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| 1 | Improved quantum bacterial foraging algorithm for tuning parameters of fractional-order PID controller显示文摘The quantum bacterial foraging optimization(QBFO)algorithm has the characteristics of strong robustness and global searching ability. In the classical QBFO algorithm, the rotation angle updated by the rotation gate is discrete and constant,which cannot affect the situation of the solution space and limit the diversity of bacterial population. In this paper, an improved QBFO(IQBFO) algorithm is proposed, which can adaptively make the quantum rotation angle continuously updated and enhance the global search ability. In the initialization process, the modified probability of the optimal rotation angle is introduced to avoid the existence of invariant solutions. The modified operator of probability amplitude is adopted to further increase the population diversity.The tests based on benchmark functions verify the effectiveness of the proposed algorithm. Moreover, compared with the integerorder PID controller, the fractional-order proportion integration differentiation(PID) controller increases the complexity of the system with better flexibility and robustness. Thus the fractional-order PID controller is applied to the servo system. The tuning results of PID parameters of the fractional-order servo system show that the proposed algorithm has a good performance in tuning the PID parameters of the fractional-order servo system. | LIU Lu SHAN Liang DAI Yuewei LIU Chenglin QI Zhidong | 2018 | Journal of Systems Engineering and Electronics2018，29，1： | 6 |
| 2 | A pH-sensitive supramolecular nanosystem with chlorin e6 and triptolide co-delivery for chemo-photodynamic combination therapy显示文摘The combination of Ce6,an acknowledged photosensitizer,and TPL,a natural anticancer agent,has been demonstrated as a useful strategy to reinforce the tumor growth suppression,as well as decrease the systemic side effects compared with their monotherapy.However,in view of the optimal chemo-photodynamic combination efficiency,there is still short of the feasible nanovehicle to steadily co-deliver Ce6 and TPL,and stimuli-responsively burst release drugs in tumor site.Herein,we described the synergistic antitumor performance of a pH-sensitive supramolecular nanosystem,mediated by the host–guest complexing betweenβ-CD and acid pH-responsive amphiphilic co-polymer mPEG-PBAE-mPEG,showing the shell–core structural micelles with the tightβ-CD layer coating.Both Ce6 and TPLwere facilely co-loaded into the spherical supramolecular NPs(TPL+Ce6/NPs)by one-step nanoprecipitation method,with an ideal particle size(156.0 nm),acid pH-responsive drug release profile,and enhanced cellular internalization capacity.In view of the combination benefit of photodynamic therapy and chemotherapy,as well as co-encapsulation in the fabricated pH-sensitive supramolecular NPs,TPL+Ce6/NPs exhibited significant efficacy to suppress cellular proliferation,boost ROS level,lower MMP,and promote cellular apoptosis in vitro.Particularly,fluorescence imaging revealed that TPL+Ce6/NPs preferentially accumulated in the tumor tissue area,with higher intensity than that of free Ce6.As expected,upon 650-nm laser irradiation,TPL+Ce6/NPs exhibited a cascade of amplified synergistic chemo-photodynamic therapeutic benefits to suppress tumor progression in both hepatoma H22 tumor-bearingmice and B16 tumor-bearingmice.More importantly,lower systemic toxicitywas found in the tumor-bearingmice treated with TPL+Ce6/NPs.Overall,the designed supramolecular TPL+Ce6/NPs provided a promising alternative approach for chemo-photodynamic therapy in tumor treatment. | Yihan Wu Jingjing Li Xuemei Zhong Jinfeng Shi Yanfen Cheng Chenglin He Jiaxin Li Liang Zou Chaomei Fu Meiwan Chen Jinming Zhang Huile Gao | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，2： | 4 |
| 3 | Light-triggered interfacial charge transfer and enhanced photodetection in CdSe/ZnS quantum dots/MoS_(2)mixed-dimensional phototransistors显示文摘Mix-dimensional van der Waals heterostructures(vdWHs)have inspired worldwide interests and efforts in the field of ad-vanced electronics and optoelectronics.The fundamental understanding of interfacial charge transfer is of vital import-ance for guiding the design of functional optoelectronic applications.In this work,type-Ⅱ0D-2D CdSe/ZnS quantum dots/MoS_(2)vdWHs are designed to study the light-triggered interfacial charge behaviors and enhanced optoelectronic performances.From spectral measurements in both steady and transient states,the phenomena of suppressed photolu-minescence(PL)emissions,shifted Raman signals and changed PL lifetimes provide strong evidences of efficient charge transfer at the 0D-2D interface.A series of spectral evolutions of heterostructures with various QDs overlapping concentrations at different laser powers are analyzed in details,which clarifies the dynamic competition between exciton and trion during an efficient doping of 3.9×10^(13)cm^(−2).The enhanced photoresponses(1.57×10^(4)A·W^(-1))and detectivities(2.86×10^(11)Jones)in 0D/2D phototransistors further demonstrate that the light-induced charge transfer is still a feasible way to optimize the performance of optoelectronic devices.These results are expected to inspire the basic understand-ing of interfacial physics at 0D/2D interfaces,and shed the light on promoting the development of mixed-dimensional op-toelectronic devices in the near future. | Ziwei Li Wen Yang Ming Huang Xin Yang Chenguang Zhu Chenglin He Lihui Li Yajuan Wang Yunfei Xie Zhuoran Luo Delang Liang Jianhua Huang Xiaoli Zhu Xiujuan Zhuang Dong Li Anlian Pan | 2021 | Opto-Electronic Advances2021，4，9： | 4 |
| 4 | Discrete Particle Simulation of Gas-Solid Flow in Air-Blowing Seed Metering Device显示文摘In this paper,the gas and seed flow characters in the air-blowing seed metering device are investigated by using the coupled computational fluid dynamics and discrete element method(CFD-DEM)in three dimensions(3D).The method of establishing boundary model based on the computer-aided design(CAD)drawing,has been used to build the boundary model of seed metering device.The 3D laser scanning technique and multi-element method are adopted to establish the particle model.Through a combined numerical and experimental effort,using 3D CFD-DEM software,which is based on the in-house codes,the mechanisms governing the gas and solid dynamic behaviors in the seed metering device have been studied.The gas velocity field and the effect of different rotational speeds and air pressures on the seeding performance and particle velocity have been studied,similar agreements between numerical and experimental results are gained.This reveals that the 3D CFD-DEM model established is able to predict the performance of the air-blowing seed metering device.It can be used to design and optimize the air-blowing seed metering device and other similar agriculture devices. | Zhengquan Li Pei Zhang Yongchang Sun Chenglin Zheng Liang Xu Dianyu E | 2021 | Computer Modeling in Engineering & Sciences2021，，6： | 2 |
| 5 | A reactive oxygen species burst causes haploid induction in maize显示文摘Haploid induction (HI) is an important tool in crop breeding. Phospholipase A1 (ZmPLA1)/NOT LIKE DAD (NLD)/MATRILINEAL (MTL) is a key gene controlling HI in maize;however, the underlying molecular mechanism remains unclear. In this study, to dissect why loss of ZmPLA1 function could mediate HI we performed a comprehensive multiple omics analysis of zmpla1 mutant anthers by integrating transcriptome, metabolome, quantitative proteome, and protein modification data. Functional classes of significantly enriched or differentially abundant molecular entities were found to be associated with the oxidative stress response, suggesting that a reactive oxygen species (ROS) burst plays a critical role in HI. In support of this, we further discovered that a simple chemical treatment of pollen with ROS reagents could lead to HI. Moreover, we identified ZmPOD65, which encodes a sperm-specific peroxidase, as a new gene controlling HI. Taken together, our study revealed a likely mechanism of HI, discovered a new gene controlling HI, and created a new method for HI in maize, indicating the importance of ROS balance in maintaining normal reproduction and providing a potential route to accelerate crop breeding. | Chenglin Jiang Ju Sun Rui Li Shijuan Yan Wei Chen Liang Guo Guochen Qin Pengcheng Wang Cheng Luo Wenjie Huang Qinghua Zhang Alisdair R.Fernie David Jackson Xiang Li Jianbing Yan | 2022 | Molecular Plant2022，15，6： | 2 |
| 6 | Characterization of a Lacustrine Shale Reservoir and the Evolution of its Nanopores: A Case Study of the Upper Cretaceous Qingshankou Formation in the Songliao Basin, Northeastern China显示文摘The Songliao Basin is one of the most important petroliferous basins in northern China. With a recent gradual decline in conventional oil production in the basin, the exploration and development of unconventional resources are becoming increasingly urgent. The Qingshankou Formation consists of typical Upper Cretaceous continental strata, and represents a promising and practical replacement resource for shale oil in the Songliao Basin. Previous studies have shown that low-mature to mature Qingshankou shale mainly preserves type Ⅰ and type Ⅱ1 organic matter, with relatively high total organic carbon(TOC) content. It is estimated that there is a great potential to explore for shale oil resources in the Qingshankou Formation in this basin. However, not enough systematic research has been conducted on pore characteristics and their main controlling factors in this lacustrine shale reservoir. In this study, 19 Qingshankou shales from two wells drilled in the study area were tested and analyzed for mineral composition, pore distribution and feature evolution using Xray diffraction(XRD), scanning electron microscopy(SEM), low-pressure nitrogen gas adsorption(N2-GA), and thermal simulation experiments. The XRD results show that clay, quartz, and feldspar are the dominant mineral constituents of Qingshankou shale. The clay minerals are mostly illite/smectite mixed layers with a mean content of 83.5%, followed by illite, chlorite, and kaolinite. There are abundant deposits of clay-rich shale in the Qingshankou Formation in the study area, within which many mineral and organic matter pores were observed using SEM. Mineral pores contribute the most to shale porosity;specifically, clay mineral pores and carbonate pores comprise most of the mineral pores in the shale. Among the three types of organic matter pores, type B is more dominant the other two. Pores with diameters greater than 10 nm supply the main pore volume;most are half-open slits and wedge-shaped pores. The total pore volume had no obvious linear relationship with TOC content, but had some degree of positive correlation with the content of quartz + feldspar and clay minerals respectively. However, it was negatively correlated with carbonate mineral content. The specific surface area of the pores is negatively related to TOC content, average pore diameter, and carbonate mineral content. Moreover, it had a somewhat positive correlation with clay mineral content and no clear linear relationship with the content of quartz + feldspar. With increases in maturity, there was also an increase in the number of carbonate mineral dissolution pores and organic matter pores, average pore diameter, and pore volume, whereas there was a decrease in specific surface area of the pores. Generally, the Qingshankou shale is at a low-mature to mature stage with a TOC content of more than 1.0%, and could be as thick as 250 m in the study area. Pores with diameters of more than 10 nm are well-developed in the shale. This research illustrates that there are favorable conditions for shale oil occurrence and enrichment in the Qingshankou shale in the study area. | ZHANG Xu LIU Chenglin LI Bing WU Linqiang GUI Herong WANG Ziling ZHANG Zhihui LIANG Dexiu | 2020 | Acta Geologica Sinica(English Edition)2020，94，2： | 2 |
| 7 | Combination effects of graphene and layered double hydroxides on intumescent flame-retardant poly(methyl methacrylate) nanocomposites显示文摘 | Guobo Huang Suqing Chen Pingan Song Pingping Lu Chenglin Wu Huading Liang | 2013 | Applied Clay Science2013，，： | 1 |
| 8 | Boosting 5-ALA-based photodynamic therapy by a liposomal nanomedicine through intracellular iron ion regulation显示文摘5-Aminolevulinic acid(5-ALA)has been approved for clinical photodynamic therapy(PDT)due to its negligible photosensitive toxicity.However,the curative effect of 5-ALA is restricted by intracellular biotransformation inactivation of 5-ALA and potential DNA repair of tumor cells.Inspired by the crucial function of iron ions in 5-ALA transformation and DNA repair,a liposomal nanomedicine(MFLs@5-ALA/DFO)with intracellular iron ion regulation property was developed for boosting the PDT of 5-ALA,which was prepared by co-encapsulating 5-ALA and DFO(deferoxamine,a special iron chelator)into the membrane fusion liposomes(MFLs).MFLs@5-ALA/DFO showed an improved pharmaceutical behavior and rapidly fused with tumor cell membrane for 5-ALA and DFO co-delivery.MFLs@5-ALA/DFO could efficiently reduce iron ion,thus blocking the biotransformation of photosensitive protoporphyrin IX(Pp IX)to heme,realizing significant accumulation of photosensitivity.Meanwhile,the activity of DNA repair enzyme was also inhibited with the reduction of iron ion,resulting in the aggravated DNA damage in tumor cells.Our findings showed MFLs@5-ALA/DFO had potential to be applied for enhanced PDT of 5-ALA. | Airong Li Chenglin Liang Lihua Xu Yiyang Wang Wei Liu Kaixiang Zhang Junjie Liu Jinjin Shi | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 1 |
| 9 | Petroleum resource assessment of the East Greenland Basin显示文摘The onshore and offshore parts of the East Greenland Basin are important areas for petroleum exploration at the North Pole. Although assessments by the US Geological Survey suggest a substantial petroleum potential in this area, their estimates carry a high risk because of uncertainties in the exploration data. This paper compares the reservoir-forming conditions based on data from the East Greenland Basin and the North Sea Basin. The petroleum resources of the East Greenland Basin were assessed by geochemical and analogy methods. The East Greenland Basin was a rift basin in the late Paleozoic–Mesozoic. Its basement is metamorphic rock formed by the Caledonian Orogeny in the Archean to Late Ordovician. In the basin, Devonian–Paleogene strata were deposited on the basement. Lacustrine source rock formed in the late Paleozoic and marine source rocks in the Late Jurassic. Shallow-marine sandstone reservoirs formed in the Middle Jurassic and deep-marine turbiditic sandstone reservoirs formed in the Cretaceous.The trap types are structure traps, horst and fault-block traps, salt structure traps, and stratigraphic traps. The East Greenland Basin possesses superior reservoir-forming conditions, favorable petroleum potential and preferable exploration prospects. Because of the lack of exploration data, further evaluation of the favorable types of traps, essential amount of source rock, petroleum-generation conditions and appropriate burial histories in the East Greenland Basin are required. | LI Bin LIU Chenglin ZHAO Yue HONG Weiyu PING Yingqi LIANG Dexiu | 2017 | Advances in Polar Science2017，28，4： | 0 |
| 10 | A long-term retaining molecular coating for corneal regeneration显示文摘Corneal injuries will cause corneal surface diseases that may lead to blindness in millions of people worldwide.There is a tremendous need for biomaterials that can promote corneal regeneration with practical feasibility.Here we demonstrate a strategy of a protein coating for corneal injury regeneration.We synthesize an o-nitrosobenzaldehyde group(NB)-modified gelatin(GelNB),which could adhere directly to the corneal surface with covalent bonding to form a thin molecular coating.The molecular coating could avoid rapid clearance and provide a favorable environment for cell migration,thereby effectively accelerating corneal repair and regeneration.The histological structure of the regenerated cornea is more similar to the native cornea.This molecular coating can be used conveniently as an eye drop solution,which makes it a promising strategy for corneal regeneration. | Yi Zhang Chenglin Li Qiuwen Zhu Renjie Liang Chang Xie Shufang Zhang Yi Hong Hongwei Ouyang | 2021 | Bioactive Materials2021，6，12： | 0 |
| 11 | A genome-wide loss-of-function screening method for minimizing false-negatives caused by functional redundancy显示文摘 | Li Mao Chenglin Liu Zhen Wang Xiaofeng Niu Liang Xue Zhilei Zhou Zhenying Cai Meng Yu Yixue Li Dianqing Wu Lin Li | 2016 | Cell Research2016，26，9： | 0 |
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