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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Jurassic Tectonic Revolution in China and New Interpretation of the “Yanshan Movement”显示文摘摘要:与结构的地质的调查的新数据和高分辨率的同位素的标明日期数据的获得和累积,我们极大地改进了我们从迟了的侏罗记在时期期间发生在东方中国到早白垩纪的构造事件的理解并且可以给性质的新解释,预定并且 Yanshan 运动的 geodynamic 背景。在中间迟了的侏罗记期间(165 挠慬獳漠 ?? | DONG Shuwen ZHANG Yueqiao LONG Changxing YANG Zhenyu JI Qiang WANG Tao HU Jianmin CHEN Xuanhua | 2008 | Acta Geologica Sinica(English Edition)2008，82，2： | 41 |
| 3 | Effects of Cr, Ni and Cu on the Corrosion Behavior of Low Carbon Microalloying Steel in a Cl^- Containing Environment显示文摘The effects of Cr, Ni and Cu on the corrosion behavior of low carbon microalloying steel in a Cl containing environment were investigated. The results revealed that the corrosion process could be divided into the initia stage in which the corrosion rate increased with accumulation of corrosion products and the later stage in which homogeneous and compact inner rust layers started to protect steel substrate out of corrosion mediums. The results of X-ray diffraction (XRD) indicated that the rust layers of the three-group steels (Cr Cr-Ni and Cr-Ni-Cu steels) were composed of α-FeOOH,β-FeOOH,γ-FeOOH, Fe3O4 and large amounts o amorphous compounds. The content of amorphous compounds of CreNieCu steel was about 2%-3% more than that of CreNi steel. The results of electron probe microanalysis (EPMA) showed that Cr concentrated mainly in the inner region of the rust of Cr-Ni-Cu steel, inner/outer interface especially, whereas Ni was uniformly distributed all over the rust and Cu was noticed rarely after 73 wet/dry cycles. The addition of C and Ni was beneficial to the formation of dense and compact inner rust layer, which was the most importan reason for the improvement of corrosion resistance of experimental steel. | Yanlei Zhou Jun Chen Yang Xu Zhenyu Liu | 2013 | Journal of Materials Science & Technology2013，29，2： | 29 |
| 4 | A Strigolactone Biosynthesis Gene Contributed to the Green Revolution in Rice显示文摘Plant architecture is a complex agronomic trait and a major factor of crop yield,which is affected by several important hormones.Strigolactones(SLs)are identified as a new class hormoneinhibiting branching in many plant species and have been shown to be involved in various developmental processes.Genetical and chemical modulation of the SL pathway is recognized as a promising approach to modify plant architecture.However,whether and how the genes involved in the SL pathway could be utilized in breeding still remain elusive.Here,we demonstrate that a partial loss-of-function allele of the SL biosynthesis gene,HIGH TILLERING AND DWARF 1/DWARF17(HTD1/D17),which encodes CAROTENOID CLEAVAGE DIOXYGENASE 7(CCD7),increases tiller number and improves grain yield in rice.We found that the HTD1 gene had been widely utilized and co-selected with Semidwarf 1(SD1),both contributing to the improvement of plant architecture in modern rice varieties since the Green Revolution in the 1960s.Understanding how phytohormone pathway genes regulate plant architecture and how they have been utilized and selected in breeding will lay the foundation for developing the rational approaches toward improving crop yield. | Yuexing Wang Lianguang Shang Hong Yu Longjun Zeng Jiang Hu Shen Ni Yuchun Rao Sanfeng Li Jinfang Chu Xiangbing Meng Lei Wang Ping Hu Jijun Yan Shujing Kang Minghao Qu Hai Lin Tao Wang Quan Wang Xingming Hu Hongqi Chen Bing Wang Zhenyu Gao Longbiao Guo Dali Zeng Xudong Zhu Guosheng Xiong Jiayang Li Qian Qian | 2020 | Molecular Plant2020，13，6： | 23 |
| 5 | Anatomy of composition and nature of plate convergence: Insights for alternative thoughts for terminal India-Eurasia collision显示文摘The pattern and timing of collision between India and Eurasia have long been a major concern of the international community. However, no consensus has been reached hitherto. To explore and resolve the disagreements in the Himalayan study,in this paper we begin with the methodology and basic principles for the anatomy of composition and nature of convergent margins,then followed by an effort to conduct a similar anatomy for the India-Eurasia collision. One of the most common patterns of plate convergence involves a passive continental margin, an active continental margin and intra-oceanic basins together with accreted terranes in between. The ultimate configuration and location of the terminal suture zone are controlled by the basal surface of the accretionary wedge, which may show fairly complex morphology with Z-shape and fluctuant geometry. One plausible method to determine the terminal suture zone is to dissect the compositions and structures of active continental margins. It requires a focus on various tectonic elements belonging to the upper plate, such as accretionary wedges, high-pressure(HP)-ultra-high-pressure(UHP) metamorphic rocks, Barrovian-type metamorphic rocks and basement nappes, together with superimposed forearc basins.Such geological records can define the extreme limits and the intervening surface separating active margin from the passive one,thus offering a general sketch for the surface trace of the terminal suture zone often with a cryptic feature. Furthermore, the occurrence of the cryptic suture zone in depth may be constrained by geophysical data, which, in combination with outcrop studies of HP-UHP metamorphic rocks, enables us to outline the terminal suture zone. The southern part of the Himalayan orogen records complicated temporal and spatial features, which are hard to be fully explained by the classic 'two-plate-one-ocean' template,therefore re-anatomy of the compositions and nature for this region is necessitated. Taking advantage of the methodology and basic principles of plate convergence anatomy and synthesizing previous studies together with our recent research, we may gain new insights into the evolution of the Himalayan orogeny.(1) The Yarlung-Zangbo ophiolite is composed of multiple tectonic units rather than a single terminal suture zone, and a group of different tectonic units were juxtaposed against each other in the backstop of the Gangdese forearc.(2) The Tethyan Himalayan Sequence(THS) contains mélanges with typical block-in-matrix structures, uniform southwards paleocurrents and age spectra of detrital zircons typical of Eurasia continent. All of these facts indicate that the THS belonged to Eurasia plate before the terminal collision, emplaced in the forearc of the Gangdese arc.(3) The Greater Himalayan Crystalline Complex(GHC) and Lesser Himalayan Sequence(LHS) comprise complex components including eclogites emplaced into the GHC and the upper part of the LHS. Judging from the fact that HP-UHP metamorphic rocks are exhumed and emplaced in the upper plate, the GHC and the upper part of the LHS where eclogite occur should be assigned to the upper plate, lying above the terminal subduction zone surface. It is the very surface along which the continuous subduction of the India subcontinent occurred, therefore acting as the terminal, cryptic suture. From the suture further southward, the bulk rock associations of the LHS and Sub-Himalayan Sequence(Siwalik) show little affinity of mélange, probably belonging to the foreland system of the India plate. By the anatomy of tectonic features of all the tectonic units in the Himalayan orogen as well as the ages of the subduction-accretion related deformation, we conclude that the terminal India-Eurasia collision occurred after 14 Ma, the timing of the metamorphism of the eclogites emplaced into the upper plate. The development of rifts stretching in N-S direction in Tibet and tectonic events with the transition from sinistral to dextral movements in shear zones, such as the Ailaoshan fault in East Tibet, can coordinately reflect the scale and geodynamic influence of the India-Eurasia convergence zone.By conducting a detailed anatomy of the southern Himalayas, we propose a new model for the final collision-accretion of the Himalayan orogeny. Our study indicates that the anatomy of structures, composition, and tectonic nature is the key to a better understanding of orogenic belts, which may apply to all the orogenic belts around the world. We also point out that several important issues regarding the detailed anatomy of the structures, compositions and tectonic nature of the Himalayan orogeny in future. | XIAO WenJiao AO SongJian YANG Lei HAN ChunMing WAN Bo ZHANG Ji'En ZHANG ZhiYong LI Rui CHEN ZhenYu SONG ShuaiHua | 2017 | Science China Earth Sciences2017，60，6： | 20 |
| 6 | The Origin and Tectonic Significance of the Volcanic Rocks of the Yeba Formation in the Gangdese Magmatic Belt, South Tibet显示文摘Zircon U-Pb geochronology, Hf isotope and whole-rock geochemistry were performed on the tuffs of the Yeba Formation in the Gangdese magmatic belt, South Tibet. The results are used to detail the age, source nature and tectonic processes that led to the formation of the Gangdese belt. Dating results indicate that the rhyolitic-andesitic tuffs were formed at 174–170 Ma. Positive and variable zircon ε_(Hf)(t) values of the rhyolitic tuffs reveal that the source was dominated by juvenile material, however, experienced crustal contamination. The basaltic tuffs have low HREEs, high contents of compatible elements(V and Cr) and no Eu anomaly. In contrast, the rhyolitic-andesitic tuffs show low compatible trace elements, depletion in Eu but enrichment in incompatible elements(Rb, Zr and Hf). According to the discrimination diagrams of P_2O_5-SiO_2 and Th-Rb, the rhyolitic-andesitic tuffs show a close affinity to Ⅰ-type granitoids. Moreover, these tuffs are marked by significant depletion in Nb, Ta and Ti, plotted in calc-alkaline field, and with the andesitic-rhyolitic tuffs falling into an active continental margin setting. We suggest that these tuffs of the Yeba Formation were probably generated in an active continental margin above the northward subduction of the Neo-Tethyan oceanic lithosphere. | Xuxuan Ma Zhiqin Xu Xijie Chen Joseph G.Meert Zhenyu He Fenghua Liang Yuanku Meng Shiwei Ma | 2017 | Journal of Earth Science2017，28，2： | 20 |
| 7 | A huge oceanic-type UHP metamorphic belt in southwestern Tianshan, China: Peak metamorphic age and P-T path显示文摘Recent progress in the study of the UHP metamorphic belt in southwestern Tianshan,China,is summarized in this paper.This about 80-km-long and over 10-km-wide UHP belt has been recognized by the discovery of coesite,coesite pseudomorphs and other UHP minerals.It is the largest oceanic-type UHP metamorphic belt reported so far.It has formed due to northward subduction of the Tianshan Paleo-Ocean.U-Pb dating of metamorphic rims of zircons from a coesite-bearing garnet-phengite schist yields a peak UHP metamorphic ages of 320±3.7 Ma.Combined with ages of 233–226 Ma obtained from rims of zircons from retrograded eclogites,a long retrograde metamorphic evolution(>70 Ma)has been revealed.According to phase equilibria modeling,the P-T paths of both coesite-bearing eclogites and garnet-phengite schists are characterized by thermal relaxation,i.e.,the metamorphic temperature peak lags behind the pressure peak,indicating that the UHP rocks experienced slow and long heating and decompression during exhumation in the subduction channel.On the basis of the field observation that a small amount of eclogite lenses is wrapped in large volumes of metapelites,and the similar P-T paths of both rock types,we propose that the exhumation of the UHP eclogites from southwestern Tianshan,China,may have resulted from the exhumation of large volumes of low-density metapelites,which carried the denser eclogites to the Earth’s surface. | ZHANG LiFei DU JinXue Lü Zeng YANG Xin GOU LongLong XIA Bin CHEN ZhenYu WEI ChunJing SONG ShuGuang | 2013 | Chinese Science Bulletin2013，58，35： | 19 |
| 8 | Hydrochemical characteristics and recharge sources of Lake Nuoertu in the Badain Jaran Desert显示文摘We present a case study of physical and chemical indicators and isotope characteristics of Lake Nuoertu,one of the largest and deepest lakes of the Badain Jaran Desert.We analyze the concentrations of eight ions,total dissolved solids,and stable isotope composition of the lake and groundwater,as well as radioactive isotope tritium concentration in groundwater.The results show that annual and seasonal variations of the physical and chemical characteristics of Lake Nuoertu water are significantly greater than those of groundwater.The lake is uniformly mixed in the horizontal and vertical directions,and the hydrochemical types of the lake at different depths are consistent for Na–Cl–CO3–(SO4).Stable isotope composition of the lake and groundwater at Nuoertu is distributed along the local evaporation line(EL)slope,which is less than the slope of the global meteoric water line.The comparatively small slope shows the characteristic strong evaporation in the study area.Lake water isotopes are mostly in the upper right corner of the EL,whereas groundwater is mostly in the lower left corner.The main recharge source of Nuoertu lake water is groundwater,in combination with lake water and groundwater level change.The age of tufa springs around Nuoertu is about75–80 a,which shows that the initial recharge source of the lake is a mix between modern and 1952 or older;however,further research is required. | Yue Wu Naiang Wang Liqiang Zhao Zhenyu Zhang Li Chen Ying Lu Xiaonan L Jinlong Chang | 2014 | Chinese Science Bulletin2014，59，9： | 12 |
| 9 | MiR-375 suppresses invasion and metastasis by direct targeting of SHOX2 in esophageal squamous cell carcinoma显示文摘食道的有鳞的房间癌(ESCC ) 是在中国的最普通的组织学的类型。MicroRNAs 内长地在哺乳动物被表示并且由指向潜在的下游的基因在肿瘤侵略和转移起一个重要作用。在现在的学习, microarray 分析证明那 miR-375 表情是显然在 ESCC 的 downregulated 与那相比在正常食道的上皮纸巾。然后,酶记者试金证明 SHOX2 是 miR-375 的直接下游的目标,这个相互作用被营救实验证实。量的聚合酶链反应结果也证明那 SHOX2 表情是在 ESCC 房间和纸巾的 upregulated。进一步的分析证明 SHOX2 在 vivo 并且在 vitro 导致了 ESCC 的增长,侵略,和转移。而且,在 miR-375 和 SHOX2 之间的相互作用影响了 epithelial-to-mesenchymal 转变。我们断定 miR-375 可以由直接指向 SHOX2 压制 ESCC 的侵略和转移。miR-375/SHOX2 轴可以是为 ESCC 的一个新奇治疗学的目标。 | Jun Yi Li Jin Jing Chen BingFeng Zhenyue He Longbang Chen Haizhu Song | 2017 | Acta Biochimica et Biophysica Sinica2017，49，2： | 11 |
| 10 | MiR-630 inhibits invasion and metastasis in esophageal squamous cell carcinoma显示文摘食道的有鳞的房间癌(ESCC ) 在最好攻击的恶意之中并且在中国有高发生。MicroRNAs (miRNAs ) 是调整多重 tumorigenic 过程的小内长的 RNA,包括增长,侵略,转移和预后。用 miRNA 表示 proling 分析,我们发现 miR-630 在配对的正常食道的纸巾与那相比在三件 ESCC 织物样品是显著地下面调整的。微分 miR-630 表示随后用量的即时 PCR 被证实。决定 miR-630 下面规定是否能被看作诊断指示物和不利预示的因素,我们与 ESCC 在病人调查了在 miR-630 和 clinicopathological 特征之间的协会。减少的 miR-630 表示总的来说与穷人被联系,这被发现在这些病人的幸存。另外,我们也由指向蛞蝓探索了 miR-630 的生物功能并且调查了在 miR-630 表示和上皮间充质的转变(EMT ) 之间的关联在 vivo 并且在 vitro 的前进。,宫外的 miR-630 表示能禁止增长,侵略和转移 miR-630 击倒的导致的增长,侵略,转移和 EMT 特点。总的来说,我们的学习在 ESCC 作为一个批评新奇调节的人为 miR-630 支持一个角色。 | Li Jin Jun Yi Yanping Gao Siqi Han Zhenyue He Longbang Chen Haizhu Song | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 11 |
| 11 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 12 | Realization Methodology of a 5-axis Spline Interpolator in an Open CNC System显示文摘由使用不一致的合理B花键( NURBS )曲线的优点代表空间曲线,有对5轴合适的两倍 NURBS 曲线的一种说明格式协调了即时插值被介绍代替当前的5轴协调线性插值方法有缺陷者在低速度,在 sculptured 的低精确性、庞大的数字控制( NC )文件出现用机器制造。有介绍格式的 NC 文件的一个产生过程被介绍并且在一台开的计算机认识到插值的方法数字控制(计算机数值控制) 系统自己被开发。这些说明了建议方法和它避免 5 轴的所有缺乏的能力的可行性线性插值方法。 | Wang Yongzhang Ma Xiongbo Chen Liangji Han Zhenyu | 2007 | Chinese Journal of Aeronautics2007，20，4： | 10 |
| 13 | Modern human behaviors during the late stage of the MIS3 and the broad spectrum revolution:Evidence from a Shuidonggou Late Paleolithic site显示文摘The last glacial period was vital for the distribution and evolution of early modern humans in Asia. The Shuidonggou Late Paleolithic site, dated at 30-20 ka BP, accumulated cultural remains during the important late stage of MIS 3 period in the last glacial. These remains represent characteristics of typical Late Paleolithic conditions in North China:high degree of standardization and morphological variability of tool types, exploitation of bone materials, systematic use of body decorations, extensive use of earth-pit hearths, distinct functional spatial organization within habitations, and conversion of subsistence patterns. These characteristics illustrate early modern human behaviors during the late MIS3 period, and provide clues and perspectives for the analysis of early modern human origins in China. At the same time, the conversion of subsistence patterns is considered to be a combination of multiple early modern human behaviors, as well as the result of the Broad Spectrum Revolution. In this paper, we argue for the dynamic mechanism of Broad Spectrum Revolution from a human behavioral and ecological perspective. | GUAN Ying GAO Xing LI Feng PEI ShuWen CHEN FuYou ZHOU ZhenYu | 2012 | Chinese Science Bulletin2012，57，4： | 10 |
| 14 | Geochemical characteristics and geological significance of the Neoproterozoic carbonates from northern Anhui Province, China显示文摘Petrographical and geochemical studies were carried out of the Neoproterozoic carbonates from northern Anhui Province, China. These carbonates can be subdivided into two types, including purified limestone (PL) and mixed limestone and siliclastic rocks (MLS). PLs are low in Si, Al, Zr and total REE but high in CaO compared with MLSs. Correlations between Zr, Fe2O3, P2O5 and total REE are also less remarkable, indicating that they were not obviously contaminated by continental materials but directly precipitated from seawater. So they can be used for the inversion of paleo-seawater REE patterns. The inversed results indicated that the REE pattern of Neoproterozoic seawater was similar to that of the modern seawater except for the lack of Ce depletion, which was probably affected by the reduced hydrothermal solution. In combination with previous studies, the geochemical trending of these carbonatic samples towards the continental arc in the La- Th-Sc and Th-Sc-Zr/10 diagrams is interpreted as the contamination of arc volcanism. The tectonic background of the southern margin of the North China Craton in the Neoproterozoic was probably related to the Grenville orogeny during the convergence of the Rodinia supercontinent, rather than an intra-plate environment. | SUN Linhua GUI Herong CHEN Song MA Yanping HE Zhenyu | 2011 | Chinese Journal Of Geochemistry2011，30，1： | 9 |
| 15 | Xa7, a new executor R gene that confers durable and broad-spectrum resistance to bacterial blight disease in rice显示文摘Bacterial blight(BB)is a globally devastating rice disease caused by Xanthomonas oryzae pv.oryzae(Xoo).The use of disease resistance(R)genes in rice breeding is an effective and economical strategy for the control of this disease.Nevertheless,a majority of R genes lack durable resistance for long-term use under global warming conditions.Here,we report the isolation of a novel executor R gene,Xa7,that confers extremely durable,broad-spectrum,and heat-tolerant resistance to Xoo.The expression of Xa7 was induced by incompatible Xoo strains that secreted the transcription activator-like effector(TALE)AvrXa7 or PthXo3,which recognized effector binding elements(EBEs)in the Xa7 promoter.Furthermore,Xa7 induction was faster and stronger under high temperatures.Overexpression of Xa7 or co-transformation of Xa7 with avrXa7 triggered a hypersensitive response in plants.Constitutive expression of Xa7 activated a defense response in the absence of Xoo but inhibited the growth of transgenic rice plants.In addition,analysis of over 3000 rice varieties showed that the Xa7 locuswas found primarily in the indica and aus subgroups.A variation consisting of an 11-bp insertion and a base substitution(G to T)was found in EBEAvrXa7 in the tested varieties,resulting in a loss of Xa7 BB resistance.Through a decade of effort,we have identified an important BB resistance gene and characterized its distinctive interaction with Xoo strains;these findings will greatly facilitate research on the molecular mechanism of Xa7-mediated resistance and promote the use of this valuable gene in breeding. | Xifeng Chen Pengcheng Liu Le Mei Xiaoling He Long Chen Hui Liu Shurong Shen Zhandong Ji Xixi Zheng Yuchen Zhang Zhenyu Gao Dali Zeng Qian Qian Bojun Ma | 2021 | Plant Communications2021，2，3： | 9 |
| 16 | Zr-in-rutile thermometry in eclogite at Jinheqiao in the Dabie orogen and its geochemical implications显示文摘Trace element analysis was made by an electron microprobe on rutiles from ultrahigh-pressure ec-logite at Jinheqiao in the Dabie orogen. The results show Zr contents of 37 to 118 μg·g?1, with signifi-cant variations between grains within the same thin section. Zr-in-rutile temperatures were calculated by the pressure-dependent thermometer, yielding 595 to 678℃ at 4.1 GPa for the upper limit of meta-morphic pressures. The temperatures are about 200 to 250℃ lower than temperatures of 846±70℃ calculated from garnet-omphacite Fe-Mg partition geothermometry, but 150 to 200℃ higher than ~460℃ from quartz-rutile O isotope temperatures and rutile Pb diffusion closure temperature for the same specimen. This indicates that the diffusion rate of Zr in rutile is remarkably slower than that of Pb and O in rutile, and that the temperature of Zr-in-rutile is higher than the closure temperature corre-sponding to cooling age as dated by rutile U-Pb radiometric system. The latter is consistent with ex-perimental result of Zr diffusion in rutile. Diffusion and re-crystallization with intensive retrograde fluid during exhumation of UHP metamorphic rocks may be the major reason why the Zr contents in rutile decreased and thus did not provide the record of the peak metamorphic temperatures. The remarkable difference in Zr content between rutile grains suggests that the distribution of Zr in rutile was in the state of disequilibrium due to differential diffusion and retrograde resetting. | CHEN ZhenYu LI QiuLi | 2008 | Chinese Science Bulletin2008，53，5： | 9 |
| 17 | New radiocarbon and archaeobotanical evidence reveal the timing and route of southward dispersal of rice farming in south China显示文摘The origins and spreads of rice agriculture have been enduring topics, yet the timing and southward dispersal from the Yangtze River Basin have been difficult to trace, due to the scarcity of archaeobotanical data, especially systematic macro-plant remains examination, combined with the poor preservation in the humid climate and acidic soils of China's southern provinces.Here, we report new radiocarbon dating and preserved rice phytolith evidence, derived from three Late Neolithic archaeological sites in south China, dated about 5,000–4,100 cal a BP.Our results demonstrate that rice farming had spread southward through the mountainous regions of Wuyi and Nanling, then entered the areas of Western Fujian and North Guangdong by 5,000 cal a BP, followed by continued expansion into coastal areas of East China Sea and South China Sea, also crossing the Taiwan Strait, around 4,500–4,000 cal a BP.The North River,East River, Min River, and possibly other river systems likely were influential as pathways or conduits. | Xiaoyan Yang Qiuhe Chen Yongchao Ma Zhao Li Hsiao-chun Hung Qianglu Zhang Zhiwei Jin Suoqiang Liu Zhenyu Zhou Xianguo Fu | 2018 | Science Bulletin2018，63，22： | 9 |
| 18 | Heterogeneous parallel computing accelerated iterative subpixel digital image correlation显示文摘Parallel computing techniques have been introduced into digital image correlation(DIC) in recent years and leads to a surge in computation speed. The graphics processing unit(GPU)-based parallel computing demonstrated a surprising effect on accelerating the iterative subpixel DIC, compared with CPU-based parallel computing. In this paper, the performances of the two kinds of parallel computing techniques are compared for the previously proposed path-independent DIC method, in which the initial guess for the inverse compositional Gauss-Newton(IC-GN) algorithm at each point of interest(POI) is estimated through the fast Fourier transform-based cross-correlation(FFT-CC) algorithm. Based on the performance evaluation, a heterogeneous parallel computing(HPC) model is proposed with hybrid mode of parallelisms in order to combine the computing power of GPU and multicore CPU. A scheme of trial computation test is developed to optimize the configuration of the HPC model on a specific computer. The proposed HPC model shows excellent performance on a middle-end desktop computer for real-time subpixel DIC with high resolution of more than 10000 POIs per frame. | HUANG JianWen ZHANG LingQi JIANG ZhenYu DONG ShouBin CHEN Wei LIU YiPing LIU ZeJia ZHOU LiCheng TANG LiQun | 2018 | Science China(Technological Sciences)2018，61，1： | 9 |
| 19 | Will polycentric cities cause more CO2 emissions? A case study of 232 Chinese cities显示文摘From 2000 to 2010 China experienced rapid economic development and urbanization.Many cities in economically developed areas have developed from a single-center status to polycentricity.In this study,we used exploratory spatial data analysis (ESDA) to identify the population centers,which identified 232 cities in China as having urban centers.COMP was used to represent urban agglomeration,and POLYD (representing how far is the city’s sub-centers to the main center),POLYC (representing the number of a city’s centers),and POLYP (representing the population distributed between the main center and the sub-centers) were used to indicate urban polycentricity.Night light data were used to determine the CO2 emissions from various cities in China.A mixed model was used to study the impact of urban aggregation and polycentric data on the CO2 emission efficiency in 2000 and 2010.The study found that cities with higher compactness were distributed in coastal areas,and the cities with higher multicentricity were distributed in the Yangtze River Delta and Shandong Province.The more compact the city was,the less conducive it was to improving CO2 emission efficiency.Polycentric development of the city was conducive to improving the CO2 emission efficiency,but the number of urban centers had no significant relationship with the CO2 emission efficiency.Our research showed that the compactness and multicentricity of the city had an impact on the CO2 emission efficiency and provided some planning suggestions for the low carbon development of the city. | Wei Sha Ying Chen Jiansheng Wu Zhenyu Wang | 2020 | Journal of Environmental Sciences2020，32，10： | 9 |
| 20 | Microvesicles(MIVs)secreted from adipose-derived stem cells(ADSCs)contain multiple microRNAs and promote the migration and invasion of endothelial cells显示文摘Extracellular vesicles(EVs)such as microvesicles(MIVs)play an important role in intercellular communications.MIVs are small membrane vesicles sized 100e1000 nm in diameter that are released by many types of cells,such as mesenchymal stem cells(MSCs),tumor cells and adipose-derived stem cells(ADSC).As EVs can carry out autocrine and paracrine functions by controlling multiple cell processes,it is conceivable that EVs can be used as delivery vehicles for treating several clinical conditions,such as to improve cardiac angiogenesis after myocardial infarction(MI).Here,we seek to investigate whether ADSC-derived MIVs contain microRNAs that regulate angiogenesis and affect cell migration of endothelial cells.We first characterized the ADSC-derived MIVs and found that the MIVs had a size range of 100 e300 nm,and expressed the MIV marker protein Alix.We then analyzed the microRNAs in ADSCs and ADSC-derived MIVs and demonstrated that ADSC-derived MIVs selectively released a panel of microRNAs,several of which were related to angiogenesis,including two members of the let-7 family.Furthermore,we demonstrated that ADSC-derived MIVs promoted the cell migration and invasion of the HUVEC endothelial cells.The PKH26-labeled ADSC-derived MIVs were effectively uptaken into the cytoplasm of HUVEC cells.Collectively,our results demonstrate that the ADSC-derived MIVs can promote migration and invasion abilities of endothelial cells,suggesting pro-angiogenetic potential.Future studies should focus on investigating the roles and mechanisms through which ADSC-derived MIVs regulate angiogenesis. | Bo Huang Lin-Feng Huang Ling Zhao Zongyue Zeng Xi Wang Daigui Cao Lijuan Yang Zhenyu Ye Xian Chen Bin Liu Tong-Chuan He Xiaozhong Wang | 2020 | Genes & Diseases2020，7，2： | 8 |
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