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| 1 | Mesoporous silica nanorods intrinsically doped with photosensitizers as a multifunctional drug carrier for combination therapy of cancer显示文摘Mesoporous 硅石 nanoparticles (MSN ) 由于他们的大表面区域,悦耳的尺寸,灵巧的修正和可观的 biocompatibility 作为药交货搬运人在最近的年里吸引了巨大的注意。在这个工作,我们制作内在地与使分子具有感光性被做的 MSN 的一种有趣的类型,氯 e6 (Ce6 ) 。由增加在硅石矩阵内做的 Ce6 的数量, MSN 的形态学从范围改变到像杆的形状,这被发现。获得的做 Ce6 的 mesoporous 硅石 nanorods (CMSNR ) 不仅能为光力学的治疗,而且罐头生产汗衫氧也与由利用他们的 mesoporous 结构装载能力的高药用作一个药交货平台。比作球形的 nanoparticles,有更大的方面比率的 CMSNR 由癌症房间显示出许多更快的举起,这被发现。与作为模型药采用的 doxorubicin (纪录影片) ,联合光力学并且化疗被执行,在 vitro 并且在 vivo 完成 synergistic 反肿瘤效果。我们的学习介绍一个基于 MSN 的药交货平台的一个新图案,它内在地荧光灯、有能力用作一个光力学的代理人,为未来答应癌症的指导成像的联合治疗。 | Guangbao Yang Hua Gong Xiaoxin Qian Pengli Tan Zhiwei Li Teng Liu Jingjing Liu Youyong Li Zhuang Liu | 2015 | Nano Research2015，8，3： | 11 |
| 2 | Thermodynamic study and syntheses of β-SiAlON ceramics显示文摘Based on the thermodynamic study of β-SiAlON and one section of Si-Al-O-N phase diagram for Si/Al=9 at 1773 K, the pure β-SiAlON (Si6-ZAlZOZN8-Z) ceramics with different Z values (viz. 1.4, 1.8, 2.2, 2.6, 3.0) were synthesized at different temperatures using the pressure-less technique. The relationship of the experimental-saturated Z value (the maximum Z value at a constant temperature) with temperature was then discussed. The experimental results indicated that there is a good linear relationship between Z value and temperature, which is Z=_10.76+0.0071T (R=0.9985). The β-SiAlON stability regions at different temperatures were exhibited in a sketch phase diagram of Si3N4-SiO2-Al2O3-AlN system. In addi- tion, the relationship between experimental-saturated Z value and the lattice parameters was also characterized, and the linear regression results a=7.604+0.02872Z and c=2.908+0.02496Z were obtained, respectively. | DONG PengLi WANG XiDong ZHANG Mei GUO Min LI WenChao | 2009 | Science China(Technological Sciences)2009，52，11： | 5 |
| 3 | A preliminary analysis of the surface chemistry of atmospheric aerosol particles in a typical urban area of Beijing显示文摘Atmospheric aerosol particle samples were collected using an Ambient Eight Stage(Non-Viable) Cascade Impactor Sampler in a typical urban area of Beijing from 27 th Sep.to 5th Oct.,2009.The surface chemistry of these aerosol particles was analyzed using Static Time of Flight-Secondary Ion Mass Spectrometry(Static TOF-SIMS).The factors influencing surface compositions were evaluated in conjunction with the air pollution levels,meteorological factors,and air mass transport for the sampling period.The results show that a variety of organic ion groups and inorganic ions/ion groups were accumulated on the surfaces of aerosol particles in urban areas of Beijing;and hydrophobic organic compounds with short-or middle-chain alkyl as well as hydrophilic secondary inorganic compounds were observed.All these compounds have the potential to affect the atmospheric behavior of urban aerosol particles.PM1.1–2.1and PM3.3–4.7had similar elements on their surfaces,but some molecules and ionic groups demonstrated differences in Time of Flight-Secondary Ion Mass Spectrometry spectra.This suggests that the quantities of elements varied between PM1.1–2.1and PM3.3–4.7.In particular,more intense research efforts into fluoride pollution are required,because the fluorides on aerosol surfaces have the potential to harm human health.The levels of air pollution had the most significant influence on the surface compositions of aerosol particles in our study.Hence,heavier air pollution was associated with more complex surface compositions on aerosol particles.In addition,wind,rainfall,and air masses from the south also greatly influenced the surface compositions of these urban aerosol particles. | Zhengzheng Zhang Hong Li Hongyan Liu Runxiang Ni Jinjuan Li Liqun Deng Defeng Lu Xueli Cheng Pengli Duan Wenjun Li | 2016 | Journal of Environmental Sciences2016，28，9： | 5 |
| 4 | Highly sensitive flexible capacitive pressure sensor with a broad linear response range and finite element analysis of micro-array electrode显示文摘With the continuous development of wearable electronics,health care and smart terminals,highly performance flexible pressure sensors present a huge application prospect.In this study,by introducing the micro-array structured electrodes and dielectric layers with high dielectric constant,capacitive pressure sensor fabricated with a brand new preparation strategy and highly sensitive is proposed.The prepared micro-array structure is the basis for sensors with high sensitivity.Besides,the contact area between the two electrodes changes from linear to planar with the increased loading,which result in a wider linear responding range.In addition,by introducing ceramic dielectric material-barium titanate(BT)fillers into the dielectric layer to increase it’s the dielectric constant,the sensitivity of the sensor shows two-fold increase.Moreover,the sensitivity gradients can be tuned by changing the loading contents of BT particles.Hence,compared with parallel board capacitive sensors with ordinary dielectric layer,these sensors exhibit excellent performance as follow,high sensitivity(up to 4.9 kPa^(-1))under low pressure range(0-2500 Pa),low detection limit(<1.7 Pa),short response time(<50 ms),a stable response over 5000 loading-unloading cycles,bending stability and an adjustable sensitivity.Further,the flexible pressure sensor can detect the pressure of the water droplets and monitor human movement behavior.With the facile design and excellent comprehensive properties,the flexible pressure sensor provides a new approach to improve the sensitivity and shows a broad application prospects in the wearable electronics,health care and smart terminals. | Longquan Ma Xuecheng Yu Yuanyuan Yang Yougen Hu Xinyu Zhang Huayuan Li Xing Ouyang Pengli Zhu Rong Sun Ching-ping Wong | 2020 | Journal of Materiomics2020，6，2： | 4 |
| 5 | NLRP3 inflammasome activation determines the fibrogenic potential of PM_(2.5) air pollution particles in the lung显示文摘Airborne fine particulate matter(PM_(2.5))is known to cause respiratory inflammation such as chronic obstructive pulmonary disease and lung fibrosis.NLRP3 inflammasome activation has been implicated in these diseases;however,due to the complexity in PM_(2.5)compositions,it is difficult to differentiate the roles of the components in triggering this pathway.We collected eight real-life PM_(2.5)samples for a comparative analysis of their effects on NLRP3 inflammasome activation and lung fibrosis.In vitro assays showed that although the PM_(2.5)particles did not induce significant cytotoxicity at the dose range of 12.5to 100μg/m L,they induced potent TNF-αand IL-1βproduction in PMA differentiated THP-1 human macrophages and TGF-β1 production in BEAS-2B human bronchial epithelial cells.At the dose of 100μg/m L,PM_(2.5)induced NLRP3 inflammasome activation by inducing lysosomal damage and cathepsin B release,leading to IL-1βproduction.This was confirmed by using NLRP3-and ASC-deficient cells as well as a cathepsin B inhibitor,ca-074 ME.Administration of PM_(2.5)via oropharyngeal aspiration at 2 mg/kg induced significant TGF-β1 production in the bronchoalveolar lavage fluid and collagen deposition in the lung at 21days post-exposure,suggesting PM_(2.5)has the potential to induce pulmonary fibrosis.The ranking of in vitro IL-1βproduction correlates well with the in vivo total cell count,TGF-β1 production,and collagen deposition.In summary,we demonstrate that the PM_(2.5)is capable of inducing NLRP3 inflammasome activation,which triggers a series of cellular responses in the lung to induce fibrosis. | Wei Cao Xiang Wang Jiulong Li Ming Yan Chong Hyun Chang Joshua Kim Jinhong Jiang Yu-Pei Liao Shannon Tseng Sydney Kusumoputro Candice Lau Marissa Huang Pengli Han Pengju Lu Tian Xia | 2022 | Journal of Environmental Sciences2022，34，1： | 3 |
| 6 | Neuroprotective effects of Ginkgo biloba dropping pills in Parkinson's disease显示文摘Parkinson's disease(PD) is the second most common neurodegenerative disease in the world;however,it lacks effective and safe treatments. Ginkgo biloba dropping pill(GBDP), a unique Chinese G. biloba leaf extract preparation, exhibits antioxidant and neuroprotective effects and has a potential as an alternative therapy for PD. Thus, the aims of this study were to evaluate the effects of GBDP in in vitro and in vivo PD models and to compare the chemical constituents and pharmacological activities of GBDP and the G. biloba extract EGb 761. Using liquid chromatography tandem-mass spectrometry, 46 GBDP constituents were identified. Principal component analysis identified differences in the chemical profiles of GBDP and EGb 761. A quantitative analysis of 12 constituents showed that GBDP had higher levels of several flavonoids and terpene trilactones than EGb 761, whereas EGb 761 had higher levels of organic acids.Moreover, we found that GBDP prevented 6-hydroxydopamine-induced dopaminergic neuron loss in zebrafish and improved cognitive impairment and neuronal damage in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced PD mice. Although similar effects were observed after EGb 761 treatment,the neuroprotective effects were greater after GBDP treatment on several endpoints. In addition, in vitro results suggested that the Akt/GSK3β pathway may be involved in the neuroprotective effects of GBDP.These findings demonstrated that GBDP have potential neuroprotective effects in the treatment of PD. | Dingyi Yu Pengli Zhang Junying Li Ting Liu Yaodan Zhang Qingqing Wang Jianbing Zhang Xiaoyan Lu Xiaohui Fan | 2021 | Journal of Pharmaceutical Analysis2021，11，2： | 3 |
| 7 | Plant buffering against the high-light stress- induced accumulation of CsGA2ox8 transcripts via alter native splici ng to fi n ely tune gibberelli n levels and maintain hypocotyl elongation显示文摘In plants,alternative splicing(AS)is markedly induced in response to environmental stresses,but it is unclear why plants generate multiple transcripts under stress conditions.In this study,RNA-seq was performed to identify AS events in cucumber seedlings grown under different light intensities.We identi fi ed a novel transcript of the gibberellin(GA)-deactivating enzyme Gibberellin 2-beta-dioxygenase 8(CsGA2ox8).Compared with canonical CsGA2ox8.1,the CsGA2ox8.2 isoform presented intron retention between the second and third exons.Functional analysis proved that the transcript of CsGA2ox8.1 but not CsGA2ox8.2 played a role in the deactivation of bioactive GAs.Moreover,expression analysis demonstrated that both transcripts were upregulated by increased light intensity,but the expression level of CsGA2ox8.1 increased slowly when the light intensity was>400μmol-m-2-s-1 PPFD(photosynthetic photon fl ux density),while the CsGA2ox8.2 transcript levels increased rapidly when the light intensity was>200 pmol-m-2-s-1 PPFD.Our fi ndings provide evidence that plants might fi nely tune their GA levels by buffering against the normal transcripts of CsGA2ox8 through AS. | Bin Liu Shuo Zhao Pengli Li Yilu Yin Qingliang Niu Jinqiang Yan Danfeng Huang | 2021 | Horticulture Research2021，8，1： | 2 |
| 8 | TOF–SIMS surface analysis of chemical components of size–fractioned urban aerosols in a typical heavy air pollution event in Beijing显示文摘Size–fractioned atmospheric aerosol particles were collected during a typical heavy air pollution event in Beijing. The organic and inorganic components on the surfaces of the samples were analyzed using time–of–flight secondary ion mass spectrometry(TOF–SIMS).The variation characteristics of the surface chemical composition and influencing factors were studied, and the possible sources of these chemical compositions were identified through principal component analysis. The results showed that inorganic components such as crustal elements and sulfate, and organic components such as aliphatic hydrocarbons and oxygen–containing organic groups were present. Some surface components, such as polycyclic aromatic hydrocarbons, heavy metals and fluorides may exert adverse effects on human health. The species and relative percentages of the chemical components varied with particle size, diurnal and pollution progress. During a heavy pollution event, the species and relative percentages of secondary components such as oxygen–containing organic groups and sulfurous compounds increased, indicating that particles aged during this event. The surface chemical composition of the aerosol particles was affected mainly by emissions from coal combustion and motor vehicles. In addition, air pollution, meteorological factors, and air mass transport also exerted a significant effect on the surface chemical composition of aerosol particles. | Wenjun Li Hong Li Jinjuan Li Xueli Cheng Zhengzheng Zhang Fahe Chai Hao Zhang Ting Yang Pengli Duan Defeng Lu Yizhen Chen | 2018 | Journal of Environmental Sciences2018，30，7： | 2 |
| 9 | The effects of laser shock peening on fatigue life in Ni-based superalloy显示文摘 | HE Weifeng LI Yinghong QI Pengli | 2010 | Advanced Materials Research2010，135，： | 1 |
| 10 | Self-cleaning of superhydrophobic nanostructured surfaces at low humidity enhanced by vertical electric field显示文摘Self-cleaning is the key factor that makes superhydrophobic nanostructured materials have wide applications.The self-cleaning effect,however,strongly depends on formations and movement of water droplets on superhydrophobic nanostructured surfaces,which is greatly restricted at low humidity(<7.6 g·kg^(-1)).Therefore,we propose a self-cleaning method at low humidity in which the pollution is electro-aggregated and driven in the electric field to achieve the aggregation and cleaning large areas.The cleaning efficiency of this method is much higher than that of water droplet roll-off,and will not produce'pollution bands'.A simplified numerical model describing pollution movements is presented.Simulation results are consistent with experimental results.The proposed method realizes the self-cleaning of superhydrophobic nanostructured surfaces above dew point curve for the first time,which extends applications of superhydrophobic nanostructured materials in low humidity,and is expected to solve self-cleaning problems of outdoor objects in low humidity areas(<5.0 g·kg^(-1)). | Yijie Liu Yujun Guo Xueqin Zhang Guoqiang Gao Chaoqun Shi Guizao Huang Pengli Li Qi Kang Xingyi Huang Guangning Wu | 2022 | Nano Research2022，15，5： | 1 |
| 11 | Two new taxoids from the needles and stems of Taxus chinensis 显示文摘 | Xia Z H PengLY Li RT | 2005 | Heterocycles2005，65，6： | 1 |
| 12 | Caffeine protects against alcoholic liver injury by attenuating inflammatory response and oxidative stress显示文摘 | Xiongwen Lv Zhen Chen Jun Li Lei Zhang Hongfeng Liu Cheng Huang Pengli Zhu | 2010 | Inflammation Research2010，，8： | 1 |
| 13 | PL1 fusion gene: a novel visual selectable marker gene that confers tolerance to multiple abiotic stresses in transgenic tomato显示文摘 | Feng Jin Shu Li Lijie Dang Wenting Chai Pengli Li Ning Wang | 2012 | Transgenic Research2012，，5： | 1 |
| 14 | Preparation, Characterization and Pharmacokinetics of Fluorescence Labeled Propylene Glycol Alginate Sodium Sulfate显示文摘A rapid and sensitive fluorescence labeling method was developed and validated for the microanalysis of a sulfated polysaccharide drug,namely propylene glycol alginate sodium sulfate(PSS), in rat plasma. Fluorescein isothiocyanate(FITC) was selected to label PSS, and 1, 6-diaminohexane was used to link PSS and FITC in order to prepare FITC-labeled PSS(F-PSS) through a reductive amination reaction. F-PSS was identified by UV-Vis, FT-IR and 1H-NMR spectrum. The cell stability and cytotoxicity of F-PSS were tested in Madin-Darby canine kidney(MDCK) cells. The results indicated that the labeling efficiency of F-PSS was 0.522% ± 0.0248% and the absolute bioavailability was 8.39%. F-PSS was stable in MDCK cells without obvious cytotoxicity. The method was sensitive and reliable; it showed a good linearity, precision, recovery and stability. The FITC labeling method can be applied to investigating the absorption and metabolism of PSS and other polysaccharides in biological samples. | LI Pengli LI Chunxia XUE Yiting ZHANG Yang LIU Hongbing ZHAO Xia YU Guangli GUAN Huashi | 2014 | Journal of Ocean University of China2014，13，4： | 1 |
| 15 | Modification of polyethersulfone membrane by grafting bovine serum albumin on the surface of polyethersulfone/poly(acrylonitrile-co-acrylic acid) blended membrane显示文摘 | Baohong Fang Qiyao Ling Weifeng Zhao Yunli Ma Pengli Bai Qiang Wei Haifeng Li Changsheng Zhao | 2008 | Journal of Membrane Science2008，，1： | 1 |
| 16 | Preparation of polyethersulfone–organophilic montmorillonite hybrid particles for the removal of bisphenol A显示文摘 | Fuming Cao Pengli Bai Haocheng Li Yunli Ma Xiaopei Deng Changsheng Zhao | 2008 | Journal of Hazardous Materials2008，，2： | 1 |
| 17 | The inhibitory effect of BKca channels induced by autoantibodies against angiotensin Ⅱ type 1 receptor is independent of ATIR显示文摘 | Peng Wang Suli Zhang Jie Ren Li Yan Lina Bai Li Wang Pengli Wang Jingwei Bian Xiaochen Yin Huirong Liu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，6： | 1 |
| 18 | Facile preparation of monodisperse,impurity-free,and antioxidation copper nanoparticles on a large scale for application in conductive ink显示文摘 | Zhang Yu Zhu Pengli Li Gang | 2014 | ACS Application Material Interfaces2014，6，5： | 1 |
| 19 | Cloning and expressional characterization of soybean GmLls1 gene显示文摘Maize Lls1 (lethal leaf-spot 1) gene and its Arabidopsis orthologue AtAcd1 have been sug-gested to encode pheide a oxygenase (PaO), a key enzyme catalyzing chlorophyll breakdown. To further elucidate the molecular mechanism that regulates chlorophyll catabolism during soybean leaf senes-cence, a soybean Lls1 homolog was cloned and designated as GmLls1 (GenBank Accession No. DQ154009). Database searches using the deduced protein sequence revealed that it was highly ho-mologous to Lls1 genes or Lls1 orthologues in Arabidopsis, maize, cowpea and tomato. Structural analysis of the predicted GmLLS1 protein revealed typical Rieske [2Fe-2S] and mononuclear iron-bind- ing domains as well as the C-terminus CxxC motif that were conserved in and featured PaO homo-logues. RT-PCR results showed that the transcription of GmLls1 was up-regulated in all the three tested senescence systems: the natural leaf senescence process, the dark-induced primary leaf senescence and senescing cotyledons. We have previously de-scribed the involvement of an LRR receptor-like kinase (RLK), RLPK2 in regulation of soybean leaf senescence. Here we report that the expression of GmLls1 gene was dramatically down-regulated by the RNAi-mediated suppression of rlpk2 and, as ex-pected, greatly up regulated by the CaMV 35S pro-moter derived overexpression of this RLK gene. These results suggested that the expression of GmLls1 was controlled by the RLPK2-mediated se-nescence signaling pathway. The observation that the detached rlpk2-RNAi transgenic leaves exhibitedlight-dependent necrotic lesions, which featured | LI Pengli MA Yuanyuan LI Xiaoping ZHANG Liwen WANG Yong WANG Ningning | 2006 | Chinese Science Bulletin2006，51，10： | 1 |
| 20 | Burning Cave-Pipe Coil-Kang Coupled Heating System Research显示文摘Nowadays,people still rely on traditional heating methods in rural areas of northern China,such as Kang(bed-stoves) and burning caves in cold winter.Field measurements of indoor environment were carried out in several rural houses with burning-cave-coil-Kang coupling heating system in northern China.The results show that this system is able to realize the graded use of internal energy of burning cave.The temperature of supply pipe water ranged from 30 ℃ to 50 ℃ which met the demands in 74.7% of time.The surface temperature of Kang maintained at above 25 ℃.Compared with traditional burning cave,using burning-cave-coil-Kang coupled with heating system has a higher thermal efficiency of 48.9%,which is 8.32% higher than the traditional one. | Baogang Zhang Lin Lyu Ming Liu Guanglei Li Pengli Yuan | 2018 | Journal of Harbin Institute of Technology(New Series)2018，25，4： | 0 |
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