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| 1 | Genetic and epigenetic aspects of initiation and progression of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is a primary cancer of the liver that is predominant in developing countries and is responsible for nearly 600000 deaths each year worldwide. Similar to many other tumors, the development of HCC must be understood as a multistep process involving the accumulation of genetic and epigenetic alterations in regulatory genes, leading to the activation of oncogenes and the inactivation or loss of tumor suppressor genes. Extensive research over the past decade has identified a number of molecular biomarkers, including aberrant expression of HCCrelated genes and microRNAs. The challenge facing HCC research and clinical care at this time is to address the heterogeneity and complexity of these genetic and epigenetic alterations and to use this information to direct rational diagnosis and treatment strategies. The multikinase inhibitor sorafenib was the first molecularly targeted drug for HCC to show some extent of survival benefits in patients with advanced tumors. Although the results obtained using sorafenib support the importance of molecular therapies in the treatment of HCC, there is still room for improvement. In addition,no molecular markers for drug sensitivity, recurrence and prognosis are currently clinically available. In this review, we provide an overview of recently published articles addressing HCC-related genes and microRNAs to update what is currently known regarding genetic and epigenetic aspects of the pathogenesis of HCC and propose novel promising candidates for use as diagnostic and therapeutic targets in HCC. | Mitsuro Kanda Hiroyuki Sugimoto Yasuhiro Kodera | 2015 | World Journal of Gastroenterology2015，21，37： | 22 |
| 2 | Recent advances in the molecular diagnostics of gastric cancer显示文摘Gastric cancer(GC) is the third most common cause of cancer-related death in the world,representing a major global health issue. Although the incidence of GC is declining,the outcomes for GC patients remain dismal because of the lack of effective biomarkers to detect early GC and predict both recurrence and chemosensitivity. Current tumor markers for GC,including serum carcinoembryonic antigen and carbohydrate antigen 19-9,are not ideal due to their relatively low sensitivity and specificity. Recent improvements in molecular techniques are better able to identify aberrant expression of GC-related molecules,including oncogenes,tumor suppressor genes,micro RNAs and long non-coding RNAs,and DNA methylation,as novel molecular markers,although the molecular pathogenesis of GC is complicated by tumor heterogeneity. Detection of genetic and epigenetic alterations from gastric tissue or blood samples has diagnostic value in the management of GC. There are high expectations for molecular markers that can be used as new screening tools for early detection of GC as well as for patient stratification towards personalized treatment of GC through prediction of prognosis and drug-sensitivity. In this review,the studies of potential molecular biomarkers for GC that have been reported in the publicly available literature between 2012 and 2015 are reviewed and summarized,and certain highlighted papers are examined. | Mitsuro Kanda Yasuhiro Kodera | 2015 | World Journal of Gastroenterology2015，21，34： | 20 |
| 3 | Molecular mechanisms of peritoneal dissemination in gastric cancer显示文摘Peritoneal dissemination represents a devastating form of gastric cancer(GC) progression with a dismal prognosis. There is no effective therapy for this condition. The 5-year survival rate of patients with peritoneal dissemination is 2%, even including patients with only microscopic free cancer cells without macroscopic peritoneal nodules. The mechanism of peritoneal dissemination of GC involves several steps: detachment of cancer cells from the primary tumor, survival in the free abdominal cavity, attachment to the distant peritoneum, invasion into the subperitoneal space and proliferation with angiogenesis. These steps are not mutually exclusive, and combinations of different molecular mechanisms can occur in each process of peritoneal dissemination. A comprehensive understanding of the molecular events involved in peritoneal dissemination is important and should be systematically pursued. It is crucial to identify novel strategies for the prevention of this condition and for identification of markers of prognosis and the development of molecular-targeted therapies. In this review, we provide an overview of recently published articles addressing the molecular mechanisms of peritoneal dissemination of GC to provide an update on what is currently known in this field and to propose novel promising candidates for use in diagnosis and as therapeutic targets. | Mitsuro Kanda Yasuhiro Kodera | 2016 | World Journal of Gastroenterology2016，22，30： | 15 |
| 4 | Clinical utility of the platelet-lymphocyte ratio as a predictor of postoperative complications after radical gastrectomy for clinical T2-4 gastric cancer显示文摘AIM To identify simple and sensitive markers for postoperative complications after gastrectomy, the predictive values were compared among candidate preoperative factors. METHODS Three-hundred and twelve patients with previously untreated clinical T2-4 gastric cancer who underwent a D2 standard gastrectomy(distal gastrectomy or total gastrectomy) were included in the analysis.Correlations between 21 parameters that can be determined by preoperative routine blood tests and clinically relevant postoperative complications(grade Ⅱ or higher according to the Clavien-Dindo classification) were evaluated. The optimal cutoff values and clinical significance of the selected markers were further evaluated by subgroup analyses according to age, body mass index, operative procedure and clinical disease stage.RESULTS Sixty-six patients(21.1%) experienced grade Ⅱ or higher postoperative complications. The plateletlymphocyte ratio(PLR, total lymphocyte count/platelet count × 100) exhibited the highest area under the curve value(0.639) for predicting postoperative complications among the 21 parameters, and the optimal cutoff value was determined to be 0.71(sensitivity = 70%, specificity = 56%). In the univariate analysis, the odds ratio of a low PLR for the occurrence of postoperative complications was 2.94(95%CI: 1.66-5.35, P < 0.001), and a multivariate binomial logistic analysis involving other potential risk factors identified a low PLR as an independent risk factor for postoperative complications(OR = 3.32, 95%CI: 1.82-6.25, P < 0.001). In subgroups classified according to age, body mass index, operative procedure and clinical disease stage, the low PLR group exhibited an increased incidence of postoperative complications. CONCLUSION The preoperative PLR is a simple and useful predictor of complications after curative gastrectomy in patients with clinical T2-4 gastric cancer. | Kenichi Inaoka Mitsuro Kanda Hiroaki Uda Yuri Tanaka Chie Tanaka Daisuke Kobayashi Hideki Takami Naoki Iwata Masamichi Hayashi Yukiko Niwa Suguru Yamada Tsutomu Fujii Hiroyuki Sugimoto Kenta Murotani Michitaka Fujiwara Yasuhiro Kodera | 2017 | World Journal of Gastroenterology2017，23，14： | 13 |
| 5 | Chemotherapy as a component of multimodal therapy for gastric carcinoma显示文摘局部地先进的胃的癌症的预后仍然保持差,并且几多,包含外科,化疗,和放射的形式策略在临床的试用被测试了。独自与外科在治疗上测试手术后的辅助化疗的利益的阶段 III 试用几乎没在幸存上揭示很少影响,与在西方的国家的一些小试用的例外。从探索手术后的 chemoradiation 的美国的大试用是在这个范畴的第一主要成功。从日本试用的结果建议有口头的 fluoropyrimidines 的中等化疗可能对更少进展(T2 阶段) 是有效的癌症,尽管另一确定的试用被需要证明这,指。调查者最近转到 neoadjuvant 化疗,并且一些有希望的结果从阶段 II trials using 被报导了活跃的药联合。在 2005,测试在前和手术后的化疗的大阶段 III 试用为将切除证明了它的幸存利益有能力的胃的癌症。因为病理学的完全的反应的率被认为影响这策略的治疗结果,进一步增加病理学的完全的反应的发生的 neoadjuvant chemoradiation 能是突破,并且分阶段执行测试这策略的 III 研究在不久的将来可以被保证。 | Yasuhiro Kodera Michitaka Fujiwara Masahiko Koike Akimasa Nakao | 2006 | World Journal of Gastroenterology2006，12，13： | 12 |
| 6 | Long-lasting discussion: Adverse effects of intraoperative blood loss and allogeneic transfusion on prognosis of patients with gastric cancer显示文摘Gastrectomy with radical lymph node dissection is the most promising treatment avenue for patients with gastric cancer. However, this procedure sometimes induces excessive intraoperative blood loss and requires perioperative allogeneic blood transfusion. There are lasting discussions and controversies about whether intraoperative blood loss or perioperative blood transfusion has adverse effects on the prognosis in patients with gastric cancer. We reviewed laboratory and clinical evidence of these associations in patients with gastric cancer. A large amount of clinical evidence supports the correlation between excessive intraoperative blood loss and adverse effects on the prognosis. The laboratory evidence revealed three possible causes of such adverse effects: anti-tumor immunosuppression, unfavorable postoperative conditions, and peritoneal recurrence by spillage of cancer cells into the pelvis. Several systematic reviews and meta-analyses have suggested the adverse effects of perioperative blood transfusions on prognostic parameters such as all-cause mortality, recurrence, and postoperative complications. There are two possible causes of adverse effects of blood transfusions on the prognosis: Anti-tumor immunosuppression and patient-related confounding factors (e.g., preoperative anemia). These factors are associated with a worse prognosis and higher requirement for perioperative blood transfusions. Surgeons should make efforts to minimize intraoperative blood loss and transfusions during gastric cancer surgery to improve patients’ prognosis. | Koki Nakanishi Mitsuro Kanda Yasuhiro Kodera | 2019 | World Journal of Gastroenterology2019，25，22： | 11 |
| 7 | Prognostic significance of perioperative tumor marker levels in stage Ⅱ/Ⅲ gastric cancer显示文摘AIM To evaluate the prognostic significance of perioperative carcinoembryonic antigen(CEA) and carbohydrate antigen 19-9(CA19-9) levels in stage Ⅱ/Ⅲ gastric cancer.METHODS From a multi-institutional retrospective database compiled by integrating clinical data from nine institutions, data of 998 patients who underwent curative resection for stage Ⅱ/Ⅲ gastric cancer between 2010 and 2014 were retrieved and analyzed. The prognostic impact of the preoperative and postoperative levels and chronological changes in CEA, CA19-9 and their combination were evaluated. To test whether postoperative adjuvant chemotherapy alters the prognostic impact of perioperative CEA and CA19-9 levels, the hazard ratios for mortality were compared between patients who underwent surgery alone and patients who underwent surgery followed by adjuvant chemotherapy.RESULTS The prognostic impact of postoperative CEA and CA19-9 was superior to that of the preoperative levels. Multivariable analysis identified high postoperative CEA and CA19-9 levels as independent prognostic factors for overall survival.Disease-free survival rates clearly decreased in a stepwise manner in association with postoperative CEA and CA19-9 levels, and patients with high levels of both markers showed significantly poorer prognosis than other patient groups. When we analyzed perioperative changes in serum CEA and CA19-9 levels, patients with high levels before and after surgery had the worst disease-free survival rates among all patient groups. Patients with normalized CEA levels after surgery had a significantly lower disease-free survival rate than those with normal perioperative levels, whereas patients with normalized CA19-9 levels after surgery had equivalent survival to those with normal perioperative levels. The prognostic impact of high CEA levels was observably smaller in patients who underwent adjuvant chemotherapy than in patients who underwent surgery alone, whereas that of high CA19-9 was greater in patients who underwent adjuvant chemotherapy. High postoperative CEA levels were significantly associated with an increased prevalence of liver, lung and bone recurrences, and high postoperative CA19-9 levels were significantly associated with increased frequencies of lymph node and liver recurrences.CONCLUSION The evaluation of serum CEA and CA 19-9 levels both before and after surgery provides useful information for precise risk stratification after curative gastrectomy. | Yasuhito Suenaga Mitsuro Kanda Seiji Ito Yoshinari Mochizuki Hitoshi Teramoto Kiyoshi Ishigure Toshifumi Murai Takahiro Asada Akiharu Ishiyama Hidenobu Matsushita Chie Tanaka Daisuke Kobayashi Michitaka Fujiwara Kenta Murotani Yasuhiro Kodera | 2019 | World Journal of Gastrointestinal Oncology2019，11，1： | 7 |
| 8 | Gastric cancer treated in 2002 in Japan: 2009 annual report of the JGCA nationwide registry显示文摘 | Atsushi Nashimoto Kohei Akazawa Yoh Isobe Isao Miyashiro Hitoshi Katai Yasuhiro Kodera Shunichi Tsujitani Yasuyuki Seto Hiroshi Furukawa Ichiro Oda Hiroyuki Ono Satoshi Tanabe Michio Kaminishi | 2013 | Gastric Cancer2013，，1： | 6 |
| 9 | Emerging evidence of the molecular landscape specific for hematogenous metastasis from gastric cancer显示文摘Gastric cancer(GC) is one of the most frequentlydiagnosed cancers in the world. Most GC patients are diagnosed when the cancer is in an advanced stage, and consequently, some develop metastatic lesions that generally cause cancer-related death. Metastasis establishment is affected by various conditions, such as tumor location, hemodynamics and organotropism. While digestive cancers may share a primary site, certain cases develop hematogenous metastasis with the absence of peritoneal metastasis, and vice versa. Numerous studies have revealed the clinicopathological risk factors for hematogenous metastasis from GC, such as vascular invasion, advanced age, differentiation, Borrmann type 1 or 2 and expansive growth. Recently, molecular mechanisms that contribute to metastatic site determination have been elucidated by advanced molecular biological techniques. Investigating the molecules that specifically participate in metastasis establishment in distinct secondary organs will lead to the development of novel biomarkers for patient stratification according to their metastatic risk and strategies for preventing and treating distinct metastases. We reviewed articles related to the molecular landscape of hematogenous metastasis from GC. | Dai Shimizu Mitsuro Kanda Yasuhiro Kodera | 2018 | World Journal of Gastrointestinal Oncology2018，10，6： | 5 |
| 10 | Oncological problems in pancreatic cancer surgery显示文摘尽管有更复杂的诊断技术的发展,胰腺的癌还没在早阶段被检测了。外科的切除术为痊愈或长期的幸存提供唯一的机会。切除术率在外科的技术和广泛的外科的申请由于最近的进展增加了。然而,手术后的预后由于通常发生的肝转移,本地复发和腹传播是差的。最近的分子生物的研究在胰腺的癌症澄清了秘密转移,微转移和系统病。在胰腺的癌症外科的几个 oncological 问题在现在的评论被讨论。 | Akimasa Nakao Tsutomu Fujii Hiroyuki Sugimoto Naohito Kanazumi Shuji Nomoto Yasuhiro Kodera Soichiro Inoue Shin Takeda | 2006 | World Journal of Gastroenterology2006，12，28： | 5 |
| 11 | Dietary Factors and the Risk of Gastric Cancer Among Japanese Women显示文摘 | Lucy Sayuri Ito Manami Inoue Kazuo Tajima Yoshitaka Yamamura Yasuhiro Kodera Kaoru Hirose Toshiro Takezaki Nobuyuki Hamajima Tetsuo Kuroishi Suketami Tominaga | 2002 | Annals of Epidemiology2002，，1： | 4 |
| 12 | Gain in polycrystalline Nd-doped alumina: leveraging length scales to create a new class of high-energy, short pulse, tunable laser materials显示文摘Traditionally accepted design paradigms dictate that only optically isotropic(cubic)crystal structures with high equilibrium solubilities of optically active ions are suitable for polycrystalline laser gain media.The restriction of symmetry is due to light scattering caused by randomly oriented anisotropic crystals,whereas the solubility problem arises from the need for sufficient active dopants in the media.These criteria limit material choices and exclude materials that have superior thermo-mechanical properties than state-of-the-art laser materials.Alumina(Al_(2)O_(3))is an ideal example;it has a higher fracture strength and thermal conductivity than today’s gain materials,which could lead to revolutionary laser performance.However,alumina has uniaxial optical proprieties,and the solubility of rare earths(REs)is two-to-three orders of magnitude lower than the dopant concentrations in typical RE-based gain media.We present new strategies to overcome these obstacles and demonstrate gain in a RE-doped alumina(Nd:Al_(2)O_(3))for the first time.The key insight relies on tailoring the crystallite size to other important length scales—the wavelength of light and interatomic dopant distances,which minimize optical losses and allow successful Nd doping.The result is a laser gain medium with a thermo-mechanical figure of merit of R_(s)~19,500 Wm^(−1) a 24-fold and 19,500-fold improvements over the high-energy-laser leaders Nd:YAG(R_(s)~800Wm^(−1))and Nd:Glass(R_(s)~1Wm^(−1)),respectively.Moreover,the emission bandwidth of Nd:Al_(2)O_(3) is broad:~13 THz.The successful demonstration of gain and high bandwidth in a medium with superior R_(s) can lead to the development of lasers with previously unobtainable highpeak powers,short pulses,tunability,and high-duty cycles. | Elias H.Penilla Luis F.Devia-Cruz Matthew A.Duarte Corey L.Hardin Yasuhiro Kodera Javier E.Garay | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 13 | Factors affecting the quality of life of patients after gastrectomy as assessed using the newly developed PGSAS-45 scale: A nationwide multi-institutional study显示文摘AIM To identify certain clinical factors other than the type of gastrectomy which affect the postoperative quality of life(QOL) of patients after gastrectomy.METHODS The postgastrectomy syndrome assessment scale(PGSAS)-45 was designed to assess the severity of symptoms, the living status and the QOL of gastrectomized patients. It consists of 45 items, of which 22 are original items while 23 were retrieved from the SF-8 and Gastrointestinal Symptoms Rating Scale questionnaires with permission. A nationwide surveillance study to validate PGSAS was conducted and 2368 gastric cancer patients who underwent various types of gastrectomy at 52 medical institutions were enrolled. Of these, 1777 patients who underwent total gastrectomy(TG) reconstructed with Roux-Y(n = 393), distal gastrectomy(DG) reconstructed with Billroth-I(n = 909), or DG reconstructed with Roux-Y(n = 475) were evaluated in the current study. The influence of the type of gastrectomy and other clinical factors such as age, sex, duration after surgery, the symptom severity, the degree of weight loss, dietary intake, and the ability for working on the postoperative QOL(i.e., dissatisfaction for daily life subscale, physical component summary and mental component summary of the SF-8) were examined by multiple regression analysis(MRA). In addition, importance of various symptoms such as esophageal reflux, abdominal pain, meal-related distress, indigestion, diarrhea, constipation and dumping on the postoperative living status and QOL were also appraised by MRA.RESULTS The postoperative QOL were significantly deteriorated in patients who underwent TG compared to those after DG. However, the extent of gastrectomy was not an influential factor on patients' QOL when adjusted by the MRA. Among various clinical factors, the symptom severity, ability for working, and necessity for additional meals were the most influential factorsto the postoperative QOL. As for the individual symptoms, meal-related distress, dumping, abdominal pain, and esophageal reflux significantly affected the postoperative QOL in that order, while the influence of indigestion, diarrhea and constipation was insignificant. CONCLUSION Several clinical factors such as the symptom severity(especially in meal-related distress and dumping), ability for working and necessity for additional meals were the main factors which affected the patients' wellbeing after gastrectomy. | Koji Nakada Masazumi Takahashi Masami Ikeda Shinichi Kinami Masashi Yoshida Yoshikazu Uenosono Yoshiyuki Kawashima Sayumi Nakao Atsushi Oshio Yoshimi Suzukamo Masanori Terashima Yasuhiro Kodera | 2016 | World Journal of Gastroenterology2016，22，40： | 4 |
| 14 | Follow-up after gastrectomy for cancer:results of an international web round table显示文摘Oncological follow-up after radical gastrectomy for cancer still represents a discrepancy in the field,with many retrospective series demonstrating that early diagnosis of recurrence does not result in an improvement in patient survival;yet,many centers with high quality of care still provide routine patient follow-up after surgery by clinical and instrumental controls.This was the topic for a web round table entitled'Rationale and limits of oncological follow-up after gastrectomy for cancer'that was launched one year before the 10th International Gastric Cancer Congress.Authors having specific expertise were invited to comment on their previous publications to provide the subject for an open debate.During a three-month-long discussion,32 authors from 12 countries participated,and 2299people visited the dedicated web page.Substantial differences emerged between the participants:authors from Japan,South Korea,Italy,Brazil,Germany and France currently engage in instrumental follow-up,whereas authors from Eastern Europe,Peru and India do not,and British and American surgeons practice it in a rather limited manner or in the context of experimental studies.Although endoscopy is still considered useful by most authors,all the authors recognized that computed tomography scanning is the method of choice to detect recurrence;however,many limit follow-up to clinical and biochemical examinations,and acknowledge the lack of improved survival with early detection. | Gian Luca Baiocchi Yasuhiro Kodera Daniele Marrelli Fabio Pacelli Paolo Morgagni Franco Roviello Giovanni De Manzoni | 2014 | World Journal of Gastroenterology2014，20，34： | 4 |
| 15 | Modified docetaxel, cisplatin and capecitabine for stage Ⅳ gastric cancer in Japanese patients: A feasibility study显示文摘AIM To evaluate the feasibility of chemotherapy including fluoropyrimidine, platinum and taxane with modified dosages for unresectable gastric cancer in Japanese patients.METHODS We performed a feasibility study of a modified docetaxel, cisplatin and capecitabine (DCX) regimen for stage Ⅳ gastric cancer. In particular, 30 or 40 mg/m^2 of docetaxel on day 1, 60 mg/m^2 of cisplatin on day 1, and 2000 mg/m^2 of capecitabine for 2 wk were administered every three weeks.RESULTS Three patients were treated with modified DCX(m DCX) with 30 mg/m^2 docetaxel, and five patients were treated with this regimen with 40 mg/m^2 docetaxel. Grade 3 or 4 neutropenia was observed in six of the eight patients; no patients exhibited febrile neutropenia. Partial response was achieved in four of the eight patients. Three patients underwent gastrectomy, which achieved R0 resection without residual tumors in dissected lymph nodes. In one of these three patients, resected specimens revealed pathological complete response in the primary lesion and in lymph nodes.CONCLUSION m DCX was well tolerated by Japanese patients with stage Ⅳ gastric cancer. This regimen might be useful for allowing gastric cancer patients with distant lymph node metastasis to undergo conversion surgery. | Osamu Maeda Ayumu Matsuoka Ryoji Miyahara Kohei Funasaka Yoshiki Hirooka Masahide Fukaya Masato Nagino Yasuhiro Kodera Hidemi Goto Yuichi Ando | 2017 | World Journal of Gastroenterology2017，23，6： | 4 |
| 16 | Prognostic Significance of Intraperitoneal Cancer Cells in Gastric Carcinoma: Analysis of Real Time Reverse Transcriptase-Polymerase Chain Reaction after 5 Years of Followup显示文摘 | Yasuhiro Kodera Hayao Nakanishi Seiji Ito Yoshinari Mochizuki Norifumi Ohashi Yoshitaka Yamamura Michitaka Fujiwara Masahiko Koike Masae Tatematsu Akimasa Nakao | 2006 | Journal of the American College of Surgeons2006，，： | 3 |
| 17 | 斯洛伐克西喀尔巴阡山Koice-Medvedia菱镁矿床的矿物学、流体包裹体和碳-氧-锶同位素研究(英文)显示文摘Kosice矿床是斯洛伐克第二大的菱镁矿床(150Mt),位于Gemeric的东部.其镁质碳酸盐矿体赋存于石炭纪石灰石和含白云石的石灰石中,同时下盘黑色片岩中也含有被铁质碳酸盐交代的薄层碳酸盐透镜体.在华力西期造山运动(M1)中,古生代岩石受到了低级变质作用(绿泥石带).镁交代作用始于白云岩1的结晶作用,其后形成菱镁矿,最终沿裂隙形成铁菱镁矿.铁质碳酸盐包括早期铁白云石-白云石,铁白云石和后期含方解石和石英的菱铁矿.根据碳酸盐矿物对地质温度计,白云石l结晶作用发生在300~340℃.这一结果与M1的变质矿物组合(绿泥石,白云母-伊利石)吻合.铁白云石的结晶作用发生在320~370℃.少量细脉中可见白云石2,绿泥石和伊利石-多硅白云母,它们是由于阿尔卑斯期造山运动M2变质作用形成的更晚的矿物组合.菱镁矿的流体包裹体(FI)研究,显示存在不同成分的热卤水,卤水成分变化相当于NaCl含量21~42 wt%,但其它成分的盐含量高于NaCl,溶解的CO2含量也有变化.两相包裹体均一温度(Th)的范围为164~217℃,含石盐子晶包裹体均一温度的范围为217~344℃.富CO2包裹体(盐度相当于NaCl含量1~22wt%,CO2的密度为0.28~0.77 g·cm-3,均一温度为289~344℃)在菱镁矿中是次要的,但这种包裹体在与矿石伴生的石英中是主要的,并且与含石盐子晶流体包裹体共生.在后期镁交代过程中流体中的CO2逐渐增加.和铁质碳酸盐伴生的石英中只有两相包裹体,包裹体中CO2含量有所变化,盐度范围为17~24 wt%的NaCl(或者34~36 wt%的MgCl2),均一温度为152~195℃.包裹体的数据结合碳酸盐地质温度计显示镁交代作用的压力范围是180~320MPa(7~12km),铁交代作用的压力范围是280~420MPa(10~16km),说明地热梯度约为25~35℃/km.包裹体浸出液的分析表明Cl/Br和Na/Br的比值存在变化,但仍旧说明富镁的卤水来源是上二叠纪和下三叠纪的分馏蒸发岩来源.铁质碳酸盐流体的高溴和高碘含量,说明在铁交代过程中周围黑色片岩的明显影响.菱镁矿和铁交代作用,表明交代流体中的碳和二氧化碳,主要是海洋沉积的来源.菱铁矿的'Sr/86Sr比值((0.71124~0.71140),说明锶的多来源,最初应是石炭纪和二叠纪的海水,但它被当地其它陆壳中的锶混染. | Martin RADVANEC Peter KODERA Walter PROCHASKA | 2004 | 岩石学报2004，20，4： | 3 |
| 18 | B?cell translocation gene 1 serves as a novel prognostic indicator ofhepatocellular carcinoma显示文摘 | Mitsuro Kanda Hiroyuki Sugimoto Shuji Nomoto Hisaharu Oya Soki Hibino Dai Shimizu Hideki Takami Ryoji Hashimoto Yukiyasu Okamura Suguru Yamada Tsutomu Fujii Goro Nakayama Masahiko Koike Michitaka Fujiwara Yasuhiro Kodera | 2015 | International Journal of Oncology2015，，2： | 3 |
| 19 | Quality of life after total vs distal gastrectomy with Rouxen-Y reconstruction: Use of the Postgastrectomy Syndrome Assessment Scale-45显示文摘AIM To investigate the detrimental impact of loss of reservoir capacity by comparing total gastrectomy(TGRY) and distal gastrectomy with the same Rouxen-Y(DGRY) reconstruction. The study was conducted using an integrated questionnaire, the Postgastrectomy Syndrome Assessment Scale(PGSAS)-45, recently developed by the Japan Postgastrectomy Syndrome Working Party.METHODS The PGSAS-45 comprises 8 items from the Short Form-8, 15 from the Gastrointestinal Symptom Rating Scale, and 22 newly selected items. Uni-and multivariate analysis was performed on 868 questionnaires completed by patients who underwent either TGRY(n = 393) or DGRY(n = 475) for stage I gastric cancer(52 institutions). Multivariate analysis weighed of six explanatory variables, including the type of gastrectomy(TGRY/DGRY), interval after surgery, age, gender, surgical approach(laparoscopic/open), and whether the celiac branch of the vagus nerve was preserved/divided on the quality of life(QOL).RESULTS The patients who underwent TGRY experienced the poorer QOL compared to DGRY in the 15 of 19 main outcome measures of PGSAS-45. Moreover, multiple regression analysis indicated that the type of gastrectomy, TGRY, most strongly and broadly impaired the postoperative QOL among six explanatory variables. CONCLUSION The results of the present study suggested that TGRY had a certain detrimental impact on the postoperative QOL, and the loss of reservoir capacity could be a major cause. | Masazumi Takahashi Masanori Terashima Hiroshi Kawahira Eishi Nagai Yoshikazu Uenosono Shinichi Kinami Yasuhiro Nagata Masashi Yoshida Keishiro Aoyagi Yasuhiro Kodera Koji Nakada | 2017 | World Journal of Gastroenterology2017，23，11： | 3 |
| 20 | Systemic hemodynamics in advanced cirrhosis: Concerns during perioperative period of liver transplantation显示文摘Advanced liver cirrhosis is usually accompanied by portal hypertension. Long-term portal hypertension results in various vascular alterations. The systemic hemodynamic state in patients with cirrhosis is termed a hyperdynamic state. This peculiar hemodynamic state is characterized by an expanded blood volume, high cardiac output, and low total peripheral resistance. Vascular alterations do not disappear even long after liver transplantation(LT), and recipients with cirrhosis exhibit a persistent systemic hyperdynamic state even after LT. Stability of optimal systemic hemodynamics is indispensable for adequate portal venous flow(PVF) and successful LT, and reliable parameters for optimal systemic hemodynamics and adequate PVF are required. Even a subtle disorder in systemic hemodynamics is precisely indicated by the balance between cardiac output and blood volume. The indocyanine green(ICG) kinetics reflect the patient's functional hepatocytes and effective PVF, and PVF is a major determinant of the ICG elimination constant(kICG) in the well-preserved allograft. The kICG value is useful to set the optimal PVF during living-donor LT and to evaluate adequate PVF after LT. Perioperative management has a large influence on the postoperative course and outcome; therefore, key points and unexpected pitfalls for intensive management are herein summarized. Transplant physicians should fully understand the peculiar systemic hemodynamic behavior in LT recipients with cirrhosis and recognize the critical importance of PVF after LT. | Tomohide Hori Yasuhiro Ogura Yasuharu Onishi Hideya Kamei Nobuhiko Kurata Motoshi Kainuma Hideo Takahashi Shogo Suzuki Takashi Ichikawa Shoko Mizuno Tadashi Aoyama Yuki Ishida Takahiro Hirai Tomoko Hayashi Kazuko Hasegawa Hiromu Takeichi Atsunobu Ota Yasuhiro Kodera Hiroyuki Sugimoto Taku Iida Shintaro Yagi Kentaro Taniguchi Shinji Uemoto | 2016 | World Journal of Hepatology2016，8，25： | 3 |
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