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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Effect of Mixing on Properties and Microstructure of Magnesium Oxychloride Cement显示文摘This paper investigated the effect of mixing on the properties of magnesium oxychloride cement, such as apparent viscosity, setting time, compressive strength, and specific strength as well. The phase composition and crystallographic structure of the cement were determined by X-ray diffraction and scanning electron microscopy. The results indicate that the increases of stirring rate and mixing time change apparent viscosity distinctly, shorten setting time and enhance mechanical property. Magnesium oxychloride cement after mixing for 20 min exhibits the optimal mechanical performance. The effect of stirring rate on the phase composition of magnesium oxychloride cement dominates over the effect of mixing time. The increases of stirring rate and mixing time can increase the dispersion state and accelerate the neutralization, thus promoting the strength of magnesium oxychloride cement due to the formation of stable 5·1·8 phase, needle-like crystals and continuous crystalline structure in the whole cement matrix. The properties and microstructure of magnesium oxychloride cement at a stirring rate of 280 rpm are better than those at 140 rpm. | HE Zhenhui YANG Hongjian SONG Hui GUO Tao WU Songyi | 2016 | Journal of the Chinese Ceramic Society2016，，1： | 5 |
| 3 | Stochastic resonance in the growth of a tumor induced bycorrelated noises显示文摘Multiplicative noise is found to divide the growth law of tumors into two parts in a logistic model, which is driven by additive and multiplicative noises simul- taneously. The Fokker-Planck equation was also derived to explain the fact that the influence of the intensity of multi- plicative noise on the growth of tumor cells has a stochastic resonance-like characteristic. An appropriate intensity of multiplicative noise is benefit to the growth of the tumor cells. The correlation between two sorts of noises weakens the sto- chastic resonance-like characteristic. Homologous noises promote the growth of the tumor cells. | ZHONG Weirong SHAO Yuanzhi HE Zhenhui | 2005 | Chinese Science Bulletin2005，50，20： | 3 |
| 4 | A radiomics prognostic scoring system for predicting progression-free survival in patients with stageⅣnon-small cell lung cancer treated with platinum-based chemotherapy显示文摘Objective:To develop and validate a radiomics prognostic scoring system(RPSS)for prediction of progressionfree survival(PFS)in patients with stageⅣnon-small cell lung cancer(NSCLC)treated with platinum-based chemotherapy.Methods:In this retrospective study,four independent cohorts of stageⅣNSCLC patients treated with platinum-based chemotherapy were included for model construction and validation(Discovery:n=159;Internal validation:n=156;External validation:n=81,Mutation validation:n=64).First,a total of 1,182 three-dimensional radiomics features were extracted from pre-treatment computed tomography(CT)images of each patient.Then,a radiomics signature was constructed using the least absolute shrinkage and selection operator method(LASSO)penalized Cox regression analysis.Finally,an individualized prognostic scoring system incorporating radiomics signature and clinicopathologic risk factors was proposed for PFS prediction.Results:The established radiomics signature consisting of 16 features showed good discrimination for classifying patients with high-risk and low-risk progression to chemotherapy in all cohorts(All P<0.05).On the multivariable analysis,independent factors for PFS were radiomics signature,performance status(PS),and N stage,which were all selected into construction of RPSS.The RPSS showed significant prognostic performance for predicting PFS in discovery[C-index:0.772,95%confidence interval(95%CI):0.765-0.779],internal validation(C-index:0.738,95%CI:0.730-0.746),external validation(C-index:0.750,95%CI:0.734-0.765),and mutation validation(Cindex:0.739,95%CI:0.720-0.758).Decision curve analysis revealed that RPSS significantly outperformed the clinicopathologic-based model in terms of clinical usefulness(All P<0.05).Conclusions:This study established a radiomics prognostic scoring system as RPSS that can be conveniently used to achieve individualized prediction of PFS probability for stageⅣNSCLC patients treated with platinumbased chemotherapy,which holds promise for guiding personalized pre-therapy of stageⅣNSCLC. | Lan He Zhenhui Li Xin Chen Yanqi Huang Lixu Yan Changhong Liang Zaiyi Liu | 2021 | Chinese Journal of Cancer Research2021，33，5： | 3 |
| 5 | Coupling radiomics analysis of CT image with diversification of tumor ecosystem: A new insight to overall survival in stage Ⅰ-Ⅲ colorectal cancer显示文摘Objective: This study aimed to establish a method to predict the overall survival(OS) of patients with stage Ⅰ-Ⅲ colorectal cancer(CRC) through coupling radiomics analysis of CT images with the measurement of tumor ecosystem diversification.Methods: We retrospectively identified 161 consecutive patients with stage Ⅰ-Ⅲ CRC who had underwent radical resection as a training cohort. A total of 248 patients were recruited for temporary independent validation as external validation cohort 1, with 103 patients from an external institute as the external validation cohort 2. CT image features to describe tumor spatial heterogeneity leveraging the measurement of diversification of tumor ecosystem, were extracted to build a marker, termed the EcoRad signature. Multivariate Cox regression was used to assess the EcoRad signature, with a prediction model constructed to demonstrate its incremental value to the traditional staging system for OS prediction.Results: The EcoRad signature was significantly associated with OS in the training cohort [hazard ratio(HR)=6.670;95% confidence interval(95% CI): 3.433-12.956;P<0.001), external validation cohort 1(HR=2.866;95% CI: 1.646-4.990;P<0.001) and external validation cohort 2(HR=3.342;95% CI: 1.289-8.663;P=0.002).Incorporating the EcoRad signature into the prediction model presented a higher prediction ability(P<0.001) with respect to the C-index(0.813, 95% CI: 0.804-0.822 in the training cohort;0.758, 95% CI: 0.751-0.765 in the external validation cohort 1;and 0.746, 95% CI: 0.722-0.770 in external validation cohort 2), compared with the reference model that only incorporated tumor, node, metastasis(TNM) system, as well as a better calibration,improved reclassification and superior clinical usefulness.Conclusions: This study establishes a method to measure the spatial heterogeneity of CRC through coupling radiomics analysis with measurement of diversification of the tumor ecosystem, and suggests that this approach could effectively predict OS and could be used as a supplement for risk stratification among stage Ⅰ-Ⅲ CRC patients. | Yanqi Huang Lan He Zhenhui Li Xin Chen Chu Han Ke Zhao Yuan Zhang Jinrong Qu Yun Mao Changhong Liang Zaiyi Liu | 2022 | Chinese Journal of Cancer Research2022，34，1： | 2 |
| 6 | Acidity-triggered TAT-presenting nanocarriers augment tumor retention and nuclear translocation of drugs显示文摘 | Wei Jiang Jilong Wang Jinbin Yang Zhiwei He Zhenhui Hou Yingli Luo Li Wang Jing Liu Houbing Zhang Yangyang Zhao Guoqing Zhang Fang Huang Xuechang Zhou Lifeng Yan Xianzhu Yang Yucai Wang Jun Wang | 2018 | Nano Research2018，11，10： | 2 |
| 7 | Nonequilibrium dynamic transition in a kinetic Ising model driven by both deterministic modulation and correlated stochastic noises显示文摘We report the nonequilibrium dynamical phase transition (NDPT) appearing in a kinetic Ising spin system (ISS) subject to the joint application of a deterministic ex-ternal field and the stochastic mutually correlated noises simultaneously. A time-dependent Ginzburg-Landau sto-chastic differential equation, including an oscillating modu-lation and the correlated multiplicative and additive white noises, was addressed and the numerical solution to the rele-vant Fokker-Planck equation was presented on the basis of an average-period approach of driven field. The correlated white noises and the deterministic modulation induce a kind of dynamic symmetry-breaking order, analogous to the sto-chastic resonance in trend, in the kinetic ISS, and the reen-trant transition has been observed between the dynamic disorder and order phases when the intensities of multiplicative and additive noises were changing. The dependencies of a dynamic order parameter Q upon the intensities of additive noise A and multiplicative noise M, the correlation λ between two noises, and the amplitude of applied external field h were investigated quantitatively and visualized vividly. Here a brief discussion is given to outline the underlying mechanism of the NDPT in a kinetic ISS driven by an external force and correlated noises. | SHAO Yuanzhi ZHONG Weirong HE Zhenhui | 2005 | Chinese Science Bulletin2005，50，21： | 2 |
| 8 | Effects of aqueous extracts of raw pu-erh tea and ripened pu-erh tea on proliferation and differentiation of 333-L1 preadipocytes 显示文摘 | CAO Zhenhui YANG Hui HE Zhanlong | 2013 | Phytotherapy Research2013，27，8： | 1 |
| 9 | A pH-responsive mesoporous silica nanoparticles-based drug delivery system with controlled release of andrographolide for OA treatment显示文摘Andrographolide(AG)has favorable anti-inflammatory and antioxidative capacity.However,it has low bioavailability due to high lipophilicity and can be easily cleared by the synovial fluid after intra-articular injection,leading to low therapeutic efficiency in osteoarthritis(OA).Herein,we designed a nano-sized pH-responsive drug delivery system(DDS)for OA treatment by using modified mesoporous silica nanoparticles(MSNs)with pH-responsive polyacrylic acid(PAA)for loading of AG to form AG@MSNs-PAA nanoplatform.The nanoparticles have uniform size(120 nm),high drug loading efficiency(22.3860.71%)and pH-responsive properties,beneficial to sustained release in OA environment.Compared with AG,AG@MSNs-PAA showed enhanced antiarthritic efficacy and chondro-protective capacity based on IL-1b-stimulated chondrocytes and anterior cruciate ligament transection-induced rat OA model,as demonstrated by lower expression of inflammatory factors and better prevention of proteoglycan loss.Therefore,the AG@MSNs-PAA nanoplatform may be developed as a promising OA-specific and on-demand DDS. | Mingwei He Zainen Qin Xiaonan Liang Xixi He Bikang Zhu Zhenhui Lu Qingjun Wei Li Zheng | 2021 | Regenerative Biomaterials2021，8，4： | 1 |
| 10 | Water soluble carbon nanoparticles: Hydrothermal synthesis and excellent photoluminescence properties显示文摘 | Xiaodie He Haitao Li Yang Liu Hui Huang Zhenhui Kang Shuit-Tong Lee | 2011 | Colloids and Surfaces B: Biointerfaces2011，，2： | 1 |
| 11 | Statistics of cloud heights over the Tibetan Plateau and its surrounding region derived from CloudSat data显示文摘Cloud-radiation interaction has a large impact on the Earth's weather and climate change,and clouds with different heights cause different radiative forcing.Thus,the information on the statistics of cloud height and its variation in space and time is very important to global climate change studies.In this paper,cloud top height(CTH),cloud base height(CBH) and cloud thickness over regions of the Tibetan Plateau,south slope of the plateau and South Asian Monsoon are analyzed based on Cloud Sat data during the period from June 2006 to December 2007.The results show that frequency of CTH and CBH in unit area over the studied regions have certain temporal-spatial continuity.The CTH and CBH of different cloud types have different variation scopes,and their seasonal variations are distinct.Cloud thickness is large(small) in summer(winter),and the percentages of different cloud types also have certain regularity. | ShengJie Wang WenYing He HongBin Chen JianChun Bian ZhenHui Wang | 2016 | Research in Cold and Arid Regions2016，8，1： | 1 |
| 12 | One-step ultrasonic synthesis of water-soluble carbon nanoparticles with excellent photoluminescent properties显示文摘 | Haitao Li Xiaodie He Yang Liu Hui Huang Suoyuan Lian Shuit-Tong Lee Zhenhui Kang | 2010 | Carbon2010，，2： | 1 |
| 13 | Study of LED array fill light based on parallel particle swarm optimization in greenhouse planting显示文摘Agricultural productivity is crucial to the economy.The output and quality of crops have a direct impact on people’s daily lives and a country’s food and clothing.Therefore,harvesting high-quality crops efficiently and maximizing yield per unit area are the most important goals pursued by farmers.As an important parameter of plant growth,light intensity is one of the important factors that affects plant growth and development,morphological establishment and accumulation of functional chemical substances.When light intensity cannot meet the plant’s needs,the optimal light intensity or uneven light distribution will have a greater impact on plant growth and development.This paper aims to address the optimal plant light intensity problem.The paper presents an expert system technology database storing the empirical value of real-time light intensity values and compares it with a parallel particle swarm optimization algorithm to identify the optimal locations where LED lights need to be turned on and where drive circuit lit LED arrays need to be situated,to identify the number of LED fill lights and to solve light intensity optimization problems. | Feifei He Lihua Zeng Dongming Li Zhenhui Ren | 2019 | Information Processing in Agriculture2019，6，1： | 1 |
| 14 | Water - soluble fluorescent carbon quantum dots and photocatalyst design 显示文摘 | Li Haitao He Xiaodie Kang Zhenhui | 2010 | Angewandte Chemie International Edition2010，49，26： | 1 |
| 15 | Water-souble fluorescent carbon quantum dots and photocatalyst design显示文摘 | Li Haitao He Xiaodie Kang Zhenhui | 2010 | Angew Chem Int Ed2010，49，26： | 1 |
| 16 | Synthesis of amino-functionalized epoxy acrylate film by magnetic-filtered plasma stream显示文摘 | LI Li HE Zhenhui WANG Weiwei | 2006 | Prog Orag Coat2006，56，23： | 1 |
| 17 | Structure and blood compatibility of tetrahedral amorphous hydrogenated carbon formed by a magnetic-field-filter plasma stream显示文摘 | Zheyi Li Zhenhui He | 2007 | Surface & Coatings Technology2007，201，： | 1 |
| 18 | Water-soluble fluorescent carbon quantum dots and photocata- lyst design 显示文摘 | Li Haitao He Xiaodie Kang Zhenhui | 2010 | Angew Chem Int Ed2010，49，26： | 1 |
| 19 | Experimental investigation on mechanical pumped cooling loop for application in future space missions 显示文摘 | Liu Jie Pei Nianqiang Guo Kaihua He Zhenhui Li Tingxuen Lü Mou | 2008 | Energy Conversion and Management2008，49，10： | 1 |
| 20 | Experimental investigation on a mechanically pumped two-phase cooling loop with dual-evaporator 显示文摘 | Liu Jie Pei Nianqiang Guo Kaihua He Zhenhui Li Tingxue | 2008 | International Journal of Refrigeration2008，31，7： | 1 |
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