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| 1 | Zircon SHRIMP U-Pb geochronology of the Neoproterozoic Chengjiang Formation in central Yunnan Province(SW China) and its geological significance显示文摘The Chengjiang Formation is the earliest continental clastic deposit after the Jinning Orogeny in central Yunnan Province,and therefore its accurate depositional age is significant for understanding the formation and evolution of the Neoproterozoic rift basins in southern China.However,hampered by accuracy of the dating technique,the existing age data for the Chengjiang Formation are not very reliable.A large number of magmatic zircons were obtained from the tuff interbed in the lower part of the Chengjiang Formation in Jinyang area and the bottom part of the Chengjiang Formation in Dongchuan area,central Yunnan Province,and high-precision SHRIMP U-Pb dating was carried out on these zircons.The results show that the weighted mean 206 Pb/238 U ages are 797.8±8.2 and 803.1±8.7 Ma respectively.In combination with related geological evidence,it has been demonstrated that the bottom boundary age of the Chengjiang Formation should be 800±5 Ma,whereas the top boundary age could be ca 725 Ma.By synthetically analyzing the latest age data for the relevant strata,it has been confirmed that the Chengjiang Formation should be correlated with the Suxiong Formation and the Kaijianqiao Formation in western Sichuan Province,the Liantuo Formation in the middle and lower Yangtze,the Hongchicun Formation and the Shangshu Formation in northern Zhejiang Province,the Puling Formation in southern Anhui Province,the Luokedong Formation and the Majianqiao Formation in northwestern Jiangxi Province,the Wuqiangxi Formation in northwestern Hunan Province,the Fanzhao Formation and the Qingshuijiang Formation in southeastern Guizhou Province,and the Sanmenjie Formation and the Gongdong Formation in northern Guangxi Province.Sedimentary cycle analysis shows that the sedimentary filling sequence of the Neoproterozoic rift basins in southern China can be divided into four cycles.Among them,Cycle II began at ca.800 Ma,accompanied by intensive tectonic-thermal events.The zircon U-Pb ages from the bottom of the Chengjiang Formation reported in this paper indicate that the Neoproterozoic Kangdian rift subbasin probably started to develop at ca.800 Ma and therefore missed Cycle I of the Neoproterozoic sedimentary filling sequence in southern China. | JIANG XinSheng WANG Jian CUI XiaoZhuang ZHUO JieWen XIONG GuoQing LU JunZe LIU JianHui | 2012 | Science China Earth Sciences2012，55，11： | 25 |
| 2 | Deformation mechanism of roadways in deep soft rock at Hegang Xing’an Coal Mine显示文摘Engineering geomechanics characteristics of roadways in deep soft rock at Hegang Xing'an Coal Mine were studied and the nature of clay minerals of roadway surrounding rock was analyzed. This paper is to solve the technical problems of high stress and the difficulty in supporting the coal mine, and provide a rule for the support design. Results show that mechanical deformation mechanisms of deep soft rock roadway at Xing'an Coal Mine is of ⅠABⅡABCⅢABCD type, consisting of molecular water absorption (the ⅠAB -type), the tectonic stress type + gravity deformation type + hydraulic type (the ⅡABC -type), and the ⅢABCD -type with fault, weak intercalation and bedding formation. According to the compound mechanical deformation mechanisms, the corresponding mechanical control measures and conversion technologies were proposed, and these technologies have been successfully applied in roadway supporting practice in deep soft rock at Xing'an Coal Mine with good effect. Xing'an Coal Mine has the deepest burial depth in China, with its overburden ranging from Mesozoic Jurassic coal-forming to now. The results of the research can be used as guidance in the design of roadway support in soft rock. | Yang Xiaojie Pang Jiewen Liu Dongming Liu Yang Tian Yihong Ma Jiao Li Shaohua | 2013 | International Journal of Mining Science and Technology2013，23，2： | 21 |
| 3 | Chronology and geochemistry of the volcanic rocks in Woruo Mountain region,Northern Qiangtang depression:Implications to the Late Triassic volcanic-sedimentary events显示文摘A suite of sedimentary-volcaniclastic rocks intercalated with the volcanic rocks unconformably overlies the Triassic Xiaochaka Formation in the Woruo Mountain region, Qiangtang Basin, northern Tibet. The vitric tuff from the base of these strata gives a SHRIMP zircon U-Pb age of 216 ± 4.5 Ma, which represents the age of the Late Triassic volcanic-sedimentary events in the Woruo Mountain region, and is consistent with that of the formation of the volcanic rocks from the Nadi Kangri Formation in the Nadigangri-Shishui River zone. There is a striking similarity in geochemical signatures of the volcanic rocks from the Woruo Mountain region and its adjacent Nadigangri-Shishui River zone, indicating that all the volcanic rocks from the Qiangtang region might have the same magmatic source and similar tectonic setting during the Late Triassic. The proper recognition of the Late Triassic large-scale volcanic eruption and volcanic-sedimentary events has important implications for the interpretation of the Late Triassic biotic extinction, climatic changes and regressive events in the eastern Tethyan domain, as well as the understanding of the initiation and nature, and sedimentary features of the Qiangtang Basin during the Late Triassic-Jurassic. | WANG Jian FU XiuGen CHEN WenXi WANG ZhengJiang TAN FuWen CHEN Ming ZHUO JieWen | 2008 | Science China Earth Sciences2008，51，2： | 21 |
| 4 | Overexpression of Dlx2 enhances osteogenic differentiation of BMSCs and MC3T3-E1 cells via direct upregulation of Osteocalcin and Alp显示文摘Genetic studies have revealed a critical role of Distal-homeobox (Dlx) genes in bone formation,and our previous study showed that Dlx2 overexpressing in neural crest cells leads to profound abnormalities of the craniofacial tissues.The aim of this study was to investigate the role and the underlying molecular mechanisms of Dlx2 in osteogenic differentiation of mouse bone marrow stromal cells (BMSCs) and pre-osteoblast MC3T3-E1 cells.Initially,we observed upregulation of Dlx2 during the early osteogenesis in BMSCs and MC3T3-E1 cells.Moreover,Dlx2 overexpression enhanced alkaline phosphatase (ALP) activity and extracellular matrix mineralization in BMSCs and MC3T3-E1 cell line.In addition,micro-CT of implanted tissues in nude mice confirmed that Dlx2 overexpression in BMSCs promoted bone formation in vivo.Unexpectedly,Dlx2 overexpression had little impact on the expression level of the pivotal osteogenic transcription factors Runx2,Dlx5,Msx2,and Osterix,but led to upregulation of Alp and Osteocalcin (OCN),both of which play critical roles in promoting osteoblast maturation.Importantly,luciferase analysis showed that Dlx2 overexpression stimulated both OCN and Alp promoter activity.Through chromatin-immunoprecipitation assay and site-directed mutagenesis analysis,we provide molecular evidence that Dlx2 transactivates OCN and Alp expression by directly binding to the Dlx2-response cis-acting elements in the promoter of the two genes.Based on these findings,we demonstrate that Dlx2 overexpression enhances osteogenic differentiation in vitro and accelerates bone formation in vivo via direct upregulation of the OCN and Alp gene,suggesting that Dlx2 plays a crucial role in osteogenic differentiation and bone formation. | Jianfei Zhang Wenbin Zhang Jiewen Dai Xudong Wang Steve Guofang Shen | 2019 | International Journal of Oral Science2019，11，2： | 19 |
| 5 | Floor heave in the west wing track haulage roadway of the Tingnan Coal Mine: Mechanism and control显示文摘Floor heave of a roadway is a dynamic phenomenon that often happens in the roadways of coal mines. It seriously affects safe production in the coal mine. Floor heave has long been one of the most difficult problems to be resolved during coal mining. An analysis of floor heave in the soft rock surrounding the roadway, and the factors influencing it, allowed the deformation mechanism in the west wing double track haulage roadway of the Tingnan Coal Mine to be deduced. Three types of floor heave are observed there: intumescent floor heave, extrusion and mobility floor heave, and compound floor heave. Control measures are proposed that have been adopted during a recent repair engineering project. Control of the floor heave in the west wing track haulage roadway was demonstrated. The reliability and rationality of a combined support technology including floor anchors, an inverted arch, and anchoring of both sides was verified by mine pressure data and the field observations. Waterproofing measures were also under-taken to assist in the control of floor heave. | Wang Jiong | 2012 | International Journal of Mining Science and Technology2012，22，3： | 18 |
| 6 | Progress of heat-hazard treatment in deep mines显示文摘在深煤矿把为深热的危险的控制技术基于,我们学习了国内外的深热的损坏和冷却技术的地位,总结了深热的危险的原因,分析并且比较热危险控制的紧急。结果证明深热的损坏的原因能被归因于三个方面,即,气候,地质并且采矿因素,地质的因素被认为为热危险的主要原因。也,我们比较了国内、海外的起源的很多种冷却技术,例如使使技术凉下来的技术,冰冷却技术和水凉下来的中央空调,与一种另外的冷却技术,即,使技术凉下来的 HEMS ,它与它的唯一的纯空气有大、重要的效果使技术凉下来,认识到从地下利用热资源到地面。这种技术使用秘密地获得的热;因此,技术能在煤矿支持低碳的环境经济开发,以便在中国完成低碳的煤生产。 | Yang Xiaojie Han Qiaoyun Pang Jiewen Shi Xiaowei Hou Dinggui Liu Chao | 2011 | Mining Science and Technology2011，21，2： | 15 |
| 7 | Edaravone injection reverses learning and memory deficits in a rat model of vascular dementia显示文摘Edaravone 是由禁止 endothelial 损害并且由改善施加 neuroprotective 效果的新奇免费激进的 scavenger 在大脑局部缺血的 neuronal 损坏。最近, edaravone 能减轻病理和 Alzheimers 疾病病人的认知赤字,这被报导。然而,它到脉管的痴呆(VaD ) 的关联不是清楚的。在这研究,我们部分堵塞了老鼠的双边的颈动脉动脉通过手术导致长期的服的 hypoperfusion (CCH ) , VaD 的一个著名老鼠模型。水迷宫和电压降低的禁止的测试被用来评估记忆赤字。superoxide dismutase 的活动 ?( 草皮) 并且喂奶脱氢酶(LDH ) , malondialdehyde 的内容 ?(MDA ) 并且全部的反应的氧种类被测量评估氧化压力水平。西方的污点分析被用来计算 synaptic 蛋白质表达式。有为一个 5 星期的时期的 edaravone 的治疗在有 CCH 的老鼠对空间的颠倒和害怕记忆赤字有能力,这被发现。Edaravone 显著地由增加草皮活动并且减少与 CCH 在老鼠的大脑减少了氧化应力的水平 MDA, LDH,和全部的反应的氧种类的内容。而且, edaravone 处理也与 CCH 在老鼠的海马恢复了多重 synaptic 蛋白质的层次。我们的数据提供在 VaD 支持 edaravone 的 neuroprotective 效果的直接证据。我们建议氧化应力的缓和和 synaptic 蛋白质的恢复在 neuroprotection 起重要作用。 | Xu Li Fen Lu Wei Li Lingzhi Qin Yong Yao Xuerong Ge Qingkai Yu Xinliang Liang Dongmei Zhao Xiaohong Li Jiewen Zhang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 14 |
| 8 | Opening time and filling pattern of the Neoproterozoic Kangdian Rift Basin,western Yangtze Continent,South China显示文摘The Neoproterozoic Kangdian Rift Basin is a continental rift basin in the western Yangtze Continent.Determining its time of opening and subsequent filling pattern is an important aspect of understanding the formation and evolution of the Yangtze Continent,South China.The Luliang Formation is the early filling in the eastern part of this rift basin,and its deposition age and filling sequence are significant for studies of the regional stratigraphic correlation,opening time,and filling pattern of this basin.Having been correlated to the upper part of the Mesoproterozoic Kunyang Group or to the Neoproterozoic Chengjiang Formation,the age and regional stratigraphic correlation of the Luliang Formation have long been uncertain.This is due to a lack of reliable absolute age constraints.To address this issue,the first zircon SHRIMP U-Pb geochronology has been established for this formation,yielding two high-precision isotopic ages of 818.6±9.2 and 805±14 Ma for the tuff layers at the bottoms of the lower and upper members of the Luliang Formation,respectively.Given the error factor,the bottom age of the lower member of the Luliang Formation can be interpreted as ca.820 Ma,corresponding to the bottom age of the lower part of the Banxi Group,which is the early filling of the Neoproterozoic Xianggui Rift Basin,a representative basin of the Neoproterozoic rift basins in the Yangtze Continent,South China.The bottom age of the upper member of the Luliang Formation can be interpreted as ca.800±5 Ma,corresponding to the bottom age of the Chengjiang Formation in the western part of the Neoproterozoic Kangdian Rift Basin and also corresponding to the bottom age of the upper part of the Banxi Group in the Neoproterozoic Xianggui Rift Basin.These ages indicate that the Neoproterozoic Kangdian Rift Basin shares the same opening time and filling sequences as those of the other Neoproterozoic rift basins in South China.Basin analysis shows that the Neoproterozoic Kangdian Rift Basin is a typical half-graben basin,with its main boundary fault in the west and basin center in the east.This basin consisted of mini unidirectional half-graben basins in its juvenile stage and simplified to become a large united half-graben basin in its mature stage,i.e.,a supradetachment basin. | ZHUO JieWen JIANG XinSheng WANG Jian CUI XiaoZhuang XIONG GuoQing LU JunZe LIU JianHui MA MingZhu | 2013 | Science China Earth Sciences2013，56，10： | 12 |
| 9 | An experimental and thermodynamic equilibrium investigation of the Pb,Zn,Cr,Cu,Mn and Ni partitioning during sewage sludge incineration显示文摘The effects of different chlorides and operational conditions on the distribution and speciation of six heavy metals(Pb, Zn, Cr, Cu, Mn and Ni) during sludge incineration were investigated using a simulated laboratory tubular-furnace reactor. A thermodynamic equilibrium investigation using the Fact Sage software was performed to compare the experimental results. The results indicate that the volatility of the target metals was enhanced as the chlorine concentration increased. Inorganic-Cl influenced the volatilization of heavy metals in the order of Pb > Zn > Cr > Cu > Mn > Ni. However, the effects of organic-Cl on the volatility of Mn, Pb and Cu were greater than the effects on Zn, Cr and Ni.With increasing combustion temperature, the presence of organic-Cl(PVC) and inorganic-Cl(NaCl) improved the transfer of Pb and Zn from bottom ash to fly ash or fuse gas. However,the presence of chloride had no obvious influence on Mn, Cu and Ni. Increased retention time could increase the volatilization rate of heavy metals; however, this effect was insignificant. During the incineration process, Pb readily formed Pb SiO4 and remained in the bottom ash. Different Pb compounds, primarily the volatile PbCl2, were found in the gas phase after the addition of NaCl; the dominant Pb compounds in the gas phase after the addition of PVC were PbCl2, Pb(ClO4)2and Pb Cl2O4. | Jingyong Liu Jiewen Fu Xun'an Ning Shuiyu Sun Yujie Wang Wuming Xie Shaosong Huang Sheng Zhong | 2015 | Journal of Environmental Sciences2015，27，9： | 11 |
| 10 | Distribution of ground stress on Puhe Coal Mine显示文摘Puhe Coal Mine is a typical Tertiary coal in Shenbei mining area. With an increase in mining depth, tectonic stress field becomes more complex, leading to increased deformation and failure of the soft rock roadway. Stress becomes an important factor of mine safety and stability. This paper analyzes the distribution of the regional tectonic field, and determines the distribution of situ stress measurement through measuring the ground stress field in the main mining area level of Puhe Coal Mine using stress relief method. The acquired in situ stress data at different locations and depths provide a reference for the rational arrangement of the stop and mine roadway supporting design, which are of great significance for the efficient safety production of the mine. | Guo Zhibiao Jiang Yulin Pang Jiewen Liu Jiawei | 2013 | International Journal of Mining Science and Technology2013，23，1： | 10 |
| 11 | Comparative efficacy and safety of Chinese herbal injections combined with transcatheter hepatic arterial chemoembolization in treatment of liver cancer: a bayesian network Meta-analysis显示文摘OBJECTIVE: To address the optimal Chinese herbal injections(CHIs) against liver cancer, the present network Meta-analysis is designed to investigate the comparative efficacy and safety of different CHIs.METHODS: Several electronic databases were searched up to June 1 st, 2017. The quality assessment was conducted and network Meta-analysis was performed to compare the efficacy and safety of different CHIs plus transcatheter hepatic arterial chemoembolization(TACE). Primary outcomes were 1-year and 2-year survival rate, the secondary outcomes includes the clinical effective rate, performance status and the adverse reactions(ADRs). Data analysis was applied Stata 13.0 and Win BUGS 1.4 software.RESULTS: A total of 105 randomized controlled trials(RCTs) were identified for inclusion in this analysis, with data for 7683 patients and 13 CHIs. The results suggested that Javanica oil emulsion,Huachansu injection plus TACE were more favorable for 1-year and 2-year survival rate than other CHIs. Kanglaite, Astragalus polysaccharide injection plus TACE showed superiority in the clinical effective rate and performance status over other CHIs.And Shenmai injection plus TACE was superior to reducing ADRs than other CHIs for patients with liver cancer.CONCLUSION: Our findings indicated that receiving CHIs combined with TACE may have therapeutic benefits for patients with liver cancer in improving survival rate, clinical effective rate, the performance status and alleviating the ADRs. | Zhang Dan Wang Kaihuan Zheng Jiewen Wu Jiarui Duan Xiaojiao Ni Mengwei Liu Shuyu Zhang Bing Zhao Yi | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 9 |
| 12 | Tetramethylpyrazine reverses intracerebroventricular streptozotocin-induced memory deficits by inhibiting GSK-3β显示文摘大脑机能障碍,特别认知的缺陷,是在 Alzheimers 疾病(广告) 的主要复杂并发症之一,它威胁世界范围的 4680 万个人的健康。目前,认知机能障碍的致病仅仅部分被理解,并且为在广告的记忆损失的有效治疗留下逃犯。Tetramethylpyrazine (TMP ) 是从 Chuanxiong 净化的主要 bioactive 混合物之一,中国植物为神经与血管、心血管的疾病的处理使用了。TMP 的 neuroprotective 性质在一些 neurodegenerative 疾病是明显的,包括 Parkinsons 疾病。然而, TMP 是否在广告起一个 neuroprotective 作用,仍然是未知的。这里,我们报导有 TMP 的 2 星期的处理救了记忆缺陷在一个著名广告老鼠模型由 streptozotocin 的 intracerebroventricular 注射导致了的短期、长期的害怕。TMP 的管理也恢复了在注射 streptozotocin 的老鼠的空间学习和记忆保留能力。而且, TMP 禁止了 GSK-3 的活动,调停的重要 kinase 在糖尿病 mellitus 的海马趾的 synaptic 和记忆混乱。最后,我们发现 TMP 处理恢复了胆碱能的神经原的功能。我们的数据建议 TMP 的那饮食的举起能在广告对存储器损失提供保护,并且 GSK-3 的抑制可以在这保护的效果起一个重要作用。 | Fen Lu Xu Li Wei Li Ke Wei Yong Yao Qianlin Zhang Xinliang Liang Jiewen Zhang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 9 |
| 13 | Optimization of mechanical property, antibacterial property and corrosion resistance of Ti-Cu alloy for dental implant显示文摘Ti-Cu alloys with different Cu contents(3, 5 and 7 wt%) were fabricated and studied as novel antibacterial biomaterials for dental application. The Ti-Cu alloys were annealing treated at different temperatures(740℃, 830℃ and 910℃) in order to obtain three typical microstructures, β-Ti + Ti2Cu, β-Ti + transformed α-Ti, and transformed α-Ti. Mechanical, antibacterial and biocorrosion properties of Ti-Cu alloys with different microstructures were well analyzed by scanning electron microscopy(SEM),X-ray diffraction(XRD), transmission electron microscopy(TEM), tensile test, electrochemical test and antibacterial test. The results indicated that the Ti-Cu alloys with microstructure of β-Ti + Ti2 Cu showed the best ductility compared with other Ti-Cu alloys with microstructures of β-Ti + transformed α-Ti and complete transformed α-Ti, and meanwhile, increase of the Cu content significantly contributed to the decreased ductility due to the increasing amount of Ti2 Cu, which brought both solid solution strengthening and precipitation strengthening. Finally, the Ti-5 Cu alloy with microstructure of β-Ti + Ti2 Cu exhibited excellent ductility, antibacterial property and corrosion resistance, providing a great potential in clinical application for dental implants. | Jiewen Wang Shuyuan Zhang Ziqing Sun Hai Wang Ling Ren Ke Yang | 2019 | Journal of Materials Science & Technology2019，35，10： | 9 |
| 14 | Study on expresion of adherent proteins related to regulation of hematopoiesis in long-term cultured human bone marrow stromal cells显示文摘Studyonexpresionofadherentproteinsrelatedtoregulationofhematopoiesisinlongtermculturedhumanbonemarrowstromalcels.LiuJiewen,... | Liu Jiewen, Qi Shuling, E de Wynter, et al. Institute of Hematology, CAMS and PUMC, Tianjin 300020, China. | 1998 | Chinese Medical Journal1998，，2： | 8 |
| 15 | Tidal flat erosion of the Huanghe River Delta due to local changes in hydrodynamic conditions显示文摘An ideal nature system for the study of post-depositional submarine mass changing under wave loading was selected in the inter-tidal platform of the subaqueous Huanghe River Delta, a delta formed during period from 1964 to 1976 as the Huanghe River discharged into the Bohai Gulf by Diaokou distributary. A road embankment constructed for petroleum recovery on the inter-tidal platform in 1995 induced the essential varieties of hydrodynamic conditions on the both sides of the road. With both sides sharing similarities in(1) initial sedimentary environment,(2) energetic wave loading,(3) differential hydrodynamic conditions in later stages,(4) enough long-range action, and(5) extreme shallow water inter-tidal platforms; the study is representative and feasible as well. Two study sites were selected on each side of the road, and a series of measurements, samplings, laboratory experiments have been carried out, including morphometry, hydrodynamic conditions, sediment properties, granularity composition, and fractal dimension calculation of the topography in the two adjacent areas. It was observed that in the outer zone, where wave loading with high magnitude prevailed, the tidal flat was bumpy and exhibited a high erosion rate and high fractal dimension. Further, the fractal dimension diminished quickly, keeping with the enlarging of calculative square size. However in the inner zone, where the hydrodynamic condition was weak, the tidal flat was flat and exhibited a low erosion rate and low fractal dimensions; the fractal dimension diminished with the enlarging of calculative square size. The fractal dimensions in the different hydrodynamic areas equalized increasingly as the calculative square size accreted to threshold, indicating that the hydrodynamic condition plays a significant role in topography construction and submarine delta erosion process. Additionally, the later differentiation of sediment properties, granularity composition, microstructure characteristics, and mineral composition induced by the different hydrodynamic conditions can also contribute to the variation of topography and sea-bed erosion in the two adjacent areas. | JIA Yonggang ZHENG Jiewen YUE Zhongqi LIU Xiaolei SHAN Hongxian | 2014 | Acta Oceanologica Sinica2014，33，7： | 7 |
| 16 | Resveratrol improves cognition and reduces oxidative stress in rats with vascular dementia显示文摘Resveratrol possesses beneficial biological effects,which include anti-oxidant,anti-inflammatory and anti-carcinogenic properties.Recently,resveratrol has been shown to exhibit neuroprotective effects in models of Parkinson's disease,cerebral ischemia and Alzheimer's disease.However,its effects on vascular dementia remain unclear.The present study established a rat model of vascular dementia using permanent bilateral common carotid artery occlusion.At 8-12 weeks after model induction,rats were intragastrically administered 25 mg/kg resveratrol daily.Our results found that resveratrol shortened the escape latency and escape distances in the Morris water maze,and prolonged the time spent percentage and swimming distance percentage in the target quadrant during the probe test,indicating that resveratrol improved learning and memory ability in vascular dementia rats.Further experiments found that resveratrol decreased malonyldialdehyde levels,and increased superoxide dismutase activity and glutathione levels in the hippocampus and cerebral cortex of vascular dementia rats.These results confirmed that the neuroprotective effects of resveratrol on vascular dementia were associated with its anti-oxidant properties. | Xingrong Ma Zhikun Sun Yanru Liu Yanjie Jia Boai Zhang Jiewen Zhang | 2013 | Neural Regeneration Research2013，8，22： | 7 |
| 17 | Chimeric antigen receptor T cells in solid tumors: a war against the tumor microenvironment显示文摘Chimeric antigen receptor(CAR) T cell is a novel approach, which utilizes anti-tumor immunity for cancer treatment. As compared to the traditional cell-mediated immunity, CAR-T possesses the improved specificity of tumor antigens and independent cytotoxicity from major histocompatibility complex molecules through a monoclonal antibody in addition to the Tcell receptor. CAR-T cell has proven its effectiveness, primarily in hematological malignancies, specifically where the CD19 CAR-T cells were used to treat B-cell acute lymphoblastic leukemia and B-cell lymphomas. Nevertheless, there is little progress in the treatment of solid tumors despite the fact that many CAR agents have been created to target tumor antigens such as CEA,EGFR/EGFRvIII, GD2, HER2, MSLN, MUC1, and other antigens. The main obstruction against the progress of research in solid tumors is the tumor microenvironment, in which several elements, such as poor locating ability, immunosuppressive cells,cytokines, chemokines, immunosuppressive checkpoints, inhibitory metabolic factors, tumor antigen loss, and antigen heterogeneity, could affect the potency of CAR-T cells. To overcome these hurdles, researchers have reconstructed the CAR-T cells in various ways. The purpose of this review is to summarize the current research in this field, analyze the mechanisms of the major barriers mentioned above, outline the main solutions, and discuss the outlook of this novel immunotherapeutic modality. | Zijun Zhao Xiaoyun Xiao Phei Er Saw Wei Wu Hongyan Huang Jiewen Chen Yan Nie | 2020 | Science China(Life Sciences)2020，63，2： | 7 |
| 18 | A Genome Sequence of Novel SARS-CoV Isolates: the Genotype, GD-Ins29, Leads to a Hypothesis of Viral Transmission in South China显示文摘We report a complete genomic sequence of rare isolates (minor genotype) of theSARS-CoV from SARS patients in Guangdong, China, where the first few casesemerged. The most striking discovery from the isolate is an extra 29-nucleotidesequence located at the nucleotide positions between 27,863 and 27,864 (referredto the complete sequence of B J01) within an overlapped region composed of BGI-PUP5 (BGI-postulated uncharacterized protein 5) and BGI-PUP6 upstream ofthe N (nucleocapsid) protein. The discovery of this minor genotype, GD-Ins29,suggests a significant genetic event and differentiates it from the previously re-ported genotype, the dominant form among all sequenced SARS-CoV isolates. A17-nt segment of this extra sequence is identical to a segment of the same size intwo human mRNA sequences that may interfere with viral genome replication andtranscription in the cytosol of the infected cells. It provides a new avenue for theexploration of the virus-host interaction in viral evolution, host pathogenesis, andvaccine development. | E‘deQin XiongleiHe WeiTian YongLiu WeiLi JieWen BingyinSi YongwuHu WenmingPeng LinTaug TaoJiang JianpingShi JiaJia YuZhang JiaYe Cui’eWang YujunHan JingqiangWang BaochangFan QingfaWu GuohuiChang WuchunCao ZuyuanXu RuifuYang JmgWang ManYu YanLi JingXu JunZhou YajumDeng XiaoyuLi JianfeiHu CaipingWang ChunxiaYan QingrunZhang JingyueBao GuoqingLi HaiqingZhang YilinZhang HuiZhao XiaoweiZhang ShuangliLi XiaoJieCheng XiuqingZhang BinLiu ChangqingZeng HuanmingYang WeijunChen LinFang ChangfengLi MengLei DaweiLi WeiTong XiangjunTian JianWang BoZhang SonggangLi XuehaiTan SiqiLiu WeiDong JunWang GaneKa-ShuWong JunYu QingyuZhu | 2003 | Genomics, Proteomics & Bioinformatics2003，1，2： | 6 |
| 19 | Amniotic fluid-derived stem cells mixed with platelet rich plasma for restoration of rat alveolar bone defect显示文摘从羊膜的液体孤立的干细胞作为房间治疗和织物工程的一个有希望的候选人被显示出。然而, maxillofacial 骨头织物工程的地里的羊膜的导出液体的干细胞(AFSC ) 的试验性、现出症状之前的潜的应用仍然是有限的。在这研究,老鼠 AFSC 成功地在 vitro 被收获并且描绘。老鼠 AFSC 显示出典型 fibroblastoid 形态学,稳定的增长活动和多区别潜力。Flow-cytometry 分析为象 CD34 和 CD45 那样的造血的标记证明这些房间为 CD29, CD44,和 CD90 是积极的,当否定时。与血小板富人一起的 AFSCs-premixed 的再生表演在牙槽的骨头缺点的恢复的血浆(PRP ) 胶化进一步用一只修改老鼠被调查颚的牙槽的缺点模型。微型电脑断层摄影术和组织学的检查在操作与控制组作比较以后在 4 和 8 个星期与 PRP 胶化显示出 AFSCs-premixed 的一个优异再生能力。而且,植入的 AFSC 能在缺点地点幸存并且直接参予骨头织物新生。一起拿,这些结果为牙槽的缺点恢复显示了基于 AFSCs 的牙槽的骨头织物工程策略的可行性。 | Minjiao Wang Hongliang Li Jiawen Si Jiewen Dai Jun Shi Xudong Wang Lihe Guo Guofang Shen | 2017 | Acta Biochimica et Biophysica Sinica2017，49，3： | 5 |
| 20 | An infectious disease of ducks caused by a newly emerged Tembusu virus strain in mainland China显示文摘 | Pixi Yan Youshu Zhao Xu Zhang Dawei Xu Xiaoguang Dai Qiaoyang Teng Liping Yan Jiewen Zhou Xiwen Ji Shumei Zhang Guangqing Liu Yanjun Zhou Yoshihiro Kawaoka Guangzhi Tong Zejun Li | 2011 | Virology2011，，1： | 5 |
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