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| 1 | Accumulation of soil organic carbon during natural restoration of desertified grassland in China's Horqin Sandy Land显示文摘China's Horqin Sandy Land,a formerly lush grassland,has experienced extensive desertification that caused considerable carbon(C) losses from the plant-soil system.Natural restoration through grazing exclusion is a widely suggested option to sequester C and to restore degraded land.In a desertified grassland,we investigated the C accumulation in the total and light fractions of the soil organic matter from 2005 to 2013 during natural restoration.To a depth of 20 cm,the light fraction organic carbon(LFOC) storage increased by 221 g C/m2(84%) and the total soil organic carbon(SOC) storage increased by 435 g C/m2(55%).The light fraction dry matter content represented a small proportion of the total soil mass(ranging from 0.74% in 2005 to 1.39% in 2013),but the proportion of total SOC storage accounted for by LFOC was remarkable(ranging from 33% to 40%).The C sequestration averaged 28 g C/(m2·a) for LFOC and 54 g C/(m2·a) for total SOC.The total SOC was strongly and significantly positively linearly related to the light fraction dry matter content and the proportions of fine sand and silt+clay.The light fraction organic matter played a major role in total SOC sequestration.Our results suggest that grazing exclusion can restore desertified grassland and has a high potential for sequestering SOC in the semiarid Horqin Sandy Land. | YuQiang LI XueYong ZHAO FengXia ZHANG Tala AWADA ShaoKun WANG HaLin ZHAO TongHui ZHANG YuLin LI | 2015 | Journal of Arid Land2015，7，3： | 21 |
| 2 | Rice Ferredoxin-Dependent Glutamate Synthase Regulates Nitrogen-Carbon Metabolomes and Is Genetically Differentiated between japonica and indica Subspecies显示文摘当通过夫酸安 synthetase/glutamine:2-oxoglutarate amidotransferase (GS/GOGAT ) 的 Gln 和 Glu 骑车,植物吸收从土壤吸收进器官的形式的无机的氮。而 GS 从 Glu 和氨催化 Gln 的形成, GOGAT 从 Gln 催化一个酰胺组的转移到 2-oxoglutarate 生产 Glu 的二个分子。然而,处于碳氮平衡的 GS/GOGAT 周期的规章的角色很好没被理解。这里,我们报导米饭的功能的描述反常细胞激动素反应 1 (ABC1 ) 编码一个铁氧化还原蛋白依赖者(Fd ) 的基因 -GOGAT。弱变异的等位基因 abc1-1 异种显示出典型氮缺乏的症候群,而 T-DNA insertional 异种 abc1-2 是幼苗致命。Metabolomics 分析在 abc1-1 在 tricarboxylic 酸周期与高 N/C 比率(Gln 和 Asn ) 和几中介揭示了氨基酸的过多的数量的累积,建议 ABC1 起在氮吸收和碳氮平衡的一个关键作用。五非同义的单个核苷酸的多型性在编码区域的 ABC1 被识别并且作为三不同 haplotypes 描绘了,它高度并且明确地在装饰用的梨树和 indica 亚种之间被区分了。一起,这些结果建议 ABC1/OsFd-GOGAT 由 modulating 氮吸收和碳氮平衡为植物生长和开发是必要的。 | Xiaolu Yang Jinqiang Nian Qincliun xie Jian Feng Fengxia Zhang Hongwei Jing Jian Zhang Guojun Dong Yan Liang Juli Peng GuodongWang Qian Qian Jianru Zuo | 2016 | Molecular Plant2016，9，11： | 14 |
| 3 | Natural Variations at TIG1 Encoding a TCP Tran scription Factor Contribute to Plant Architecture Domestication in Rice显示文摘The modification of plant architecture is a crucial target in rice domestication and modern genetic improvement.Although several genes regulating rice plant architecture have been characterized,the molecular mechanisms underlying rice plant architecture domestication remain largely unclear.Here we show that the inclined tiller growth in wild rice is controlled by a single dominant gene,TILLER INCLINED GROWTH 1 (T/Gf),which is located on chromosome 8 and encodes a TCP transcriptional activator.TIG1 is primarily expressed in the adaxial side of the tiller base,promotes cell elongation,and enlarges the tiller angle in wild rice.Variations in the TIG1 promoter of indica cultivars {tig1 allele) resulted in decreased expression of TIG1 in the adaxial side of tiller base and reduced cell length and tiller angle,leading to the transition from inclined tiller growth in wild rice to erect tiller growth during rice domestication.TIG1 positively regulates the expression of EXP A3,EXPB5,and SAUR39 to promote cell elongation and increase the tiller angle.Selective sweep analysis revealed that the tig1 allele was selected in indica cultivars by human beings.The cloning and characterization of TIG1 supports a new scenario of plant architecture evolution in rice. | Weifeng Zhang Lubin Tan Hongying Sun Xinhui Zhao Fengxia Liu Hongwei Cai Yongcai Fu Xianyou Sun Ping Gu Zuofeng Zhu Chuanqing Sun | 2019 | Molecular Plant2019，12，8： | 13 |
| 4 | Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China:A multicenter retrospective study显示文摘Importance:The clinical characteristics of infectious mononucleosis(IM)in Chinese children have not been evaluated in multicenter studies,and the effectiveness of antiviral treatment are controversial.Objective:To investigate the clinical characteristics of Chinese children with IM and current status of antiviral therapy for affected patients.Methods:Hospitalized patients with IM were enrolled between 2018 and 2020 in five children’s hospitals in China.The clinical characteristics were compared among four age groups:<3 years,3-<6 years,6-<10 years,and≥10 years.The clinical characteristics of IM and effectiveness of antiviral therapy were compared among patients receiving acyclovir(ACV),ganciclovir(GCV),and no antiviral therapy(i.e.,non-antiviral group).Results:In total,499 patients were analyzed;most patients were 3-<6 years of age.The most common symptoms and signs included fever(100%),lymphadenopathy(98.6%),pharyngitis(86.4%),eyelid edema(76.8%),and snoring(72.9%).There were significant differences in rash,hepatomegaly,and liver dysfunction among the four age groups.Patients aged<3 years had a lower incidence of liver dysfunction and a higher incidence of rash.Among the 499 patients,50.1%were treated with GCV,26.3%were treated with ACV,and 23.6%received no antiviral therapy.Compared with the non-antiviral group,patients in the ACV and GCV groups had longer durations of fever(P<0.001).There were no significant differences in the incidences of complications among the three treatment groups.Interpretation:The incidence of IM in Chinese children peaked at 3-<6 years of age.Clinical features of IM varied according to age.Patients receiving antiviral therapy exhibited more serious clinical manifestations than did patients without antiviral therapy.The effectiveness of antiviral therapy for IM requires further analysis. | Huili Hu Huiling Deng Jing Bi Yi Xu Shuangjie Li Yue Xie Xinrong Sun Dongmeng Wang Xufang Li Wenxian Ouyang Bing Hu Yufeng Zhang He Tang Chunxiao Fang Hui Zhang Lingyun Guo Chen Wang Tianyi Wang Fengxia Yang Tao Jiang Zhengde Xie Gang Liu | 2021 | Pediatric Investigation2021，5，3： | 12 |
| 5 | Recently duplicated sesterterpene(C25) gene clusters in Arabidopsis thaliana modulate root microbiota显示文摘Land plants co-speciate with a diversity of continually expanding plant specialized metabolites(PSMs) and root microbial communities(microbiota).Homeostatic interactions between plants and root microbiota are essential for plant survival in natural environments.A growing appreciation of microbiota for plant health is fuelling rapid advances in genetic mechanisms of controlling microbiota by host plants.PSMs have long been proposed to mediate plant and single microbe interactions.However,the effects of PSMs,especially those evolutionarily new PSMs,on root microbiota at community level remain to be elucidated.Here,we discovered sesterterpenes in Arabidopsis thaliana,produced by recently duplicated prenyltransferase-terpene synthase(PT-TPS) gene clusters,with neo-functionalization.A single-residue substitution played a critical role in the acquisition of sesterterpene synthase(sesterTPS) activity in Brassicaceae plants.Moreover,we found that the absence of two root-specific sesterterpenoids,with similar chemical structure,significantly affected root microbiota assembly in similar patterns.Our results not only demonstrate the sensitivity of plant microbiota to PSMs but also establish a complete framework of host plants to control root microbiota composition through evolutionarily dynamic PSMs. | Qingwen Chen Ting Jiang Yong-Xin Liu Haili Liu Tao Zhao Zhixi Liu Xiangchao Gan Asis Hallab Xuemei Wang Juan He Yihua Ma Fengxia Zhang Tao Jin M. Eric Schranz Yong Wang Yang Bai Guodong Wang | 2019 | Science China(Life Sciences)2019，62，7： | 11 |
| 6 | Successive inverse and normal magnetocaloric effects in the Mn-vacancy compound Mn0.95Co0.75Cu0.25Ge显示文摘Ferromagnetic-structural transformation has been studied widely in MnCoGe-based materials. However, the magnetostructural transition(MST) from antiferromagnetic(AFM) orthorhombic phase to ferromagnetic(FM) hexagonal phase, which may lead to a large inverse magnetocaloric effect(MCE), has rarely been reported. Here, the introduction of Mn vacancy lowers the structural transition temperature while retains the AFM state in the orthorhombic phase, thus successfully realizing the AFM-FM MST in Mn0.95Co0.75Cu0.25Ge. Moreover, successive inverse and normal MCEs are observed around the first-order AFM-FM MST and the second-order FM-paramagnetic(PM) transition, respectively. A thermostat is proposed based on this special feature, which could release heat above the critical temperature while absorb heat below the critical temperature by simply applying the same magnetization/demagnetization cycles. This thermostat can be very useful in many applications where a constant temperature is required, such as cryostats and incubators. | FengXia Liu Hu Zhang He Zhou DaoYong Cong RongJin Huang LiChen Wang Yi Long | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，7： | 9 |
| 7 | Characterization of the Formation of Branched Short-Chain Fatty Acid:CoAs for Bitter Acid Biosynthesis in Hop Glandular Trichomes显示文摘痛苦的酸,作为啤酒香料并且为他们的多样的生物活动为他们的使用知道,主要 formedin 跳跃(Humulus lupulus ) 腺的毛状体。分叉的短链的 acyl-CoAs (例如 isobutyryl-CoA, isovaleryl-CoA 和 2-methylbutyryl-CoA ) , derivedfrom 分支链氨基酸(BCAA ) 的降级,为痛苦的 acidsin 的生合成的必要积木跳跃。然而,很少关于部件被需要生产并且维持分叉的 short-chainacyl-CoAs 的水池在的被知道跳跃毛状体。这里,我们在场 CoA ligases 和 thioesterases 是在痛苦的酸生合成的 likelyinvolved 的证据的几根线。蛋白质有的 Recombinant HlCCL2 ( carboxyl CoA ligase )为象底层酸的 isovaleric 的高特定的活动( K 猫 /K m = 4100 s 1 M 1),而 recombinant HlCCL4 明确地利用了 isobutyric 酸( K 猫 /K m = 1800 s 1 M 1)并且 2-methylbutyric 酸( K 猫 /K m = 6900 s 1 M 1)作为底层。两 HlCCLs 跳跃 valerophenone synthase (HlVPS ) ,在腺的毛状体强烈被表示并且对细胞质局部性。有在酵母的 HlVPS 的 HlCCL2 和 HlCCL4 的合作表示导致了 acylphloroglucinols (为痛苦的酸生合成的直接先锋) 的重要生产, whichfurther 在 vivo 证实了这二 HlCCLs 的生物化学的功能。在线粒体催化 CCL 的反向的反应的 thioesterase 的功能的鉴定,和 thecomprehensive,基因的分析包含了 BCAA 分解代谢,支持了 cytosolic CoA ligases 在腺的毛状体为 linkingBCAA 降级和痛苦的酸生合成被要求的想法。进化和另外的可能的生理的 rolesof 分叉短链的丰满的酸: 在 planta 的 CoA ligases 也是 discussed.Key 词: | Haiyang Xu Fengxia Zhang Baoxiu Liu David V. Huhman Lloyd W. Sumner Richard A. Dixon Guodong Wang | 2013 | Molecular Plant2013，6，4： | 9 |
| 8 | Control of Bird Feeding Behavior by Tannin1 through Modulating the Biosynthesis of Polyphenols and Fatty Acid-Derived Volatiles in Sorghum显示文摘Bird predation during seed maturation causes great loss to agricultural production.In this study,through GWAS analysis of a large-scale sorghum germplasm diversity panel,we identified that Tannin1,which encodes a WD40 protein functioning in the WD40/MYB/bHLH complex,controls bird feeding behavior in sorghum.Metabolic profiling analysis showed that a group of sorghum accessions preferred by birds contain mutated tan1-a/b alleles and accumulate significantly lower levels of anthocyanins and condensed tannin compounds.In contrast,a variety of aromatic and fatty acid-derived volatiles accumulate at significantly higher levels in these bird-preference accessions.We subsequently conducted both sparrow feeding and sparrow volatile attractant assays,which confirmed,respectively,the antifeedant and attractant functions of these differentially accumulated metabolites.In addition,the connection between the biosynthesis pathway of anthocyanin and proanthocyanidin and the pathway of fatty acid–derived volatile biosynthesis was demonstrated by discovering that Tannin1 complex modulates fatty acid biosynthesis by regulating the expression of SbGL2 in sorghum,thus affecting the accumulation of fatty acid-derived volatiles.Taken together,our study identified Tannin1 as the gene underlying the major locus controlling bird feeding behavior in sorghum,illustrating an example of the identification of an ecologically impactful molecular mechanism from field observation and providing significant insights into the chemistry of bird–plant ecological interactions. | Peng Xie Jiayang Shi Sanyuan Tang Chengxuan Chen Aimal Khan Fengxia Zhang Ying Xiong Chao Li Wei He Guodong Wang Fumin Lei Yaorong Wu Qi Xie | 2019 | Molecular Plant2019，12，10： | 8 |
| 9 | Effects of interstitial H and/or C atoms on the magnetic and magnetocaloric properties of La(Fe, Si)_(13)-based compounds显示文摘La(Fe,Si)13-based compounds have been considered as promising candidates for magnetic refrigerants particularly near room temperature.Herein we review recent progress particularly in the study of the effects of interstitial H and/or C atoms on the magnetic and magnetocaloric properties of La(Fe,Si)13compounds.By introducing H and/or C atoms,the Curie temperature TC increases notably with the increase of lattice expansion which makes the Fe 3d band narrow and reduces the overlap of the Fe 3d wave functions.The first-order itinerant-electron metamagnetic transition is conserved and the MCE still remains high after hydrogen absorption.In contrast,the characteristic of magnetic transition varies from first-order to second-order with the increase of C concentration,which leads to remarkable reduction of thermal and magnetic hysteresis.In addition,the introduction of interstitial C atoms promotes the formation of NaZn13-type(1:13)phase in La(Fe,Si)13compounds,and thus reducing the annealing time significantly from 40 days for LaFe11.7Si1.3to a week for LaFe11.7Si1.3C0.2.The pre-occupied interstitial C atoms may depress the rate of hydrogen absorption and release,which is favorable to the accurate control of hydrogen content.It is found that the reduction of particle size would greatly depress the hysteresis loss and improve the hydrogenation process.By the incorporation of both H and C atoms,large MCE without hysteresis loss can be obtained in La(Fe,Si)13compounds around room temperature,for instance,La0.7Pr0.3Fe11.5Si1.5C0.2H1.2exhibits a large|SM|of 22.1 J/(kg·K)at TC=321 K without hysteresis loss for a field change of 0 5 T. | ZHANG Hu HU FengXia SUN JiRong SHEN BaoGen | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，12： | 6 |
| 10 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 11 | An analytical biomarker for treatment of patients with recurrent B-ALL after remission induced by infusion of anti-CD19 chimeric antigen receptor T(CAR-T) cells显示文摘Anti-CD19 chimeric antigen receptor-modified T(CAR-T-19) cells have emerged as a powerful targeted immunotherapy for B-cell lineage acute lymphoblastic leukemia with a remarkable clinical response in recent trials. Nonetheless, few data are available on the subsequent clinical monitoring and treatment of the patients, especially those with disease recurrence after CAR-T-19 cell infusion. Here, we analyzed three patients who survived after our phase I clinical trial and who were studied by means of biomarkers reflecting persistence of CAR-T-19 cells in vivo and predictive factors directing further treatment. One patient achieved 9-week sustained complete remission and subsequently received an allogeneic hematopoietic stem cell transplant. Another patient who showed relapse after 20 weeks without detectable leukemia in the cerebrospinal fluid after CAR-T-19 cell treatment was able to achieve a morphological remission under the influence of stand-alone low-dose chemotherapeutic agents. The third patient gradually developed extensive extramedullary involvement in tissues with scarce immune-cell infiltration during a long period of hematopoietic remission after CAR-T-19 cell therapy. Long-term and discontinuous increases in serum cytokines(mainly interleukin 6 and C-reactive protein) were identified in two patients(Nos. 1 and 6) even though only a low copy number of CAR molecules could be detected in their peripheral blood. This finding was suggestive of persistent functional activity of CAR-T-19 cells. Combined analyses of laboratory biomarkers with their clinical manifestations before and after salvage treatment showed that the persistent immunosurveillance mediated by CAR-T-19 cells would inevitably potentiate the leukemia-killing effectiveness of subsequent chemotherapy in patients who showed relapse after CAR-T-19-induced remission. | Yajing Zhang Wenying Zhang Hanren Dai Yao Wang Fengxia Shi Chunmeng Wang Yelei Guo Yang Liu Meixia Chen Kaichao Feng Yan Zhang Chuanjie Liu Qingming Yang Suxia Li Weidong Han | 2016 | Science China(Life Sciences)2016，59，4： | 6 |
| 12 | Estrogen and insulin synergistically promote endometrial cancer progression via crosstalk between their receptor signaling pathways显示文摘Objective: Despite evidence that estrogens and insulin are involved in the development and progression of many cancers, their synergistic role in endometrial carcinoma(EC) has not been analyzed yet.Methods: Here, we investigated how estrogens act synergistically with insulin to promote EC progression. Cell growth in vitro and in vivo, effects of estradiol and insulin on apoptosis and cell cycle distribution, and expression and activation of estrogen receptor(ER), insulin receptor(InsR), and key proteins in the PI3K and MAPK pathways were examined after combined stimulation with estradiol and insulin.Results: Compared to EC cells treated with estradiol or insulin alone, those treated with both estradiol and insulin exhibited stronger stimulation. Estradiol significantly induced phosphorylation of InsR-β and IRS-1, whereas insulin significantly induced phosphorylation of ER-α. In addition, treatment with both insulin and estradiol together significantly increased the expression and phosphorylation of Akt, MAPK, and ERK. Notably, InsR-β inhibition had a limited effect on estradiol-dependent proliferation,cell cycle, and apoptosis, whereas ER-α inhibition had a limited insulin-dependent effect, in EC cell lines. Insulin and estradiol individually and synergistically promoted EC xenograft growth in mice.Conclusions: Estrogen and insulin play synergistic roles in EC carcinogenesis and progression by activating InsR-β and ER-α,promoting a crosstalk between them, and thereby resulting in the activation of downstream PI3K/Akt and MAPK/ERK signaling pathways. | Wenyan Tian Fei Teng Jinping Gao Chao Gao Guoyan Liu Yanfang Zhang Shizhu Yu Wei Zhang Yingmei Wang Fengxia Xue | 2019 | Cancer Biology & Medicine2019，16，1： | 6 |
| 13 | Astragalus injection inhibits c-Jun N terminal kinase mRNA expression following oxygen-glucose deprivation and reintroduction in rat hippocampal neurons显示文摘BACKGROUND:In studies concerning cell injury induced by cerebral ischemia-reperfusion,current experiments have primarily focused on altered protein levels.In addition,the apoptotic proteins Bax and Bcl-2 have been thoroughly studied with regard to initiating neuronal apoptosis. OBJECTIVE:To establish an in vitro model of oxygen-glucose deprivation and reintroduction in the rat hippocampus to simulate cerebral ischemia-reperfusion injury;to observe c-Jun N-terminal kinase 3(JNK3) mRNA expression in hippocampal neurons following Astragalus injection;and thus to determine changes in the signaling and downstream pathways of neuronal apoptosis at the cellular and molecular level. DESIGN,TIME AND SETTING:A randomized,controlled,cellular and molecular experiment was performed at the Department of Central Laboratory,Chengde Medical College from February to June 2008. MATERIALS:Astragalus injection,the main ingredient of astragaloside,was purchased from Chengdu Di'ao Jiuhong Pharmaceutical Manufactory,China.JNK3 mRNA probe and in situ hybridization kit were purchased from Tianjin Haoyang Biological Technology,China,and JNK3 RT-PCR primers were designed by Shanghai Bio-engineering,China. METHODS:Primary cultures of hippocampal neurons derived from Sprague Dawley rats,aged 1-2 days,were established.After 8 days,the hippocampal neurons were assigned to the following interventions:model group,Astragalus group,and vehicle control group,cells were subjected to oxygen-glucose reintroduction after oxygen-glucose deprivation for 30 minutes in sugar-free Earle's solution and a hypoxia device,which contained high-purity nitrogen.The normal control group was subjected to primary culture techniques and was not treated using above-mentioned interventions. In addition,the Astragalus and vehicle control groups were treated with Astragalus injection(0.5 g/L raw drug) or sterile,deionized water at 2 hours prior to oxygen-glucose deprivation,respectively. MAIN OUTCOME MEASURES:JNK3 mRNA expression was measured by in situ hybridization and RT-PCR at 0,0.5,2,6,24,72,and 120 hours after oxygen-glucose reintroduction. RESULTS:Hippocampal neuronal morphology was normal in the normal control group. Hippocampal neurons exhibited apparent apoptosis-like pathological changes in the model,as well as the vehicle control,groups.The apoptosis-like pathological changes in the hippocampal neurons were less in the Astragalus group.Results from in situ hybridization and RT-PCR showed that JNK3 mRNA expression significantly increased in hippocampal neurons from model group,as well as the vehicle control group,compared with the normal control group(P<0.05).In addition,JNK3 mRNA expression significantly decreased in hippocampal neurons of the Astragalus group,compared with the model group and vehicle control group(P<0.05). CONCLUSION:Astragalus injection inhibited apoptosis-related JNK3 mRNA expression following oxygen-glucose deprivation and reintroduction,and accordingly played a role in inhibiting hippocampal neuronal apoptosis. | Dongqing Ye Weijuan Gao Fengxia Yan Tao Qian Yali Zhang | 2009 | Neural Regeneration Research2009，4，11： | 6 |
| 14 | GATA family members as inducers for cellular reprogramming to pluripotency显示文摘GATA 蛋白质家庭的成员在系说明和 transdifferentiation 起重要作用。以前的报告证明 GATA 蛋白质家庭罐头的一些成员也由代替 Oct4 在体的房间导致 pluripotency,一个关键联系 pluripotency 的因素。然而,连接指定系的暗示的机制和 pluripotency 的激活留下逃犯。这里,我们报导所有 GATA 家庭成员能代替让 Oct4 导致 pluripotency。我们发现 GATA 家庭的所有成员能禁止 overrepresented ectodermal 系基因,它与以前的报告显示不同指定系的力量的平衡为 pluripotency 的恢复是重要的一致。一根保存锌手指在 C 终点的 DNA 有约束力的领域是批评的让 GATA 家庭导致 pluripotency。用 RNA-seq 和 ChIP-seq,我们决定 pluripotency 相关的基因 Sall4 在 reprogramming 期间是 GATA 家庭成员的一个直接目标并且用作连接指定系的 GATA 家庭到 pluripotency 电路的一座桥。因此, GATA 家庭是所有成员能作为 reprogramming 进程的 inducers 工作并且能代替 Oct4 的第一个蛋白质家庭。我们的结果建议在 reprogramming 的 GATA 家庭的角色被低估了并且 GATA 家庭可以担任房间命运变换的一个重要调停人。 | Jian Shu Ke Zhang Minjie Zhang Yao Sida Shao Fengxia Du Caiyun Yang Wenhan Chen Chen Wu Weifeng Yang Yingli Sun Hongkui Deng | 2015 | Cell Research2015，25，2： | 5 |
| 15 | Study on Energy Conversion Characteristics in Volute of Pump as Turbine显示文摘A volute is a curved funnel with cross-sectional area increasing towards the discharge port.The volute of a centrifugal pump is the casing hosting the fluid being pumped by the impeller.In Pump-as-turbine devices(PAT),vice versa the volute plays the role of energy conversion element.In the present analysis,this process is analyzed using CFD.The results show that in the contraction section of volute the conversion between dynamic pressure energy and static pressure energy essentially depends on the reduction of flow area,while in the spiral section,frictional losses also play a significant role.From the throat to the end of the volute,the flow decreases in a wave-like manner. | Senchun Miao Hongbiao Zhang Fengxia Shi Xiaohui Wang Xijin Ma | 2021 | Fluid Dynamics & Materials Processing2021，17，1： | 5 |
| 16 | An improved trust region method for unconstrained optimization显示文摘In this paper,we propose an improved trust region method for solving unconstrained optimization problems.Different with traditional trust region methods,our algorithm does not resolve the subproblem within the trust region centered at the current iteration point,but within an improved one centered at some point located in the direction of the negative gradient,while the current iteration point is on the boundary set.We prove the global convergence properties of the new improved trust region algorithm and give the computational results which demonstrate the effectiveness of our algorithm. | ZHOU QingHua ZHANG YaRui XU FengXia GENG Yan SUN XiaoDian | 2013 | Science China Mathematics2013，56，2： | 5 |
| 17 | miR-506: a regulator of chemo-sensitivity through suppression of the RAD51-homologous recombination axis显示文摘Ovarian carcinoma is the most lethal gynecologic malignancy. Resistance to platinum is considered the major problem afecting prognosis. Our recent study established that micro RNA-506(mi R-506) expression was closely associated with progression-free survival and overall survival in two independent patient cohorts totaling 598 epithelial ovarian cancer cases. Further functional study demonstrated that mi R-506 could augment the response to cisplatin and olaparib through targeting RAD51 and suppressing homologous recombination in a panel of ovarian cancer cell lines. Systemic delivery of mi R-506 in an orthotopic ovarian cancer mouse model signiicantly augmented the cisplatin response, thus recapitulating the clinical observation. Therefore, mi R-506 plays a functionally important role in homologous recombination and has important therapeutic value for sensitizing cancer cells to chemotherapy, especially in chemo-resistant patients with attenuated expression of mi R-506. | Guoyan Liu Fengxia Xue Wei Zhang | 2015 | Chinese Journal of Cancer2015，34，11： | 4 |
| 18 | The spectra and temperature of cloud lightning discharge channel显示文摘Spectra of seven cloud lightning discharges are reported for the first time after captured with a Slit-less Spectrograph on Chinese Tibet Plateau. The structural characters are analyzed and compared with the spectra of cloud-to-ground lightning, and the results indicate that the spectra of cloud lightning show two different kinds of structure characteristics. One has the similar structure as those of cloud-to-ground lightning discharge, and the other is absolutely different. Meanwhile, more lines of OII with high excited energy are recorded in the spectra of cloud lightning discharge in comparison with that of cloud-to-ground lighting happening in the same region. Temperatures at different positions are calculated and temperature characteristics of these two sorts are analyzed, based to the wavelength, relative intensities and other transition parameters. We suggest that the physical process in the cloud discharge channels changes with much more rapid velocity and wider range compared to cloud-to-ground lightning. The differences between the two types of cloud discharge also reflect some discrepancies between the discharge characteristics. | WANG Jie YUAN Ping GUO FengXia QIE XiuShu OUYANG YuHua ZHANG YiJun | 2009 | Science China Earth Sciences2009，52，7： | 4 |
| 19 | Clinical value of Tongguanteng(Radix seu Herba Marsdeniae Tenacissimae) extract combined with chemotherapy in the treatment of advanced non-small cell lung cancer: a Meta-analysis显示文摘OBJECTIVE: To investigate the clinical efficacy and safety of Tongguanteng(Radix seu Herba Marsdeniae Tenacissimae) extract combined with chemotherapy in the treatment of advanced non-small celllung cancer(NCSLC) compared with chemotherapy alone.METHODS: Databases including Chinese National Knowledge Infrastructure, China Biology Medicine Disc, Wanfang, and MEDLINE were searched until April 1, 2014. Two assessors independently reviewed each trial. The primary outcome was the effective rate(ER) of Tongguanteng(Radix seu Herba Marsdeniae Tenacissimae) extract combined with chemotherapy. The secondary outcomes included quality of life improvement rate(QOLIR) and adverse reactions. Statistical calculations were performed by using Cochrane Collaboration Review Manager 5.2.RESULTS: A total of 888 patients from 15 studies,13 randomized controlled trials(RCT) and two controlled clinical trials, were included. Compared with chemotherapy alone, Tongguanteng(Radix seu Herba Marsdeniae Tenacissimae) extract plus chemotherapy significantly improved ER [Risk ratio(RR) =1.32, 95% CI,(1.14, 1.54)](based on 15 studies) and QOLIR [RR = 2.04, 95% CI,(1.69, 2.47)](based on 13studies). Compared with chemotherapy alone,Tongguanteng(Radix seu Herba Marsdeniae Tenacissimae) extract plus chemotherapy significantly inhibited chemotherapy-induced white blood cell decline [RR = 0.79, 95% CI,(0.70, 0.90)(based on 10 studies), chemotherapy-induced platelet decline[RR = 0.77, 95% CI,(0.60, 0.98)](based on 8 studies),and significantly alleviated nausea and vomiting(NV) [RR = 0.83, 95% CI,(0.71, 0.97)](based on 7studies). There was no significant difference in hemoglobin decline between the two therapies [RR =0.88, 95% CI,(0.70, 1.09)](based on 6 studies).CONCLUSION: This Meta-analysis suggests that Tongguanteng(Radix seu Herba Marsdeniae Tenacissimae) extract combined with chemotherapy may be more efficacious in the treatment of advanced NSCLC than chemotherapy alone. This effect includes enhancing ER and QOLIR, and weakening chemotherapy toxicity. However, large-scale RCTs are required to further investigate the short- and long-term effects of Tongguanteng(Radix seu Herba Marsdeniae Tenacissimae) extract. | Zhang Haiming Zhang Junli Ding Hao Chen Rui Liang Fengxia | 2016 | Journal of Traditional Chinese Medicine2016，36，3： | 4 |
| 20 | Flanking sequence determination and event-specific detection of genetically modified wheat B73-6-1显示文摘以便建立一个特定的鉴定方法因为遗传上修改了(美国通用汽车公司) 小麦,外长在外长的碎片和美国通用汽车公司小麦 B73-6-1 的 recombinant 染色体之间插入 DNA 和 flanking 顺序成功地借助于常规聚合酶链反应(PCR ) 被获得并且热不对称交叉(尾巴)-PCR 策略。最新获得的外长的碎片包括标记 uidA,除草剂抵抗的酒吧, ubiquitin 倡导者,和 high-molecular-weight 面筋子单元盖住象转变 plasmid 那样的转变基因和相应功能的基因的全身的顺序。flanking 顺序在之间插入高揭示的 DNA 有 Triticum turgidum 的类似基因(GenBank:AY494981.1 ) 。为美国通用汽车公司小麦 B73-6-1 的一个特定的 PCR 察觉方法根据根据 flanking 顺序设计的教材被建立。这个特定的 PCR 方法被美国通用汽车公司小麦,美国通用汽车公司玉米,美国通用汽车公司大豆,美国通用汽车公司米饭,和非美国通用汽车公司小麦验证。明确地放大的目标乐队仅仅在美国通用汽车公司小麦 B73-6-1 被观察。这个方法具有为美国通用汽车公司小麦 B73-6-1 的鉴定的高特性,高重制度,快速的鉴定,和优秀精确性。 | Junyi Xu Jijuan Cao Dongmei Cao Tongtong Zhao Xin Huang Piqiao Zhang Fengxia Luan | 2013 | Acta Biochimica et Biophysica Sinica2013，45，5： | 4 |
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