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| 1 | Genetic correction of p-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice显示文摘 | Yixuan Wang Chen-Guang Zheng Yonghua Jiang Jiqin Zhang Jiayu Chen Chao Yao Qingguo Zhao Sheng Liu Ke Chen Juan Du Ze Yang Shaorong Gao | 2012 | Cell Research2012，22，4： | 27 |
| 2 | A Single Nucleotide Deletion in J Encoding GmELF3 Confers Long Juvenility and Is Associated with Adaption of Tropic Soybean显示文摘 | Yanlei Yue Nianxi Liu Bingjun Jiang Mu Li Haijie Wang Ze Jiang Huanting Pan Qiuju Xia Qibin Ma Tianfu Han Hai Nian | 2017 | Molecular Plant2017，10，4： | 20 |
| 3 | EFFECTS OF SUBMERGED MACROPHYTES ON SEDIMENT SUSPENSION AND NH_4-N RELEASE UNDER HYDRODYNAMIC CONDITIONS显示文摘Aquatic vegetation affects sediment suspension and nutrient release by changing the flow structure.Experiments on the influence of submerged vegetation on flow structure,sediment suspension,and NH4-N release were carried in a flume with natural submerged vegetation.Turbulence characteristics in the vegetation section were measured using a three-dimensional acoustic Doppler velocimeter.The effects of submerged vegetation on bed shear stress(),sediment suspension,and NH4-N release were analyzed.Results show that with vegetation,bed shear stress is reduced by about 20%-80%,which,in turn,reduces sediment suspension.The impact of submerged vegetation on sediment suspension and NH4-N release should be considered along with flow intensity.When the flow Reynolds number is relatively small,the submerged vegetation is quite capable of inhibiting sediment suspension and reducing NH4-N release,but when the Reynolds number reaches a certain value,the presence of aquatic plants exacerbates sediment suspension and promotes NH4-N release.Results also reveal that a highly significant positive correlation exists between NH4-N concentration and water turbidity in both vegetated and non-vegetated channels. | WANG Chao WANG Cun WANG Ze | 2010 | Journal of Hydrodynamics2010，22，6： | 19 |
| 4 | Relationship between Two Blood Stasis Syndromes and Inflammatory Factors in Patients with Acute Coronary Syndrome显示文摘Objective: To investigate the relationship between inflammatory factors and two Chinese medicine(CM) syndrome types of qi stagnation and blood stasis(QSBS) and qi deficiency and blood stasis(QDBS) in patients with acute coronary syndrome(ACS). Methods: Sixty subjects with ACS, whose pathogenesis changes belongs to qi disturbance blood stasis syndrome, were divided into 2 groups: 30 in the QSBS group and 30 in the QDBS group. The comparative analysis on them was carried out through comparing general information, coronary angiography and inflammatory factors including intracellular adhesion molecule-1(ICAM-1), chitinase-3-like protein 1(YKL-40) and lipoprotein-associated phospholipase A2(Lp-PLA2). Results: Compared with the QSBS group, Lp-PLA2 and YKL-40 levels in the QDBS group showed no-significant difference(P>0.05); ICAM-1 was significantly higher in the QDBS group than in the QSBS group in the pathological processes of qi disturbance and blood stasis syndrome of ACS(P<0.05). Conclusion: Inflammatory factor ICAM-1 may be an objective basis for syndrome typing of QSBS and QDBS, which provides a research direction for standardization research of CM syndrome types. | MA Cai-yun LIU Jing-hua LIU Jian-xun SHI Da-zhuo XU Zhen-ye WANG Shao-ping JIA Min ZHAO FU-hai JIANG YUE-rong MA Qin PENG Hong-yu LU Yuan ZHENG Ze REN Feng-xue | 2017 | Chinese Journal of Integrative Medicine2017，23，11： | 19 |
| 5 | Carbon carry capacity and carbon sequestration potential in China based on an integrated analysis of mature forest biomass显示文摘Forests play an important role in acting as a carbon sink of terrestrial ecosystem.Although global forests have huge carbon carrying capacity(CCC)and carbon sequestration potential(CSP),there were few quantification reports on Chinese forests.We collected and compiled a forest biomass dataset of China,a total of 5841 sites,based on forest inventory and literature search results.From the dataset we extracted 338 sites with forests aged over 80 years,a threshold for defining mature forest,to establish the mature forest biomass dataset.After analyzing the spatial pattern of the carbon density of Chinese mature forests and its controlling factors,we used carbon density of mature forests as the reference level,and conservatively estimated the CCC of the forests in China by interpolation methods of Regression Kriging,Inverse Distance Weighted and Partial Thin Plate Smoothing Spline.Combining with the sixth National Forest Resources Inventory,we also estimated the forest CSP.The results revealed positive relationships between carbon density of mature forests and temperature,precipitation and stand age,and the horizontal and elevational patterns of carbon density of mature forests can be well predicted by temperature and precipitation.The total CCC and CSP of the existing forests are 19.87 and 13.86 Pg C,respectively.Subtropical forests would have more CCC and CSP than other biomes.Consequently,relying on forests to uptake carbon by decreasing disturbance on forests would be an alternative approach for mitigating greenhouse gas concentration effects besides afforestation and reforestation. | LIU Ying Chun YU Gui Rui WANG Qiu Feng ZHANG Yang Jian XU Ze Hong | 2014 | Science China(Life Sciences)2014，57，12： | 15 |
| 6 | Generation of B Cell-Deficient Pigs by Highly Efficient CRISPR/Cas9-Mediated Gene Targeting显示文摘Generating B cell-deficient mutant is the first step to produce human antibody repertoires in large animal models. In this study, we applied the clustered regularly interspaced short palindromic repeat(CRISPR)/CRISPR-associated(Cas) system to target the JHregion of the pig Ig M heavy chain gene which is crucial for B cell development and differentiation. Transfection of Ig M-targeting Cas9 plasmid in primary porcine fetal fibroblasts(PFFs) enabled inducing gene knock out(KO) in up to 53.3% of colonies analyzed, a quarter of which harbored biallelic modification, which was much higher than that of the traditional homologous recombination(HR). With the aid of somatic cell nuclear transfer(SCNT) technology, three piglets with the biallelic Ig M heavy chain gene mutation were produced. The piglets showed no antibody-producing B cells which indicated that the biallelic mutation of the Ig M heavy chain gene effectively knocked out the function of the Ig M and resulted in a B cell-deficient phenotype. Our study suggests that the CRISPR/Cas9 system combined with SCNT technology is an efficient genome-editing approach in pigs. | Fengjiao Chen Ying Wang Yilin Yuan Wei Zhang Zijian Ren Yong Jin Xiaorui Liu Qiang Xiong Qin Chen Manling Zhang Xiaokang Li Lihua Zhao Ze Li Zhaoqiang Wu Yanfei Zhang Feifei Hu Juan Huang Rongfeng Li Yifan Dai | 2015 | Journal of Genetics and Genomics2015，42，8： | 15 |
| 7 | A case-control study of risk factors for severe hand-foot-mouth disease in Yuxi, China, 2010–2012显示文摘Dear Editor,Here,we report the risk factors for severe hand-foot-mouth disease(HFMD)determined by our case-controlstudy.Our findings could help disease prevention and in-tervention initiatives.Patients with severe HFMD displayfatal clinical manifestations with sequelae,requiring≥7days of hospitalization.A tota1 of 249 severe cases treat-ed at Yuxi Children’s Hospital were included in the | Ze Liu Shukun Wang Rusong Yang Xia Ou | 2014 | Virologica Sinica2014，29，2： | 14 |
| 8 | RESTplus: an improved toolkit for resting-state functional magnetic resonance imaging data processing显示文摘Resting-state functional magnetic resonance imaging (RS-fMRI)[1,2] provides relatively high spatial and temporal resolution for mapping spontaneous brain activity non-invasively. It has been widely used in cognitive neuroscience and clinical studies. A number of comprehensive software packages have been developed for RS-fMRI data analysis, among which a MATLAB package named REST (RESing-state fMRI data analysis Toolkit, released in October 2008 at http://gffzz99d25abdda23474bhocuonwx5vubv6woq.ffgz.tsg.suse.edu.cn)[3] is the earliest one dedicated to RS-fMRI analysis. REST focuses on RS-fMRI postprocessing metrics. | Xi-Ze Jia Jue Wang Hai-Yang Sun Han Zhang Wei Liao Ze Wang Chao-Gan Yan Xiao-Wei Song Yu-Feng Zang | 2019 | Science Bulletin2019，64，14： | 14 |
| 9 | Synergistically Directed Assembly of Aromatic Stacks Based Metal-Organic Frameworks by Donor-Acceptor and Coordination Interactions显示文摘A synergistically directed assembly approach to distinctive metal-organic frameworks utilizing both donor-acceptor (D-A) interaction from aromatic systems and coordination interactions is presented.Based on such an approach,the coronene-tpt (tpt =2,4,6-tri(4-pyridyl)-1,3,5-triazine) stacks based coronene-MOF-1-4 have been successfully fabricated.Their structural discrepancies with coroneneabsent control products,1'-4',illustrate clearly the significance of coronene-tpt based D-A interactions in these architectures.All these coronene-MOFs contain varied coronene-tpt stacks as organic secondary building blocks (SBUs),which are closely interrelated with the coordination based framework structures.Moreover,porous coronene-MOF-1 and-2 exhibit high physicochemical stability and significant light hydrocarbons storage and separation performances. | Xi Wang Ying Zhang Ze Chang Hui Huang Xiao-Ting Liu Jialiang Xu Xian-He Bu | 2019 | Chinese Journal of Chemistry2019，37，9： | 11 |
| 10 | How Work Organization Affects the Prevalence of WMSDs: A Case-control Study显示文摘Objective In this study, we aimed at exploring the association between work-related musculoskeletal disorders(WMSDs) and work organization based on a case-control study. Methods A total of 1938 workers who claimed to suffer from WMSDs were selected from Beijing, Henan, Hubei, and the Guangdong province. The control group consisted of 2009 workers employed in similar industries without severe disease or musculoskeletal discomforts. We used a modified version of the questionnaire developed by the NMQ and the DMQ to investigate individual and work-related factors. Results A total of 13 variables(P<0.1) were selected by the chi-square test and finally, 7 variables entered into the equation, with 6 variables reaching statistical significance(P<0.05). The odds ratios(OR) of ‘work changing with season' and ‘sufficient rest time' did not reach 1(0.749 and 0.441, respectively). In addition, ‘sufficient rest time' seemed to be the stronger protective factor according to its higher standardized coefficient. And ‘repetitive work every minute', ‘constantly repetitive work'(every day), ‘shortage of site personnel', and ‘often switching shifts with others' seemed to be the risk factors. Conclusion Work organization may have comprehensive effects on the occurrence of WMSDs. This pattern of associations suggests that further investigation into the mechanism of how work organization affects the prevalence of WMSDs is required. | LIU Lu CHEN Song Gen TANG Shi Chuan WANG Sheng HE Li Hua GUO Ze Hua LI Jing Yun YU Shan Fa WANG Zhong Xu | 2015 | Biomedical and Environmental Sciences2015，28，9： | 11 |
| 11 | Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs显示文摘干皮病 pigmentosum (XP ) 是联系 XP 的基因的变化引起的一组基因混乱,导致 DNA 修理的缺陷。XP 病人经常展出神经病学的退化,而是内在的机制是未知的,部分地由于合适的疾病模型的缺乏。这里,我们产生了包括 XPA, XPB, XPC, XPG,和 XPV 在五不同 XP 基因怀有变化的病人特定的导致的 pluripotent 干细胞(iPSCs ) 。这些 iPSCs 进一步被区分到神经房间,并且他们到 DNA 损坏应力的危险性被调查。在神经干细胞(NSC ) 或神经原的 XPA 的变化导致了严重 DNA 损坏修理缺点,并且有变异的 XPA 的这些神经房间对 DNA 导致损坏的 apoptosis 过分敏感。因此, XP 变异的神经房间代表珍贵工具在 XP 病人澄清神经病学的畸形的分子的机制。 | Lina Fu Xiuling Xu Ruotong Ren Jun Wu Weiqi Zhang Jiping Yang Xiaoqing Ren Si Wang Yang Zhao Liang Sun Yang Yu Zhaoxia Wang Ze Yang Yun Yuan Jie Qiao Juan Carlos Izpisua Belmonte Jing Qu Guang-Hui Liu | 2016 | Protein & Cell2016，7，3： | 11 |
| 12 | A Dormant Multi-Controller Model for Software Defined Networking显示文摘In order to improve the scalability and reliability of Software Defined Networking(SDN),many studies use multiple controllers to constitute logically centralized control plane to provide load balancing and fail over.In this paper,we develop a flexible dormant multi-controller model based on the centralized multi-controller architecture.The dormant multi-controller model allows part of controllers to enter the dormant state under light traffic condition for saving system cost.Meanwhile,through queueing analysis,various performance measures of the system can be obtained.Moreover,we analyze the real traffic of China Education Network and use the results as the parameters of computer simulation and verify the effects of parameters on the system characteristics.Finally,a total expected cost function is established,and genetic algorithm is employed to find the optimal values of various parameters to minimize system cost for the deployment decision making. | FU Yonghong BI Jun WU Jianping CHEN Ze WANG Ke LUO Min | 2014 | China Communications2014，11，3： | 11 |
| 13 | Characteristics of phosphorus fractionated from the sediment resuspension in abrupt expansion flow experiments显示文摘Phosphorous(P) fraction characteristics in sediment resuspension were investigated under adequately hydrodynamic conditions. Four forms of P in overlying water,including dissolved inorganic P,dissolved total P,total P,and particulate P,and six fractions of P in suspended particulate matter(SPM) ,including loosely sorbed P(NH4Cl-P) ,redox-sensitive P(BD-P) ,aluminum-bound P(Al-P) ,organic P(NaOH-nrP) ,calcium-bound P(Ca-P) and residual P(Res-P) ,were quantified,respectively.Diflerent hydrodynamic conditions resulted in different P form changes.Four states could be ascribed:(1) P desorption by sediment and SPM,and P adsorption by overlying water;(2) P desorption by SPM,and P adsorption by overlying water;(3) P adsorption by SPM,and P desorption by overlying water;and(4) P equilibrium between SPM and overlying water.The contents of P in overlying water acquired peak values in the middle position of the vertical P distribution due to the combined actions of SPM and sediment.P fractions in SPM were in the following order:BD-P>NaOH-nrp>Ca-P>Al-P>Res-P>NH4Cl-P.BD-P in SPM frequently exchanged with P forms in overlying water.Resuspension was favorable to forming Ca-P in SPM. | Jun Wan Ze Wang Hezhong Yuan | 2010 | Journal of Environmental Sciences2010，22，10： | 11 |
| 14 | Fabrication and properties of foam geopolymer using circulating fluidized bed combustion fly ash显示文摘In recent years,circulating fluidized bed combustion fly ash(CFA) is used as a raw material for geopolymer synthesis.Hydrogen peroxide was employed as a foaming agent to prepare CFA-based foam geopolymer.The particle distribution,mineral composition,and chemical composition of CFA were examined firstly.Geopolymerization products were characterized by mechanical testing,scanning electron microscopy(SEM),X-ray diffraction(XRD),and X-ray fluorescence(XRF).The CFA-based foam geopolymer was successfully fabricated with different contents of hydrogen peroxide and exhibited uncompleted alkali reaction and reasonable strength with relative low atomic ratios of Si/Al and Si/Na.Type-C CFA in this research could be recycled as an alternative source material for geopolymer production. | Ze Liu Ning-ning Shao Dong-min Wang Jun-feng Qin Tian-yong Huang Wei Song Mu-xi Lin Jin-sha Yuan Zhen Wang | 2014 | International Journal of Minerals,Metallurgy and Materials2014，21，1： | 11 |
| 15 | CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs显示文摘 | Lixia Wang Fei Yi Lina Fu Jiping Yang Si Wang Zhaoxia Wang Keiichiro Suzuki Liang Sun Xiuling Xu Yang Yu Jie Qiao Juan Carlos Izpisua Belmonte Ze Yang Yun Yuan Jing Qu Guang-Hui Liu | 2017 | Protein & Cell2017，8，5： | 10 |
| 16 | Critical velocity in phosphorus exchange processes across the sediment-water interface显示文摘Sediments are ultimate sinks of nutrients in lakes that record the pollution history evolutionary processes, and anthropogenic activities of a lake. However, sediments are considered as inner sources of environmental factor changes such as the variation in hydrodynamic conditions because of the nutrients they release. How does this process happen? This study investigates a typical nutrient phosphorus(P) exchange among sediment, suspended particle matter(SPM), and water. Compared with numerical and experimental studies, this study confirms that the critical velocity that occurs at a lower flow rate state exists in the range of 7 to 15 cm/sec. Critical velocity below the critical flow rate promotes the migration of particulate phosphorus(PP) to the SPM. On the other hand, critical velocity above the critical flow rate promotes the release of PP in water. | Jun Wan Ze Wang Zhijie Li Huiling Duan HezhongYuan | 2013 | Journal of Environmental Sciences2013，25，10： | 9 |
| 17 | The anti-inflammatory effects of asiatic acid in lipopolysaccharide-stimulated human corneal epithelial cells显示文摘AIM: To investigate the anti-inflammatory effects of asiatic acid(AA) on lipopolysaccharide(LPS)-induced inflammatory response in human corneal epithelial cells(HCECs).METHODS: Cell viability was measured using a cell counting kit-8(CCK-8) assay.Quantitative real-time polymerase chain reaction(qR T-PCR) was used to determine the mR NA expression of interleukin-8(IL-8),interleukin-6(IL-6),interleukin-1β(IL-1β),tumor necrosis factor-alpha(TNF-α),and transforming growth factor-β(TGF-β) in HCECs.Intracellular reactive oxygen species(ROS) was measured using the ROS assay kit.Glutathione(GSH) concentration was measured using the total GSH assay kit.Akt1 and Akt phosphorylation(p-Akt1) levels were measured by Western blotting and immunofluorescence.RESULTS: AA induced toxicity at high concentrations and significantly stimulated the proliferation of HCECs at concentrations of 20 μmol/L for 1h.LPS at concentrations of 300 ng/mL for 1h significantly stimulated the mR NA expression of IL-8,IL-6,IL-1β,TNF-α,and TGF-β in HCECs,while the stimulation effects were significantly inhibited by AA(20 μmol/L).In addition,AA was found to decrease the content of ROS,increase GSH generation,and also inhibit LPS-induced p-Akt in HCECs.CONCLUSION: AA decreases the generation of inflammatory factors IL-8,IL-6,IL-1β,TNF-α,and TGF-β in LPSstimulated HCECs.AA significantly inhibites the intracellular concentrations of ROS and increases GSH generation.AA also inhibites LPS-induced p-Akt in HCECs.These findings reveal that AA has anti-inflammation effects in LPS-stimulated HCECs. | Hao Chen Xiao-Min Hua Bai-Chen Ze Bin Wang Li Wei | 2017 | International Journal of Ophthalmology(English edition)2017，10，2： | 9 |
| 18 | A novel HfNbTaTiV high-entropy alloy of superior mechanical properties designed on the principle of maximum lattice distortion显示文摘This paper reports a synergistic design of high-performance BCC high-entropy alloy based on the combined consideration of the principles of intrinsic ductility of elements,maximum atomic size difference for solid solution strengthening and the valence electron concentration criterion for ductility.The single-phase BCC HfNbTaTiV alloy thus designed exhibited a high compressive yield strength of 1350 MPa and a high compressive ductility of>45%at the room temperature.This represents a 50%increase in yield strength relative to a HfNbTaTiZr alloy.This is attributed to the maximized solid solution strengthening effect caused by lattice distortion,which is estimated to be 1094 MPa.The alloy was also able to retain 53%of its yield strength and 77%of its ductility at 700℃.These properties are superior to those of most refractory BCC high-entropy alloys reported in the literature. | Zibing An Shengcheng Mao Yinong Liu Li Wang Hao Zhou Bin Gan Ze Zhang Xiaodong Han | 2021 | Journal of Materials Science & Technology2021，，20： | 9 |
| 19 | Cytological and Molecular Characteristics of Pollen Abortion in Lily with Dysplastic Tapetum显示文摘Lily was grown worldwide as a fresh cutting flower because of its colorful petals, but its anther contained a large number of pollen grains that cause serious pollen contamination, however, pollen abortion can effectively reduce the level of pollen pollution. Our analysis aims to use cytological observation to detect the critical stage when pollen abortion occurs and to provide comprehensive gene expression information at the transcriptional level. The result showed that pollen abortion in ‘Little Kiss’ began at the mononuclear stage and the callose that covers the microspores failed to degenerate when young pollens were released from the tetrads. In addition, compared with the normally developed one,the tapetum of ‘Little Kiss’ degraded in advance while the degradation of callose was delayed. Furthermore, 103 differentially expressed genes(DEGs) related to the advance degeneration of tapetum cells and callose were found in the expression levels, including 22 transcription factors(TFs). In particular, two β-glucanase genes(endo-1,3(4)-β-glucanase, exo-β-glucanase) responsible for callose degeneration were significantly down-regulated. These results suggested that pollen abortion may occur at mononuclear stage and that early degeneration of tapetum cells resulted in a significant down-regulation of β-glucanase genes. As a result, the callose to cover microspores impedes the formation of pollen walls, which may possibly lead to pollen abortion. | Xueqian Wang Ze Wu Lanqing Wang Meijiao Wu Dehua Zhang Weimin Fang Fadi Chen Nianjun Teng | 2019 | Horticultural Plant Journal2019，5，6： | 9 |
| 20 | Effect of SiO_2/Na_2O mole ratio on the properties of foam geopolymers fabricated from circulating fluidized bed fly ash显示文摘Geopolymers are three-dimensional aluminosilicates formed in a short time at low temperature by geopolymerization. In this paper, alkali-activated foam geopolymers were fabricated from circulating fluidized bed fly ash(CFA), and the effect of SiO2/Na2O mole ratio(0.91–1.68) on their properties was studied. Geopolymerization products were characterized by mechanical testing, scanning electron microscopy(SEM), energy-dispersive X-ray spectroscopy(EDX), and X-ray diffraction(XRD). The results show that SiO2/Na2O mole ratio plays an important role in the mechanical and morphological characteristics of geopolymers. Foam samples prepared in 28 d with a SiO2/Na2O mole ratio of 1.42 exhibit the greatest compressive strength of 2.52 MPa. Morphological analysis reveals that these foam geopolymers appear the relatively optimized pore structure and distribution, which are beneficial to the structure stability. Moreover, a combination of the Si/Al atomic ratio ranging between 1.47 and 1.94 with the Na/Al atomic ratio of about 1 produces the samples with high strength. | Ze Liu Ning-ning Shao Tian-yong Huang Jun-feng Qin Dong-min Wang Yu Yang | 2014 | International Journal of Minerals,Metallurgy and Materials2014，21，6： | 8 |
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