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| 1 | Edaravone injection reverses learning and memory deficits in a rat model of vascular dementia显示文摘Edaravone 是由禁止 endothelial 损害并且由改善施加 neuroprotective 效果的新奇免费激进的 scavenger 在大脑局部缺血的 neuronal 损坏。最近, edaravone 能减轻病理和 Alzheimers 疾病病人的认知赤字,这被报导。然而,它到脉管的痴呆(VaD ) 的关联不是清楚的。在这研究,我们部分堵塞了老鼠的双边的颈动脉动脉通过手术导致长期的服的 hypoperfusion (CCH ) , VaD 的一个著名老鼠模型。水迷宫和电压降低的禁止的测试被用来评估记忆赤字。superoxide dismutase 的活动 ?( 草皮) 并且喂奶脱氢酶(LDH ) , malondialdehyde 的内容 ?(MDA ) 并且全部的反应的氧种类被测量评估氧化压力水平。西方的污点分析被用来计算 synaptic 蛋白质表达式。有为一个 5 星期的时期的 edaravone 的治疗在有 CCH 的老鼠对空间的颠倒和害怕记忆赤字有能力,这被发现。Edaravone 显著地由增加草皮活动并且减少与 CCH 在老鼠的大脑减少了氧化应力的水平 MDA, LDH,和全部的反应的氧种类的内容。而且, edaravone 处理也与 CCH 在老鼠的海马恢复了多重 synaptic 蛋白质的层次。我们的数据提供在 VaD 支持 edaravone 的 neuroprotective 效果的直接证据。我们建议氧化应力的缓和和 synaptic 蛋白质的恢复在 neuroprotection 起重要作用。 | Xu Li Fen Lu Wei Li Lingzhi Qin Yong Yao Xuerong Ge Qingkai Yu Xinliang Liang Dongmei Zhao Xiaohong Li Jiewen Zhang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 14 |
| 2 | Mesoscale simulation of discontinuous dynamic recrystallization using the cellular automaton method显示文摘A dynamic recrystallization (DRX) cellular automaton (CA) model that can mark the microstructure with DRX circle was developed. The effects of initial grain size on the stress-strain curve, mean grain size and DRX fraction were mainly investigated, and the simulated results were compared with those obtained from previous researches. The results show that the shape of the stress-strain curve is sensitive, while the stress and mean grain size at the steady state are insensitive to the initial grain size. The transition from a multiple-peak stress-strain curve to a single-peak one can be explained by variations in DRX circle fraction, and the initial grain size to make this transition is between 70 and 80 μm. | Baojun YU Xiaojun GUAN Lijun WANG Qingkai ZENG Qianqian LIU Yu CAO | 2011 | Acta Metallurgica Sinica(English Letters)2011，24，4： | 6 |
| 3 | Sea ice conditions and navigability through the Northeast Passage in the past 40 years based on remote-sensing data显示文摘Sea ice conditions and navigability along four typical routes of the Northeast Passage(NEP)are analysed using remote-sensing data from 1979 to 2019.The influence of air temperature(T_(air))and surface wind on the sea ice concentration(SIC)and the navigability of routes is determined.It is found that the annually averaged SICs of the different routes have decreased over the past 41 years.The fastest rate of decrease occurred in the Kara Sea(∼−1%per year),while the slowest rates of decrease occurred in the Laptev/East Siberian Sea(∼−0.42%per year).The number of navigable days for the Kara Sea has become∼1–2 months longer than the Laptev/East Siberian Sea route as a result.The effect of T_(air) on SIC,quantified byΔSIC/ΔT_(air) in the routes through the eastern Kara Sea and Laptev/East Siberian Sea in 2010s was∼−0.04/℃,two to three times that seen during the 1980s.Air temperature is becoming a significant driving force of melting ice in these routes.Surface winds are also a crucial factor for the navigability of the Vilkitsky Strait and Long Strait,as they drive ice drift,and affect the navigability of the Kara Strait by introducing warm air. | Miao Yu Peng Lu Zhiyuan Li Zhijun Li Qingkai Wang Xiaowei Cao Xiaodong Chen | 2021 | International Journal of Digital Earth2021，14，5： | 3 |
| 4 | Low-cost photoacoustic imaging systems based on laser diode and light-emitting diode excitation显示文摘Photoacoustic imaging,an emerging biomedical imaging modality,holds great promise for preclinical and clinical researches.It combines the high optical contrast and high ultrasound resolution by converting laser excitation into ultrasonic emission.In order to generate photoacoustic signal e±-ciently,bulky Q-switched solid-state laser systems are most commonly used as excitation sources and hence limit its commercialization.As an alternative,the miniaturized semiconductor laser system has the advantages of being inexpensive,compact,and robust,which makes a signi¯cant e®ect on production-forming design.It is also desirable to obtain a wavelength in a wide range from visible to nearinfrared spectrum for multispectral applications.Focussing on practical aspect,this paper reviews the state-of-the-art developments of low-cost photoacoustic system with laser diode and light-emitting diode excitation source and highlights a few representative installations in the past decade. | Qingkai Yao Yu Ding Guodong Liu Lvming Zeng | 2017 | Journal of Innovative Optical Health Sciences2017，，4： | 1 |
| 5 | Nonlinear stability and bifurcation of multi-DOF chatter system in grinding process显示文摘 | HAN Qingkai YU Tao ZHANG Zhiwei | 2006 | Key Engineering Materials2006，，： | 1 |
| 6 | time frequency features of rotor systems with slowly varying mass显示文摘 | Tao Yu Qingkai Han | | 0，，18： | 1 |
| 7 | Vibration measurement and fault analysis of large scale rotating machinery显示文摘 | Han Qingkai Yu Jiancheng Gong Zhaomin | 2003 | Journal of Vibration Measurement Diagnosis2003，23，1： | 1 |
| 8 | Growth from below: bilayer graphene on copper by chemical vapor deposition显示文摘 | Shu Nie Wei Wu Shirui Xing Qingkai Yu Jiming Bao Shin-shem Pei Kevin F McCarty | 2012 | New Journal of Physics2012，，9： | 1 |
| 9 | Growth from below: bilayer graphene on copper by chemical vapor deposition显示文摘 | Shu Nie Wei Wu Shirui Xing Qingkai Yu Jiming Bao Shin-shem Pei Kevin F McCarty | 2012 | New Journal of Physics2012，，9： | 1 |
| 10 | Simulation study on interaction coefficient of DEM in non-spherical large size (5-30 mm) coal particles显示文摘The pneumatic conveying system of coal particles can greatly reduce the dust and improve the environmental quality at underground mining workface and the surrounding of coal enterprises.The particle shape and the interaction coefficients between particles and the contact surface play important roles in the pneumatic conveying and CFD-DEM simulation.In order to build the semblable shape models and obtain the accurate interaction coefficients of large coal particles,this article establishes the con tact model by the particle overlap method and describes the mathematical model of the shape characteristics for large coal particle.The particle models are simulated by adopting the multi-index mixed orthogonal experiments.The accumulation density,the porosity and the error between simulation and experiment are taken as the indexes,and the particle models and the particle contact coefficients are taken as the orthogonal test factors.As a result,three more accurate particle models and their interaction coefficients are obtained,which provide the model basis for the pneumatic conveying of large coal particles. | Daolong Yang Yanxiang Wang Jianping Li Qingkai Wang Yuntao Wang Yanting Yu | 2020 | Particuology2020，18，6： | 1 |
| 11 | Aggregation-Induced Synthesis (AIS): Asymmetric Synthesis via Chiral Aggregates显示文摘A new chiral aggregate-based tool for asymmetric synthesis has been developed by taking advantage of chiral aggregates of GAP(Group-Assisted Purification)reagents,N-phosphonyl imines.This tool was proven to be successful in the asymmetric GAP synthesis of functionalized 2,3-dihydrobenzofurans by reacting salicyl N-phosphonyl imines with dialkyl bromomalonates in various cosolvent systems.The chiral induction can be controlled by differentiating between two asymmetric directions simply by changing the ratios of cosolvents which are commonly adopted in AIE(aggregation-induced emission)systems.The formation of chiral aggregates was witnessed by a new analytical tool-aggregation-induced polarization(AIP).The present synthetic method will be broadly extended for general organic synthesis,particularly,for asymmetric synthesis and asymmetric catalysis in the future. | Hossein Rouh Yao Tang Ting Xu Qingkai Yuan Sai Zhang Jia-Yin Wang Shengzhou Jin Yu Wang Junyi Pan Hannah LWood James D.McDonald Guigen Li | 2022 | Research2022，，4： | 0 |
| 12 | Effect of Pyrolysis Temperature on Resonant Frequency of PDC-SiBCN Ceramic Based Wireless Passive Temperature Sensors显示文摘Wireless passive temperature sensors fabricated by polymer-derived SiBCN ceramic(PDC-SiBCN) pyrolyzed at different temperatures was studied.The resonant frequency of the sensors was measured in the temperature range of50 to 610℃.For the sensor made of the PDC-SiBCN pyrolyzed at 1000,1100 and 1200℃ individually,the resonant frequency decreased monotonically with developing the testing temperature.While for the sensor made of the PDC-SiBCN pyrolyzed at 1300℃,the resonant frequency showed a non-monotonic variation with testing temperature.The results suggest a possibility of tuning the resonant frequency of PDC-SiBCN based wireless passive temperature sensors by altering the pyrolysis temperature. | YU Yuxi HUANG Qifan XIA Fansen SAN Haisheng HAN Qingkai | 2016 | Journal of the Chinese Ceramic Society2016，，4： | 0 |
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