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| 1 | Chronic Food Antigen-specific IgG-mediated Hypersensitivity Reaction as A Risk Factor for Adolescent Depressive Disorder显示文摘Major depressive disorder (MDD) is the most common nonfatal disease burden world-wide. Systemic chronic low-grade inflammation has been reported to be associated with MDD pro-gression by affecting monoaminergic and glutamatergic neurotransmission. However,whether various proinflammatory cytokines are abnormally elevated before the first episode of depression is still largely unclear. Here,we evaluated 184 adolescent patients who were experiencing their first episode of depressive disorder,and the same number of healthy individuals was included as con-trols. We tested the serum levels of high-sensitivity C-reactive protein (hs-CRP),tumor necrosis factor-α(TNF-α),IgE,14 different types of food antigen-specific IgG,histamine,homocysteine,S100 calcium-binding protein B,and diamine oxidase. We were not able to find any significant dif-ferences in the serum levels of hs-CRP or TNF-αbetween the two groups. However,the histamine level of the patients (12.35μM) was significantly higher than that of the controls (9.73μM,P<0.001,Mann–Whitney U test). Moreover,significantly higher serum food antigen-specific IgG positive rates were also found in the patient group. Furthermore,over 80% of patients exhibited prolonged food intolerance with elevated levels of serum histamine,leading to hyperpermeability of the blood–brain barrier,which has previously been implicated in the pathogen-esis of MDD. Hence,prolonged high levels of serum histamine could be a risk factor for depressive disorders,and antihistamine release might represent a novel therapeutic strategy for depression treatment. | Ran Tao Zhicheng Fu Lijun Xiao | 2019 | Genomics, Proteomics & Bioinformatics2019，17，2： | 11 |
| 2 | Relationship between fluorescence characteristics and molecular weight distribution of natural dissolved organic matter in Lake Hongfeng and Lake Baihua,China显示文摘Dissolved organic matter (DOM) is one of the most interesting and difficult problems in recent years due to its important functions in the ecological and environmental system and the complexity of its chemical composition and structure. It is well ac- cepted that fluorescence characteristics and mo- lecular weight distribution are two important pa- rameters in the DOM characterization. However, the relationship between them is still unknown. In this study, fluorescence and molecular weight distribution of DOM in Lake Hongfeng, Lake Baihua and their rivers, and their relationship were investigated using the combination of fluorescence spectroscopy and high-performance size exclusion chromatography (HPSEC) with on-line UV absorbance and fluores- cence detectors. The results show that there were two obvious humic-like fluorescence peaks (Peaks A and B) in DOM from lake water. But there was an- other obvious protein-like fluorescence peak (Peak C) in DOM from river water. The humic-like fluorescence material consisted of DOM fraction with smaller mo- lecular weight, ranging from 1.0 to 3.0 kDa, while the protein-like fluorescence material mainly consisted of DOM fraction with MW larger than 2.0 kDa. The cal- culation of MW using HPSEC was related to the UV absorbance wavelength chosen. | YUE Lanxiu WU Fengchang LiU Congqiang LI Wen FU Pingqing BAI Yingchen WANG Liying YIN Zuoying Lü Zhicheng | 2006 | Chinese Science Bulletin2006，51，1： | 9 |
| 3 | Catalytic conversion of lignocellulosic biomass into chemicals and fuels显示文摘In the search of alternative resources to make commodity chemicals and transportation fuels for a low carbon future,lignocellulosic biomass with over 180-billion-ton annual production rate has been identified as a promising feedstock.This review focuses on the state-of-the-art catalytic transformation of lignocellulosic biomass into value-added chemicals and fuels.Following a brief introduction on the structure,major resources and pretreatment methods of lignocellulosic biomass,the catalytic conversion of three main components,i.e.,cellulose,hemicellulose and lignin,into various compounds are comprehensively discussed.Either in separate steps or in one-pot,cellulose and hemicellulose are hydrolyzed into sugars and upgraded into oxygen-containing chemicals such as 5-HMF,furfural,polyols,and organic acids,or even nitrogen-containing chemicals such as amino acids.On the other hand,lignin is first depolymerized into phenols,catechols,guaiacols,aldehydes and ketones,and then further transformed into hydrocarbon fuels,bioplastic precursors and bioactive compounds.The review then introduces the transformations of whole biomass via catalytic gasification,catalytic pyrolysis,as well as emerging strategies.Finally,opportunities,challenges and prospective of woody biomass valorization are highlighted. | Weiping Deng Yunchao Feng Jie Fu Haiwei Guo Yong Guo Buxing Han Zhicheng Jiang Lingzhao Kong Changzhi Li Haichao Liu Phuc T.T.Nguyen Puning Ren Feng Wang Shuai Wang Yanqin Wang Ye Wang Sie Shing Wong Kai Yan Ning Yan Xiaofei Yang Yuanbao Zhang Zhanrong Zhang Xianhai Zeng Hui Zhou | 2023 | Green Energy & Environment2023，8，1： | 6 |
| 4 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 5 | Planar Velocity Distribution of Viscous Debris Flow at Jiangjia Ravine,Yunnan,China:A Field Measurement Using Two Radar Velocimeters显示文摘Characteristics of planar velocity distribution of vis-cous debris flow were analyzed using the measured data at Jiangjia Ravine,Yunnan,China. The velocity data were measured through using two radar velocimeters. The cross-sectional mean velocities were calculated and used to examine Kang et al's(2004) relation-ship,which was established for converting the flow velocity at river centerline measured by a radar velocimeter into the mean velocity based on the stop-watch method. The velocity coefficient,K,defined by the ratio of the mean velocity to the maximum ve-locity,ranges from 0.2 to 0.6. Kang et al's(2004) relationship was found being inapplicable to flows with K smaller than 0.43. This paper contributes to show the complexity of the planar velocity distribution of viscous debris flows and the applicability of Kang et al's relationship. | FU Xudong WANG Guangqian KANG Zhicheng FEI Xiangjun | 2007 | Wuhan University Journal of Natural Sciences2007，12，4： | 5 |
| 6 | Transcriptomic and metabolomic analyses reveal that melatonin promotes melon root development under copper stress by inhibiting jasmonic acid biosynthesis显示文摘Melatonin has been shown to alleviate the effects of abiotic stress and to regulate plant development.Copper,a common heavy metal and soil pollutant,can suppress plant growth and development.In this work,we explored the protective effects of exogenous melatonin on lateral root formation in response to copper stress using melon seeds subjected to three germination treatments:CK1(control),CK2(300μmol/L CuSO4),and MT3(300μmol/L melatonin+300μmol/L CuSO4).Melatonin pretreatment increased the antioxidant enzyme activities and root vigor,and decreased the proline and malondialdehyde(MDA)contents in the roots of copper-stressed melon seedlings.We then used transcriptomic and metabolomic analyses to explore the mechanisms by which exogenous melatonin protects against copper stress.There were 70 significant differentially expressed genes(DEGs)(28 upregulated,42 downregulated)and 318 significantly differentially expressed metabolites(DEMs)(168 upregulated,150 downregulated)between the MT3 and CK2 treatments.Melatonin pretreatment altered the expression of genes related to redox and cell wall formation processes.In addition,we found that members of the AP2/ERF,BBR/BPC,GRAS,and HD-ZIP transcription factor families may have vital roles in lateral root development.Melatonin also increased the level of Glutathione(GSH),which chelates excess Cu^(2+).The combined transcriptomic and metabolomic analysis revealed DEGs and DEMs involved in jasmonic acid(JA)biosynthesis,including four lipoxygenase-related genes and two metabolites(linoleic acid and lecithin)related to melatonin’s alleviation effect on copper toxicity.This research elucidated the molecular mechanisms of melatonin’s protective effects in copper-stressed melon. | Zhicheng Hu Qiushi Fu Jing Zheng Aiai Zhang Huaisong Wang | 2020 | Horticulture Research2020，7，1： | 4 |
| 7 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hufk6ckqwk6bu6b6w.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 8 | High-speed multiwavelength InGaAs/InP quantum well nanowire array micro-LEDs for next generation optical communications显示文摘Miniaturized light sources at telecommunication wavelengths are essential components for on-chip optical communication systems.Here,we report the growth and fabrication of highly uniform p-i-n core-shell InGaAs/InP single quantum well(QW)nanowire array light emitting diodes(LEDs)with multi-wavelength and high-speed operations.Two-dimensional cathodoluminescence mapping reveals that axial and radial QWs in the nanowire structure contribute to strong emission at the wavelength of~1.35 and~1.55μm,respectively,ideal for low-loss optical communications.As a result of simultaneous contributions from both axial and radial QWs,broadband electroluminescence emission with a linewidth of 286 nm is achieved with a peak power of~17μW.A large spectral blueshift is observed with the increase of applied bias,which is ascribed to the band-filling effect based on device simulation,and enables voltage tunable multi-wavelength operation at the telecommunication wavelength range.Multi-wavelength operation is also achieved by fabricating nanowire array LEDs with different pitch sizes on the same substrate,leading to QW formation with different emission wavelengths.Furthermore,high-speed GHz-level modulation and small pixel size LED are demonstrated,showing the promise for ultrafast operation and ultracompact integration.The voltage and pitch size controlled multi-wavelength highspeed nanowire array LED presents a compact and efficient scheme for developing high-performance nanoscale light sources for future optical communication applications. | Fanlu Zhang Zhicheng Su Zhe Li Yi Zhu Nikita Gagrani Ziyuan Li Mark Lockrey Li Li Igor Aharonovich Yuerui Lu Hark Hoe Tan Chennupati Jagadish Lan Fu | 2023 | Opto-Electronic Science2023，2，5： | 1 |
| 9 | Serum Helicobacter pylori CagA antibody may not be used as a tumor marker for diagnosing gastric cancer in east Asian countries显示文摘 | Zhicheng Zhao Yuhong Li Shengxin Liu Weihua Fu | 2014 | Tumor Biology2014，，12： | 1 |
| 10 | Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and inhibiting inflammation by regulating the AKT,p38 MAPK/NF-κB pathways显示文摘Alcoholic liver disease(ALD)is the most frequent liver disease worldwide,resulting in severe harm to personal health and posing a serious burden to public health.Based on the reported antioxidant and anti-inflammatory capacities of scutellarin(SCU),this study investigated its protective role in male BALB/c mice with acute alcoholic liver injury after oral administration(10,25,and 50 mg/kg).The results indicated that SCU could lessen serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)levels and improve the histopathological changes in acute alcoholic liver;it reduced alcohol-induced malondialdehyde(MDA)content and increased glutathione peroxidase(GSH-Px),catalase(CAT),and superoxide dismutase(SOD)activity.Furthermore,SCU decreased tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and IL-1βmessenger RNA(mRNA)expression levels,weakened inducible nitric oxide synthase(iNOS)activity,and inhibited nucleotide-binding oligomerization domain(NOD)-like receptor protein 3(NLRP3)inflammasome activation.Mechanistically,SCU suppressed cytochrome P450 family 2 subfamily E member 1(CYP2E1)upregulation triggered by alcohol,increased the expression of oxidative stress-related nuclear factor erythroid 2-related factor 2(Nrf2)and heme oxygenase-1(HO-1)pathways,and suppressed the inflammation-related degradation of inhibitor of nuclear factor-κB(NF-κB)-α(IκBα)as well as activation of NF-κB by mediating the protein kinase B(AKT)and p38 mitogen-activated protein kinase(MAPK)pathways.These findings demonstrate that SCU protects against acute alcoholic liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and suppressing inflammation by regulating the AKT,p38 MAPK/NF-κB pathways. | Xiao ZHANG Zhicheng DONG Hui FAN Qiankun YANG Guili YU Enzhuang PAN Nana HE Xueqing LI Panpan ZHAO Mian FU Jingquan DONG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，7： | 0 |
| 11 | Determination of Double Beta Decay Half-Life of 136Xe with the PandaX-4T Natural Xenon Detector显示文摘Precise measurement of two-neutrino double beta decay(DBD)half-life is an important step for the searches of Majorana neutrinos with neutrinoless double beta decay.We report the measurement of DBD half-life of 136xe using the Pandax-4T dual-phase Time Projection Chamber(TPC)with 3.7-tonne natural xenon and the first 94.9-day physics data release. | Lin Si Zhaokan Cheng Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Yunshan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Jinrong He Di Huang Yanlin Huang Zhou Huang Ruquan Hou Xiangdong Ji Yonglin Ju Chenxiang Li Jiafu Li Mingchuan Li Shu Li Shuaijie Li Qing Lin Jianglai Liu Xiaoying Lu Lingyin Luo Yunyang Luo Wenbo Ma Yugang Ma Yujun Mao Yue Meng Nasir Shaheed Xiaofeng Shang Xuyang Ning Ningchun Qi Zhicheng Qian Xiangxiang Ren Changsong Shang Guofang Shen Wenliang Sun Andi Tan Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Yuehuan Wei Mengmeng Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Xiyu Yan Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Zhe Yuan Dan Zhang Minzhen Zhang Peng Zhang Shibo Zhang Shu Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou Yong Zhou | 2023 | Research2023，，2： | 0 |
| 12 | Elevated Kir2.1/nuclear N2ICD defines a highly malignant subtype of non-WNT/SHH medulloblastomas显示文摘Medulloblastoma(MB)is one of the most common childhood malignant brain tumors(WHO grade IV),traditionally divided into WNT,SHH,Group 3,and Group 4 subgroups based on the transcription profiles,somatic DNA alterations,and clinical outcomes.Unlike WNT and SHH subgroup MBs,Group 3 and Group 4 MBs have similar transcriptomes and lack clearly specific drivers and targeted therapeutic options.The recently revised WHO Classification of CNS Tumors has assigned Group 3 and 4 to a provisional non-WNT/SHH entity.In the present study,we demonstrate that Kir2.1,an inwardly-rectifying potassium channel,is highly expressed in non-WNT/SHH MBs,which promotes tumor cell invasion and metastasis by recruiting Adam10 to enhance S2 cleavage of Notch2 thereby activating the Notch2 signaling pathway.Disruption of the Notch2 pathway markedly inhibited the growth and metastasis of Kir2.1-overexpressing MB cell-derived xenograft tumors in mice.Moreover,Kir2.1^(high)/nuclear N2ICD^(high)MBs are associated with the significantly shorter lifespan of the patients.Thus,Kir2.1^(high)/nuclear N2ICD^(high)can be used as a biomarker to define a novel subtype of non-WNT/SHH MBs.Our findings are important for the modification of treatment regimens and the development of novel-targeted therapies for non-WNT/SHH MBs. | Yan-Xia Wang Haibo Wu Yong Ren Shengqing Lv Chengdong Ji Dongfang Xiang Mengsi Zhang Huimin Lu Wenjuan Fu Qing Liu Zexuan Yan Qinghua Ma Jingya Miao Ruili Cai Xi Lan Bin Wu Wenying Wang Yinhua Liu Dai-Zhong Wang Mianfu Cao Zhicheng He Yu Shi Yifang Ping Xiaohong Yao Xia Zhang Peng Zhang Ji Ming Wang Yan Wang Youhong Cui Xiu-Wu Bian | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 0 |
| 13 | Low Temperature Heat Capacity of Zn Substituted Cobalt Ferrite Nanosphere:The Relation between Magnetic Properties and Microstructure显示文摘Co_((1-x))ZnxFe_(2)O_(4)nanospheres(x=0,0.5,0.8)with a unidirectional cubic spinel structure were prepared by a solvothermal method.By using a range of theoretical and empirical models,the experimental heat capacity values were fitted as a function of temperature over a suitable temperature range to explain the possible relationship between the magnetic properties and microstructure of the nanospheres.As a result,at a low temperature(T<10 K),the parameter Bfswdecreases with increasing Zn concentration,implying that the exchange interaction between A and B sites decreases.At a relatively high temperature(T>50 K),the Debye temperature decreases with increasing Zn concentration,which is due to the weakening of the interatomic bonding force after the addition of non-magnetic materials to the Co Fe_(2)O_(4)spinel ferrite. | YUAN Meng GU Xiaojie FU Jie WANG Shaoxu SHI Quan TAN Zhicheng XU Fen | 2023 | Journal of Wuhan University of Technology(Materials Science)2023，38，5： | 0 |
| 14 | Bulk CsPbCl_(x)Br_(3-x)(1≤x≤3)perovskite nanocrystals/polystyrene nanocomposites with controlled Rayleigh scattering for light guide plate显示文摘Perovskite nanocrystals(PNCs)/polymer nanocomposites can combine the advantages of each other,but extremely few works can achieve the fabrication of PNCs/polymer nanocomposites by bulk polymerization.We originally adopt a two-type ligand strategy to fabricate bulk PNCs/polystyrene(PS)nanocomposites,including a new type of synthetic polymerizable ligand.The CsPbCl_(3)PNCs/PS nanocomposites show extremely high transparency even the doping content up to 5 wt%.The high transparency can be ascribed to the Rayleigh scattering as the PNCs distribute uniformly without obvious aggregation.Based on this behavior,we first exploit the potential of PNCs to serve as scatters inside light guided plate(LGP),whose surface illuminance and uniformity can be improved,and this new kind of LGP is compatible with the advanced liquid crystal display technology.Thanks to the facile composition adjustment of CsPbCl_(x)Br_(3-x)(1≤x≤3)PNCs,the Rayleigh scattering behavior can also be adjusted so as to the performance of LGP.The best-performing 5.0-inch LGP based on CsPbCl_(2.5)Br_(0.5)PNCs/PS nanocomposites shows 20.5 times higher illuminance and 1.8 times higher uniformity in display than the control.The LGP based on PNCs/PS nanocomposite exhibits an enormous potential in commercialization no matter based on itself or combined with the LGP-related technology. | Chongming Liu Zhicheng Zhu Kaibo Pan Yuan Fu Kai Zhang Bai Yang | 2023 | Light(Science & Applications)2023，12，11： | 0 |
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