|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Long-term follow-up of the effects of fecal microbiota transplantation in combination with soluble dietary fiber as a therapeutic regimen in slow transit constipation显示文摘As some studies have reported that strategies targeting the gut microbiota such as fecal microbiota transplantation(FMT) with or without other microecological therapy might have efficacy in treating slow transit constipation(STC), we conducted a singlecenter, open-label trial to study the long-term effect of FMT combined with soluble dietary fiber(pectin) on STC. Thirty-one adult patients with STC were enrolled into the trial. Patients received 6-day FMT procedures repeatedly for the first 3 months and soluble dietary fiber(pectin) daily during the follow-up. The rate of clinical remission and improvement, stool consistency, the Wexner constipation scale, and assessment of constipation-related symptoms were evaluated at week 4 and 1 year later. The clinical remission and improvement rates at week 4 were 69.0%(20/29) and 75.9%(22/29), respectively. At the end of the study,48.3%(14/29) of patients continued to have at least three complete spontaneous bowel movements per week and 58.6%(17/29)of patients showed clinical improvements. Stool consistency, the Wexner constipation scale, and constipation symptoms improved both at short-term and long-term follow-up. The results indicated that FMT in combination with soluble dietary fiber(pectin) had both short-term and long-term efficacy in treating STC. | Xueying Zhang Hongliang Tian Lili Gu Yongzhan Nie Chao Ding Xiaolong Ge Bo Yang Jianfeng Gong Ning Li | 2018 | Science China(Life Sciences)2018，61，7： | 33 |
| 2 | Genetic diversity of rice cultivars (Oryza sativa L.) in China and the temporal trends in recent fifty years显示文摘To understand geographical distribution of the genetic diversity of rice cultivars {Oryza sativa L.) and its trends in recent fifty years in China, 453 ’ accessions were analyzed by 36 microsatellites loci and 42 phenotypic traits. Results revealed that the genetic diversity by SSRs is highly consistent with that by phenotypic traits and the genetic diversity of indica cultivars was higher than that of japonica cultivars; the genetic diversity of cultivars declined from 1950s to 1980s and then increased greatly; among the six rice ecological zones (REZs), genetic diversity of REZTl was the highest and those of REZV and REZVT were the lowest at both DNA and phenotypic level. Jiangsu and Jiangxi provinces in the middle and lower reaches of Yangtze River and Sichuan province in southwest of China were the areas with the highest genetic diversity. Breeders in REZV which is an important japonica rice area but with very low genetic diversity should explore more gene resources to widen the genetic backgrounds of cultivars. | QI Yonawen ZHANG Dongling ZHANG Hongliang WANG Meixing SUN Junli WEI Xinghua QIU Zongen TANG Shengxiang CAO Yongsheng WANG Xiangkun LI Zichao | 2006 | Chinese Science Bulletin2006，51，6： | 27 |
| 3 | Agriculture Green Development: a model for China and the world显示文摘Realizing sustainable development has become a global priority.This holds,in particular,for agriculture.Recently,the United Nations launched the Sustainable Development Goals(SDGs),and the Nineteenth National People’s Congress has delivered a national strategy for sustainable development in China—realizing green development.The overall objective of Agriculture Green Development(AGD)is to coordinate'green'with'development'to realize the transformation of current agriculture with high resource consumption and high environmental costs into a green agriculture and countryside with high productivity,high resource use efficiency and low environmental impact.This is a formidable task,requiring joint efforts of government,farmers,industry,educators and researchers.The innovative concept for AGD will focus on reconstructing the whole crop-animal production and food production-consumption system,with the emphasis on high thresholds for environmental standards and food quality as well as enhanced human well-being.This paper addresses the significance,challenges,framework,pathways and potential solutions for realizing AGD in China,and highlights the potential changes that will lead to a more sustainable agriculture in the future.Proposals include interdisciplinary innovations,whole food chain improvement and regional solutions.The implementation of AGD in China will provide important implications for the countries in developmental transition,and contribute to global sustainable development. | Jianbo SHEN Qichao ZHU Xiaoqiang JIAO Hao YING Hongliang WANG Xin WEN Wen XU Tingyu LI Wenfeng CONG Xuejun LIU Yong HOU Zhenling CUI Oene OENEMA William JDAVIES Fusuo ZHANG | 2020 | Frontiers of Agricultural Science and Engineering2020，7，1： | 18 |
| 4 | Formability of AA 2219-O sheet under quasi-static,electromagnetic dynamic,and mechanical dynamic tensile loadings显示文摘The mechanism by which electromagnetic forming(EMF)enhances the formability of metals is unclear owing to the coupling effect of multi-physics fields.In the present work,the associated formability improvement mechanisms were qualitatively categorized and illustrated.This was realized by comparing the formability of fully annealed 2219 aluminum alloy(AA 2219-O)sheet under quasi-static(QS),electromagnetic dynamic(EM),and mechanical dynamic(MD)tensile loadings.It was found that the forming limit of AA 2219-O sheet under EM tensile loading was significantly(45.4%)higher than that under QS tensile loading,and was marginally(3.7%–4.3%)higher than that under MD tensile loading.In addition,the forming limit of AA 2219-O sheet demonstrated a negative dependency on the strain rate within the range of the dynamic tensile tests conducted.The deformation conditions common to EM and MD tensile loadings were responsible for the significant formability improvement compared with QS tensile loading.In particular,the inertial effect was dominant.The different deformation conditions that distinguish EM tensile loading from MD tensile loading resulted in the marginal improvement in formability.This was caused by the absence of a sustaining contact force at the later deformation stage and the lower strain rate.The body force exerted little influence on the formability improvement,and the thermal effect under the two dynamic tensile loadings was negligible. | Hongliang Su Liang Huang Jianjun Li Wang Xiao Hui Zhu Fei Feng Hongwei Li Siliang Yan | 2021 | Journal of Materials Science & Technology2021，，11： | 13 |
| 5 | Cardiac autonomic nerve fiber regeneration in chronic heart failure Do Akt gene-transduced mesenchymal stem cells promote repair?显示文摘BACKGROUND: Transplantation of Akt-over-expressing mesenchymal stem cells (Akt-MSCs) has been shown to repair infarcted myocardium and improve cardiac function. However, little is known about the therapeutic effects of Akt-MSCs on cardiac autonomic neuropathy in chronic heart failure (CHF). OBJECTIVE: The present study used adriamycin-induced CHF rat models to observe the effect of Akt-MSCs on cardiac autonomic nervous regeneration and the factors mediating this effect. DESIGN, TIME AND SETTING: A randomized, controlled animal experiment was performed at the Central Laboratory of Basic Medical College, China Medical University, between September 2008 and April 2009. MATERIALS: Rabbit anti-choline acetyltransferase (ChAT), growth associated protein-43 (GAP-43), synaptophysin (SYN) polyclonal antibodies and the secondary antibody (goat anti-rabbit IgG) were purchased from Boster, China. Cat-A-Kit assay system was provided by Amersham, USA. METHODS: (1) Adult rat MSCs were isolated and cultured for the preparation of Akt-MSCs. (2) Forty male Wistar rats were intramyocardially administered adriamycin at 2 mg/kg over 3 days for a total of five times and once a week for additional five times thereafter to establish CHF models. At 2 weeks after final adriamycin treatment, 34 successful CHF rat models were randomized to three groups: Akt-MSCs (n = 11), simple MSCs (s-MSCs, n =11), and control (n = 12). Each group was intravenously administered Akt-MSCs (2×106 cells in 100 μL PBS), s-MSCs (2×106 cells in 100 μL PBS) or equal volume of phosphate buffered saline, once a day for a total of three times. MAIN OUTCOME MEASURES: At 4 weeks after final adriamycin treatment, myocardial norepi- nephrine (NE) content was detected using a Cat-A-Kit assay system. Myocardial ChAT, SYN and GAP-43 were performed by immunohistochemistry and Western blot analysis. Prior to, 2 and 4 weeks after adriamycin treatment, echocardiographic examination was performed and left ventricular ejection fraction (LVEF) was determined. RESULTS: Myocardial NE content, as well as SYN-positive and GAP-43-positive nerve fiber density and expression, and LVEF, was the greatest in the Akt-MSCs group, followed by the s-MSCs group, and lastly the control group (P < 0.05 or P < 0.01). ChAT expression was similar between Akt-MSCs and s-MSCs groups, but it was higher compared with the control group (P < 0.05). NE contents were negatively correlated to LVEF (r = -0.64, P = 0.015). CONCLUSION: Transplantation of MSCs, in particular Akt-MSCs, promotes cardiac nervous regeneration in failing heart, which might be mediated by GAP-43. | Hongliang Kong Zhanquan Li Shumei Zhao Li Zhu Yingjun Zhao Weiwei Zhang GuipingXu Wenjun Hao Huijun Li Guoxian Qi | 2010 | Neural Regeneration Research2010，5，1： | 13 |
| 6 | Serum IgA,IgM,and IgG responses in COVID-19显示文摘Currently,detecting SARS-CoV-2 RNAs is a standard approach for COVID-19 diagnosis.However,there is an urgent need for reliable and rapid serological diagnostic methods to screen SARS-CoV-2-infected people including those who do not have overt symptoms.Most emerging studies described serological tests based on detection of SARS-CoV-2-specific IgM and IgG.1–4 Although detection of SARS-CoV-2-specific IgA in serum has been reported in few papers,5,6 analyses of IgA levels in a larger number of COVID-19 patients are still lacking. | Huan Ma Weihong Zeng Hongliang He Dan Zhao Dehua Jiang Peigen Zhou Linzhao Cheng Yajuan Li Xiaoling Ma Tengchuan Jin | 2020 | Cellular & Molecular Immunology2020，17，7： | 12 |
| 7 | Sedimentary records of eutrophication in the Changjiang Estuary upwelling area over last 100 a显示文摘The upwelling area in the Changjiang Estuary was selected to collect the core, where the red tide occurred frequently and hypoxic existed. The total organic carbon (TOC), total nitrogen (TN), biogenic silica (BSi) and stable organic carbon isotopic ratios(δ13 Corg) were determined on the 210Pb-dated sediment core. The concentrations of TOC, TN, BSi as well as their sedimentation fluxes have increased to some extent since the 1970s. TOC and TN fluxes increased about 45%, 36% respectively. The average δ13 Corg value in the core was -23.67×10-3 which remained nearly constant before the 20 century. The δ13 Corg values increased after the 1900s, two marked increases were observed from the 1950s and the 1970s. A simple δ13 Corg model was used to estimate the contribution of terrigenous and marine organic matter inputs for the sediment, which indicated the increase in accumulation since the 1970s has been almost exclusively marine. The increasing of marine organic matter accumulation (TOC, TN and BSi) was corresponding with the increasing of fertilizer consumption and the NO3-N budgets from the Changjiang River. The riverine runoff of fertilizers and nutrients stimulated the algae blooming. Enhanced primary production resulted in an enrichment of organic matter in the sediment. These data support the hypothesis that anthropogenic nutrient loading has been a significant factor on the eutrophication in the Changjiang Estuary. | FENG Xuwen JING Xianglong YU Xiaoguo LI Hongliang CHEN Jianfang QIAN Jiangchu | 2008 | Acta Oceanologica Sinica2008，27，6： | 12 |
| 8 | Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure显示文摘SIRT1,a mammalian ortholog of yeast silent information regulator 2(Sir2),is an NAD+-dependent protein deacetylase that plays a critical role in the regulation of vascular function.The current study aims to investigate the functional significance of deacetylase activity of SIRT1 in heart.Here we show that the early postnatal hearts expressed the highest level of SIRT1deacetylase activity compared to adult and aged hearts.We generated transgenic mice with cardiac-specific expression of a dominant-negative form of the human SIRT1(SIRT1H363Y),which represses endogenous SIRT1 activity.The transgenic mice displayed dilated atrial and ventricular chambers,and died early in the postnatal period.Pathological,echocardiographic and molecular phenotype confirmed the presence of dilated cardiomyopathy.Terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling analysis revealed a greater abundance of apoptotic nuclei in the hearts of transgenic mice.Furthermore,we show that cardiomyocyte apoptosis caused by suppression of SIRT1 activity is,at least in part,due to increased p53acetylation and upregulated Bax expression.These results indicate that dominant negative form of SIRT1(SIRT1H363Y)overexpression in mouse hearts causes cardiomyocyte apoptosis and early-onset heart failure,suggesting a critical role of SIRT1 in preserving normal cardiac development during the early postnatal period. | MU WenLi ZHANG QingJun TANG XiaoQiang FU WenYan ZHENG Wei LU YunBiao LI HongLiang WEI YuSheng LI Li SHE ZhiGang CHEN HouZao LIU DePei | 2014 | Science China(Life Sciences)2014，57，9： | 12 |
| 9 | TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells显示文摘免疫疗法和化疗的联合为癌症的某些类型的治疗被认为是一条有希望的途径。然而,内在的机制需要充分被调查为癌症 chemoimmunotherapy 指导更有效的协议的设计。联系危险的分子的模式(阻尼) 能激活有免疫力的房间,是众所周知的,包括树枝状的房间(DC ) ,经由像使用费的受体(TLR ) ;然而,在有免疫力的反应的激活免除化学对待药的肿瘤房间的阻尼的角色需要进一步被阐明。这里,我们发现那 colorectal 与 oxaliplatin (OXA ) 对待的癌症(CRC ) 房间或 5 氟尿嘧啶(5-Fu ) 释放了高活动性的组盒子 1 的高水平(HMGB1 ) 和热吃惊蛋白质 70 (HSP70 ) 。在 OXA/5-Fu 治疗以后,也展出的 CRC 病人的 sera 增加了 HMGB1 和 HSP70 的层次,哪个是著名阻尼。与 OXA/5-Fu 对待的垂死的 CRC 房间的上层清液支持了老鼠和人的 DC 成熟,与 HLA 医生, CD80 和 CD86 表示和 IL-1β 的改进的 upregulation;, TNF-α, MIP-1α, MIP-1β, RANTES 和 IP-10 生产。由 DC 组成的疫苗与导致的化学上强调的 CRC 房间的上层清液搏动了更重要的 IFN-γ在 vitro 并且在 vivo 生产 Th1 反应。然而,化学上强调的 CRC 房间的上层清液没能在 TLR4 缺乏的 DC 导致 phenotypic 成熟和 cytokine 生产,显示在导致阻尼的 DC 成熟和激活的 TLR4 的一个必要角色。而且,有化学上强调的 CRC 房间的上层清液的 pulsing 高效地没导致 IFN-γ在 TLR4 缺乏的 DC 生产 Th1 反应。一起,这些结果证明免除化学上强调的癌症房间的阻尼能经由 TLR4 激活 DC 并且提高反肿瘤 T 房间有免疫力的回答的正式就职,描出一条临床上相关的免疫助手小径由阻尼被触发。 | Hongliang Fang Bing Ang Xinyun Xu Xiaohui Huang Yanfeng Wu Yanping Sun Wenying Wang Nan Li Xuetao Cao Tao Wan | 2014 | Cellular & Molecular Immunology2014，11，2： | 11 |
| 10 | A multi-index assessment method for evaluating coverage effectiveness of remote sensing satellite显示文摘This paper deals with the multi-index assessment method for evaluating coverage effectiveness of remote sensing satellite. Because a series of satellite activities such as imaging, moving target observation, and environment investigation need to know the coverage characteristics, the coverage capability of the remote sensing satellite is the most important index. Thus, it is very important to establish the method of effectiveness evaluation of coverage characteristics. This paper focuses on the assessment of coverage effectiveness of remote sensing satellite, and proposes and designs a multi-index evaluation method based on index weight using entropy weight method and analytic hierarchy process. With a simulation case, the effectiveness evaluation results of single satellite coverage and multi-satellite coverage performance are given for the proposed assessment.The experimental results show that the established coverage characteristic model and the proposed assessment method are effective and right. | Hongliang LI Dong LI Yunhua LI | 2018 | Chinese Journal of Aeronautics2018，31，10： | 11 |
| 11 | The chemosensory protein of Chinese honeybee, Apis cerana cerana: Molecular cloning of cDNA, immunocytochemical localization and expression显示文摘Chemosensory proteins (CSPs) are ubiquitous soluble small proteins isolated from sensory organs thought to be involved in chemical communication. Here we report the first cDNA of CSPs, called Ac-ASP3, cloned and characterized from antennas of adult worker bees in Chinese honeybee, Apis cerana cerana. The Ac-ASP3 cDNA comprises 2 exons, with an ORF of 393-bp encoding 130 aa. Protein signature analyses show that the protein consists of four conserved cysteines and a signal peptide with 19 aa in the N-terminal sequence. The deduced protein sequence shares high homology with Am-ASP3 of Apis mellifera and low similarity with other species of insects. Immunocytochemical localization shows that Ac-ASP3 is only specifically expressed on the antenna contact chemosensilla such as sensilla trichodea B and sensilla basiconica, whereas Ac-ASP3 is scarcely expressed on olfactory chemosensilla such as sensilla placodea. Real-time PCR of Ac-ASP3 transcripts shows that Ac-ASP3 is highly expressed on wings and legs, but expression is lower on antenna. Temporal expression patterns suggest that Ac-ASP3 is expressed during the period of pupa and adults from 1-d to 6-d stages when bees act as house bees, cleaning the comb and taking care of the queen and larvae in comb. The above evidence suggests that Ac-ASP3 is unique in species and is generally not involved in olfaction during searching for honey and pollen. Rather, the protein seems to function in recognition of chemosensory substances on bees' cuticle and mechanical movement of antenna. | LI HongLiang LOU BingGan CHENG Jia'An GAO QiKang | 2007 | Chinese Science Bulletin2007，52，10： | 10 |
| 12 | Decolorization of Methyl Orange by a new clay-supported nanoscale zero-valent iron:Synergetic effect,efficiency optimization and mechanism显示文摘In this study, a novel nanoscale zero-valent iron(n ZVI) composite material was successfully synthesized using a low-cost natural clay, 'Hangjin 2#clay'(HJ clay) as the support and tested for the decolorization of the azo dye Methyl Orange(MO) in aqueous solution by n ZVI particles. According to the characterization and MO decolorization experiments, the sample with 5:1 HJ clay-supported n ZVI(HJ/n ZVI) mass ratio(HJ-n ZVI5) showed the best dispersion and reactivity and the highest MO decolorization efficiency. With the same equivalent Fe0 dosage, the HJ-n ZVI1 and HJ-n ZVI5 samples demonstrated a synergetic effect for the decolorization of MO: their decolorization efficiencies were much higher than that achieved by physical mixing of HJ clay and n ZVIs, or the sum of HJ clay and n ZVIs alone. The synergetic effect was primarily due to the improved dispersion and more effective utilization of the n ZVI particles on/in the composite materials. Higher decolorization efficiency of MO was obtained at larger HJ-n ZVI dosage, higher temperature and under N2 atmosphere, while the MO initial concentration and p H were negatively correlated to the efficiency. HJ clay not only works as a carrier for n ZVI nanoparticles, but also contributes to the decolorization through an 'adsorption-enhanced reduction' mechanism. The high efficiency of HJ-n ZVI for decontamination gives it great potential for use in a variety of remediation applications. | Xiaoguang Li Ying Zhao Beidou Xi Xiaoguang Meng Bin Gong Rui Li Xing Peng Hongliang Liu | 2017 | Journal of Environmental Sciences2017，29，2： | 9 |
| 13 | Brain-derived neurotrophic factor induces neuron-like cellular differentiation of mesenchymal stem cells derived from human umbilical cord blood cells in vitro显示文摘Human umbilical cord blood was collected from full-term deliveries scheduled for cesarean section.Mononuclear cells were isolated,amplified and induced as mesenchymal stem cells.Isolated mesenchymal stem cells tested positive for the marker CD29,CD44 and CD105 and negative for typical hematopoietic and endothelial markers.Following treatment with neural induction medium containing brain-derived neurotrophic factor for 7 days,the adherent cells exhibited neuron-like cellular morphology.Immunohistochemical staining and reverse transcription-PCR revealed that the induced mesenchymal stem cells expressed the markers for neuron-specific enolase and neurofilament.The results demonstrated that human umbilical cord blood-derived mesenchymal stem cells can differentiate into neuron-like cells induced by brain-derived neurotrophic factor in vitro. | Lei Chen Zhongguo Zhang Bing Chen Xiaozhi Liu Zhenlin Liu Hongliang Liu Gang Li Zhiguo Su Junfei Wang Guozhen Hui | 2011 | Neural Regeneration Research2011，6，13： | 8 |
| 14 | Geographical genetic diversity and divergence of common wild rice (O. rufipogon Griff.) in China显示文摘Using 36 SSR markers and 889 accessions of common wild rice in China, the genetic diversity and the divergence among different geographical populations are investigated. Guangdong Province has the largest number of alleles, which account for 84% of the total alleles detected in the study, followed by Guangxi Province. The Nei's gene diversity indices, from high to low, are in the sequence of Hainan, Guangdong, Guangxi, Fujian, Hunan, Jiangxi, and Yunnan provinces. Two genetic diversity centers of Chinese common wild rice are detected on the basis of geographic analysis, i.e., the region covering Boluo, Zijin, Lufeng, Haifeng, Huidong and Huiyang counties of Guangdong Province and the region covering Yongning, Longan, Laibin and Guigang counties of Guangxi Province. The common wild rice in Yunnan, Hunan, Jiangxi, and Fujian provinces are diverged into respectively independent populations with relatively large genetic distances, whereas, those in Hainan, Guangdong and Guangxi provinces have relatively low genetic divergence. Under the condition of geographic separation, natural selection is considered as one of the primary forces contributing to the divergence of common wild rice in China. | WANG MeiXing ZHANG HongLiang ZHANG DongLing PAN DaJian LI DaoYuan FAN ZhiLan QI YongWen SUN JunLi YANG QingWen LI Chen LI ZiChao | 2008 | Chinese Science Bulletin2008，53，22： | 8 |
| 15 | Variations in paleoproductivity and the environmental implications over the past six decades in the Changjiang Estuary显示文摘Total organic carbon and organic carbon stable isotope, biogenic silica, chlorin were measured from a high resolution sediment core to indicate the variation in paleoproductivity and the environmental implications over the past decades (1942 to 1997) in the Changjiang Estuary. Based on these biomarkers, the shift in the phytoplankton community structure in the past decades was discussed in response to the long-term variations in nutrient concentrations and nutrient ratios. The results showed that the δ 13 C values varied from –26.15‰ to –19.5‰, suggesting the combined organic carbon sources of riverine and marine organisms. Based on the biogenic proxies, paleoproductivity changes were categorized into three stages: low production before 1950; an increase in production with the dominance of diatoms during 1950 to 1980, consistent with increasing of nutrient concentrations; a decrease in production after 1980 when the diatom production decreased while the production of non-silicious phytoplankton increased due to high nutrient inputs, and high N/P and P/Si ratios in the Changjiang Estuary. The sedimentation records also indicated that the riverine organic carbon increased since 1980. | JIN Haiyan CHEN Jianfang WENG Huanxin LI Hongliang ZHANG Weiyan XU Jie BAI Youcheng WANG Kui | 2010 | Acta Oceanologica Sinica2010，29，3： | 8 |
| 16 | Phytoplankton composition and its ecological effect in subsurface cold pool of the northern Bering Sea in summer as revealed by HPLC derived pigment signatures显示文摘CHEMTAX analysis of high-performance liquid chromatography(HPLC) pigment was conducted to study phytoplankton community structure in the northern Bering Sea shelf, where a seasonal subsurface cold pool emerges. The results showed that fucoxanthin(Fuco) and chlorophyll a(Chl a) were the most abundant diagnostic pigments, with the integrated water column values ranging from 141 to 2 160 μg/m2 and 477 to 5 535 μg/m2, respectively. Moreover, a diatom bloom was identified at Sta. BB06 with the standing stock of Fuco up to 9 214 μg/m3. The results of CHEMTAX suggested that the phytoplankton community in the northern Bering Sea shelf was dominated by diatoms and chrysophytes with an average relative contribution to Chl a of 80% and 12%, respectively, followed by chlorophytes, dinoflagellates, and cryptophytes. Diatoms were the absolutely dominant algae in the subsurface cold pool with a relative contribution exceeding 90%, while the contribution of chrysophytes was generally higher in oligotrophic upper water. Additionally, the presence of a cold pool would tend to favor accumulation of diatom biomass and a bloom that occurred beneath the halocline would be beneficial to organic matter sinks, which suggests that a large part of the phytoplankton biomass would settle to the seabed and support a rich benthic biomass. | ZHUANG Yanpei JIN Haiyan LI Hongliang CHEN Jianfang WANG Bin CHEN Fajin BAI Youcheng LU Yong TIAN Shichao | 2014 | Acta Oceanologica Sinica2014，33，6： | 7 |
| 17 | Role of endoplasmic reticulum stress in the loss of retinal ganglion cells in diabetic retinopathy显示文摘Endoplasmic reticulum stress is closely involved in the early stage of diabetic retinopathy.In the present study,a streptozotocin-induced diabetic animal model was given an intraperitoneal injection of tauroursodeoxycholic acid.Results from immunofluorescent co-localization experiments showed that both caspase-12 protein and c-Jun N-terminal kinase 1 phosphorylation levels significantly increased,which was associated with retinal ganglion cell death in diabetic retinas.The C/ERB homologous protein pathway directly contributed to glial reactivity,and was subsequently responsible for neuronal loss and vascular abnormalities in diabetic retinopathy.Our experimental findings indicate that endoplasmic reticulum stress plays an important role in diabetes-induced retinal neuronal loss and vascular abnormalities,and that inhibiting the activation of the endoplasmic reticulum stress pathway provides effective protection against diabetic retinopathy. | Liping Yang Lemeng Wu Dongmei Wang Ying Li Hongliang Dou Mark O.M.Tso Zhizhong Ma | 2013 | Neural Regeneration Research2013，8，33： | 7 |
| 18 | 粪菌移植应用于慢传输型便秘的临床疗效及疗效影响因素:一项前瞻性研究的长期随访结果显示文摘背景和目的肠道菌群参与结肠动力的调控,菌群失调是便秘是病因之一。粪菌移植被证实可以恢复肠道平衡。本研究旨在评估粪菌移植治疗慢传输型便秘(STC)的临床疗效和预后影响因素。方法:52例STC患者接受标准的粪菌移植入组研究,对其进行至少6个月的随访。记录入组患者的排便习惯、结肠传输时间、便秘相关的症状(PAC-SYM评分)、生活质量(PAC-QOL评分)、治疗满意度和不良反应。主要疗效指标是平均每周完全自主排便≥3次的患者比例。结果:治疗后34周、912周、2124周,每周完全自主排便≥3次患者的比例分别为50.0%、38.5%和32.7%,均较治疗前显著提高(均P<0.01)。其他排便情况、结肠传输时间、便秘相关症状和生活质量方面,治疗后亦有显著改善;但这些短期改善在治疗后12周和24周逐渐减小。治疗前排便不尽是唯一的疗效影响因素。治疗和随访期间未发现任何治疗相关的不良反应。结论:本研究显示粪菌移植治疗STC安全有效,但远期疗效有所降低。治疗前排便不尽感较少甚至没有的患者接受粪菌移植的治疗效果更佳。 | Chao Ding Wenting Fan Lili Gu Hongliang Tian Xiaolong Ge Jianfeng Gong Yongzhan Nie Ning Li | 2018 | Gastroenterology Report2018，6，2： | 7 |
| 19 | A novel Cu-bearing high-entropy alloy with significant antibacterial behavior against corrosive marine biofilms显示文摘The design of novel high-entropy alloys(HEAs)provides a unique opportunity for the development of structure-function integrated materials with high mechanical and antimicrobial properties.In this study,by employing the antibacterial effect of copper,a novel Al0.4CoCrCuFeNi HEA with broad-spectrum antibacterial and strong mechanical properties was designed.High concentrations of copper ions released from the HEA prevented growth and biofilm formation by biocorrosive marine bacterial species.These findings serve as a proof-of-concept for further development of unique HEA materials with high antimicrobial efficiency and mechanical properties,compared to conventional antibacterial alloys. | Enze Zhou Dongxu Qiao Yi Yang Dake Xu Yiping Lu Jianjun Wang Jessica A.Smith Huabing Li Hongliang Zhao Peter K.Liaw Fuhui Wang | 2020 | Journal of Materials Science & Technology2020，42，11： | 6 |
| 20 | Manipulation of Band Degeneracy and Lattice Strain for Extraordinary PbTe Thermoelectrics显示文摘Maximizing band degeneracy and minimizing phonon relaxation time are proven to be successful for advancing thermoelectrics.Alloying with monotellurides has been known to be an effective approach for converging the valence bands of PbTe for electronic improvements,while the lattice thermal conductivity of the materials remains available room for being further reduced.It is recently revealed that the broadening of phonon dispersion measures the strength of phonon scattering,and lattice dislocations are particularly effective sources for such broadening through lattice strain fluctuations.In this work,a fine control of MnTe and EuTe alloying enables a significant increase in density of electron states near the valence band edge of PbTe due to involvement of multiple transporting bands,while the creation of dense in-grain dislocations leads to an effective broadening in phonon dispersion for reduced phonon lifetime due to the large strain fluctuations of dislocations as confirmed by synchrotron X-ray diffraction.The synergy of both electronic and thermal improvements successfully leads the average thermoelectric figure of merit to be higher than that ever reported for p-type PbTe at working temperatures. | Yixuan Wu Pengfei Nan Zhiwei Chen Zezhu Zeng Siqi Lin Xinyue Zhang Hongliang Dong Zhiqiang Chen Hongkai Gu Wen Li Yue Chen Binghui Ge Yanzhong Pei | 2020 | Research2020，，1： | 6 |
您所在的机构暂未开通此部分的功能，请联系管理员