| 1 | Discovery of a mammalian FASN inhibitor against xenografts of non-small cell lung cancer and melanoma显示文摘Dear Editor,Cancer cells need to reprogram fatty acid(FA)metabolism to promote cell growth and survival through exogenous lipid uptake and FA biosynthesis catalyzed by the multidomain containing mammalian FA synthase(FASN).1,2 The bidirectional relationships of oncogenic signaling and de novo lipogenesis(DNL)suggest that FASN is a druggable target in many cancers. | Danfeng Cao Jie Yang Youchao Deng Meng Su Yeji Wang Xueqiong Feng Yi Xiong Enhe Bai Yanwen Duan Yong Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 1 |
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