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| 1 | Structural basis for blocking PD-l-mediated immune suppression by therapeutic antibody pembrolizumab显示文摘 | Zhenkun Na Siok Ping Yeo Sakshibeedu R Bharath Matthew W Bowler Esra Ballkci Cheng-I Wang Haiwei Song | 2017 | Cell Research2017，27，1： | 10 |
| 2 | 骨折相关性感染定义的共识显示文摘骨折相关性感染(fracture related infection,FRI)是创伤骨科一种常见的严重并发症.迄今为止,尚无明确定义,因此很难对该并发症带来的影响进行准确评估和对现有的研究展开比较.为解决这一难题,在AO基金会的支持下,我们成立了一个由科学家和医学专家组成的专家组,旨在对FRI定义达成的共识. | Metsemakers WJ Morgenstern M McNally MA Moriarty TF McFadyen I Scarborough M Athanasou NA Ochsner PE Kuehl R Raschke M Borens O 谢肇 Velkes S Hungerer S Kates SL Zalavras C Giannoudis PV Richard RG Verhofstad MH 喻胜鹏 孙东 汪小华 | 2018 | 中华骨科杂志2018，38，9： | 8 |
| 3 | Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis. | Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 4 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 5 | Influence of Coal Nature and Structure on Ash Size Formation Characteristic and Related Pollutant Emissions During CFB Combustion显示文摘The size distribution of coal particles in a Circulating Fluidized Bed (CFB) boiler plays a crucial role in the complicated combustion, heat exchange and pollutant emissions in such a plat. Therefore, it is fundamental to study the different factors having influence on the size distribution of coal particles. Above all, the coal itself and in particular, the coal combination phenomenon is a very influent factor. In the frame of this work, the coal nature (elementary composition) and coal internal structure (mineral components) are studied in detail. At this intermediary stage, experiments on three typical Chinese coals on a l.5 MWt CFBC pilot plant have been made. Some primary fragmentation tests have also been made in a small lab scale fluidized bed reactor. The results from the hot pilot test show i) the variation of coal ash distributions and other CFB performance data due to the cyclone and the coal characteristics and ii) the variation of desulfurization efficiency with limestone. Whereas the bench scale primary fragmentation test, likely linked to the caking propriety of a coal, does not seem to change considerably the char size distribution. | Min QIAN Arnaud BOELLE Philippe JAUD ( Electricite de France Division R&D, 6 quai Watier B.P.49 78401 Chatou, France ) Yongjie NA Qinggang LU Shaolin BAO ding CUI Weihong JIAO Huanming ZHAO (Institute of Engineering Thermophysics, Chinese Academ | 2000 | Journal of Thermal Science2000，9，3： | 2 |
| 6 | The pathological interaction between diabetes and presymptomatie Alzheimer' s disease 显示文摘 | BURDO J R CHEN Q CALCUTT NA | 2008 | Neurobiol Aging2008，3，4： | 1 |
| 7 | Multimodal reperfusion therapy for acute isehemie stroke: factors predicting vessel recanalization 显示文摘 | Gupta R Vora NA Horowitz MB | 2006 | Stroke2006，37，4： | 1 |
| 8 | The anatomic location of the dorsal ramus of the cervical nerve and its relation to the superior articular process of the lateral mass显示文摘 | Ebraheim NA Haman ST Xu R | 1998 | Spine1998，23，18： | 1 |
| 9 | The effect of selective phosphodiesterase isoenzyme inhibition on neutrophil function in vltro显示文摘 | Jones NA Boswell-Smith V Lever R | 2005 | Pulm Pharmacol Ther2005，1，2： | 1 |
| 10 | Analysis of catechins in extracts of Cistus species by microemulsion electrokinetic chromatography显示文摘 | Pomponio R Gotti R Santagati NA | 2003 | Chromatogr A2003，990，： | 1 |
| 11 | Influence of environmental factors on seed germination and seedling emergence of American sloughgrass (Beckmannia syzigachne)显示文摘 | Na R Dong L Y Li J | 2008 | Weed Science2008，56，： | 1 |
| 12 | Anatomic considerations of pedicle screw placement in the thoracic spine:Roy-Camille technique versus open-lamina technique显示文摘 | Xu R Ebraheim NA Ou Y | 1998 | Spine1998，23，9： | 1 |
| 13 | Endovascular treatment of tandem extracranial/intracranial anterior circulation occlusions:preliminary single-center experience显示文摘 | Malik AM Vora NA Lin R | 2011 | Stroke2011，42，： | 1 |
| 14 | Altered expression of the plasminogen activation pathway in peripheral blood mononuclear ceils in multiple sclerosis : possible pathomechanism of matrix met- alloproteinase activation 显示文摘 | Cox MB Bowden NA Scott R J | 2013 | Mult Scler2013，19，10： | 1 |
| 15 | High catalytic activity of Pd2+-exchanged mesoporous sodalite and NaA zeolite for bulky aryls coupling:reusability under aerobic condition显示文摘 | Choi M Lee D H Na K Yu B W Ryoo R | | 0，，20： | 1 |
| 16 | Differentiating social, phobia from shyness 显示文摘 | Heiser NA Turner SM Beidel DC Roberson-Nay R | 2009 | Journal of anxiety disorders2009，23，： | 1 |
| 17 | The synthesis of a zeolite via pseudomorphic crystallization 显示文摘 | CHOI M NA K RYO0 hierarchically porous BEA R | 2009 | Chemical Communications2009，，20： | 1 |
| 18 | Anatomic relations of the thoracic pedicle to the adjacent neu~zd structures 显示文摘 | Ebraheim NA Jabaly G Xu R | 1997 | Spine1997，22，14： | 1 |
| 19 | An aspect-based approach to modeling access control concerns 显示文摘 | lndrakshi R Robert B F Li Na | 2004 | Information & Software Technology2004，46，9： | 1 |
| 20 | Treatment of cerebral vasospasm with biocompatible controlled-release systems for intracranial drug delivery 显示文摘 | Omeis I Jayson NA Murali R | 2008 | Neurosurgery2008，63，6： | 1 |
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