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| 1 | Growth-associated protein 43 and neural cell adhesion molecule expression following bone marrow-derived mesenchymal stem cell transplantation in a rat model of ischemic brain injury显示文摘BACKGROUND:Transplantation of bone marrow-derived mesenchymal stem cells(BMSCs) improves motor functional recovery,but the mechanisms remain unclear.OBJECTIVE:To investigate expression of growth-associated protein 43(GAP-43) and neural cell adhesion molecule following BMSC transplantation to the lateral ventricle in rats with acute focal cerebral ischemic brain damage.DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment using immunohistochemistry was performed at the laboratories of Department of Neurology,Renmin Hospital of Wuhan University and Doctoral Scientific Research Work Station of C-BONS PHARMA,Hubei Province,China,from January 2007 to December 2008.MATERIALS:Monoclonal mouse anti-rat 5-bromo-2-deoxyuridine and neural cell adhesion molecule antibodies were purchased from Sigma,USA;monoclonal mouse anti-rat GAP-43 antibody was purchased from Wuhan Boster,China.METHODS:Rat models of right middle cerebral artery occlusion were established using the thread method.At 1 day after middle cerebral artery occlusion,20 μL culture solution,containing 5 × 105 BMSCs,was transplanted to the left lateral ventricle using micro-injection.MAIN OUTCOME MEASURES:Scores of neurological impairment were measured to assess neural function.Expression of GAP-43 and neural cell adhesion molecule at the lesion areas was examined by immunohistochemistry.RESULTS:GAP-43 and neural cell adhesion molecule expression was low in brain tissues of the sham-operated group,but expression increased at the ischemic boundary(P < 0.05).Transplantation of BMSCs further enhanced expression of GAP-43 and neural cell adhesion molecule(P < 0.05) and remarkably improved neurological impairment of ischemic rats(P < 0.05).CONCLUSION:BMSC transplantation promoted neurological recovery in rats by upregulating expression of GAP-43 and neural cell adhesion molecule. | Yu Peng Qimei Zhang Hui You Weihua Zhuang Ying Zhang Chengyan Li | 2010 | Neural Regeneration Research2010，5，13： | 18 |
| 2 | TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy显示文摘 | Chengyan Wang Xuming Tang Xiaomeng Sun Zhenchuan Miao Yaxin Lv Yanlei Yang Huidan Zhang Pengbo Zhang Yang Liu LiyingDu Yang Gao Ming Yin Mingxiao Ding Hongkui Deng | 2012 | Cell Research2012，22，1： | 17 |
| 3 | Prostate cancer identification: quantitative analysis of T2-weighted MR images based on a back propagation artificial neural network model显示文摘Computer-aided diagnosis(CAD) systems have been proposed to assist radiologists in making diagnostic decisions by providing helpful information. As one of the most important sequences in prostate magnetic resonance imaging(MRI), image features from T2-weighted images(T2WI) were extracted and evaluated for the diagnostic performances by using CAD. We extracted 12 quantitative image features from prostate T2-weighted MR images. The importance of each feature in cancer identification was compared in the peripheral zone(PZ) and central gland(CG), respectively. The performance of the computer-aided diagnosis system supported by an artificial neural network was tested. With computer-aided analysis of T2-weighted images, many characteristic features with different diagnostic capabilities can be extracted. We discovered most of the features(10/12) had significant difference(P<0.01) between PCa and non-PCa in the PZ, while only five features(sum average, minimum value, standard deviation, 10 th percentile, and entropy) had significant difference in CG. CAD prediction by features from T2 w images can reach high accuracy and specificity while maintaining acceptable sensitivity. The outcome is convictive and helpful in medical diagnosis. | ZHAO Kai WANG ChengYan HU Juan YANG XueDong WANG He LI FeiYu ZHANG XiaoDong ZHANG Jue WANG XiaoYing | 2015 | Science China(Life Sciences)2015，58，7： | 16 |
| 4 | The impacts of conservation agriculture on crop yield in China depend on specific practices, crops and cropping regions显示文摘For smooth and wide application of conservation agriculture(CA), remaining uncertainties about its impacts on crop yield need to be reduced. Based on previous field experiments in China, a meta-analysis was performed to quantify the actual impacts of CA practices(NT: no/reduced-tillage only, CTSR: conventional tillage with straw retention, NTSR: NT with straw retention) on crop yields as compared to conventional tillage without straw retention(CT).Although CA practices increased crop yield by 4.6% on average, there were large variations in their impacts. For each CA practice, CTSR and NTSR significantly increased crop yield by 4.9%and 6.3%, respectively, compared to CT. However, no significant effect was found for NT. Among ecological areas, significant positive effects of CA practices were found in areas with an annual precipitation below 600 mm. Similar effects were found in areas with annual mean air temperature above 5 °C. For cropping regions, CA increased crop yield by 6.4% and 5.5%compared to CT in Northwest and South China, respectively, whereas no significant effects were found in the North China and Northeast China regions. Among crops, the positive effects of CA practices were significantly higher in maize(7.5%) and rice(4.1%) than in wheat(2.9%). NT likely decreased wheat yield. Our results indicate that there are great differences in the impacts of CA practices on crop yield, owing to regional variation in climate and crop types. CA will most likely increase maize yield but reduce wheat yield. It is strongly recommended to apply CA with crop straw retention in maize cropping areas and seasons with a warm and dry climate pattern. | Chengyan Zheng Yu Jiang Changqing Chen Yanni Sun Jinfei Feng Aixing Deng Zhenwei Song Weijian Zhang | 2014 | The Crop Journal2014，2，5： | 15 |
| 5 | Quantitative analysis of diffusion-weighted magnetic resonance images:differentiation between prostate cancer and normal tissue based on a computer-aided diagnosis system显示文摘Diffusion-weighted imaging(DWI) is considered to be one of the dominant modalities used in prostate cancer(PCa) detection and the assessment of lesion aggressiveness,especially for peripheral zone(PZ) PCa.Computer-aided diagnosis(CAD),which is capable of automatically extracting and evaluating image features,can integrate multiple parameters and improve the detection of PCa.In this study,13 quantitative image features were extracted from DWI by CAD,and diagnostic efficacy was analyzed in both the PZ and transition zone(TZ).The results demonstrated that there was a significant difference(P<0.05) between PCa and non-PCa for nine of the 13 features in the PZ and five of the 13 features in the TZ.Besides,the prediction outcome of CAD had a strong correlation with the DWI scores that were graded by experienced radiologists according to the Prostate Imaging-Reporting and Data System Version 2(PI-RADS v2). | Ge Gao Chengyan Wang Xiaodong Zhang Juan Hu Xuedong Yang He Wang Jue Zhang Xiaoying Wang | 2017 | Science China(Life Sciences)2017，60，1： | 13 |
| 6 | Organic amendments increase corn yield by enhancing soil resilience to climate change显示文摘A 22-year field experiment was conducted in Gongzhuling, Jilin province, China to investigate corn yield response to fertilization practice. Compared to an unfertilized control(CK), all fertilization treatments, including inorganic nitrogen fertilizer only(N), balanced inorganic fertilizers(NPK), NPK plus corn straw(SNPK), and NPK plus farmyard manure(MNPK), resulted in significant increases in corn yield. However, only organic matter amendments sustained increasing yield trends, with annual rates of 0.137 and 0.194 t ha-1for the SPNK and MNPK treatments, respectively(P < 0.05). During the 22 years, the daily mean, maximum and minimum temperatures increased by 0.50, 0.53, and 0.46 °C per decade, whereas precipitation displayed no significant change but showed large seasonal variation. According to a regression analysis, increased air temperature exerted positive effects on corn yields under the SNPK and the MNPK treatments. Under both treatments,soil organic carbon contents and soil nutrient availabilities increased significantly compared to their initial levels in 1990, whereas soil bulk density and total porosity changed slightly under the two treatments, which showed higher soil water storage than other treatments. In contrast, significant increases in soil bulk density and decreases in soil total porosity and soil nutrient availability were observed under the CK, N and NPK treatments. The contributions of soil fertility to corn yield were 28.4%, 37.9%, 38.4%, 39.0%,and 42.9% under CK, N, NPK, SNPK, and MNPK treatments, respectively, whereas climate changes accounted for 27.0%, 14.6%, 12.4%, 11.8%, and 10.8%. These results indicate that, in Northeast China, organic matter amendments can mitigate negative and exploit positive effects of climate change on crop production by enhancing soil quality. | Zhenwei Song Hongjun Gao Ping Zhu Chang Peng Aixing Deng Chengyan Zheng Md Abdul Mannaf Md Nurul Islam Weijian Zhang | 2015 | The Crop Journal2015，3，2： | 8 |
| 7 | Seismic Sedimentology Interpretation Method of Meandering Fluvial Reservoir:From Model to Real Data显示文摘Reservoir architecture of meandering river deposition is complex and traditional seismic facies interpretation method cannot characterize it when layer thickness is under seismic vertical resolution.In this study,a seismic sedimentology interpretation method and workflow for point bar characterization is built.Firstly,the influences of seismic frequency and sandstone thickness on seismic reflection are analyzed by outcrop detection with ground penetrating radar(GPR) and seismic forward modeling.It is found that(1) sandstone thickness can influence seismic reflection of point bar architecture.With the increasing of sandstone thickness from 1/4 wavelength(λ) to λ/2,seismic reflection geometries various from ambiguous reflection,'V' type reflection to 'X' type reflection;(2) seismic frequency can influence reservoirs' seismic reflection geometry.Seismic events follow inclined lateral aggradation surfaces,which is isochronic depositional boundaries,in high frequency seismic data while the events extend along lithologic surfaces,which are level,in low frequency data.Secondly,strata slice interpretation method for thin layer depositional characterization is discussed with seismic forward modeling.Lastly,a method and workflow based on the above study is built which includes seismic frequency analysis,90 o phasing,stratal slicing and integrated interpretation of slice and seismic profile.This method is used in real data study in Tiger shoal,the Gulf of Mexico.Two episodes of meandering fluvial deposition is recognized in the study layer.Sandstone of the lower unit,which is formed in low base level stage,distributes limited.Sandstone distribution dimension and channel sinuosity become larger in the upper layer,which is high base level deposition. | Tao Zhang Xianguo Zhang Chengyan Lin Jingfeng Yu Shouxiu Zhang | 2015 | Journal of Earth Science2015，26，4： | 8 |
| 8 | Activated cytotoxic lymphocytes promote tumor progression by increasing the ability of 3LL tumor cells to mediate MDSC chemoattraction via Fas signaling显示文摘Fas/FasL 系统播送细胞内部的 apoptotic 发信号,导致房间 apoptosis。然而,船边交货发信号也除了导致肿瘤房间 apoptosis 施加 non-apoptotic 功能。例如,船边交货发信号导致肺癌症肿瘤房间生产前列腺素 E2 (PGE2 ) 和成员导出 myeloid 的 suppressor 房间(MDSC ) 。激活的细胞毒素的 T 淋巴细胞(CTL ) 导致并且表示 FasL 在房间仍然是的 apoptosis 抵抗的肿瘤上在 CTL 开始的船边交货激活的 FasL,而是效果的高水平大部分不清楚。我们从 OT-1 老鼠净化了激活的 CD8 + T 房间,在肿瘤房间逃跑上评估了船边交货激活的规章的效果并且调查了相关机制。我们发现 CTL 导致了肿瘤细胞分泌 PGE2 和增加肿瘤经由船边交货发信号的 MDSC 的调停房间的 chemoattraction,它对肿瘤生长有利。我们的结果显示 CTL 可以参予肿瘤免疫者避免过程。就我们的知识而言,这是 CTL 在肿瘤逃跑由起一个作用的新奇机制。我们的调查结果含有经由对肿瘤的否定有免疫力的回答的减小提高 antitumor 免疫者反应的策略通过船边交货发信号由 CTL 支持了。 | Fei Yang Yinxiang Wei Zhijian Cai Lei Yu Lingling Jiang Chengyan Zhang Huanmiao Yan Qingqing Wang Xuetao Cao Tingbo Liang Jianli Wang | 2015 | Cellular & Molecular Immunology2015，12，1： | 6 |
| 9 | High-density genetic map construction and identification of loci controlling flower-type traits in Chrysanthemum(Chrysanthemum×morifolium Ramat.)显示文摘Flower type is an important and extremely complicated trait of chrysanthemum.The corolla tube merged degree(CTMD)and the relative number of ray florets(RNRF)are the two key factors affecting chrysanthemum flower type.However,few reports have clarified the inheritance of these two complex traits,which limits directed breeding for flower-type improvement.In this study,305 F1 hybrids were obtained from two parents with obvious differences in CTMD and RNRF performance.Using specific-locus amplified fragment sequencing(SLAF-seq)technology,we constructed a high-density genetic linkage map with an average map distance of 0.76 cM.Three major QTLs controlling CTMD and four major QTLs underlying RNRF were repeatedly detected in the 2 years.Moreover,the synteny between the genetic map and other Compositae species was investigated,and weak collinearity was observed.In QTL regions with a high degree of genomic collinearity,eight annotated genes were probed in the Helianthus annuus L.and Lactuca sativa L.var.ramosa Hort.genomes.Furthermore,20 and 11 unigenes were identified via BLAST searches between the SNP markers of the QTL regions and the C.vestitum and C.lavandulifolium transcriptomes,respectively.These results lay a foundation for molecular marker-assisted breeding and candidate gene exploration in chrysanthemum without a reference assembly. | Xuebin Song Yuhui Xu Kang Gao Guangxun Fan Fan Zhang Chengyan Deng Silan Dai He Huang Huaigen Xin Yingying Li | 2020 | Horticulture Research2020，7，1： | 5 |
| 10 | Long-term inorganic plus organic fertilization increases yield and yield stability of winter wheat显示文摘An understanding of wheat yield and yield stability response to fertilization is important for sustainable wheat production. A 36-year long-term fertilization experiment was employed to evaluate the yield and yield stability of winter wheat. Five fertilization regimes were compared,including(1) CK, no fertilizer;(2) NPK, inorganic fertilizer only;(3) O, organic fertilizer only;(4)NPKO, 50% of NPK plus 50% of O, and(5) HNPKO, 80% of NPK plus 80% of O. The greatest yield increase was recorded in HNPKO, followed by NPKO, with O producing the lowest mean yield increase. Over the 36 years, the rate of wheat yield increase in fertilized plots ranged from95.31 kg ha-1 year-1 in the HNPKO to 138.65 kg ha-1 year-1 in the O. Yield stability analysis using the additive main effects and multiplicative interactions(AMMI) method assigned 62.3%, 26.3%,and 11.4% of sums of squares to fertilization effect, environmental effect, and fertilization ×environment interaction effect, respectively. The combination of inorganic and organic fertilization(NPKO and HNPKO) appeared to produce more stable yields than O or NPK, with lower coefficients of variation and AMMI stability value. However, wheat grown with O seemed to be the most susceptible to climate change and the least productive among the fertilized plots.Significant correlations of grain yield with soil properties and with mean air temperature were observed. These findings suggest that inorganic + organic fertilizer can increase wheat yield and its stability by improvement in soil fertility and reduction in variability to climate change. | Huan Chen Aixing Deng Weijian Zhang Wei Li Yuqiang Qiao Taiming Yang Chengyan Zheng Chengfu Cao Fu Chen | 2018 | The Crop Journal2018，6，6： | 5 |
| 11 | Optimal yield-related attributes of irrigated rice for high yield potential based on path analysis and stability analysis显示文摘Improvement of yield in rice(Oryza sativa L.) is vital for ensuring food security in China. Both rice breeders and growers need an improved understanding of the relationship between yield and yield-related traits. New indica cultivars(53 in 2007 and 48 in 2008) were grown in Taoyuan,Yunnan province, to identify important components contributing to yield. Additionally, two standard indica rice cultivars with similar yield potentials, II You 107(a large-panicle type) and Xieyou 107(a heavy-panicle type), were planted in Taoyuan, Yunnan province and Nanjing,Jiangsu province, from 2006 to 2008 to evaluate the stability of yield and yield-related attributes.Growth duration(GD), leaf area index(LAI), panicles per m2(PN), and spikelets per m2(SM) were significantly and positively correlated with grain yield(GY) over all years. Sequential path analysis identified PN and panicle weight(PW) as important first-order traits that influenced grain yield. All direct effects were significant, as indicated by bootstrap analysis. Yield potential varied greatly across locations but not across years. Plant height(PH), days from heading to maturity(HM), and grain weight(GW) were stable traits that showed little variation across sites or years, whereas GD(mainly the pre-heading period, PHP) and PN varied significantly across locations. To achieve a yield of 15 t ha-1, a cultivar should have a PH of 110–125 cm, a long GD with HM of approximately 40 days, a PN of 300–400 m-2, and a GW of 29–31 mg. | Ganghua Li Jun Zhang Congdang Yang Yunpan Song Chengyan Zheng Shaohua Wang Zhenghui Liu Yanfeng Ding | 2014 | The Crop Journal2014，2，4： | 4 |
| 12 | Discovery of the Proterozoic low-grade metamorphicsubmarine carbonatite lavas in China显示文摘The carbonatite lavas found in the Kunyang Group were formed in submarine extrusive environment. Many igneous features (e.g. colors, textures, structures, minerals, inclusions) are clear. But most of their petrologic characteristics are different from typical carbonatites over the world. Most petrologic details of the rocks are given by comparison with other carbonatites and adjacent sedimentary dolomites. The discovery of the lavas proves that the carbonatite volcano also existed in Kunyang rift. | Yongbei Zhang Qirong Wei Chengyan Xiu Hao Wang | 1998 | Chinese Science Bulletin1998，43，5： | 4 |
| 13 | Efficient recovery of valuable metals from waste printed circuit boards by microwave pyrolysis显示文摘The recycling of waste printed circuit board(WPCBs) is of great significance for saving resources and protecting the environment. In this study, the WPCBs were pyrolyzed by microwave and the contained valuable metals Cu, Sn and Pb were recovered from the pyrolyzed WPCBs. The effect of pyrolysis temperature and time on the recovery efficiency of valuable metals was investigated. Additionally, the characterization for morphology and surface elemental distribution of pyrolysis residues was carried out to investigate the pyrolysis mechanism. The plastic fiber boards turned into black carbides, and they can be easily separated from the metals by manual. The results indicate that 91.2%, 96.1% and 94.4% of Cu, Sn and Pb can be recovered after microwave pyrolysis at 700 °C for 60 minutes. After pyrolysis, about 79.8%(mass)solid products, 11.9%(mass) oil and 8.3%(mass) gas were produced. These gas and oil can be used as fuel and raw materials of organic chemicals, respectively. This process provides an efficient and energy-saving technology for recovering valuable metals from WPCBs. | Yubo Liu Jialiang Zhang Xu Yang Wenguang Yang Yongqiang Chen Chengyan Wang | 2021 | Chinese Journal of Chemical Engineering2021，34，12： | 2 |
| 14 | Comprehensive utilization of complex rubidium ore resources:Mineral dissociation and selective leaching of rubidium and potassium显示文摘Currently,the process of extracting rubidium from ores has attracted a great deal of attention due to the increasing application of rubidium in high-technology field.A novel process for the comprehensive utilization of rubidium ore resources is proposed in this paper.The process consists mainly of mineral dissociation,selective leaching,and desilication.The results showed that the stable silicon–oxygen tetrahedral structure of the rubidium ore was completely disrupted by thermal activation and the mineral was completely dissociated,which was conducive to subsequent selective leaching.Under the optimal conditions,extractions of 98.67% Rb and 96.23%K were obtained by leaching the rubidium ore.Moreover,the addition of a certain amount of activated Al(OH)_(3) during leaching can effectively inhibit the leaching of silicon.In the meantime,the leach residue was sodalite,which was successfully synthesized to zeolite A by hydrothermal conversion.The proposed process provided a feasible strategy for the green extraction of rubidium and the sustainable utilization of various resources. | Quankuang Zhang Baozhong Ma Chengyan Wang Yongqiang Chen Wenjuan Zhang | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，5： | 2 |
| 15 | Evidence for metasomatic mantle carbonatitic magma extrusion in Mesoproterozoic ore-hosting dolomite rocks in the middle Kunyang rift, central Yunnan, China显示文摘The Kunyang rift lying on the western margin of the Yangtze platform is a rare Precambrian Fe-Cu mineralization zone. WudingLufeng basin that is an important part of the zone is located on the west edge in the middle of the rift. The most important ore-hosting rocks are Mesoproterozoic dolomite rocks in the basin controlled by a ring fracture system, which is a fundamental structure of the basin. Plenty of silicate minerals and acicular apatite, feldspar phenocrysts and small vesicular, flown line and flown plane structures, melt inclusion and high temperature fluid inclusion found in most ore-hosting dolomites suggest that this kind of rocks could not be sedimentary dolomite, marble or hydrothermal carbonate rocks. The Zr/Hf and Nb/Ta values of the rocks are identical with those of associated mantle-derived rocks, and vary widely. For the monomineral dolomite, d18OSMOW‰ = +5.99 to +18.4 and d13CPDB‰ = à3.01 to +0.94, which fall within the range for all carbonatitic volcanic rocks of the world. As for the accessory minerals, the values of d18OSMOW‰ of magnetite (=+3.47 to +5.99‰) are close to that of the mantle (<5.7%), and the d34S‰ values of sul?des (à5.09 to +5.78, averaging +1.50) are close to that of meteorite. For all the ore-bearing dolomite rocks, eNd = +0.19 to +2.27, and the calculated ISr = 0.699143, while for the associated mantle-derived rocks, eNd = +3.18 to +3.72. All the data suggest that the mineral assemblage is not only igneous but also of metasomatic mantle origin. And the presence of acicular apatite indicates that the rocks were formed by magma rapidly cooling. And the phenocryst texture and vesicular, flown and ropy and pyroclastic structures suggest that the igneous rocks were extrusive. Therefore, the ore-bearing dolomite rocks are carbonatitic volcanic rocks. This conclusion implies that most iron and copper ore deposits hosted in the dolomite rocks should be of the carbonatite type. | Yongbei Zhang Hua Bi Longshi Yu Shihua Sun Jiaxiang Qiu Chengyan Xu Hao Wang Renjing Wang | 2008 | Progress in Natural Science:Materials International2008，18，8： | 2 |
| 16 | Performance evaluation of acetone–butanol continuous flash extractive fermentation process显示文摘 | Zhongping Shi Chengyan Zhang Jianxin Chen Zhonggui Mao | 2005 | Bioprocess and Biosystems Engineering2005，，3： | 1 |
| 17 | New development of microstack insulator technology显示文摘 | REN Chengyan YUAN Weiqun ZHANG Dongdong | 2011 | IEEE Transactions on Dielectrics and Electrical Insulation2011，18，4： | 1 |
| 18 | Impacts of planting systems on soil moisture, soil temperature and corn yield in rainfed area of Northeast China显示文摘 | Zhenwei Song Jinrui Guo Zhenping Zhang Taiji Kou Aixing Deng Chengyan Zheng Jun Ren Weijian Zhang | 2013 | European Journal of Agronomy2013，，： | 1 |
| 19 | Boric acid inhibits LPS-induced TNF- α formation through a thiol-dependent mechanism in THP-1 cells显示文摘 | Jun Cao Liping Jiang Xiaomei Zhang Xiaofeng Yao Chengyan Geng Xiangxin Xue Laifu Zhong | 2008 | Journal of Trace Elements in Medicine and Biology2008，，： | 1 |
| 20 | Tumor extracellular vesicles mediate anti-PD-L1 therapyresistance by decoying anti-PD-L1显示文摘PD-L1+tumor-derived extracellular vesicles(TEVs)cause systemic immunosuppression and possibly resistance to anti-PD-L1 antibody(αPD-L1)blockade.However,whether and how PD-L1+TEVs mediateαPD-L1 therapy resistance is unknown.Here,we show that PD-L1+TEVs substantially decoyαPD-L1 and that TEV-boundαPD-L1 is more rapidly cleared by macrophages,causing insufficient blockade of tumor PD-L1 and subsequentαPD-L1 therapy resistance.Inhibition of endogenous production of TEVs by Rab27a or Coro1a knockout reversesαPD-L1 therapy resistance.Either an increasedαPD-L1 dose or macrophage depletion mediated by the clinical drug pexidartinib abolishesαPD-L1 therapy resistance.Moreover,in the treatment cycle with the same total treatment dose ofαPD-L1,high-dose and low-frequency treatment had better antitumor effects than low-dose and highfrequency treatment,induced stronger antitumor immune memory,and eliminatedαPD-L1 therapy resistance.Notably,in humanized immune system mice with human xenograft tumors,both increasedαPD-L1 dose and high-dose and low-frequency treatment enhanced the antitumor effects ofαPD-L1.Furthermore,increased doses ofαPD-L1 andαPD-1 had comparable antitumor effects,butαPD-L1 amplified fewer PD-1+Treg cells,which are responsible for tumor hyperprogression.Altogether,our results reveal a TEV-mediated mechanism ofαPD-L1-specific therapy resistance,thus providing promising strategies to improveαPD-L1 efficacy. | Jiming Chen Jie Yang Wenhui Wang Danfeng Guo Chengyan Zhang Shibo Wang Xinliang Lu Xiaofang Huang Pingli Wang Gensheng Zhang Jing Zhang Jianli Wang Zhijian Cai | 2022 | Cellular & Molecular Immunology2022，19，11： | 1 |
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