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| 1 | Facile synthesis and electrochemical sodium storage of CoS2 micro/nano-structures显示文摘我们报导合成和钴二硫化物的电气化学的钠存储(有各种各样的 micro/nano-structures 的公司 2) 。有 microscale 尺寸的公司 2 也被 nanoparticles 装配(经由一条灵巧的 solvothermal 线路或 nanooctahedrons 的 P 公司 2) 构造了固体(O 公司 2) 和空微观结构(H 公司 2) 由热水的方法制作了。在三形态学之中, H 公司 2 作为钠离子电池(亲族) 的阳极展出最大的分泌物能力和最好的率性能。而且, H 公司 2 交付 690 妈 | Xue Liu Kai Zhang Kaixiang Lei Fujun Li Zhanliang Tao Jun Chen | 2016 | Nano Research2016，9，1： | 8 |
| 2 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 3 | Radiological thera py with low enery He Nelaser显示文摘 | WEI XINGCHANG LIU KAIXIANG FENG JUNLIN | 1995 | Chinese Physical Therapy Journal1995，18，2： | 1 |
| 4 | Y-Shaped Circular Aptamer–DNAzyme Conjugates for Highly Efficient in Vivo Gene Silencing显示文摘Oligonucleotide drugs have been used widely as therapeutic agents for gene therapy,while their instability in biological media and inefficiency for intracellular delivery remain major hurdles for practical in vivo applications.Herein,we report a circular Y-shaped aptamer–DNAzyme conjugate(cYAD)for highly efficient in vivo gene silencing via RNA cleavage,which can been employed in various disease treatments,including cancer,inflammation,as well as viral infections.Systematic studies revealed that cyclization of the DNA structure could improve the stability of oligonucleotide drugs in vivo.Besides,the bivalent aptamer motifs provided a specific and enhanced tumor cell targeting ability for accumulation and retention of the oligonucleotide drugs at the tumor site.As a proof of concept,a widely applicable Na+-dependent fluorescent sensor,NaA43 DNAzyme,was used to inhibit MET gene expression in mice tumor model tissues,which exhibited highly efficient gene silencing performance in vivo,which confirmed our findings with cYAD.This strategy provides a novel approach for the construction of oligonucleotide drugs for practical therapeutic applications. | Kaixiang Zhang Yanan Li Junjie Liu Xue Yang Yuanhong Xu Jinjin Shi Wei Liu Jinghong Li | 2020 | CCS Chemistry2020，2，6： | 1 |
| 5 | Boosting 5-ALA-based photodynamic therapy by a liposomal nanomedicine through intracellular iron ion regulation显示文摘5-Aminolevulinic acid(5-ALA)has been approved for clinical photodynamic therapy(PDT)due to its negligible photosensitive toxicity.However,the curative effect of 5-ALA is restricted by intracellular biotransformation inactivation of 5-ALA and potential DNA repair of tumor cells.Inspired by the crucial function of iron ions in 5-ALA transformation and DNA repair,a liposomal nanomedicine(MFLs@5-ALA/DFO)with intracellular iron ion regulation property was developed for boosting the PDT of 5-ALA,which was prepared by co-encapsulating 5-ALA and DFO(deferoxamine,a special iron chelator)into the membrane fusion liposomes(MFLs).MFLs@5-ALA/DFO showed an improved pharmaceutical behavior and rapidly fused with tumor cell membrane for 5-ALA and DFO co-delivery.MFLs@5-ALA/DFO could efficiently reduce iron ion,thus blocking the biotransformation of photosensitive protoporphyrin IX(Pp IX)to heme,realizing significant accumulation of photosensitivity.Meanwhile,the activity of DNA repair enzyme was also inhibited with the reduction of iron ion,resulting in the aggravated DNA damage in tumor cells.Our findings showed MFLs@5-ALA/DFO had potential to be applied for enhanced PDT of 5-ALA. | Airong Li Chenglin Liang Lihua Xu Yiyang Wang Wei Liu Kaixiang Zhang Junjie Liu Jinjin Shi | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 1 |
| 6 | An improved evaluation of the neutron background in the PandaX-Ⅱ experiment显示文摘In dark matter direct detection experiments,neutron is a serious source of background,which can mimic the dark matter-nucleus scattering signals.In this paper,we present an improved evaluation of the neutron background in the PandaX-II dark matter experiment by a novel approach.Instead of fully relying on the Monte Carlo simulation,the overall neutron background is determined from the neutron-induced high energy signals in the data.In addition,the probability of producing a dark-matter-like background per neutron is evaluated with a complete Monte Carlo generator,where the correlated emission of neutron(s)andγ(s)in the(α,n)reactions and spontaneous fissions is taken into consideration.With this method,the neutron backgrounds in the Run 9(26-ton-day)and Run 10(28-ton-day)data sets of PandaX-II are estimated to be(0.66±0.24)and(0.47±0.25)events,respectively. | QiuHong Wang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui YingJie Fan DeQing Fang ChangBo Fu LiSheng Geng Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo Ke Han ChangDa He Di Huang Yan Huang YanLin Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju YiHui Lai Kun Liang HuaXuan Liu JiangLai Liu WenBo Ma YuGang Ma YaJun Mao Yue Meng Parinya Namwongsa KaiXiang Ni JinHua Ning XuYang Ning XiangXiang Ren ChangSong Shang Lin Si AnDi Tan AnQing Wang HongWei Wang Meng Wang SiGuang Wang XiuLi Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu Jumin Yuan Dan Zhang HongGuang Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，3： | 0 |
| 7 | Designing Electrochemical Nanoreactors to Accelerate Li_(2)S_(1/2) Three-Dimensional Growth Process and Generating More Li_(2)S for Advanced Li–S Batteries显示文摘With advantages of low costs and high energy density,Li–S batteries are considered as one of the most promising energy storage devices.However,Li_(2)S_(2) with a high dissociation energy and insulative properties is hard to convert into Li_(2)S,resulting in underutilization of sulfur capacity.Herein,Co-Mo_(2)C@C yolk–shell spheres as nanoreactors were designed to confront this challenge rationally.The Co-Mo_(2)C@C-induced Li_(2)S_(1/2) nucleation and growth in the three-dimensional process and the cathode produced more Li_(2)S after full discharge.Experimental studies and theoretical calculations reveal that the conversion barrier from Li_(2)S_(2) into Li_(2)S was lowered while the diffusion of lithium ions and electron transfer accelerated when using the Co-Mo_(2)C@C catalyst.Based on the above advantages,the Co-Mo_(2)C@C/S cathode exhibits a high reversible capacity and excellent cyclic stability,such as an initial specific capacity of 1200 mAh g^(−1) at 0.1 C with 709 mAh g^(−1) at 1.0 C after 1000 cycles with a low capacity fading rate of 0.04%per cycle.Even at high densities of 3.0 C and 5.0 C,the specific capacities are 647.6 and 557.7 mAh g^(−1) after 400 cycles,respectively.Impressively,it also shows ca.770 and 900 mAh g^(−1) at 0.2 C after 50 cycles with high sulfur loadings of 4.2 and 5.1 mg cm−2,respectively.The present work may provide new insights into the design of nanoreactors to promote Li_(2)S_(1/2) growth in a three-dimensional process and accelerate conversion from solid Li_(2)S_(2) to solid Li_(2)S in high performance Li–S batteries. | Junhao Li Kaixiang Shi Jiajie Pan Junda Pan Yongxian Lin Kaixin Wang Hao Li Jinyun Liao Huafeng Dong Quanbing Liu | 2023 | Renewables2023，1，3： | 0 |
| 8 | Constraining self-interacting dark matter with the full dataset of PandaX-II显示文摘Self-interacting dark matter(SIDM)is a leading candidate proposed to solve discrepancies between predictions of the prevailing cold dark matter theory and observations of galaxies.Many SIDM models predict the existence of a light force carrier that mediates strong dark matter self-interactions.If the mediator couples to the standard model particles,it could produce characteristic signals in dark matter direct detection experiments.We report searches for signals of SIDM models with a light mediator using the full dataset of the PandaX-II experiment,basing on a total exposure of 132 tonne-days.No significant excess over background is found,and our likelihood analysis leads to a strong upper limit on the dark matter-nucleon coupling strength.We further combine the PandaX-II constraints and those from observations of the light element abundances in the early universe,and show that direct detection and cosmological probes can provide complementary constraints on dark matter models with a light mediator. | Jijun Yang Abdusalam Abdukerim Wei Chen Xun Chen Yunhua Chen Chen Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Shengming He Di Huang Yan Huang Ran Huo Yanlin Huang Zhou Huang Xiangdong Ji Yonglin Ju Shuaijie Li Qing Lin Huaxuan Liu Jianglai Liu Xiaoying Lu Wenbo Ma Yugang Ma Yajun Mao Yue Meng Nasir Shaheed Kaixiang Ni Jinhua Ning Xuyang Ning Xiangxiang Ren Changsong Shang Guofang Shen Lin Si Andi Tan Anqing Wang Hongwei Wang Meng Wang QiuHong Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Shiyong Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Yong Yang Chunxu Yu Hai-Bo Yu Jumin Yuan Ying Yuan Xinning Zeng Dan Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，11： | 0 |
| 9 | Circulating cell-free mtDNA as a new biomarker for cancer detection and management显示文摘Cancer is a major cause of death worldwide,and was responsible for 19.29 million new cases and 9.96 million deaths in 2020 alone.The total number of patients with cancer worldwide is estimated to reach 28 million by 2040.The American Association for Cancer Research has also estimated approximately 16.2 million cancer deaths by 20401. | Fan Peng Siyuan Wang Zehui Feng Kaixiang Zhou Huanqin Zhang Xu Guo Jinliang Xing Yang Liu | 2024 | Cancer Biology & Medicine2024，21，2： | 0 |
| 10 | 张氏法阴茎再造术后感觉恢复状况长期随访观察显示文摘背景与目的张氏法阴茎再造术一种较新的阴茎再造方法,于1997年首次报道。其基本方法是采用显微外科技术将原有龟头部或者阴茎残端移植到新造阴茎远端。本文旨在观察再造阴茎的感觉恢复情况。方法对27例应用张氏法进行阴茎再造患者进行长期随访。修复时吻合阴茎背神经和前臂外侧皮神经,阴茎背神经作为支配神经。采用四种方法进行触觉评估。结果平均随访时间10.3年,患者平均年龄25.7岁。再造阴茎末端(龟头或者阴茎残端)感觉和术前相似(P〉0.05)。再造阴茎除了在两点辨别觉上更优外(P〈0.01),前臂未手术区与术后皮瓣区(再造阴茎的近端)在感觉上没有差别。再造阴茎远端较近端具有更好的两点辨别觉(P〈0.01)。与单纯应用前臂桡侧游离皮瓣再造的阴茎相比,张氏法再造的阴茎远端具有更好的痛觉(P〈0.01)、振动阈值(P〈0.01)和两点辨别觉(P〈0.01)。结论应用张氏法再造的阴茎具有良好的感觉,尤其是通过转移原有龟头或阴茎残端形成的新龟头部感觉恢复更佳。 | Sunxiang Ma Yang Liu Tisheng Chang Kaixiang Cheng 曹传长 陶凯 高景恒 张晨 | 2012 | 中国美容整形外科杂志2012，23，5： | 0 |
| 11 | 吻合神经前臂桡侧游离皮瓣阴茎再造术后感觉显示文摘背景与目的经临床证实,吻合神经前臂桡侧游离皮瓣阴茎再造术疗效可靠。本文旨在确定吻合神经皮瓣能否促进再造阴茎的感觉恢复。方法对45例应用前臂桡侧游离皮瓣施行阴茎再造术的患者进行长期随访。其中,28例进行吻合神经皮瓣移植,17例未吻合神经。吻合神经组采用阴茎背神经与前臂外侧皮神经吻接修复。感觉测试项目包括痛觉、温度觉、振动阈值、静态两点辨别觉。测试由一位检查者采用双盲法按标准模式完成。结果平均随访9.1年。患者平均年龄26.4岁(18—48岁)。在痛觉和振动阈值方面,两组患者再造阴茎的近端相近,而吻合神经皮瓣移植组远端部分显著优于未吻合神经组(P〈0.01)。未吻合神经组阴茎敏感度从远端向近端逐渐增加,而吻合神经移植组阴茎近远端感觉较为一致。在温度觉和静态两点辨别觉方面,吻合神经皮瓣移植组在近端和远端均优于未吻合神经组。结论采用吻合神经前臂桡侧游离皮瓣阴茎再造有助于改善再造阴茎的感觉。在能够找到受区功能神经时,应尽可能进行神经吻合。 | Sunxiang Ma Kaixiang Cheng Yang Liu 戴晓俊 陶凯 高景恒 张晨 | 2012 | 中国美容整形外科杂志2012，23，5： | 0 |
| 12 | An Accurate and Efficient Approach for High-Frequency Transformer Parameter Extraction显示文摘Accurate parasitic parameter extraction of high-frequency transformers is one of the key techniques to efficiently design a Switched-mode power supply(SMPS). An approach to accurately and efficiently extract the parasitic parameters of high-frequency transformers is proposed. The high-frequency transformer is first de-composed into first-order RL and second-order RLC circuits according to inherent step response characteristics. Through the measured discharging pulse and damped oscillation responses of the high-frequency transformer excited by a square wave, we can extract the equivalent circuit parameters through fitting the responses with Particle swarm optimization(PSO). The equivalent circuits of the high-frequency transformer with the desired parameters are obtained for the SMPS design. We validate the effectiveness and accuracy of the proposed method with simulations and measurements. | SU Donglin ZHU Kaixiang XU Hui PENG Zhenzhen YANG Shunchuan LIU Yan | 2019 | Chinese Journal of Electronics2019，28，5： | 0 |
| 13 | Prefabricated Anterolateral Thigh Flaps for Phalloplasty in Female-to-Male Transsexuals显示文摘Background Phalloplasty is still a challenging operation because of the high urethral complication rate.Several options regarding different flaps can be chosen,but there is still no perfect solution for phalloplasty in female-to-male(FTM)transgender patients.Our group tried to use prefabricated anterolateral thigh(ALT)flaps for phalloplasty to overcome the urethral complications.Methods A total of 21 transgender patients were included from 2010 to 2019.A twostage operation was performed to reconstruct the phallus.The vaginal mucosa was prefabricated as neourethra at the first stage,and the shaft of the phallus was reconstructed at the second stage.Results All reconstructed phallus survived completely in our study,and the satisfaction rate was 76.2%.The total complication rate was 57.1%.The occurrence of fistula and strictures after the operation was 52.4%and 5.8%,respectively Conclusion Prefabricated ALT flaps with vaginal mucosa have a lower stricture rate.This technique provides a simple,effective surgical option in FTM transsexuals. | Chen CHENG Caiyue LIU Sunxiang MA Xiaohai ZHU Kaixiang CHENG Yang LIU Yingfan ZHANG | 2021 | Chinese Journal Of Plastic and Reconstructive Surgery2021，3，1： | 0 |
| 14 | A self-powered ultraviolet photodetector with van der Waals Schottky junction based on TiO_(2) nanorod arrays/Au-modulated V2CTx MXene显示文摘A self-powered ultraviolet photodetector(UV PD)with van der Waals(vdW)Schottky junction based on TiO_(2) nanorod arrays/Au-modulated V2 CTx MXene is reported.The Schottky junction enables the device to operate in self-powered mode.The dangling bond-free surface of V2 CTx MXene reduces the charge recombination at the junction interface.Meanwhile,V2 CTx MXene,with the work function(WF)increasing to 5.35 eV,forms a hole transport layer by contacting with Au electrode,which facilitates the carrier extraction.The electron lifetime in the device has prolonged to 8.95μs.As a result,the responsivity and detectivity of the PD have achieved 28 mA/W and 1.2×10^(11) cm Hz1/2/W(340 nm,65 mW/cm2,0 V),respectively.In addition,the presence of the Au electrode prevents the vanadium from coming into contact with oxygen and oxidizing,preserving the properties of the V2 CTx films.After 180 days of exposure to the atmosphere,the device performance remained at a particularly high level,indicating enhanced durability.This work points out an effective approach to modulate the properties of V2 CTx to obtain the high performance and stability of the UV PD. | Guangcan Luo Ziling Zhang Yabing Wang Qun Deng Shengtao Pan Tengfei Wang Qinghong Li Kaixiang Liu Pengfei Kong Jing Zhang Shengyun Luo Hong Lin | 2023 | Journal of Materials Science & Technology2023，，25： | 0 |
| 15 | American Barrier Option Pricing Formulas for Currency Model in Uncertain Environment显示文摘Option pricing problem is one of the central issue in the theory of modern finance.Uncertain currency model has been put forward under the foundation of uncertainty theory as a tool to portray the foreign exchange rate in uncertain finance market.This paper uses uncertain differential equation involved by Liu process to dispose of the foreign exchange rate.Then an American barrier option of currency model in uncertain environment is investigated.Most important of all,the authors deduce the formulas to price four types of American barrier options for this currency model in uncertain environment by rigorous derivation. | GAO Rong LIU Kaixiang LI Zhiguo LANG Liying | 2022 | Journal of Systems Science & Complexity2022，35，1： | 0 |
| 16 | The“ARM”principle and practice:Preventing postoperative complications of circumcision显示文摘Background: As one of the most commonly performed surgical procedures, circumcision may lead to complications. However, studies on preventing postoperative complications are scarce and still insufficient to draw any conclusions. This retrospective study aimed to summarize the surgical principles and consideration for preventing complications after circumcision.Methods: We reviewed 28 patients(aged 3–45 years;median age, 24 years) with prepuce hyperplasia or phimosis treated with our modified circumcision technique. In our modified technique, an accurate incision design is made through the stretch test, the stenosis is released, and veins and lymphatic tissues in the fascia are maintained. These surgical details for preventing complications were abbreviated to “ARM.”Results: None of the patients had complications at the 6-month follow-up postoperatively. Only mild prepuce edema was observed, which returned to the normal condition spontaneously within 2–3 weeks. The diameter of the distal penis increased by 0.4 ± 0.1 cm 6 months after the procedure.Conclusion: The “ARM” principle may help surgeons to prevent postoperative complications of circumcision.Maintaining the fascia during the procedure can increase the diameter of the surgical region. | Chen Cheng Yiwen Zhou Quan Zhang Yang Liu Kaixiang Cheng | 2022 | Chinese Journal Of Plastic and Reconstructive Surgery2022，4，3： | 0 |
| 17 | Optimized Pt-MnO_(x) interface in Pt-MnO_(x)/3DOM-Al_(2)O_(3)catalysts for enhancing catalytic soot combustion显示文摘The catalysts of three-dimensionally ordered macroporous(3 DOM)Al_(2)O_(3)-supported core-shell structured Pt@MnOx nanoparticles(3 DOM-Pt@MnO_(x)/Al_(2)O_(3))were successfully prepared by the gas bubbling-assisted membrane reduction-precipitation(GBMR/P)method.Pt@MnO_(x)core-shell nanoparticles(NPs)are highly dispersed on the inner surface of 3 DOM-Al_(2)O_(3)support.Pt@MnOx/3 DOM-Al_(2)O_(3)catalysts,which combine both advantages of high-efficiency soot-catalyst contact by 3 DOM-Al_(2)O_(3)structure and the abundant active sites by the optimized Pt-MnO_(x)interface,exhibit high catalytic activities for soot combustion,and the catalytic activities are strongly dependent on the thickness of MnO_(x)shell.Among the catalysts,3 DOM-Pt@MnO_(x)/Al_(2)O_(3)-1 catalyst with optimized Pt-MnO_(x)interface shows the highest catalytic activity for soot combustion,i.e.,its values of T_(50)and S_(CO_(2))^(m) are 351℃and98.6%,respectively.The highest density of Pt-MnO_(x)active sites for adsorptio n-activation of gaseous O_(2)is responsible for enhancing catalytic activity for soot combustion.Pt@MnOx/3 DOM-Al_(2)O_(3)catalysts are promising to practical applications for the emission reduction of soot particles. | Jing Xiong Zhenguo Li Peng Zhang Qi Yu Kaixiang Li Yilin Zhang Zhen Zhao Jian Liu Jianmei Li Yuechang Wei | 2021 | Chinese Chemical Letters2021，32，4： | 0 |
| 18 | Carrier-free programmed spherical nucleic acid for effective ischemic stroke therapy via self-delivery antisense oligonucleotide显示文摘Antisense oligonucleotide(ASO)for anti-apoptosis is emerging as a highly promising therapeutic agents for ischemic stroke with complex pathological environment.However,its therapeutic efficacy is seriously limited by a number of challenges including inefficient internalization,low blood-brain barrier(BBB)penetration,poor stability,and potential toxicity of the carrier.Herein,a carrier-free programmed spherical nucleic acid nanostructure is developed for effective ischemic stroke therapy via integrating multifunctional modules into one DNA structure.By co-encoding caspase-3-ASO and transferrin receptor(TfR)aptamer into circle template,the spherical nucleic acid nanostructure(TD)was obtained via self-assembly.The experimental results demonstrated that the developed TD displayed efficient BBB penetration capability(6.4 times)and satisfactory caspase-3 silence effect(2.3 times)due to the dense DNA packaging in TD.Taken together,our study demonstrated that the carrier-free programmed spherical nucleic acid nanostructure could significantly improve the therapeutic efficacy of ischemic stroke and was a promising therapeutic tool for various brain damage-related diseases. | Wenyan Yu Cuiping Xuan Bingbing Liu Lei Zhou Na Yin Enpeng Gong Zhenzhong Zhang Yinchao Li Kaixiang Zhang Jinjin Shi | 2023 | Nano Research2023，16，1： | 0 |
| 19 | Construction of Nanocarriers Based on Endogenous Cell Membrane and Their Application in Nanomedicine显示文摘Inspired by the adaptation of cells to the surrounding environment,the combination of cell membrane and nanomaterials has gradually become a new type of biomimetic nanocomposite.The construction of endogenous membrane biomimetic nanocarriers(EMBNs)not only retains the structure of membrane surface protein,but also has the properties of nanoparticles(NPs),also provides the ability of natural interaction between nanomaterials and organisms,thus overcoming the severe challenges faced by traditional nanodelivery systems in clinical application.In this paper,the construction methods of EMBNs are reviewed,focusing on a simple method to prepare membrane proteins.Secondly,EMBNs were classified according a variety of cell membranes.Finally,the unique advantages of EMBNs in nanomedicine are introduced,including improving biocompatibility,homologous targeting ability,prolonging blood circulation time and immune escape abilty.In nanomedicine,such as targeted delivery,phototherapy,immunotherapy and tumor imaging,multifaceted biological interfaces through membrane masking provide a new approach for the development of multifunctional NPs. | Yingshu Guo Wenxin Li Shiwei Liu Dan Jing Yifan Wang Qingfang Feng Kaixiang Zhang Jing-Juan Xu | 2022 | Chinese Journal of Chemistry2022，40，13： | 0 |
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