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| 1 | Far-field coseismic displacements associated with the 2011 Tohoku-oki earthquake in Japan observed by Global Positioning System显示文摘Analysis of GEONET observations covering the entire territory of Japan shows that the great Tohoku-oki earthquake that occurred on March 11, 2011 off the east coast of Honshu in Japan caused an eastward movement of the northern part of the island by as much as 5.3 m. The GPS data from TEONET in China were used to derive far-field coseismic displacements and to assess the impact of the Tohoku-oki earthquake on crustal deformation in eastern China. The results reveal that the coseismic horizontal displacements induced by the earthquake are the level of millimeters to centimeters in North and Northeast China, with a maximum of 35 mm. Strain analysis also indicates that the earthquake resulted in an increase in the tensile strain on the north-northeast trending faults in North and Northeast China. The tensile strain imposed on the Yilan-Yitong and Dunhua-Mishan faults is more significant than that imposed on the faults in North China; the maximum normal strain reaches about 40 nano-strain. Considering that the static Coulomb stress loaded on the faults is limited, its effect on the regional seismic activity may not be significant. | WANG Min LI Qiang WANG Fan ZHANG Rui WANG YanZhao SHI HongBo ZHANG PeiZhen SHEN ZhengKang | 2011 | Chinese Science Bulletin2011，56，23： | 34 |
| 2 | Stenting for symptomatic intracranial arterial stenosis in China:1-year outcome of a multicentre registry study显示文摘background and purpose A multicentre prospective registry study of individually tailored stenting for a patient with symptomatic intracranial atherosclerotic stenosis(ICAS)combined with poor collaterals in China showed that the short-term safety and efficacy of stenting was acceptable.However,it remained uncertain whether the low event rate could be of a long term.We reported the 1-year outcome of this registry study to evaluate the long-term efficacy of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Methods Patients with symptomatic ICAS caused by 70%-99% stenosis located at the intracranial internal carotid,middle cerebral,intracranial vertebral or basilar arteries combined with poor collaterals were enrolled.Balloon-mounted stent or balloon plus self-expanding stent were selected based on the ease of vascular access and lesion morphology determined by the operators.The primary outcome was the rate of 30-day stroke,transient ischaemic attack and death,and 12-month ischaemic stroke within the same vascular territory,haemorrhagic stroke and vascular death after stenting.results From September 2013 to January 2015,300 patients(ages 58.3±9.78 years)were recruited.Among them,159 patients were treated with balloon-mounted stent and 141 with balloon plus self-expanding stent.During the 1-year follow-up,25 patients had a primary end point event.The probability of primary outcome at 1 year was 8.1%(95% CI 5.3% to 11.7%).In 76 patients with digital subtraction angiography follow-up,27.6%(21/76)had re-stenosis≥50% and 18.4%(14/76)had re-stenosis≥70%.No baseline characteristic was associated with the primary outcome.Conclusion The event rate remains low over 1 year of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Further randomised trial of comparing individually tailored stenting with best medical therapy is needed. | Ning Ma Yong Zhang Jie Shuai Changchun Jiang Qiyi Zhu Kangning Chen Li Liu Baomin Li Xiangqun Shi Lianbo Gao Yajie Liu Feng Wang Yongli Li Tieyan Liu Hongbo Zheng Dapeng Mo Feng Gao Yilong Wang Yongjun Wang Lei Feng Zhongrong Miao | 2018 | Stroke & Vascular Neurology2018，3，3： | 29 |
| 3 | Chang'E-1 Lunar Mission:An Overview and Primary Science Results显示文摘Chang'E-1 is the first lunar mission in China,which was successfully launched on Oct.24th,2007.It was guided to crash on the Moon on March 1,2009,at 52.36°E,1.50°S,in the north of Mare Fecunditatis.The total mission lasted 495 days,exceeding the designed life-span about four months.1.37Terabytes raw data was received from Chang'E-1.It was then processed into 4Terabytes science data at different levels.A series of science results have been achieved by analyzing and applicating these data,especially 'global image of the Moon of China's first lunar exploration mission'.Four scientific goals of Chang'E-1 have been achieved.It provides abundant materials for the research of lunar sciences and cosmochemistry.Meanwhile these results will serve for China's future lunar missions. | Ouyang Ziyuan Li Chunlai Lu Chang Liu Jianzhong Zou Yongliao Zhang Hongbo Jianjun Zuo Wei Su Yah Wen Weibin Bian Wei Zhao Baochang Wang Jianyu Yang Jianfeng Chang Jin Wang Huanyu Zhang Xiaohui Wang Shijin Wang Min Ren Xin Mu Lingli Kong Deqing Wang Xiaoqian Wang Fang Geng Liang Zhang Zhoubin Zheng Lei Zhu Xinying Zheng Yongchun Li Junduo Zou Xiaoduan Xu Chun Shi Shuobiao Gao Yifei Gao Guannan | 2010 | 空间科学学报2010，30，5： | 11 |
| 4 | Biomimetic Corrugated Silicon Nanocone Arrays for Self-Cleaning Antireflection Coatings显示文摘Corrugated silicon nanocone(SiNC)arrays have been fabricated on a silicon wafer by two polystyrene-sphere-monolayer-masked etching steps in order to create high-performance antireflective coatings.The reflectance was reduced from above 35%to less than 0.7%in the range 400-1050 nm,and it remained below 0.5%at incidence angles up to 70°at 632.8 nm for both s-and p-polarized light.The fluorinated corrugated SiNC array surface exhibits superhydrophobic properties with a water contact angle of 164°. | Yandong Wang Nan Lu Hongbo Xu Gang Shi Miaojun Xu Xiaowen Lin Haibo Li Wentao Wang Dianpeng Qi Yanqing Lu Lifeng Chi | 2010 | Nano Research2010，3，7： | 8 |
| 5 | KIF2C:a novel link between Wnt/β-catenin and mTORCI signaling in the pathogenesis of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and is the fourth-leading cause of cancer-related deaths worldwide.HCC is refractory to many standard cancer treatments and the prognosis is often poor,highlighting a pressing need to identify biomarkers of aggressiveness and potential targets for future treatments.Kinesin family member 2C(KIF2C)is reported to be highly expressed in several human tumors.Nevertheless,the molecular mechanisms underlying the role of KIF2C in tumor development and progression have not been investigated.In this study,we found that KIF2C expression was significantly upregulated in HCC,and that KIF2C up-regulation was associated with a poor prognosis.Utilizing both gain and loss of function assays,we showed that KIF2C promoted HCC cell proliferation,migration,invasion,and metastasis both in vitro and in vivo.Mechanistically,we identified TBC1D7 as a binding partner of KIF2C,and this interaction disrupts the formation of the TSC complex,resulting in the enhancement of mammalian target of rapamycin complexl(mTORCI)signal transduction.Additionally,we found that KIF2C is a direct target of the Wnt/β-catenin pathway,and acts as a key factor in mediating the crosstalk between Wnt/β-catenin and mTORCI signaling.Thus,the results of our study establish a link between Wnt/β-catenin and mTORCI signaling,which highlights the potential of KIF2C as a therapeutic target for the treatment of HCC. | Shi Wei Miaomiao Dai Chi Zhang Kai Teng Fengwei Wang Hongbo Li Weipeng Sun Zihao Feng Tiebang Kang Xinyuan Guan Ruihua Xu Muyan Cai Dan Xie | 2021 | Protein & Cell2021，12，10： | 8 |
| 6 | Influence of the intensity and loading time of direct current electric field on the directional migration of rat bone marrow mesenchymal stem cells显示文摘Exogenic 电场能有效地加速骨头愈合并且向受伤区域通过骨头髓的提高的迁居改变间充质的干细胞(BMSC ) 。这研究试图决定下列:(1 ) 在到一个直接当前的电场(DCEF ) 的暴露之上的老鼠 BMSC (rBMSC ) 移植的方向,(2 ) 最佳的 DCEF 紧张和持续时间,并且(3 ) 在由 DCEF 导致了的 rBMSC 移植的 SDF-1/CXCR4 轴的可能的规章的角色。显示出的结果 rBMSCs 移居了到 DCEF 的积极电极,并且为 4 h 的 200 mV/mm 的 DCEF 被发现在提高 rBMSC 移植最佳。这 DCEF 力量和持续时间另外 upregulated osteoblastic 基因,包括的高山和 OCN 的表示,和 upregulated 高山和 Runx2 蛋白质的表示。而且当 CXCR4 被禁止时, rBMSC 移植部分由于 DCEF 被堵住。这些调查结果显示 DCEF 能有效地导致 rBMSC 移植。因为它支持 rBMSC 移植,增长,和 osteogenic 区别的能力,为 4 h 的 200 mV/mm 的 DCEF 被推荐。表明小径的 SDF-1/CXCR4 可以在调整 rBMSCs 的导致 DCEF 的迁居起一个重要作用。 | Xiaoyu Wang Yuxuan Gao Haigang Shi Na Liu Wei Zhang Hongbo Li | 2016 | Frontiers of Medicine2016，10，3： | 7 |
| 7 | The Interplay between Artificial Intelligence and Fog Radio Access Networks显示文摘The interplay between artificial intelligence(AI) and fog radio access networks(F-RANs) is investigated in this work from two perspectives: how F-RANs enable hierarchical AI to be deployed in wireless networks and how AI makes F-RANs smarter to better serve mobile devices. Due to the heterogeneity of processing capability, the cloud, fog, and device layers in F-RANs provide hierarchical intelligence via centralized, distributed, and federated learning. In addition, cross-layer learning is also introduced to further reduce the demand for the memory size of the mobile devices. On the other hand, AI provides F-RANs with technologies and methods to deal with massive data and make smarter decisions. Specifically, machine learning tools such as deep neural networks are introduced for data processing, while reinforcement learning(RL) algorithms are adopted for network optimization and decisions. Then, two examples of AI-based applications in F-RANs, i.e., health monitoring and intelligent transportation systems, are presented, followed by a case study of an RL-based caching application in the presence of spatio-temporal unknown content popularity to showcase the potential of applying AI to F-RANs. | Wenchao Xia Xinruo Zhang Gan Zheng Jun Zhang Shi Jin Hongbo Zhu | 2020 | China Communications2020，17，8： | 6 |
| 8 | Delay-Based User Association in Heterogeneous Networks with Backhaul显示文摘The Internet of things(IoT) as an important application of future communication networks puts a high premium on delay issues. Thus when Io T applications meet heterogeneous networks(HetNets) where macro cells are overlaid with small cells, some traditional problems need rethinking. In this paper, we investigate the delay-addressed association problem in two-tier Het Nets considering different backhaul technologies. Specifically, millimeter wave and fiber links are used to provide high-capacity backhaul for small cells. We first formulate the user association problem to minimize the total delay which depends on the probability of successful transmission, the number of user terminals(UTs), and the number of base stations(BSs). And then two algorithms for active mode and mixed mode are proposed to minimize the network delay. Simulation results show that algorithms based on mutual selection between UTs and BSs have better performance than those based on distance. And algorithms for mixed modes have less delay than those for active mode when the number of BSs is large enough, compared to the number of UTs. | Wenchao Xia Jun Zhang Shi Jin Hongbo Zhu | 2017 | China Communications2017，14，10： | 4 |
| 9 | Orthogonal nonnegative matrix factorization based local hidden Markov model for multimode process monitoring显示文摘Traditional data driven fault detection methods assume that the process operates in a single mode so that they cannot perform well in processes with multiple operating modes. To monitor multimode processes effectively,this paper proposes a novel process monitoring scheme based on orthogonal nonnegative matrix factorization(ONMF) and hidden Markov model(HMM). The new clustering technique ONMF is employed to separate data from different process modes. The multiple HMMs for various operating modes lead to higher modeling accuracy.The proposed approach does not presume the distribution of data in each mode because the process uncertainty and dynamics can be well interpreted through the hidden Markov estimation. The HMM-based monitoring indication named negative log likelihood probability is utilized for fault detection. In order to assess the proposed monitoring strategy, a numerical example and the Tennessee Eastman process are used. The results demonstrate that this method provides efficient fault detection performance. | Fan Wang Honglin Zhu Shuai Tan Hongbo Shi | 2016 | Chinese Journal of Chemical Engineering2016，24，7： | 3 |
| 10 | Research on variety characteristics of China's Mainland troposphere based on CMONOC显示文摘In this research, we processed the GPS and meteorological data from about 220 stations of Crustal Movement Observation Network of China(CMONOC) observed in 2014 and derived the Zenith Total Delay(ZTD) map in both spatial and temporal dimension. The results of ZTD have high accurate and reliable as IGS and all sites with varying locations show obvious variety characteristics of Chinese mainland. Meanwhile, the precipitable water vapor(PWV) correlation coefficients between GPS observation and upper air sounding is close to 1, and the comparison of GPS-derived PWV and observed PWV from meteorological sites indicating GPS observation data generated in CMONOC project applied to the weather forecast research is feasible. In addition, based on all stations covered the whole Chinese land area and using interpolation algorithms, we make contour plots of PWV distribution per hour. We observe obvious feature that the precipitable water in north and western area is less than south and east area all over this year. High latitudes area may be dry and low latitudes area is wet. | Hongbo Shi Rui Zhang Zhaosheng Nie Yu Li Zhengsong Chen Tan Wang | 2018 | Geodesy and Geodynamics2018，9，5： | 3 |
| 11 | Analysis of Stationary Queue Length Distribution for Geo/T-IPH/1 Queue显示文摘In this paper we study a Geo/T-IPH/1 queue model,where T-IPH denotes the discrete time phase type distribution defined on a birth-and-death process with countably many states.The queue model can be described by a quasi-birth-anddeath(QBD)process with countably phases.Using the operator-geometric solution method,we first give the expression of the operator and the joint stationary distribution.Then we obtain the probability generating function(PGF)for stationary queue length distribution and sojourn time distribution,respectively. | Hongbo Zhang Zhenting Hou Dinghua Shi | 2013 | Journal of the Operations Research Society of China2013，1，3： | 3 |
| 12 | Single-cell transcriptomic landscape of human blood cells显示文摘High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis.However,an elaborate and comprehensive transcriptome reference of the whole blood system is lacking.Here,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy donors.With high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between them.Notably,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified.While common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during differentiation.Furthermore,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune functions.Finally,a web portal offering transcriptome browsing and blood cell type prediction has been established.Thus,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. | Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Una Wang Wenbin Cao Shulian Chen Qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu Tao Cheng | 2021 | National Science Review2021，8，3： | 3 |
| 13 | Ionospheric total electron content disturbance associated with May 12, 2008,Wenchuan earthquake显示文摘Possible ionospheric disturbances relating to the May 12, 2008, Ms8.0 Wenchuan earthquake were identified by Global Positioning System(GPS)-derived total electron content(TEC), ionosonde observations, the global ionospheric map(GIM), and electron density profiles detected by the Constellation Observation System for Meteorology Ionosphere and Climate(COSMIC).We applied a statistical test to detect anomalous TEC signals and found that a unique enhancement in TEC, recorded at 16 GPS stations, appeared on May 9, 2008. The critical frequency at F2 peak(f0F2), observed by the Chinese ionosondes, and maximal plasma frequency,derived from COSMIC data, revealed a characteristic similar to GPS TEC variations. The GIM showed that the anomalous variations of May 9 were located southeast of the epicenter. Using GPS data from 13 stations near the epicenter, we analyzed the TEC variations of satellite orbit traces during 04:00e11:00 UT. We found that TEC decreased to the east and increased to the southeast of the epicenter during this period. Results showed that the abnormal disturbance on May 9 was probably an ionospheric precursor of the Wenchuan earthquake of May 12, 2008. | Li Jianyong Meng Guojie You Xinzhao Zhang Rui Shi Hongbo Han Yufei | 2015 | Geodesy and Geodynamics2015，6，2： | 3 |
| 14 | Large System Analysis of Downlink C-RAN with Phase Noise and Fronthaul Compression显示文摘This paper studies the effect of phase noise and fronthaul compression on a downlink cloud radio access network(C-RAN), where several remote radio heads(RRHs) are coordinated to communicate with users by a baseband unit(BBU) on the cloud server. In the system, the baseband signals are precoded at BBU, and then compressed before being transmitted to RRHs through capacity-limited fronthaul links which results in the compressive quantization noise. We assume the regularized zero-forcing precoding is performed with an imperfect channel state information and a compression strategy is applied at BBU. The effect of phase noise arising from nonideal local oscillators both at RRHs and users is considered. We propose an approximate expression for the downlink ergodic sum-rate of considered C-RAN utilizing large dimensional random matrix theory in the large-system regime. From simulation results, the accuracy of the approximate expression is validated, and the effect of phase noise and fronthaul compression can be analyzed theoretically based on the approximate expression. | Yishi Xue Jun Zhang Shi Jin Gan Zheng Hongbo Zhu | 2019 | China Communications2019，16，8： | 2 |
| 15 | on Erdos'Ten-Point Problem | Li Hongbo (MMRC,Institute of Systems Science,Academia Sinica,Beijing 100080,China)(Fax:62568364,E-mail:hli@mmrc.iss.ac.cn)Shi He (MMRC,Institute of Systems Science,Academia Sinica,Beijing 100080,China)(Fax:62568364,E-mail:hshi@mmrc.iss.ac.cn) | 1997 | Acta Mathematica Sinica,English Series1997，13，2： | 2 |
| 16 | P_1-nonconforming triangular finite element method for elliptic and parabolic interface problems显示文摘The lowest order P1-nonconforming triangular finite element method(FEM)for elliptic and parabolic interface problems is investigated. Under some reasonable regularity assumptions on the exact solutions, the optimal order error estimates are obtained in the broken energy norm. Finally, some numerical results are provided to verify the theoretical analysis. | Hongbo GUAN Dongyang SHI | 2015 | Applied Mathematics and Mechanics(English Edition)2015，36，9： | 2 |
| 17 | Multivariate statistical process monitoring using an improved independent component analysis显示文摘 | Li Wang Hongbo Shi | 2009 | Chemical Engineering Research and Design2009，，4： | 2 |
| 18 | High-dimensional immune profiling by mass cytometry revealed immunosuppression and dysfunction of immunity in COVID-19 patients显示文摘The outbreak of coronavirus disease 2019(COVID-19)caused by the new virus SARS-CoV-2 has been announced as a public health emergency of international concern.1–3 The clinical features of patients with COVID-19 range from common fever and cough to other rare symptoms,such as diarrhea and nausea.This disease can progress quickly,and 2–3%of patients die within a short time,which is generally due to multiple organ failure.4–7 Clinically,COVID-19 patients are classified into mild,moderate,severe,and critical cases.5–7 The immune response against SARS-CoV-2 is probably linked to the severity of disease.Recently,Zheng et al.8 showed that elevated levels of T-cell exhaustion and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients;however,a more comprehensive understanding of the pathology of SARS-CoV-2 infection remains to be delineated.Here,we profiled immune cellular components using mass cytometry(CyTOF)to analyze the peripheral blood mononuclear cells(PBMCs)from patients with differences in disease progression by comparing with the PBMCs from healthy donors(HDs). | Wenjing Wang Bin Su Lijun Pang Luxin Qiao Yingmei Feng Yabo Ouyang Xianghua Guo Hongbo Shi Feili Wei Xiaogang Su Jiming Yin Ronghua Jin Dexi Chen | 2020 | Cellular & Molecular Immunology2020，17，6： | 2 |
| 19 | In vitro assay of cytoskeleton nanomechanics as a tool for screening potential anticancer effects of natural plant extract, tubeimoside I on human hepatoma (HepG2) cells显示文摘Cytoskeleton nanomechanics characterizes cancer cell's physical behaviors such as how it spread and invade. For anticancer drug, cytoskeleton nanomechanics may be a target to inhibit invasiveness and metastasis of cancer cells. Therefore, in vitro assay of cytoskeleton nanomechanics may be used to evaluate the effects of potential anticancer drug on various cancer types. Here, we investigated the effects of tubeimoside I (TBMS I) on human hepatoma (HepG2) cells by using optical magnetic twisting cytometry, a well-established technique for measuring nanomechanics of the Factin cytoskeleton. TBMS I is a natural compound extracted from a traditional Chinese herbal medicine, and is reported with antitumor effect. In this study, we demonstrated that the cytoskeleton stiffness (G) of HepG2 cells was affected by TBMS I. G′ exhibited a typical power law with respect to the loading frequency (f), i.e. G^f . The magnitude of G′ and the value of exponent (α) of the HepG2 cells decreased consistently with the increase of concentration for TBMS I exposure. In addition, the HepG2 cells responded to TBMS I much faster than the normal liver (L-02) cells. Such alteration of cytoskeleton nanomechanics induced by TBMS I was reported for the first time, which was further corroborated by assays of Factin cytoskeleton structure and cell migration. Taken together, these results suggest that in vitro assay of cytoskeleton nanomechanics may have a great potential as an additional tool in screening of anticancer drug candidates. | ZHAO HongBo WANG YaShu JIANG XueMei SHI XiaoHao ZHONG HongZhe WANG YaJie CHEN Jun DENG LinHong | 2013 | Chinese Science Bulletin2013，58，21： | 2 |
| 20 | Thermal behaviour and degradation mechanism of phosphate di/triacrylate used for UV curable flame - retardant coatings 显示文摘 | HONGBO LIANG WENFANG SHI | | Polymer Degradation and Stability0，84，3： | 1 |
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