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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | A truncated hepatitis E virus ORF2 protein expressed in tobacco plastids is immunogenic in mice显示文摘瞄准:表示 23-ku pE2 到花费有效地,肝炎 E 病毒(HEV ) 的 3'-portion 包括的 E2 碎片编码的最有希望的子单元疫苗打开读物框架 2 (ORF2 ) 在烟草的质体(Nicotiana 烟 cv。SR1 ) ,在质体调查 transgene 表示和 pE2 累积,并且评估反在老鼠的导出质体的 pE2 的遗传因子的效果。方法:包含米饭 psbA 倡导者驾驶的 E2 碎片的指向质体的向量 pRB94-E2 被构造。在进烟草质体的交货之上,这构造能在质体染色体在 psaB-trnfM 和 trnG-psbC 碎片开始相应再结合,并且导致在二碎片之间插入的 transgene。pRB94-E2 与一个 biolistic 粒子轰炸方法被交付,并且转变质体的工厂被获得在补充 spectinomycin 的媒介上跟随炮轰的叶纸巾的新生。改革工厂的 Transplastomic 地位被 PCR 和南部的污点分析证实, transgene 表示被北污点分析调查,并且 pE2 的累积被 ELISA 测量。而且,蛋白浸出物被用来使老鼠免疫,并且在使免疫的老鼠的浆液样品的 pE2 反应的抗体的存在被 ELISA 学习。结果:PCR 和南部的污点分析证实的 Transplastomic 线能活跃地抄录 E2 mRNA。pE2 多肽象 13.27 microg/g 一样高被积累到水平新鲜叶子。pE2 能刺激使免疫的老鼠产生 pE2 特定的抗体。结论:HEV-E2 碎片能被插入到质体染色体,导出的 recombinant pE2 抗原是在老鼠遗传因子的反。因此,质体可以是为 HEV 疫苗的划算的生产的新奇来源。 | Yuan-Xiang Zhou Maggie Yuk-Ting Lee James Ming-Him Ng Mee-Len Chye Wing-Kin Yip Sze-Yong Zee Eric Lam | 2006 | World Journal of Gastroenterology2006，12，2： | 10 |
| 3 | A buried Neolithic paddy soil reveals loss of microbial functional diversity after modern rice cultivation显示文摘It has been documented that human activities are causing the rapid loss of taxonomic, phylogenetic, genetic and functional diversity in soils. However, it remains unclear how modern intensive rice cultivation impacts the soil microbiome and its functionality. Here we examined the microbial composition and function differences between a buried Neolithic paddy soil and an adjacent,currently-cultivated paddy soil using high throughput metagenomics technologies. Our results showed that the currently cultivated soil contained about 10-fold more microbial biomass than the buried one. Analyses based on both 16S rRNA genes and functional gene array showed that the currently cultivated soil had significantly higher phylogenetic diversity, but less functional diversity than the buried Neolithic one. The community structures were significantly different between modern and ancient soils,with functional structure shifting towards accelerated organic carbon(C) degradation and nitrogen(N) transformation in the modern soils. This study implies that, modern intensive rice cultivation has substantially altered soil microbial functional structure, leading to functional homogenization and the promotion of soil ecological functions related to the acceleration of nutrient cycling which is necessary for high crop yields. | Yong-Guan Zhu Jian-Qiang Su Zhihong Cao Kai Xue John Quensen Guang-Xia Guo Yun-Feng Yang Jizhong Zhou Hai-Yan Chu James M.Tiedje | 2016 | Science Bulletin2016，61，13： | 10 |
| 4 | AI-Based Modeling and Data-Driven Evaluation for Smart Manufacturing Processes显示文摘Smart manufacturing refers to optimization techniques that are implemented in production operations by utilizing advanced analytics approaches. With the widespread increase in deploying industrial internet of things(IIOT) sensors in manufacturing processes, there is a progressive need for optimal and effective approaches to data management.Embracing machine learning and artificial intelligence to take advantage of manufacturing data can lead to efficient and intelligent automation. In this paper, we conduct a comprehensive analysis based on evolutionary computing and neural network algorithms toward making semiconductor manufacturing smart.We propose a dynamic algorithm for gaining useful insights about semiconductor manufacturing processes and to address various challenges. We elaborate on the utilization of a genetic algorithm and neural network to propose an intelligent feature selection algorithm. Our objective is to provide an advanced solution for controlling manufacturing processes and to gain perspective on various dimensions that enable manufacturers to access effective predictive technologies. | Mohammadhossein Ghahramani Yan Qiao Meng Chu Zhou Adrian O’Hagan James Sweeney | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，4： | 9 |
| 5 | The Weng'an biota and the Ediacaran radiation of multicellular eukaryotes显示文摘The rise of multicellularity represents a major evolutionary transition and it occurred independently in multiple eukaryote clades.Although simple multicellular organisms may have evolved in the Mesoproterozoic Era or even earlier,complex multicellular eukaryotes began to diversify only in the Ediacaran Period,just before the Cambrian explosion.hus,the Ediacaran fossil record can provide key paleontological evidence about the early radiation of multicellular eukaryotes that ultimately culminated in the Cambrian explosion.he Ediacaran Weng’an biota in South China hosts exceptionally preserved eukaryote fossils,including various acanthomorphic acritarchs,pseudoparenchymatous thalli,tubular microfossils,and spheroidal fossils such as Megasphaera,Helicoforamina,Spiralicellula,and Caveasphaera.Many of these fossils have been interpreted as multicellular eukaryotes,although alternative interpretations have also been proposed.In this review,we critically examine these various interpretations,focusing particularly on Megasphaera,which has been variously interpreted as a sulfur-oxidizing bacterium,a unicellular protist,a mesomycetozoean-like holozoan,a volvocine green alga,a stem-group animal,or a crown-group animal.We conclude that Megasphaera is a multicellular eukaryote with evidence for cell-to-cell adhesion,a lexible membrane unconstrained by a rigid cell wall,spatial cellular diferentiation,germ–soma separation,and programmed cell death.hese features are inconsistent with the bacterium,unicellular protist,and mesomycetozoean-like holozoan interpretations.hus,the surviving hypotheses,particularly the stem-group animal and algal interpretations,should be further tested with additional evidence.he Weng’an biota also hosts cellularly diferentiated pseudoparenchymatous thalli with specialized reproductive structures indicative of an ainity with lorideophyte red algae.he other Weng’an fossils reviewed here may also be multicellular eukaryotes,although direct cellular evidence is lacking in some and phylogenetic ainities are poorly constrained in others.he Weng’an biota ofers many research opportunities to resolve the life histories and phylogenetic diversity of early multicellular eukaryotes and to illuminate the evolutionary prelude to the Cambrian explosion. | Shuhai Xiao A.D.Muscente Lei Chen Chuanming Zhou James D.Schiffbauer Andrew D.Wood Nicholas F.Polys Xunlai Yuan | 2014 | National Science Review2014，1，4： | 9 |
| 6 | Thickness-dependent patterning of MoS2 sheets with well-oriented triangular pits by heating in air显示文摘自从 MoS2 表的性质对边结构敏感,有常规边或可控制的形状的 Patterning ultrathin MoS2 层正在呼吁。在这个工作,我们介绍了一种简单、有效、控制得好的技术由简单地在空中加热样品与面向井的等边的三角形的坑蚀刻分层的 MoS2 表。各向异性的氧化蚀刻被包围温度和 MoS2 层的数字极大地影响,坑由此随包围温度和 MoS2 层的数字的增加缩放增加。第一原则的计算被执行了解释三角形的坑的形成机制。这种技术把一条其他的大街提供给设计 MoS2 表的结构。 | Haiqing Zhou Fang Yu Yuanyue Liu Xiaolong Zou Chunxiao Cong Caiyu Qiu Ting Yu Zheng Yan Xiaonan Shen Lianfeng Sun Boris I. Yakobson James M. Tour | 2013 | Nano Research2013，6，10： | 9 |
| 7 | High thermal conductivity of suspended few-layer hexagonal boron nitride sheets显示文摘推迟的很少层的热传导六角形的硼氮化物(h-BN ) 表试验性地用一个 noncontact micro-Raman 光谱学方法被调查。为单层(1L ) 的一阶的温度系数, bilayer (2L ) 并且九层(9L ) h-BN 表被测量是(当时, electrospinning 准备的 3.41 xide nanofibers 被期望减少了热电导率与体积样品相比。自从它包含复杂样品准备方法,热电导率正在质问的 nanofibers 的大小。在这个工作,我们在场对单个 nanofiber 的热电导率的大小合适的一个新奇方法。一 microelectro 机械(MEMS ) 设备被设计了并且制作了在单个 nanofiber 上执行热传导性大小。一个特殊 Si 模板被设计收集并且转单个 nanofibers 到 MEMS 设备名上吗? | Haiqing Zhou Jixin Zhu Zheng Liu Zheng Yan Xiujun Fan Jian Lin Gunuk Wang Qingyu Yan Ting Yu Pulickel M. Ajayan James M. Tour | 2014 | Nano Research2014，7，8： | 9 |
| 8 | 声波激励的超小型纳机电系统磁电天线显示文摘当前的小型天线依赖于电磁波的谐振,因此天线的尺寸与电磁波波长相关。典型的天线尺寸大于波长的1/10,而进一步缩小天线尺寸在近十年来都是一个公开的挑战。介绍一种通过悬浮铁氧/压电薄膜异质结构的声波激励纳机械磁电天线。这种磁电天线通过其在声波谐振频率处的磁电效应接收和发射电磁波。磁电天线中的体声波激发铁磁薄膜的磁化振荡,产生电磁波的辐射;反之,天线感应电磁波的磁场,得到压电电压输出。这种磁电天线(尺寸仅为波长的千分之一)比现有小型天线的尺寸小1到2个数量级,但性能却没有降低,在便携式无线通信系统中具有很大的应用潜力。 | Tianxiang Nan Hwaider Lin Yuan Gao Alexei Matyushov Guoliang Yu Huaihao Chen Neville Sun Shengjun Wei Zhiguang Wang Menghui Li Xinjun Wang Amine Belkessam Rongdi Guo Brian Chen James Zhou Zhenyun Qian Yu Hui Matteo Rinaldi Michael E.McConney BrANDon M.Howe Zhongqiang Hu John G.Jones Gail J.Brown Nian Xiang Sun 张建强(翻译) 陈鼎鼎(审校) | 2017 | 通信对抗2017，36，4： | 8 |
| 9 | Analyses of oligodontia phenotypes and genetic etiologies显示文摘Oligodontia is the congenital absence of six or more teeth and comprises the more severe forms of tooth agenesis.Many genes have been implicated in the etiology of tooth agenesis,which is highly variable in its clinical presentation.The purpose of this study was to identify associations between genetic mutations and clinical features of oligodontia patients.An online systematic search of papers published from January 1992 to June 2021 identified 381 oligodontia cases meeting the eligibility criteria of causative gene mutation,phenotype description,and radiographic records.Additionally,ten families with oligodontia were recruited and their genetic etiologies were determined by whole-exome sequence analyses.We identified a novel mutation in WNT10A(c.99_105dup)and eight previously reported mutations in WNT10A(c.433 G>A;c.682 T>A;c.318 C>G;c.511.C>T;c.321 C>A),EDAR(c.581 C>T),and LRP6(c.1003 C>T,c.2747 G>T).Collectively,20 different causative genes were implicated among those 393 cases with oligodontia.For each causative gene,the mean number of missing teeth per case and the frequency of teeth missing at each position were calculated.Genotype–phenotype correlation analysis indicated that molars agenesis is more likely linked to PAX9 mutations,mandibular first premolar agenesis is least associated with PAX9 mutations. | Mengqi Zhou Hong Zhang Heather Camhi Figen Seymen Mine Koruyucu Yelda Kasimoglu Jung-Wook Kim Hera Kim-Berman Ninna M.R.Yuson Paul J.Benke Yiqun Wu Feng Wang Yaqin Zhu James P.Simmer Jan C-C.Hu | 2021 | International Journal of Oral Science2021，13，3： | 5 |
| 10 | Depositional Model for Peat Swamp and Coal Facies Evolution Using Sedimentology, Coal Macerals, Geochemistry and Sequence Stratigraphy显示文摘As one of the most important source rocks and reservoirs of unconventional natural gas, the sedimentary environment and mode of peat swamp(the predecessor of coal seam) is important to the coal seam's spatial distribution, material composition, hydrocarbon generation potential, reservoir physical properties, etc. To reveal the depositional characteristics and history of environmental change in a terrestrial basin during a period of peat accumulation, the Middle Jurassic aged #7 coal from Gaoquan in the Qaidam Basin(NW China) was investigated using sedimentology, maceral composition, geochemistry and sequence stratigraphy. Based on identification of the sedimentary shoreline break belt, wave energy depletion point and position of wave base, the peat swamp system can be subdivided into(1) lakeside plain,(2) low energy lakeshore,(3) high energy lakeshore, and(4) shallow lake subfacies. A new method for determining coal facies is proposed based on the combination of environmental parameters including oxidation-reduction levels, energy conditions and the influence of terrigneous sediments. The evolution of the coal seam shows that peat was deposited mainly in the low energy lakeshore and lakeside plain subfacies. Five types of sequence stratigrpahic surface and two types of parasequence were identified. Forced lake regressions and normal lake regressions are attributed as the causes of sequence boundaries. The sequence stratigraphic framework comprises six sequences and corresponding system tracts, and the curve of base-level for each demonstrates a characteristic initial period of slow rising followed by fast rising and then returning to slow rising. A model indicating the relationship among base-level changes, coal facies evolution, and the environmental features in the swamp is proposed that shows the environmental features of the swamp were controlled by both base-level changes and coal facies. Accompanying depositional environment changes from a lakeside plain to lakeshore and shallow lake caused by increasing rate of base-level rise, water paleosalinity, acidity and the percentage of woody plants decrease, and the bog type alters from the low marsh to raised bog. | Jing Lu Longyi Shao Minfang Yang Kai Zhou James R.Wheeley Hao Wang Jason Hilton | 2017 | Journal of Earth Science2017，28，6： | 5 |
| 11 | Indication of lower neck irradiation in nasopharyngeal carcinoma without nodal metastasis: the potential impact of tumor volume显示文摘 | FU Jie ZHOU Jia-yin Vincent FH CHONG James BK Khoo | 2013 | Chinese Medical Journal2013，，11： | 5 |
| 12 | Microbial communities biostimulated by ethanol during uranium (VI) bioremediation in contaminated sediment as shown by stable isotope probing显示文摘(啜) 稳定的同位素探查被用来识别乙醇增加在包含在 US 能源部橡树理兹地点从 bioremediation 测试地区收集的二沉积的缩影刺激的微生物, TN,美国。一件样品是高度有乙醇的 bioreduced 当另外一个少些被减少时。有各自的沉积的缩影与标记乙醇并且为啜为 7 孵化了天的 13C 被修改。乙醇很快在伴有硝酸盐和硫酸盐的减小的 24 h 以内被变换成醋酸盐。醋酸盐的累积在远处坚持了 7 d 时期。水的 U 没由于 U 的解吸附作用与减少的沉积在缩影衰退,但是连续地在少些减少的样品衰退。微生物引起的生长和伴随物 < 啜 class= “ a-plus-plus ” > 13 C-DNA 生产被检测乙醇是否是精疲力尽的,丰富的醋酸盐在两个缩影积累了。这在少些减少的样品与 U (VI ) 减小与一致。< 啜 class= “ a-plus-plus ” > 13 从乙醇发源的 C 最终为生长被利用,直接或间接地,由在 7 天孵化以内的主导的微生物引起的社区成员。微生物引起的社区由包括 Desulfovibrio, Sphingomonas, Ferribacterium, Rhodanobacter, Geothrix, Thiobacillus 和其它减少细菌的已知的 denitrifiers,减少硫酸盐的细菌和铁(III ) 主要组成,包括减少细菌 Acidovorax, Anaeromyxobacter, Desulfovibrio, Geobacter 和 Desulfosporosinus 的已知的 U (VI ) 。调查结果建议那乙醇 biostimulates 由首先为硝酸盐,硫酸盐,铁( III )和 U ( VI )用作一个电子施主减少微生物引起的社区的 U ( VI )减小,并且然后为微生物引起的生长为 U ( VI )减小和碳来源作为电子施主工作的醋酸盐。 | Mary Beth LEIGH Wei-Min WU Erick CARDENAS Ondrej UHLIK Sue CARROLL Terry GENTRY Terence L. MARSH Jizhong ZHOU Philip JARDINE Craig S. CRIDDLE James M. TIEDJE | 2015 | Frontiers of Environmental Science & Engineering2015，9，3： | 5 |
| 13 | RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation显示文摘PTEN 肿瘤 suppressor 是在调整 phosphatidylinositol-3-kinase (PI3K ) 有一个中央角色的类脂化合物磷酸酶信号 transduction 串联。不过, PTEN 活动被在房间调整的机制需要进一步的说明。尽管以前的研究证明了 PTEN 的 ubiquitination 能调制它的稳定性和 subcellular 本地化,在 PTEN 功能的最批评的方面的 ubiquitination 的角色,它的磷酸酶活动,充分没被探讨。这里,我们识别 PTEN 的新奇 E3 ubiquitin ligase,沤手指蛋白质(RFP ) ,那能支持 PTEN 的不正常的 polyubiquitinations。这些 ubiquitinations 不导致 PTEN 不稳定性或本地化,但是相当显著地禁止 PTEN 磷酸酶活动因此调制它的能力调整 PI3K 信号 transduction 串联。确实, RFP overexpression 在 AKT 激活上减轻调停 PTEN 的禁止的效果;相反,调停 RNAi 内长的 RFP 击倒提高 PTEN 的能力压制 AKT 激活。而且, PTEN 的调停 RFP 的 ubiquitination 禁止小道表示的 PTEN 依赖的激活并且也压制它的能力导致 apoptosis。我们的调查结果在控制 PTEN 表明调停 RFP 的 ubiquitination 的一个关键角色活动。 | James T Lee Jing Shan Jiayun Zhong Muyang Li Brenda Zhou Amanda Zhou Ramon Parsons Wei Gu | 2013 | Cell Research2013，23，4： | 5 |
| 14 | Consensus on the digestive endoscopic tunnel technique显示文摘With the digestive endoscopic tunnel technique(DETT), many diseases that previously would have been treated by surgery are now endoscopically curable by establishing a submucosal tunnel between the mucosa and muscularis propria(MP). Through the tunnel, endoscopic diagnosis or treatment is performed for lesions in the mucosa, in the MP, and even outside the gastrointestinal(GI) tract.At present, the tunnel technique application range covers the following:(1)Treatment of lesions originating from the mucosal layer, e.g., endoscopic submucosal tunnel dissection for oesophageal large or circular early-stage cancer or precancerosis;(2) treatment of lesions from the MP layer, per-oral endoscopic myotomy, submucosal tunnelling endoscopic resection, etc.; and(3) diagnosis and treatment of lesions outside the GI tract, such as resection of lymph nodes and benign tumour excision in the mediastinum or abdominal cavity. With the increasing number of DETTs performed worldwide, endoscopic tunnel therapeutics, which is based on DETT, has been gradually developed and optimized. However, there is not yet an expert consensus on DETT to regulate its indications, contraindications, surgical procedure, and postoperative treatment.The International DETT Alliance signed up this consensus to standardize the procedures of DETT. In this consensus, we describe the definition, mechanism,and significance of DETT, prevention of infection and concepts of DETTassociated complications, methods to establish a submucosal tunnel, and application of DETT for lesions in the mucosa, in the MP and outside the GI tract(indications and contraindications, procedures, pre-and postoperative treatments, effectiveness, complications and treatments, and a comparison between DETT and other operations). | Ning-Li Chai Hui-Kai Li En-Qiang Linghu Zhao-Shen Li Shu-Tian Zhang Yu Bao Wei-Gang Chen Philip WY Chiu Tong Dang Wei Gong Shu-Tang Han Jian-Yu Hao Shui-Xiang He Bing Hu1 Bing Hu2 Xiao-Jun Huang Yong-Hui Huang Zhen-Dong Jin Mouen A Khashab James Lau Peng Li Rui Li De-Liang Liu Hai-Feng Liu Jun Liu Xiao-Gang Liu Zhi-Guo Liu Ying-Cai Ma Gui-Yong Peng Long Rong Wei-Hong Sha Pateek Sharma Jian-Qiu Sheng Shui-Sheng Shi Dong Wan Seo Si-Yu Sun Gui-Qi Wang Wen Wang Qi Wu Hong Xu Mei-Dong Xu Ai-Ming Yang Fang Yao Hong-Gang Yu Ping-Hong Zhou Bin Zhang Xiao-Feng Zhang Ya-Qi Zhai | 2019 | World Journal of Gastroenterology2019，25，7： | 5 |
| 15 | Highly stable full-color display device with VLC application potential using semipolarμLEDs and all-inorganic encapsulated perovskite nanocrystal显示文摘A promising approach for the development of effective full-color displays is to combine blue micro LEDs(μLEDs)with color conversion layers.Perovskite nanocrystals(PNCs)are notable for their tolerance to defects and provide excellent photoluminescence quantum yields and high color purity compared to metal chalcogenide quantum dots.The stability of PNCs in ambient conditions and under exposure to blue light can be improved using a SiO;coating.This study proposes a device that could be used for both display and visible light communication(VLC)applications.The semipolar blueμLED array fabricated in this study shows a negligible wavelength shift,indicating a significant reduction in the quantum confined Stark effect.Owing to its shorter carrier lifetime,the semipolar μLED array exhibits an impressive peak 3 dB bandwidth of 655 MHz and a data transmission rate of1.2 Gb/s corresponding to an injection current of 200 m A.The PNC-μLED device assembled from a semipolarμLED array with PNCs demonstrates high color stability and wide color-gamut features,achieving 127.23% and 95.00%of the National Television Standards Committee standard and Rec.2020 on the CIE 1931 color diagram,respectively.These results suggest that the proposed PNC-μLED device is suitable for both display-related and VLC applications. | TINGZHU WU YUE LIN YU-MING HUANG MENG LIU KONTHOUJAM JAMES SINGH WANSHENG LIN TINGWEI LU XI ZHENG JIANYANG ZHOU HAO-CHUNG KUO ZHONG CHEN | 2021 | Photonics Research2021，9，11： | 5 |
| 16 | Superior anti-corrosion and self-healing bi-functional polymer composite coatings with polydopamine modified mesoporous silica/graphene oxide显示文摘In this article,graphene oxide(GO)and benzotriazole-loaded mesoporous silica nanoparticles(BTA/MSNs)are combined on micro scale through the in situ polymerization of polydopamine(PDA),preparing a selfhealing bi-functional GO(fGO)used as nano-fillers for anti-corrosion enhancement of waterborne epoxy(WEP)coatings.Scanning electronic microscopy(SEM)images show that the BTA/MSNs are uniformly distributed on the surface of high aspect ratio GO nanosheets to endow GO nanocontainer characteristics.UV-vis profiles demonstrate that fGO has p H-controlled release function.Modulus at lowest frequency is generally used for comparing the corrosion resistance of organic coatings.Modulus at lowest frequency(1.42×10^(5)Ωcm^(2))after 30 days immersion in 3.5 wt.%Na Cl solution revealed 2 orders of magnitude higher that of blank WEP(1.17×10^(7)Ωcm^(2)).With artificial cracks on its coatings,fGO/WEP had no obvious rust compared with blank WEP after 240 h of immersion.We anticipate that self-healing and physical barrier bi-functional nanocontainers improve the traditional anticorrosion coating efficiency with better,longer-lasting performance for shipping,oil drilling or bridge maintenance. | Yanqi Ma Haowei Huang Hongda Zhou Michael Graham James Smith Xinxin Sheng Ying Chen Li Zhang Xinya Zhang Elena Shchukina Dmitry Shchukin | 2021 | Journal of Materials Science & Technology2021，，36： | 4 |
| 17 | Effects of reaction temperature,time and particle size on switchgrass microwave pyrolysis and reaction kinetics显示文摘This study investigated microwave pyrolysis of switchgrass with particle sizes from 0.5 mm to 4 mm and determined the effects of reaction temperature and time on the yields of bio-oil,syngas,and bio-char.A prediction model was satisfactorily developed to describe the bio-oil conversion yield as a function of reaction temperature and time.Second-order reaction kinetics was also developed to model the switchgrass pyrolysis.Switchgrass with different particle sizes was found to be similarly pyrolyzed by microwave heating.The research results indicated that thermochemical conversion reactions can take place rapidly in large-sized switchgrass by using microwave pyrolysis.GC-MS analysis indicates that the bio-oil contained a series of important and useful chemical compounds:phenols,aliphatic hydrocarbons,aromatic hydrocarbons,and furan derivatives.These chemical compounds evolved were related to the pyrolysis conditions. | Rui Zhou Hanwu Lei James L.Julson | 2013 | International Journal of Agricultural and Biological Engineering2013，6，1： | 4 |
| 18 | Cervical inlet patch-optical coherence tomography imaging and clinical significance显示文摘AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This study was conducted at the Veterans Affairs Boston Healthcare System(VABHS).Patients undergoing standard esophagogastroduodenoscopy at VABHS,including one patient with CIP,one representative patient with BE and three representative normal subjects were included.White light video endoscopy was performed and endoscopic 3D-OCT images were obtained in each patient using a prototype OCT system.The OCT imaging probe passes through the working channel of the endoscope to enable simultaneous video endoscopy and 3D-OCT examination of the human gastrointestinal(GI)tract.Standard hematoxylin and eosin(H and E)histology was performed on biopsy or endoscopic mucosal resection specimens in order to compare and validate the 3D-OCT data. RESULTS:CIP was observed from a 68-year old male with gastroesophageal reflux disease.The CIP region appeared as a pink circular lesion in the upper esophagus under white light endoscopy.OCT imaging over the CIP region showed columnar epithelium structure,which clearly contrasted the squamous epithelium structure from adjacent normal esophagus.3D-OCT images obtained from other representative patients demonstrated distinctive patterns of the normal esophagus,BE,normal stomach,and normal duodenum bulb.Microstructures,such as squamous epithelium,lamina propria, muscularis mucosa,muscularis propria,esophageal glands,Barrett's glands,gastric mucosa,gastric glands, and intestinal mucosal villi were clearly observed with OCT and matched with H and E histology.These results demonstrated the feasibility of using OCT to evaluate GI tissue morphology in situ and in real-time. CONCLUSION:We demonstrate in situ evaluation of CIP microstructures using 3D-OCT,which may be a useful tool for future diagnosis and follow-up of patients with CIP. | Chao Zhou Tejas Kirtane Tsung-Han Tsai Hsiang-Chieh Lee Desmond C Adler Joseph M Schmitt Qin Huang James G Fujimoto Hiroshi Mashimo | 2012 | World Journal of Gastroenterology2012，18，20： | 3 |
| 19 | Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function显示文摘Innate immunity mediated by Toll-like receptors(TLRs),which can recognize pathogen molecular patterns,plays a critical role in type 1 diabetes development.TLR7 is a pattern recognition receptor that senses single-stranded RNAs from viruses and host tissue cells;however,its role in type 1 diabetes development remains unclear.In our study,we discovered that Tlr7-deficient(Tlr7^(−/−))nonobese diabetic(NOD)mice,a model of human type 1 diabetes,exhibited a significantly delayed onset and reduced incidence of type 1 diabetes compared with Tlr7-sufficient(Tlr7^(+/+))NOD mice.Mechanistic investigations showed that Tlr7 deficiency significantly altered B-cell differentiation and immunoglobulin production.Moreover,Tlr7^(−/−)NOD B cells were found to suppress diabetogenic CD4^(+)T-cell responses and protect immunodeficient NOD mice from developing diabetes induced by diabetogenic T cells.In addition,we found that Tlr7 deficiency suppressed the antigen-presenting functions of B cells and inhibited cytotoxic CD8^(+)T-cell activation by downregulating the expression of both nonclassical and classical MHC class I(MHC-I)molecules on B cells.Our data suggest that TLR7 contributes to type 1 diabetes development by regulating B-cell functions and subsequent interactions with T cells.Therefore,therapeutically targeting TLR7 may prove beneficial for disease protection. | Juan Huang Jian Peng James Alexander Pearson Georgios Efthimiou Youjia Hu Ningwen Tai Yanpeng Xing Luyao Zhang Jianlei Gu Jianping Jiang Hongyu Zhao Zhiguang Zhou F.Susan Wong Li Wen | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 20 | 双频双脉冲(ND:YAG)激光机和钬(Ho:YAG)激光机在结石上移和碎石效率方面的体外比较显示文摘目的为了比较FREDDY激光机、钬激光机和气压弹道碎石机在结石上移和碎石方面的临床效果。方法上移的水下试验装置包括一个水平方向放置的硅树脂导管(直径为1.3cm),和一个固定支架,使激光机的石英光纤和气压弹道碎石机的撞针可以直接接触石头。将预先称过重的圆柱状Bego石头(BegoUSA公司提供)放于该装置中,分别由FREDDY激光机、钬激光机和气压弹道碎石机进行碎石。FREDDY激光机和钬激光机都采用相近的脉冲能量和频率。为了具有可比性,气压弹道碎石机采用了半硬性撞针和单脉冲,在100、200、300kPa各档压力设置下分别对石头进行30次撞击。“平均后退距离”定义为直接测得的石头最终静止点到原点的距离(每档设置都记录测试结果)。另外,两台激光机分别对称过重的石头(熟石膏成分)进行碎石,以比较碎石效果。石头固定于一个水下装置(由一个倒置的硅注射器和一个固定装置组成)中。激光光纤(钬激光和FREDDY激光的光纤内径分别是365μm和280μm)穿过注射器的针头出来抵住石头。总共24颗石头被分成4组,每组6颗,其中两组用FREDDY激光分别以300J和400J的总能量碎石,另两组用钬激光分别以300J和480J的总能量碎石。“碎石率”定义为石头重量缺失的百分比。结果FREDDY激光机在能量设置为160mJ时,分别以5、10和15Hz的频率碎石,石头的平均后退距离为7.6、8.1和6.8cm;钬激光机在能量设置为0.8J时,分别以5和10Hz的频率碎石,石头的平均后退距离为3.3和4.9cm;气压弹道碎石机在压力设置分别为100、200、300kPa时,石头的平均后退距离为8.5、9.9和13.8cm。一般来说,FREDDY激光机造成的石头后退距离都要少于气压弹道碎石机,尽管这只有在后者处于最高压力设置时才有统计意义(p<0.05)。而FREDDY激光机造成的石头后退距离要多于钬激光机,在临床上常见的设置中有统计意义(p<0.05)。FREDDY激光机以300J和400J的总能量碎石时,石头重量的缺失率分别为44.9%和86.8%,都有统计意义(p<0.05);钬激光机以300J和480J的总能量碎石时,石头重量的缺失率分别为3.3%和7.1%,都有统计意义(p<0.05)。结论FREDDY激光机造成的石头后退距离要明显大于钬激光机(在低频设置时),但又明显少于气压弹道碎石机(在所有设置时)。因此我们建议,在进行腔内输尿管镜碎石术,或在输尿管肾盂连接处进行腔内激光碎石术时,于接近结石处使用阻断装置,如StoneCone-石椎(BostonScientific公司提供)。FREDDY激光机在体外碎石的效率要明显好于钬激光机,对于结石病人来说,前者是个更优、更经济的选择。 | Charles G.Marguet Jeff C.Sung W.Patrick Springhart James O.F.L'esperance Songlin Zhou Per Zhong David M.Albala Glenn M.Preminger 廖国强(译) 袁涛(校) | 2005 | 国外医学(泌尿系统分册)2005，25，6： | 3 |
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