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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Vascular endothelial growth factor receptor 2(VEGFR-2) plays a key role in vasculogenic mimicry formation,neovascularization and tumor initiation by Glioma stem-like cells显示文摘Human glioblastomas(GBM)are thought to be initiated by glioma stem-like cells(GSLCs).GSLCs also participate in tumor neovascularization by transdifferentiating into vascular endothelial cells.Here,we report a critical role of GSLCs in the formation of vasculogenic mimicry(VM),which defines channels lined by tumor cells to supply nutrients to early growing tumors and | Yao X Ping Y Liu Y Chen K Yoshimura T Liu M Gong W Chen C Niu Q Guo D Zhang X Wang JM Bian X | 2013 | 中国神经肿瘤杂志2013，11，3： | 23 |
| 3 | Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells显示文摘Acute myeloid leukemia(AML)is a serious disease.The 5-year survival rates remain frustratingly low(65%for children and 26%for adults).Resistance to frontline chemotherapy(usually cytarabine)often develops;therefore a new treatment modality is needed.Bcl-2 family proteins play an important role in balancing cell survival and apoptosis.The antiapoptotic Bcl-2 family proteins have been found to be dysregulated in AML.ABT-199,a BH3 mimetic,was developed to target antiapoptotic protein Bcl-2.Although ABT-199 has demonstrated promising results,resistance occurs.Previous studies in AML show that ABT-199 alone decreases the association of proapoptotic protein Bim with Bcl-2,but this is compensated by increased association of Bim with prosurvival protein Mcl-1,stabilizing Mcl-1,resulting in resistance to ABT-199.In this study,we investigated the antileukemic activity of the Mcl-1-selective inhibitor A-1210477 in combination with ABT-199 in AML cells.We found that A-1210477 synergistically induced apoptosis with ABT-199 in AML cell lines and primary patient samples.The synergistic induction of apoptosis was decreased upon Bak,Bax and Bim knockdown.While A-1210477 treatment alone also increased Mcl-1 protein levels,combination with ABT-199 reduced binding of Bim to Mcl-1.Our results demonstrate that sequestration of Bim by Mcl-1,a mechanism of ABT-199 resistance,can be abrogated by combined treatment with the Mcl-1 inhibitor A-1201477. | Daniel A Luedtke Xiaojia Niu Yihang Pan Jianyun Zhao Shuang Liu Holly Edwards Kang Chen Hai Lin Jeffrey W Taub Yubin Ge | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 11 |
| 4 | Microbial synthesis of the energetic material precursor 1,2,4-butanetriol 显示文摘 | Niu W Molefe M N Frost J W | | J Am Chem Soc0，125，12： | 1 |
| 5 | Model of turbine optimal initial pressure under off-design operation based on SVR and GA显示文摘 | NIU P ZHANG W | 2012 | Neurocomputing2012，78，： | 1 |
| 6 | The WUSCHEL gene promotes vegetative-to-embryonic transition in Arabidopsis显示文摘 | ZUO J NIU Q W FRUGIS G | 2002 | The Plant Journal2002，30，3： | 1 |
| 7 | Compact-designed supercapacitors using free-standing single-walled carbon nanotube films显示文摘 | Niu Z Zhou W Cben J | 2011 | Energy Environ Sci2011，4，4： | 1 |
| 8 | Strong association of methylenetetra- hydrofolate reductase gene C677T polymorphism with hypertension and hypertension-in-pregnancy in Chinese:a meta-analysis显示文摘 | NIU W Q YOU Y G QI Y | 2012 | J Hum Hypertens2012，26，4： | 1 |
| 9 | Talanta显示文摘 | Li Y H Niu W F Lu J R | 2007 | 71:11242007，71，： | 1 |
| 10 | Multi-resolution shape description and clustering of three-dimensional head data显示文摘 | NIU J W LI Z Z SALVENDY G | 2009 | Ergonomics2009，52，2： | 1 |
| 11 | Optimised ultrasonic-assisted extrac- tion of flavonoids from Folium eucommiae and evaluation of antioxi- dant activity in multi-test systems in v/tro显示文摘 | HUANG W XUE A NIU H | 2009 | Food Chem2009，114，3： | 1 |
| 12 | Clonal dissemination nf linezolid- resistant Staphylococcus capitis with G2603T mutatiun in domain V of the 23S rRNA and the cfr gene at a tertim3~' care hospital in Chi- na 显示文摘 | Zhou W Niu D Cao X | 2015 | BMC Infect Dis2015，15，： | 1 |
| 13 | Electrical resistivity evolution in the annealed amorphous Fe78Si9B13 ribbons 显示文摘 | Wang W M Niu Y C Wang F | 2008 | Journal of Non-Crystalline Solids2008，354，30： | 1 |
| 14 | Reconstruction of old orbital wall fractures with mandibular outer cortex显示文摘 | LIU W NIU F ZHANG Z Y | 2010 | J Craniofac Surg2010，21，4： | 1 |
| 15 | Synthesis,crystal structure and properties of a novel coordination polymer having three-dimensional networks n显示文摘 | NIU S Y ZHANG Y L LAI W | 2001 | Acta Chimica Sinica2001，59，12： | 1 |
| 16 | Localization and surgical treatment of pancreas insulinomas guided by intraoperative ultrasond显示文摘 | Huai JC Zhang W Niu HO | 1998 | Am J Surg1998，175，： | 1 |
| 17 | Anal Chim Acta显示文摘 | Jing T Xia H Guan Q Lu W H Dai Q Niu J W Lim J M Hao Q L Lee Y Zhou Y K Mei S R | 2011 | 692:732011，692，： | 1 |
| 18 | Contraction-related stimuli reg- ulate GLUT4 traffic in C2C 12-GLUT4myc skeletal muscle cells显示文摘 | Niu W Bilan P J Ishikura S | 2010 | Am J Physiol Endocrinol Metab2010，298，5： | 1 |
| 19 | A power-balanced time-stepping finite element method for transient magnetic field computation显示文摘 | S L Ho S X Niu W N Fu | 2012 | IEEE Transactions on Magnetics2012，48，2： | 1 |
| 20 | Contraction-related stimuli regu- late GLUT4 traffic in C2C12-GLUT4myc skeletal muscle cells显示文摘 | Niu W Bilan PJ Ishikura S | 2010 | Am J Physiol Endocrinol Metab2010，298，5： | 1 |
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