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| 1 | Osteoimmunomodulatory effects of biomaterial modification strategies on macrophage polarization and bone regeneration显示文摘Biomaterials as bone substitutes are always considered as foreign bodies that can trigger host immune responses.Traditional designing principles have been always aimed at minimizing the immune reactions by fabricating inert biomaterials.However,clinical evidence revealed that those methods still have limitations and many of which were only feasible in the laboratory.Currently,osteoimmunology,the very pioneering concept is drawing more and more attention-it does not simply regard the immune response as an obstacle during bone healing but emphasizes the intimate relationship of the immune and skeletal system,which includes diverse cells,cytokines,and signaling pathways.Properties of biomaterials like topography,wettability,surface charge,the release of cytokines,mediators,ions and other bioactive molecules can impose effects on immune responses to interfere with the skeletal system.Based on the bone formation mechanisms,the designing methods of the biomaterials change from immune evasive to immune reprogramming.Here,we discuss the osteoimmunomodulatory effects of the new modification strategies—adjusting properties of bone biomaterials to induce a favorable osteoimmune environment.Such strategies showed potential to benefit the development of bone materials and lay a solid foundation for the future clinical application. | Yajuan Xie Cheng Hu Yi Feng Danfeng Li Tingting Ai Yulei Huang Xiaodan Chen Lijia Huang Jiali Tan | 2020 | Regenerative Biomaterials2020，7，3： | 22 |
| 2 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 3 | Percent free prostate-specific antigen for prostate cancer diagnosis in Chinese men with a PSA of 4.0-10.0 ng/mL:Results from the Chinese Prostate Cancer Consortium显示文摘Objective:To test the diagnostic performance of percent free prostate-specific antigen(%fPSA)in predicting any prostate cancer(PCa)and high-grade prostate cancer(HGPCa)in a retrospective multi-center biopsy cohort with a PSA level of 4.0e10.0 ng/mL in China.Methods:Consecutive patients with a PSA of 4.0-10.0 ng/mL who underwent transrectal ultrasound-guided biopsy were enrolled at 16 Chinese medical centers from January 1st,2010 to December 31st,2013.Total and free serum PSA determinations were performed using three types of electro-chemiluminescence immunoassays recalibrated to the World Health Organization(WHO)standard.The diagnostic accuracy of PSA,%fPSA,and %fPSA in combination with PSA(%fPSA t PSA)was determined using the area under the receiver operating characteristic(ROC)curve(AUC).Results:A total of 2310 consecutive men with PSA levels between 4.0 and 10.0 ng/mL were included,and the detection rate of PCa was 25.1%.The AUC of%fPSA and %fPSA t PSA in predicting any PCa was superior to PSA alone in men aged≥60 years(0.623 vs.0.534,p<0.0001)but not in men aged 40e59 years(0.517 vs.0.518,p=0.939).Similar result was yield in predicting HGPCa.Conclusion:In a clinical setting of Chinese men with 4.0e10.0 ng/mL PSA undergoing initial prostate biopsy,adding %fPSA to PSA can moderately improve the diagnostic accuracy for any PCa and HGPCa compared with PSA alone in patients≥60 but not in patients aged 40-59 years. | Rui Chen Liping Xie Xiaobing Cai Yiran Huang Liqun Zhou Lulin Ma Xu Gao Chuanliang Xu Shancheng Ren Pengfei Shao Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Li Lu Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tie Zhou Fubo Wang Biming He Yinghao Sun | 2015 | Asian Journal of Urology2015，2，2： | 8 |
| 4 | Molecular mechanism underlying Piriformospora indica-mediated plant improvement/protection for sustainable agriculture显示文摘The beneficial endophytic microorganisms have received significant attention in agriculture because of their exceptional capabilities to facilitate functions like nutrient enrichment,water status,and stress tolerance(biotic and abiotic).This review signifies the molecular mechanisms to better understand the Piriformospora indica-mediated plants improvement or protection for sustainable agriculture.P.indica,an endophytic fungus,belonging to the order Sebacinales(Basidiomycota),is versatile in building mutualistic associations with a variety of plants including pteridophytes,bryophytes,gymnosperms,and angiosperms.P.indica has enormous potential to manipulate the hormonal pathway such as the production of indole-3-acetic acid which in turn increases root proliferation and subsequently improves plant nutrient acquisition.P.indica also enhances components of the antioxidant system and expression of stress-related genes which induce plant stress tolerance under adverse environmental conditions.P.indica has tremendous potential for crop improvement because of its multi-dimensional functions such as plant growth promotion,immunomodulatory effect,biofertilizer,obviates biotic(pathogens)and abiotic(metal toxicity,water stress,soil structure,salt,and pH)stresses,phytoremediator,and bio-herbicide.Considering the above points,herein,we reviewed the physiological and molecular mechanisms underlying P.indica-mediated plants improvement or protection under diverse agricultural environment.The first part of the review focuses on the symbiotic association of P.indica with special reference to biotic and abiotic stress tolerance and host plant root colonization mechanisms,respectively.Emphasis is given to the expression level of essential genes involved in the processes that induce changes at the cellular level.The last half emphasizes critical aspects related to the seed germination,plant yield,and nutrients acquisition. | Muhammad Khalid Saeed-ur-Rahman Danfeng Huang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 4 |
| 5 | Discovery of the ancient Ordovician oil-bearing karst cave in Liuhuanggou,North Tarim Basin,and its significance显示文摘A typical ancient karst cave is found in the Yijianfang Formation of Ordovician at Liuhuanggou,North Tarim Basin.With an entrance of 4.8 m wide and 20 m high,the Liuhuanggou ancient karst cave extends to NW 315° and has been filled by sediments,which can be classified into three types according to their nature and origin:clastic sediments(gravels),chemical sediments(palaeotravertine),and mixed sediments.Among them,the Paleotravertine and gravels are most common.The palaeotravertine is laminated type and yellowish brown or black in color due to oil inside.When saturated with oil,the palaeotravertine is black.Under microscope,oil mainly accumulates in the cracks between calcite crystals.The filling period of the Liuhuanggou karst cave can be divided into three stages:mixed filling,chemical filling,and clastic(palaeotravertine breccia) filling.Numerous fractures are distributed on one side of the karst cave.The fractures can be as wide as 40 cm and over 40 m long.Fractures of different periods and sizes constitute a fracture network and are all filled with calcite veins.Oil can be found inside the fractures.In the chemical fillings,sulfur is also found,which can indicate the magma influence on karst caves.The existence of sulfur also confirms that the Liuhunggou karst cave was formed in ancient times rather than recently or nowadays.Different from normal sedimentary limestone,the ancient Liuhuanggou karst cave has a distinct isotope fractionation and the depletion of heavy carbon and oxygen isotope.Controlled by the northwest oriented vertical strike-slip shear fault,the karst cave is actually a dissolved vertical fault belt. | ZHONG JianHua MAO Cui LI Yong LI Yang YUAN XiangChun NIU YongBin CHEN Xin HuANG ZhiJuan SHAO ZhuFu WANG PeiJun LI Jia ZHANG DanFeng | 2012 | Science China Earth Sciences2012，55，9： | 4 |
| 6 | Morphophysiological and molecular evidence supporting the augmentative role of Piriformospora indica in mitigation of salinity in Cucumis melo L.显示文摘Salinity is one of the major limiting factors in plant growth and productivity.Cucumis melo L.is a widely cultivated plant,but its productivity is significantly influenced by the level of salinity in soil.Symbiotic colonization of plants with Piriformospora indica has shown a promotion in plants growth and tolerance against biotic stress.In this study,physiological markers such as ion analysis,antioxidant determination,proline content,electrolyte leakage and chlorophyll measurement were assessed in melon cultivar under two concentrations(100 and 200 mM)of NaCl with and without P.indica inoculation.Results showed that the endophytic inoculation consistently upregulated the level of antioxidants,enhanced plants to antagonize salinity stress.The expression level of an RNA editing factor(SLO2)which is known to participate in mitochondria electron transport chain was analyzed,and its full mRNA sequence was obtained by rapid amplification of cDNA ends(RACE).Under salinity stress,the expression level of SLO2 was increased,enhancing the plant’s capability to adapt to the stress.However,P.indica inoculation further elevated the expression level of SLO2.These findings suggested that the symbiotic association of fungi could help the plants to tolerate the salinity stress. | Danial Hassani Muhammad Khalid Danfeng Huang Yi-Dong Zhang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 3 |
| 7 | A polypropylene melt-blown strategy for the facile and efficient membrane separation of oil-water mixtures显示文摘Porous materials with selective wettability and permeability have significant importance in oil-water separation,but complex fabrication processes are typically required to obtain the desired structures with suitable surface chemistry.In this work,an industrial melt-blown strategy that utilized commercially available polypropylene(PP)was used for the large-scale fabrication of superhydrophobic/superoleophilic membranes with staggered fabric structures.These membranes could readily separate different oils including pump oil and crude oil from various aqueous solutions such as strongly acidic,alkaline,and saline media.In addition,the separation efficiencies of these membranes exceeded 99%,and they could remain functional even after exposure to corrosive media.We anticipate that this work will further the design of membranes and enhance their applicability in oil-water separation,and provide researchers and engineers with a more effective tool for performing challenging separations and mitigating pollution. | Zhenqiang Zhang Danfeng Yu Xiubin Xu Huayi Li Taoyan Mao Cheng Zheng Jianjia Huang Hui Yang Zihan Niu Xu Wu | 2021 | Chinese Journal of Chemical Engineering2021，34，1： | 3 |
| 8 | A novel integrated non-targeted metabolomic analysis reveals significant metabolite variations between different lettuce (Lactuca sativa. L) varieties显示文摘Lettuce is an important leafy vegetable that represents a significant dietary source of antioxidants and bioactive compounds.However,the levels of metabolites in different lettuce cultivars are poorly characterized.In this study,we used combined GC×GC-TOF/MS and UPLC-IMS-QTOF/MS to detect and relatively quantify metabolites in 30 lettuce cultivars representing large genetic diversity.Comparison with online databases,the published literature,standards as well using collision cross-section values enabled putative identification of 171 metabolites.Sixteen of these 171 metabolites(including phenolic acid derivatives,glycosylated flavonoids,and one iridoid)were present at significantly different levels in leaf and head type lettuces,which suggested the significant metabolomic variations between the leaf and head types of lettuce are related to secondary metabolism.A combination of the results and metabolic network analysis techniques suggested that leaf and head type lettuces contain not only different levels of metabolites but also have significant variations in the corresponding associated metabolic networks.The novel lettuce metabolite library and novel non-targeted metabolomics strategy devised in this study could be used to further characterize metabolic variations between lettuce cultivars or other plants.Moreover,the findings of this study provide important insight into metabolic adaptations due to natural and human selection,which could stimulate further research to potentially improve lettuce quality,yield,and nutritional value. | Xiao Yang Shiwei Wei Bin Liu Doudou Guo Bangxiao Zheng Lei Feng Yumin Liu Francisco A.Tomás-Barberán Lijun Luo Danfeng Huang | 2018 | Horticulture Research2018，5，1： | 3 |
| 9 | Plant buffering against the high-light stress- induced accumulation of CsGA2ox8 transcripts via alter native splici ng to fi n ely tune gibberelli n levels and maintain hypocotyl elongation显示文摘In plants,alternative splicing(AS)is markedly induced in response to environmental stresses,but it is unclear why plants generate multiple transcripts under stress conditions.In this study,RNA-seq was performed to identify AS events in cucumber seedlings grown under different light intensities.We identi fi ed a novel transcript of the gibberellin(GA)-deactivating enzyme Gibberellin 2-beta-dioxygenase 8(CsGA2ox8).Compared with canonical CsGA2ox8.1,the CsGA2ox8.2 isoform presented intron retention between the second and third exons.Functional analysis proved that the transcript of CsGA2ox8.1 but not CsGA2ox8.2 played a role in the deactivation of bioactive GAs.Moreover,expression analysis demonstrated that both transcripts were upregulated by increased light intensity,but the expression level of CsGA2ox8.1 increased slowly when the light intensity was>400μmol-m-2-s-1 PPFD(photosynthetic photon fl ux density),while the CsGA2ox8.2 transcript levels increased rapidly when the light intensity was>200 pmol-m-2-s-1 PPFD.Our fi ndings provide evidence that plants might fi nely tune their GA levels by buffering against the normal transcripts of CsGA2ox8 through AS. | Bin Liu Shuo Zhao Pengli Li Yilu Yin Qingliang Niu Jinqiang Yan Danfeng Huang | 2021 | Horticulture Research2021，8，1： | 2 |
| 10 | Cytoplasmic and nuclear genome variations of rice hybrids and their parents inform the trajectory and strategy of hybrid rice breeding显示文摘The male sterility(MS)line is a prerequisite for efficient production of hybrid seeds in rice,a self-pollinating species.MS line breeding is pivotal for hybrid rice improvement.Understanding the historical breeding tra-jectory will help to improve hybrid rice breeding strategies.Maternally inherited cytoplasm is an appro-priate tool for phylogenetic reconstruction and pedigree tracing in rice hybrids.In this study,we analyzed the cytoplasmic genomes of 1495 elite hybrid rice varieties and identified five major types of cytoplasm,which correspond to different hybrid production systems.As the cytoplasm donors for hybrids,461 MS lines were also divided into five major types based on cytoplasmic and nuclear genomic architecture.Spe-cific core accessions cooperating with different fertility-associated genes drove the sequence divergence of MS lines.Dozens to hundreds of convergent and divergent selective sweeps spanning several agro-nomic trait-associated genes were identified among different types of MS lines.We further analyzed the cross patterns between different types of MS lines and their corresponding restorers.This study system-atically analyzed the cytoplasmic genomes of rice hybrids revealed their relationships with nuclear ge-nomes of MS lines,and illustrated the trajectory of hybrid rice breeding and the strategies for breeding different types of MS lines providing new insights for future improvement of hybrid rice. | Zhoulin Gu Zhou Zhu Zhen Li Qilin Zhan Qi Feng Congcong Zhou Qiang Zhao Yan Zhao Xiaojian Peng Bingxin Dai Rongrong Sun Yan Li Hengyun Lu Lei Zhang Tao Huang Junyi Gong Danfeng Lv Xuehui Huang Bin Han | 2021 | Molecular Plant2021，14，12： | 2 |
| 11 | Comparison of PM_(2.5) and CO_(2) Concentrations in Large Cities of China during the COVID-19 Lockdown显示文摘Estimating the impacts on PM_(2.5)pollution and CO_(2)emissions by human activities in different urban regions is important for developing efficient policies.In early 2020,China implemented a lockdown policy to contain the spread of COVID-19,resulting in a significant reduction of human activities.This event presents a convenient opportunity to study the impact of human activities in the transportation and industrial sectors on air pollution.Here,we investigate the variations in air quality attributed to the COVID-19 lockdown policy in the megacities of China by combining in-situ environmental and meteorological datasets,the Suomi-NPP/VIIRS and the CO_(2)emissions from the Carbon Monitor project.Our study shows that PM_(2.5)concentrations in the spring of 2020 decreased by 41.87%in the Yangtze River Delta(YRD)and 43.30%in the Pearl River Delta(PRD),respectively,owing to the significant shutdown of traffic and manufacturing industries.However,PM_(2.5)concentrations in the Beijing-Tianjin-Hebei(BTH)region only decreased by 2.01%because the energy and steel industries were not fully paused.In addition,unfavorable weather conditions contributed to further increases in the PM_(2.5)concentration.Furthermore,CO_(2)concentrations were not significantly affected in China during the short-term emission reduction,despite a 19.52%reduction in CO_(2)emissions compared to the same period in 2019.Our results suggest that concerted efforts from different emission sectors and effective long-term emission reduction strategies are necessary to control air pollution and CO_(2)emissions. | Chuwei LIU Zhongwei HUANG Jianping HUANG Chunsheng LIANG Lei DING Xinbo LIAN Xiaoyue LIU Li Zhang Danfeng WANG | 2022 | Advances in Atmospheric Sciences2022，39，6： | 2 |
| 12 | Possible link between new coronavirus variants and atmospheric lightning and seawater intrusion显示文摘自新型冠状病毒肺炎暴发一年多以来,已经对全球产生深远影响.新型冠状病毒肺炎变异毒株的出现使当前疫情发展充满了不确定性.从这方面出发,我们讨论病毒变异与大气因素之间的联系.根据固氮过程和硝酸盐在人体中的转化过程,我们提出了新型冠状病毒肺炎变异毒株的出现或许和闪电以及海水入侵有联系.我们的研究对新型冠状病毒肺炎变异毒株可能的产生原因提供新的观点. | Jianping Huang Yingjie Zhao Danfeng Wang | 2022 | Atmospheric and Oceanic Science Letters2022，15，1： | 2 |
| 13 | Tumor extracellular vesicles mediate anti-PD-L1 therapyresistance by decoying anti-PD-L1显示文摘PD-L1+tumor-derived extracellular vesicles(TEVs)cause systemic immunosuppression and possibly resistance to anti-PD-L1 antibody(αPD-L1)blockade.However,whether and how PD-L1+TEVs mediateαPD-L1 therapy resistance is unknown.Here,we show that PD-L1+TEVs substantially decoyαPD-L1 and that TEV-boundαPD-L1 is more rapidly cleared by macrophages,causing insufficient blockade of tumor PD-L1 and subsequentαPD-L1 therapy resistance.Inhibition of endogenous production of TEVs by Rab27a or Coro1a knockout reversesαPD-L1 therapy resistance.Either an increasedαPD-L1 dose or macrophage depletion mediated by the clinical drug pexidartinib abolishesαPD-L1 therapy resistance.Moreover,in the treatment cycle with the same total treatment dose ofαPD-L1,high-dose and low-frequency treatment had better antitumor effects than low-dose and highfrequency treatment,induced stronger antitumor immune memory,and eliminatedαPD-L1 therapy resistance.Notably,in humanized immune system mice with human xenograft tumors,both increasedαPD-L1 dose and high-dose and low-frequency treatment enhanced the antitumor effects ofαPD-L1.Furthermore,increased doses ofαPD-L1 andαPD-1 had comparable antitumor effects,butαPD-L1 amplified fewer PD-1+Treg cells,which are responsible for tumor hyperprogression.Altogether,our results reveal a TEV-mediated mechanism ofαPD-L1-specific therapy resistance,thus providing promising strategies to improveαPD-L1 efficacy. | Jiming Chen Jie Yang Wenhui Wang Danfeng Guo Chengyan Zhang Shibo Wang Xinliang Lu Xiaofang Huang Pingli Wang Gensheng Zhang Jing Zhang Jianli Wang Zhijian Cai | 2022 | Cellular & Molecular Immunology2022，19，11： | 1 |
| 14 | Ecological farming in Europe-a model for China?显示文摘 | Philipp Lehne Song Shiwei Huang Danfeng | 2006 | Journal of Shanghai Jiaotong University:Agricultural Science2006，，： | 1 |
| 15 | Amino acids as a nitrogen source for tomato seedlings: The use of dual-labeled ( 13 C, 15 N) glycine to test for direct uptake by tomato seedlings显示文摘 | Tida Ge Shiwei Song P. Roberts D.L. Jones Danfeng Huang K. Iwasaki | 2009 | Environmental and Experimental Botany2009，，3： | 1 |
| 16 | Temperature-driven growth shape simulation and model of greenhouse melon leaves显示文摘 | Liying Chang Sanpeng He Minghan Chi Danfeng Huang | 2010 | Mathematical and Computer Modelling2010，，3： | 1 |
| 17 | Discovery of a mammalian FASN inhibitor against xenografts of non-small cell lung cancer and melanoma显示文摘Dear Editor,Cancer cells need to reprogram fatty acid(FA)metabolism to promote cell growth and survival through exogenous lipid uptake and FA biosynthesis catalyzed by the multidomain containing mammalian FA synthase(FASN).1,2 The bidirectional relationships of oncogenic signaling and de novo lipogenesis(DNL)suggest that FASN is a druggable target in many cancers. | Danfeng Cao Jie Yang Youchao Deng Meng Su Yeji Wang Xueqiong Feng Yi Xiong Enhe Bai Yanwen Duan Yong Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 1 |
| 18 | The ring - opening of dicyclopentadiene with titanocene complexes显示文摘 | Liu Jianfei Zhang Danfeng Huang Jiling | 1999 | Joumal of Molec- ular Catalysis A1999，142，3： | 1 |
| 19 | Effects of potassium levels on fruit quality of muskmelon in soilless medium culture显示文摘 | Duo Lin Danfeng Huang Shiping Wang | 2004 | Scientia Horticultruae2004，102，： | 1 |
| 20 | Nickel (显示文摘 Organozinc reagent is one of the earliest organometallic compounds prepared. Investigation of its application in organic synthesis had been completed before 1880.However, it was replaced at the turn of the century by the more reactive organomagnesiun reagent except Reformatsky reaction because of its low reactivity toward most organic electrophiles. In 1978, Mukaiyama first reported that Et2Zn reacted with benzaldehyde in the presence of aminoalcohol to give 1, 2-addition product in excellent yield. Pursuant to this report, a lot of papers about the reaction of organozinc reagent with organic electrophiles have been appeared. However, most of the researches focused on dialkylzinc regents, few papers on study of organozinc halides had appeared until 1988.
…… | HUANG DanFeng | 2001 | Chemical Research in Chinese Universities2001，17，z1： | 0 |
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