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| 1 | Connecting the P300 to the diagnosis and prognosis of unconscious patients显示文摘The residual consciousness of unconscious patients can be detected by studying the P300, a wave among event-related potentials. Previous studies have applied tones, the subject's name and other names as stimuli. However, the results were not satisfactory. In this study, we changed the constituent order of subjects' two-character names to create derived names. The subject's derived names, together with tones and their own names, were used as auditory stimuli in event-related potential experiments. Healthy controls and unconscious patients were included in this study and made to listen to these auditory stimuli. In the two paradigms, a sine tone followed by the subject's own name and the subject's derived name followed by the subject's own name were used as standard and deviant stimuli, respectively. The results showed that all healthy controls had the P300 using both paradigms, and that the P300 in the second paradigm had a longer latency and two peaks. All minimally conscious state patients had the P300 in the first paradigm and the majority of them had the P300 in the second paradigm. Most vegetative state patients had no P300. Patients who showed the P300 in the two paradigms had more residual consciousness, and patients with the two-peak P300 had a higher probability of awakening within a short time. Our experimental findings suggest that the P300 event-related potential could reflect the conscious state of unconscious patients. | Ran Li Wei-qun Song Ju-bao Du Su Huo Gui-xiang Shan | 2015 | Neural Regeneration Research2015，10，3： | 9 |
| 2 | Spider web-like carbonized bacterial cellulose/MoSe_(2) nanocomposite with enhanced microwave attenuation performance and tunable absorption bands显示文摘It is essential to manufacture microwave absorbers with strong absorption as well as tunable absorption bands at a low filler content.However,it remains challenging for pure biomass material to reach this goal without loading other components.MoSe_(2),as a transition metal chalcogenide with semiconductor properties,has emerged as a potential microwave absorber filler.Herein,bacterial cellulose(BC)-derived carbon nanofibers/MoSe_(2) nanocomposite was fabricated and phosphoric acid was used to dope phosphorus in BC,in which MoSe_(2) microspheres were dropped on the BC network like a dew-covered spider web.This unique network structure enhances conductive loss and multiple reflections of the incident wave.The collocation of BC and MoSe_(2) is helpful to impedance match and introduces interfacial/dipolar polarization loss;moreover,the P-doping of BC helps to tune the absorption bands.Overall,the optimal reflection loss of undoped one reaches−53.33 dB with only 20 wt.%filler content,whose main absorption peaks focus on X-band.Interestingly,after the P-doping of BC,the main absorption peaks move to Ku-band and the optimal reflection loss gets stronger(−66.84 dB)with the same filler loading.Strong absorption and tunable absorption bands can be realized,and thus wide frequency range is covered.This work is expected to enlighten future exploration of biomass carbon materials on high-performance microwave absorption materials. | Zhengjian Xu Man He Yuming Zhou Shuangxi Nie Yongjuan Wang Yao Huo Yifan Kang Ruili Wang Ran Xu Hao Peng Xi Chen | 2021 | Nano Research2021，14，3： | 6 |
| 3 | Responses of Primary Afferent Fibers to Acupuncture-Like Peripheral Stimulation at Different Frequencies:Characterization by Single-Unit Recording in Rats显示文摘The pain-relieving effect of acupuncture is known to involve primary afferent nerves(PANs) via their roles in signal transmission to the CNS.Using single-unit recording in rats,we characterized the generation and transmission of electrical signals in Aβ and Aδ fibers induced by acupuncture-like stimuli.Acupuncture-like signals were elicited in PANs using three techniques:manual acupuncture(MAc),emulated acupuncture(EAc),and electro-acupuncture(EA)-like peripheral electrical stimulation(PES).The discharges evoked by MAc and EAc were mostly in a burst pattern with average intra-burst and inter-burst firing rates of 90 Hz and 2 Hz,respectively.The frequency of discharges in PANs was correlated with the frequency of PES.The highest discharge frequency was 246 Hz in Aβ fibers and 180 Hz in Aδ fibers.Therefore,EA in a dense-disperse mode(at alternating frequency between 2 Hz and 15 Hz or between 2 Hz and 100 Hz) best mimics MAc.Frequencies of EA output>250 Hz appear to be obsolete for pain relief. | Ran Huo Song-Ping Han Feng-Yu Liu Xiao-Jing Shou Ling-Yu Liu Tian-Jia Song Fu-Jun Zhai Rong Zhang Guo-Gang Xing Ji-Sheng Han | 2020 | Neuroscience Bulletin2020，36，8： | 6 |
| 4 | Assessment of Flood Catastrophe Risk for Grain Production at the Provincial Scale in China Based on the BMM Method显示文摘Flood catastrophe risk assessment is imperative for the steady development of agriculture under the context of global climate change,and meanwhile,it is an urgent scientific issue need to be solved in agricultural risk assessment discipline.This paper developed the methodology of flood catastrophe risk assessment,which can be shown as the standard process of crop loss calculation,Monte Carlo simulation,the generalized extreme value distribution(GEV)fitting,and risk evaluation.Data on crop loss were collected based on hectares covered by natural disasters,hectares affected by natural disasters,and hectares destroyed by natural disasters using the standard equation.Monte Carlo simulation based on appropriate distribution was used to expand sample size to overcome the insufficiency of crop loss data.Block maxima model(BMM)approach based on the extreme value theory was for modeling the generalized extreme value distribution(GEV)of flood catastrophe loss,and then flood catastrophe risk at the provincial scale in China was calculated.The Type III Extreme distribution(Weibull)has a weighted advantage of modeling flood catastrophe risk for grain production.The impact of flood catastrophe to grain production in China was significantly serious,and high or very high risk of flood catastrophe mainly concentrates on the central and eastern regions of China.Given the scenario of suffering once-in-a-century flood disaster,for majority of the major-producing provinces,the probability of 10%reduction of grain output is more than 90%.Especially,the probabilities of more than 15%decline in grain production reach up to 99.99,99.86,99.69,and 91.60%respectively in Anhui,Jilin,Liaoning,and Heilongjiang.Flood catastrophe assessment can provide multifaceted information about flood catastrophe risk that can help to guide management of flood catastrophe. | XU Lei ZHANG Qiao ZHOU Ai-lian HUO Ran | 2013 | Journal of Integrative Agriculture2013，12，12： | 5 |
| 5 | ON APPROXIMATION BY RECIPROCALS OF POLYNOMIALS WITH POSITIVE COEFFICIENTS IN ORLICZ SPACES显示文摘This paper discusses the approximation by reciprocals of polynomials with positive coefficients in Orlicz spaces and proved that if f(x) ∈ LM*[0,1], changes its sign at most once in (0,1), then there exists x0 ∈ (0,1) and a polynomial Pn ∈Πn(+) such that f (x) -Pn (x)x-x0 M ≤ Cω( f,n-1/2 )M, where Πn(+) indicates the set of all polynomials of degree n with positive coefficients. | Xiaoli Wang Ran Huo Garidi Wu | 2008 | Analysis in Theory and Applications2008，24，4： | 5 |
| 6 | The role of ezrin-associated protein network in human sperm capacitation显示文摘在精子房间的膜修正在精子 capacitation 代表关键步;然而,这些修正的分子的基础充分没被理解。Ezrin 是 ezrin/radixin/merlin 家庭的学习最好的成员。作为在外皮的细胞骨架和血浆膜蛋白质之间的 cross-linker, ezrin 贡献膜表面结构改变。而且,激活 ezrin 和 Rho 分离禁止者, RhoGDI,通过 Rho 激活支持外皮的 cytoskeleton-polymerized 肌动朊的形成。因此, ezrin,肌动朊, RhoGDI, Rho 和血浆膜蛋白质在 vivo 形成一个复杂网络,它贡献膜表面的结构的集会。以前,我们证明 ezrin 和 RhoGDI1 在人的睾丸被表示。因此,我们寻求了决定 ezrin 鈥揜h oGDI1 鈥揳c 听鈥搈e mbrane 蛋白质网络是否在人的精子 capacitation 有一个角色。我们由西方的污点的结果显示 ezrin 被 threonine567 残余的 phosphorylation 在 capacitation 期间激活。Co-immunoprecipitation 研究表明在精子 capacitation 期间,在 ezrin 和 RhoGDI1 之间的相互作用增加,并且二维的电气泳动胶化的 phosphostaining 证明 RhoGDI1 是 phosphorylated,建议 RhoGDI1 从 RhoA 分裂并且导致精子头上的肌动朊聚合。我们推测那激活的 ezrin 在 capacitation 以后与 polymerized 肌动朊和 glycosylated 膜蛋白质 cd44 交往。用 ezrin 特定或肌动朊特定的 monoclonal 抗体堵住精子 capacitation 减少他们的 acrosome 反应(AR ) 率,但是没独自在 AR 上有效果。一起拿,我们的结果证明由 ezrin, RhoGDI1, RhoA, F 肌动朊和膜蛋白质组成的一个网络工作影响在人的精子 capacitation 期间发生在精子头的膜上的修正。 | Lei Wang Wen Chen Chun Zhao Ran Huo Xue-Jiang Guo Min Lin Xiao-Yan Huang Yun-Dong Mao Zuo-Min Zhou Jia-Hao Sha | 2010 | Asian Journal of Andrology2010，12，5： | 4 |
| 7 | Classification of brain arteriovenous malformations located in motor-related areas based on location and anterior choroidal artery feeding显示文摘Objective Surgical management of arteriovenous malformations(AVMs)involving motor cortex or fibre tracts(M-AVMs)is challenging.This study aimed to construct a classification system based on nidus locations and anterior choroidal artery(AChA)feeding to pre-surgically evaluate motor-related and seizure-related outcomes in patients undergoing resection of M-AVMs.Methods and materials A total of 125 patients who underwent microsurgical resection of M-AVMs were retrospectively reviewed.Four subtypes were identified based on nidus location:(I)nidus involving the premotor area and/or supplementary motor areas;(II)nidus involving the precentral gyrus;(III)nidus involving the corticospinal tract(CST)and superior to the posterior limb of the internal capsule;(IV)nidus involving the CST at or inferior to the level of posterior limb of the internal capsule.In addition,we divided type IV into type IVa and type IVb according to the AChA feeding.Surgical-related motor deficit(MD)evaluations were performed 1 week(short-term)and 6 months(long-term)after surgery.Results The type I patients exhibited the highest incidence(62.0%)of pre-surgical epilepsy among the four subtypes.Multivariate analysis showed that motor-related area subtypes(p=0.004)and diffuse nidus(p=0.014)were significantly associated with long-term MDs.Long-term MDs were significantly less frequent in type I than in the other types.Type IV patients acquired the highest proportion(four patients,25.0%)of long-term poor outcomes(mRS>2).Type IVb patients showed a significantly higher incidence of post-surgical MDs than type IVa patients(p=0.041).The MDs of type III or IV patients required more recovery time.Of the 62 patients who had pre-surgical seizures,90.3%(56/62)controlled their seizures well and reached Engel class I after surgery.Conclusions Combining the consideration of location and AChA feeding,the classification for M-AVMs is a useful approach for predicting post-surgical motor function and decision-making. | Yuming Jiao Hao Li Weilun Fu Jiancong Weng Ran Huo Yinyan Wang Shuo Wang Tao Jiang Yong Cao Ji Zong Zhao | 2021 | Stroke & Vascular Neurology2021，6，3： | 4 |
| 8 | DDX3X regulates cell survival and cell cycle during mouse early embryonic development显示文摘DDX3X is a highly conserved DEAD-box RNA helicase that participates in RNA transcription,RNA splicing,and mRNA transport,translation,and nucleo-cytoplasmic transport.It is highly expressed in metaphaseⅡ(MⅡ)oocytes and is the predominant DDX3 variant in the ovary and embryo.However,whether it is important in mouse early embryo development remains unknown.In this study,we investigated the function of DDX3X in early embryogenesis by cytoplasmic microinjection with its siRNA in zygotes or single blastomeres of 2-cell embryos.Our results showed that knockdown of Ddx3x in zygote cytoplasm led to dramatically diminished blastocyst formation,reduced cell numbers,and an increase in the number of apoptotic cells in blastocysts.Meanwhile,there was an accumulation of p53 in RNAi blastocysts.In addition,the ratio of cell cycle arrest during 2-cell to 4-cell transition increased following microinjection of Ddx3x siRNA into single blastomeres of 2-cell embryos compared with control.These results suggest that Ddx3x is an essential gene associated with cell survival and cell cycle control in mouse early embryos,and thus plays key roles in normal embryo development. | Qian Li Pan Zhang Chao Zhang Ying Wang Ru Wan Ye Yang Xuejiang Guo Ran Huo Min Lin Zuomin Zhou Jiahao Sha | 2014 | The Journal of Biomedical Research2014，28，4： | 4 |
| 9 | Inflammation and cutaneous nervous system involvement in hypertrophic scarring显示文摘This study aimed to use a mouse model of hypertrophic scarring by mechanical loading on the dorsum of mice to determine whether the nervous system of the skin and inflammation participates in hypertrophic scarring. Results of hematoxylin-eosin and immunohistochemical staining demonstrated that inflammation contributed to the formation of a hypertrophic scar and increased the nerve density in scar tissue.Western blot assay verified that interleukin-13 expression was increased in scar tissue. These findings suggest that inflammation and the cutaneous nervous system play a role in hypertrophic scar formation. | Shao-hua Li Heng-lian Yang Hu Xiao Yi-bing Wang De-chang Wang Ran Huo | 2015 | Neural Regeneration Research2015，10，10： | 3 |
| 10 | Investigation on mechanical exhaust of cabin fire in large-space building显示文摘A calculation model for mechanical exhaust rate in large-space building in the case of cabin fire is proposed through theoretical analysis. Full-scale hot smoke tests are then performed to study the cabin fire spreading to large-space building at dif- ferent air change rates (ACH). The result indicates that under the standard pre- scribed ACH, the effective air heights in the large spaces are respectively 6, 4 and 2 m in the case of cabin fires of 0.34, 0.67 and 1 MW. Numerical experiment has been conducted using self-developing two-zone model. The smoke control effi- ciency is compared by varying the large space’s air change rate in the case of cabin fires ranging from 0.25 to 4 MW. The calculation results show that the air change rates are respectively 3, 6, 10 and 10 ACH when the smoke layer is kept above 5 m, indicating that the centralized exhaust rates far exceed the standard prescribed value. To address this problem, a set of subsidiary distributed mechanical exhaust installing in the cabin with high fire loads is proposed. The simulation shows that both from the safety and economy point of view, the adoption of subsidiary dis- tributed cabin exhaust design may effectively reduce the demand of designed air change rate for large-space building. | SHI CongLing ZHONG MaoHua HUO Ran | 2008 | Science China(Technological Sciences)2008，51，1： | 3 |
| 11 | Involvement of Opioid Peptides in the Analgesic Effect of Spinal Cord Stimulation in a Rat Model of Neuropathic Pain显示文摘Spinal cord stimulation(SCS)-induced analgesia was characterized,and its underlying mechanisms were examined in a spared nerve injury model of neuropathic pain in rats.The analgesic effect of SCS with moderate mechanical hypersensitivity was increased with increasing stimulation intensity between the 20%and 80%motor thresholds.Various frequencies(2,15,50,100,10000 Hz,and 2/100 Hz dense-dispersed)of SCS were similarly effective.SCS-induced analgesia was maintained without tolerance within 24 h of continuous stimulation.SCS at 2 Hz significantly increased methionine enkephalin content in the cerebrospinal fluid.The analgesic effect of 2 Hz was abolished byμorκopioid receptor antagonist.The effect of 100 Hz was prevented by aκantagonist,and that of 10 kHz was blocked by any of theμ,δ,orκreceptor antagonists,suggesting that the analgesic effect of SCS at different frequencies is mediated by different endorphins and opioid receptors. | Fu-Jun Zhai Song-Ping Han Tian-Jia Song Ran Huo Xing-Yu Lan Rong Zhang Ji-Sheng Han | 2022 | Neuroscience Bulletin2022，38，4： | 3 |
| 12 | Maggot therapy for repairing serious infective wound in a severely burned patient显示文摘musca domestica 的幼虫被放在使用丢弃严重灼伤的一个盒子的死了的织物。50 000 无菌的蛆的一个总数被放到易传染的创伤表面上,并且无菌的调味品覆盖了表面。三天以后,另一 20 000 蛆为第二治疗被放到创伤上。在以后两次蛆清创术,创伤的很坏死的肌肉纸巾被清洗起来,并且最后新鲜使成粒状组织到 3 次皮 grafting 成长了,以后,创伤被盖住并且愈合。结果证明除了疼痛,那蛆治疗没有不利复杂并发症安全、有效。 | WU Jun-cheng LU Ren-rong HUO Ran FU Hong-bin | 2012 | Chinese Journal of Traumatology2012，15，2： | 2 |
| 13 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 14 | Breeding ecology of ground tits in northeastern Tibetan plateau, with special reference to cooperative breeding system显示文摘 | Xin LU Ran HUO Yang LI Wenbo LIAO Chen WANG | 2011 | Current Zoology2011，57，6： | 2 |
| 15 | Mechanical tension promotes skin nerve regeneration by upregulating nerve growth factor expression显示文摘This study aimed to explore the role of mechanical tension in hypertrophic scars and the change in nerve density using hematoxylin-eosin staining and S100 immunohistochemistry, and to observe the expression of nerve growth factor by western blot analysis. The results demonstrated that mechanical tension contributed to the formation of a hyperplastic scar in the back skin of rats, in conjunction with increases in both nerve density and nerve growth factor expression in the scar tissue. These experimental findings indicate that the cutaneous nervous system plays a role in hypertrophic scar formation caused by mechanical tension. | Hu Xiao Dechang Wang Ran Huo Yibing Wang Yongqiang Feng Qiang Li | 2013 | Neural Regeneration Research2013，8，17： | 2 |
| 16 | Synthesis and Structural Study of a N-Heterocyclic Carbene Trinuclear Silver(Ⅰ)Complex显示文摘The bis-benzimidazolium salt bis[2-(N-ethylbenzimidazoliumyl)ethyl]amine hexafluorophosphate(LH_2·(PF_6)_2) and its N-heterocyclic carbene silver(Ⅰ) complex[L_2Ag_3](PF_6)_3(1)have been prepared and characterized.In complex 1,a trinuclear silver(Ⅰ) architecture is formed by two tridentate ligands and three silver(I) atoms,in which one 12- and two 7-membered rings are contained.In the crystal packing of 1,1D chain and 2D supramolecular layer are formed via intermolecular weak interactions,including π…π interactions and C-H…π contacts.Additionally,the fluorescence emission spectra of LH_2-(PF_6)2 and 1 are described. | LIU Jun HUO Ran WEI Qing ZHAO Zhi-Xiang LIU Qing-Xiang | 2016 | Chinese Journal of Structural Chemistry2016，35，2： | 2 |
| 17 | Experi- mental studies on the rise-time of buoyant fire plume fronts induced by pool fires显示文摘 | Hu Longhua Li Yuanzhou Huo Ran | 2004 | Journal of Fire Sciences2004，22，1： | 1 |
| 18 | Flood variability in the upper Yangtze River over the last millennium——Insights from a comparison of climate-hydrological model simulated and reconstruction显示文摘Understanding hydrological responses to rising levels of greenhouse gases are essential for climate and impact research.It is,however,often limited by a lack of long record of observational data to provide a basis for understanding the longterm behavior of the climate system.Integrating reconstructed data and(global climate and hydrological)model simulations will help us to better understand the variability of climate and hydrology over timescales ranging from decades to centuries.In this study,we proposed an integrated approach to study flood variability in the upper reach of the Yangtze River over the last millennium to the end of the 21st century.To accomplish this,we first drove hydrological models using the precipitation and temperature from four Global Climate Models(GCM),BCC-CSM1.1,MIROC,MRI-CGCM3,and CCSM4,to simulate daily discharge for the upper reach of the Yangtze River during the period of the last millennium(850–1849),historical period(1850–2005),and a future period(2006–2099).Then,we evaluated whether the modeled precipitation,temperature,and extreme discharge had statistical properties similar to those shown in the documented dry-wet periods,temperature anomalies,and paleoflood records.Finally,we explored the extreme discharge variability using model simulations.The results indicate that:(1)The MIROC-ESM model,differing from the other three GCM models,revealed positive temperature changes from the warm period(Medieval Climate Anomaly;MCA)to the cold period(Little Ice Age;LIA),while the temperature variability of the other models was similar to the records.(2)The BCC-CSM1.1 model performed better than the others regarding correlations between modeled precipitation and documented dry-wet periods.(3)Over most of the subbasins in the upper Yangtze River,the magnitude of extreme discharge in the BCC-CSM1.1 model results showed that there was a decrease from the MCA to the LIA period and an increase in the historical period relative to the cold period,while a future increase was projected by the four GCMs under the influence of climate change. | Ran HUO Hua CHEN Lu LI Chong-Yu XU Jingjing LI Si HONG Chesheng ZHAN Jun XIA | 2023 | Science China Earth Sciences2023，66，3： | 1 |
| 19 | Expression of a novel alternative transcript of the novel retinal pigment epithelial cell gene NORPEG in human testes显示文摘瞄准:为了识别新奇网膜的颜料的一个新奇其他的抄本,上皮的房间基因(NORPEG ) 在人的睾丸表示了。方法:人的睾丸 cDNA 微数组被建立,有 cDNA 的 hybridized 从人的胎儿的睾丸,成年睾丸和人的精子探查。差别表示了克隆被定序并且分析。这些克隆之一是我们继续了由 RT-PCR 分析的 NORPEG 的一个短抄本。结果:NORPEG 的新奇短其他的抄本被孤立并且称为 sNORPEG。它是在长度的 3486 bp 并且包含了一个 2952-bp open 读物框架,编码 983 氨基酸的 110.4-kDa 蛋白质。氨基酸顺序分析证明 sNORPEG 蛋白质包含六次 ankyrin 重复和二个卷卷领域。它在它的顺序和主题与 NORPEG 和 ankycorbin 蛋白质分享高相同。爆炸人的染色体数据库局部性的 sNORPEG 到人的染色体 5p13.2-13.3。表示侧面证明 sNORPEG 在人的胎儿的睾丸,成年睾丸和精子被表示。而且, sNORPEG 被发现无所不在地在人的纸巾被表示。结论:sNORPEG 在睾丸的不同发展阶段被表示并且编码可以在人的睾丸开发和精子发生有角色的蛋白质。 | Wa Yuan Ying Zheng Ran Huo Li Lu Xiao-Yan Huang Lan-Lan Yin Jian-Min Li Zuo-Min Zhou Jia-Hao Sha | 2005 | Asian Journal of Andrology2005，7，3： | 1 |
| 20 | Association of atherosclerotic plaque features with collateral circulation status in elderly patients with chronic carotid stenosis显示文摘Objective To determine the association of carotid plaque features with collateral circulation status in elderly patients with moderate to severe carotid stenosis.Methods Elderly patients(>60 years)with moderate to severe carotid stenosis were recruited and categorized into good and poor collateral circulation groups,and underwent magnetic resonance imaging and computed tomography imaging.The carotid plaque features including lipid-rich necrotic core,intraplaque hemorrhage,calcification,and fibrous cap rupture(FCR)were evaluated,and maximum wall thickness,normalized wall index(NWI),and luminal stenosis were measured.The association between these variables and collateral circulation status was analyzed.Results Of the 97 patients(78 males,mean age:69.0±6.1 years),19(19.6%)had poor collaterals.The poor collateral group had a significantly higher NWI(93.7%±5.0%vs.89.0%±7.9%,P=0.011),a greater extent of stenosis(80.0%±11.4%vs.75.3%±9.4%,P=0.036)and FCR(84.2%vs.55.1%,P=0.020)compared with good collateral group.Carotid NWI(OR=3.83,95%CI:1.36–10.82,P=0.011)and more FCR(OR=6.77,95%CI:1.35–33.85,P=0.020)were associated with poor collateral circulation after adjustment for the confounding factors.The combination of NWI,FCR,systolic blood pressure,and triglycerides had the highest area-under-the-curve(AUC=0.85)for detection of poor collaterals.Conclusions Carotid plaque features,specifically NWI and FCR,are independently associated with poor collateral circulation,and the combination of carotid plaque features and traditional risk factors has a stronger predictive value for poor collateral circulation than plaque features alone. | Hui-Min XU Ran HUO Rui-Jing XIN Dan-Dan YANG Ying LIU Ning LANG Xi-Hai ZHAO Tao WANG Hui-Shu YUAN | 2020 | Journal of Geriatric Cardiology2020，17，4： | 1 |
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