidemi Goto Yoshiki Hirooka | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，4： | 12 |
| 14 | 长江口冰后期沉积物的元素组成特征显示文摘长江口冰后期钻孔沉积物的元素地球化学研究表明 ,绝大多数元素组成与表层沉积物非常接近 ,反映冰后期沉积物主要来自长江 ,其它物源及环境变化影响较小 .不同沉积环境中一些元素组成会发生变化 ,尤其是河床相沉积物中过渡金属元素组成变化最明显 .不同沉积相中稀土元素 (REE)绝对质量比虽有差异 ,但稀土的配分模式很接近 ,同样反映出冰后期沉积物物质来源的单一 . | 杨守业 李从先 赵泉鸿 Yoshiki Saito | 2000 | 同济大学学报(自然科学版)2000，28，5： | 12 |
| 15 | Cytokines in adipose-derived mesenchymal stem cells promote the healing of liver disease显示文摘Adipose-derived mesenchymal stem cells(ADSCs) are a treatment cell source for patients with chronic liver injury. ADSCs are characterized by being harvested from the patient's own subcutaneous adipose tissue, a high cell yield(i.e., reduced immune rejection response), accumulation at a disease nidus, suppression of excessive immune response, production of various growth factors and cytokines, angiogenic effects, antiapoptotic effects, and control of immune cells via cellcell interaction. We previously showed that conditioned medium of ADSCs promoted hepatocyte proliferation and improved the liver function in a mouse model of acute liver failure. Furthermore, as found by many other groups, the administration of ADSCs improved liver tissue fibrosis in a mouse model of liver cirrhosis. A comprehensive protein expression analysis by liquid chromatography with tandem mass spectrometry showed that the various cytokines and chemokines produced by ADSCs promote the healing of liver disease. In this review, we examine the ability of expressed protein components of ADSCs to promote healing in cell therapy for liver disease. Previous studies demonstrated that ADSCs are a treatment cell source for patients with chronic liver injury. This review describes the various cytokines and chemokines produced by ADSCs that promote the healing of liver disease. | Saifun Nahar Yoshiki Nakashima Chika Miyagi-Shiohira Takao Kinjo Zensei Toyoda Naoya Kobayashi Issei Saitoh Masami Watanabe Hirofumi Noguchi Jiro Fujita | 2018 | World Journal of Stem Cells2018，10，11： | 11 |
| 16 | 越南红河三角洲近五千年来的几个降温事件显示文摘根据对越南红河三角洲的2个钻孔的孢粉分析结果,结合沉积特征和高精度的 AMS14 C测年数据,恢复了近五千年来百年-千年尺度的气候变化,发现了3个分别开始于4 530 cal. aBP, 2 100 cal. aBP和620 cal. aBP的明显降温事件,其中4 530 cal. aBP和620 cal. aBP降温事件可与全球全新世气候变冷事件中的“新冰期(Neogla cial)”和“小冰期(Little Ice Age)”相对应,可能与由北大西洋地区几个短期变冷事件的全球气候响应机制有关。3 340 cal. aBP以来,人类干扰性植物成分的增加,表明人类活动对自然植被的影响改造作用增强,因此,本研究中气候的降温事件不排除人类影响的因素,仍需要进一步深入研究。 | 李珍 臧家业 SAITO Yoshiki 徐小薇 王永吉 MATSUMOTO Eiji 张志英 | 2005 | 海洋科学进展2005，23，1： | 9 |
| 17 | Endoscopic ultrasound-guided fine needle aspiration in the differentiation of type 1 and type 2 autoimmune pancreatitis显示文摘AIM:To investigate the usefulness of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) in the differentiation of autoimmune pancreatitis(AIP).METHODS:We retrospectively reviewed 47 of 56 AIP patients who underwent EUS-FNA and met the Asian diagnostic criteria.On 47 EUS-FNA specimens,we evaluated the presence of adequate material and characteristic features of lymphoplasmacytic sclerosing pancreatitis(LPSP) and idiopathic duct-centric pancreatitis(IDCP) mentioned in the International Consensus Diagnostic Criteria and examined if these findings make a contribution to the differential diagnosis of type 1 and type 2 AIP.A disposable 22-gauge needle was used for EUS-FNA.RESULTS:Adequate specimens including pancreatic tissue for differentiating AIP from cancer were obtained from 43 of 47 patients who underwent EUSFNA.EUS-FNA was performed from the pancreatic head in 21 cases,which is known to be technically difficult when performed by core biopsy;there was no significant difference in the results compared with pancreatic body-tail.Nine of 47 patients met level 1 findings of LPSP and 5 patients met level 2 findings of LPSP.No one met level 1 findings of IDCP,but 3 patients met level 2 findings of IDCP.Of 10 seronegative cases,2 cases were diagnosed with 'definitive type 1 AIP',and 3 cases were diagnosed with 'probable type 2 AIP' when considering both the level 2 histological findings and response to steroids.CONCLUSION:EUS-FNA is useful in the differentiation of type 1 and type 2 AIP,particularly in seronegative cases. | Takuya Ishikawa Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Hirosh Matsubara Yuya Itoh Yosuke Nakamura Takeshi Hiramatsu Masanao Nakamura Ryoji Miyahara Naoki Ohmiya Hidemi Goto Yoshiki Hirooka | 2012 | World Journal of Gastroenterology2012，18，29： | 8 |
| 18 | 2万年来我国东部海陆环境变化的不同步现象显示文摘冲绳海槽 DG96 0 3孔高分辨率的硅藻、有孔虫、孢粉和植物硅酸体化石的记录 ,提供了联系海洋与陆地气候变化的直接证据。结果显示 ,中国东部及邻海区最近 2 0 ka BP以来海洋环境的变化滞后陆地气候的变化约10 0 0 a。 | 吕厚远 刘振夏 刘宝柱 Serge Berné Yoshiki Saito 李铁刚 吴乃琴 | 2002 | 海洋地质与第四纪地质2002，22，1： | 8 |
| 19 | Characteristic endoscopic findings and risk factors for cytomegalovirus-associated colitis in patients with active ulcerative colitis显示文摘AIM: To identify characteristic endoscopic findings and risk factors for cytomegalovirus(CMV)-associated colitis in patients with active ulcerative colitis(UC).METHODS: A total of 149 UC patients admitted to the Department of Gastroenterology, Nagoya University Hospital, from January 2004 to December 2013 with exacerbation of UC symptoms were enrolled in this retrospective study. All medical records, including colonoscopy results, were reviewed. CMV infection was determined by the presence of CMV antigen, CMV inclusion bodies in biopsy specimens, or positive specific immunohistochemical staining for CMV. Multivariate analysis was used to identify independent risk factors for CMV colitis.RESULTS: Multivariate analysis indicated independent associations with the extent of disease(pancolitis) anduse of > 400 mg corticosteroids for the previous 4 wk. In contrast, no association was seen with sex, age at UC diagnosis, immunomodulator use, or infliximab use. Punched-out ulceration was also significantly associated with CMV infection in patients with active UC(odds ratio = 12.672, 95%CI: 4.210-38.143).CONCLUSION: Identification of a total corticosteroid dose > 400 mg for 4 wk, extensive colitis and a specific endoscopic finding of punched-out ulcer might facilitate the more rapid diagnosis and timely initiation of antiviral therapy for CMV-associated colitis in patients with active UC. | Yutaka Hirayama Takafumi Ando Yoshiki Hirooka Osamu Watanabe Ryoji Miyahara Masanao Nakamura Takeshi Yamamura Hidemi Goto | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，6： | 8 |
| 20 | 胆道肿瘤临床实践指南(英文第三版)显示文摘日本肝胆胰外科学会(JSHBPS)于2007年出版第一版胆道肿瘤(胆管癌、胆囊癌及壶腹癌)临床实践指南,于2014年更新第二版,2021年英文第三版胆道肿瘤临床实践指南围绕6个主题提出若干临床问题,基于相关循证医学证据并组织专家讨论后,最终确定推荐意见、推荐强度以及推荐说明。根据证据推荐分级的评估、制订与评价(GRADE)系统,推荐强度被分为1级(强)或者2级(弱)。英文第三版胆道肿瘤临床实践指南中提出的31个临床问题涵盖:(1)预防性治疗;(2)诊断;(3)胆道引流;(4)外科治疗;(5)化疗;(6)放疗。31个临床问题中,14个问题给予推荐强度为强的推荐意见,14个问题给予推荐强度为弱的推荐意见,剩余的3个问题未给予推荐意见。每条推荐意见都进行推荐强度说明。最新版指南基于循证医学证据,为临床提供了重要建议。未来与癌症登记数据库协作将是评估指南和建立新证据的关键。 | Masato Nagino Satoshi Hirano Hideyuki Yoshitomi Taku Aoki Katsuhiko Uesaka Michiaki Unno Tomoki Ebata Masaru Konishi Keiji Sano Kazuaki Shimada Hiroaki Shimizu Ryota Higuchi Toshifumi Wakai Hiroyuki Isayama Takuji Okusaka Toshio Tsuyuguchi Yoshiki Hirooka Junji Furuse Hiroyuki Maguchi Kojiro Suzuki Hideya Yamazaki Hiroshi Kijima Akio Yanagisawa Masahiro Yoshida Yukihiro Yokoyama Takashi Mizuno Itaru Endo 杨翼飞(译) 仇毓东(译) 赵梦珂(译) 伏旭(译) 蔡正华(译) 毛凉(审校) | 2021 | 中华消化外科杂志2021，20，4： | 7 |
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