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| 1 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 2 | Mesozoic-Cenozoic Basin Features and Evolution of Southeast China显示文摘对早第三纪(T_3-E ) 晚三叠纪盆占据 143100 km2 的一个区域,是 SE 中国的全部的第六个区域;同步 granitoid 的全部的区域是 about127300 km^2;它为理解华南的构造进化提供一把钥匙。从 SE 中国的中生代新生代盆的一张 new1:1500000 地质图,与分析结合了几何并且 petrological 特征,盆 tectonics 的一些新卓见被获得。Advancesinclude petrotectonic 集合,地球动力学的盆分类,几何特征,盆和范围的关系。根据形成盆的地球动力学的机制, SE 中国的 theMesozoic 新生代盆能也就是被划分成三种类型:1 ) 形成从的帕拉低岬盆对在有压缩性的条件下面的早侏罗记(T_3-J_1 ) 晚三叠纪;2 ) 在中间的侏罗记(J_2 ) 期间形成在下面的裂缝盆一强烈前紧张的设定;并且 3 ) 在背弧扩展下面在早白垩纪期间形成到早第三纪(K_1-E ) 的指责的消沉行动。盆的 Fromthe 岩石集合,指责的消沉能被细分进主要在早白垩纪(K_1 ) 期间形成的 avolcanic 沉积的类型和从迟了的白垩纪形成到早第三纪(K_2-E ) 的一种红床类型。统计数据建议 allpara 低岬盆(T_3-J_1 ) 的区域是 15120 km^2,裂缝盆(J_2 ) 之一包括 37850 km^2 的 K_2-E 红床的盆占据 4640 km^2,和等于 124330 km^2 的所有指责的消沉。EarlyMesozoic (T_3-J_1 ) 盆和花岗石主要在一个碰撞以后的压缩背景下面被共同产生,当从到早第三纪(J_2-E ) 的侏罗记主要是的中间的盆由地区性的前抑制了紧张的 tectonics 时。三地质并且地理带也就是被调查:1 ) 把古地理学和气候的地区与中间的侏罗记分开到的 Wuyishan 第三级;2 ) 中间的侏罗记裂缝地区;并且 3 ) 近来分开地区的 Ganjiang 中生代火山作用。盆花岗石关系的 Threetypes 被识别了,包括有压缩性(一些) ,走向滑倒(一些) ,和前紧张(普通) 。SE-Chinabasin 的三阶段的地球动力学的进化被提出:一个早中生代盆花岗石框架;过渡中间的侏罗记构造政体;intracontinental 扩展和红床的指责的消沉自从迟了的白垩纪。 | SHU Liangshu ZHOU Xinmin DENG Ping ZHU Wenbin | 2007 | Acta Geologica Sinica(English Edition)2007，81，4： | 15 |
| 3 | PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix显示文摘Biofilms 是在细胞外的矩阵嵌入的微生物的联系表面的社区。Exopolysaccharide 是在维持 biofilm 建筑学并且保护居民 biofilm 细菌免受抗菌剂和主人免疫者攻击的伤害的细胞外的矩阵的一个批评部件。然而,指向矩阵 exopolysaccharides 的自我生产的因素,仍然糟糕被理解。这里,我们显示出那 PslG,在 Pseudomonas aeruginosa 涉及关键 biofilm 矩阵 exopolysaccharide Psl 的合成的蛋白质,阻止 biofilm 形成并且拆卸存在在外长地供应的在 nanomolar 集中的分钟以内的 biofilms。PslG 的水晶结构显示 endoglycosidase 的典型特征。PslG 主要破坏 Psl 矩阵从 biofilms 驱散细菌。PslG 处理显著地提高 biofilm 敏感到抗菌素和巨噬细胞房间,导致在一只老鼠的改进 biofilm 清理植入感染模型。而且, PslG 对大量 Pseudomonas 种类显示出 biofilm 抑制和拆卸活动,显示它在与 biofilm 相关的复杂并发症作斗争的大潜力。 | Shan Yu Tiantian Su Huijun Wu Shiheng Liu Di Wang Tianhu Zhao Zengjun Jin Wenbin Du Mei-Jun Zhu Song Lin Chua Liang Yang Deyu Zhu Lichuan Gu Luyan Z Ma | 2015 | Cell Research2015，25，12： | 13 |
| 4 | Outcomes in refractory diffuse large B-cell lymphoma:results fromamulticenter real-world study in China显示文摘Background:Diffuse large B-cell lymphoma(DLBCL)patients refractory to rituximab-based immunochemotherapy have a dismal prognosis.However,the definition of refractory DLBCL remains inconsistent and no large cohort study data is available from Asian countries.To validate the definition and outcomes of refractory DLBCL in China,we conducted a multicenter,retrospective cohort study.Methods:The REtrospective AnaLysis of Treatment REspoNse of refractory DLBCL(REAL-TREND)study was performed using real-world data from 8 centers in China.DLBCL patients with curative intent were included in the REAL-TREND dataset.Overall survival(OS)was estimated using the Kaplan-Meier method and compared by the log-rank test.Due to heterogeneity in response rates among different centers,the response rates of refractory patients were pooled using random-effect models.Multivariate survival analysis was performed using the Cox regression model.Results:A total of 2778 DLBCL patients diagnosed between January,2010 and December,2015 were enrolled to this study.After validating previous definitions,the SCHOLAR-1 study was most suitable to define refractory DLBCL.The estimated 5-year cumulative incidence of refractory patients was 20%(95% confidence Interval[CI]=18%-22%).After the determination of refractory disease,overall response rate and complete remission rate were 30%(95%CI=22%-38%)and 9%(95%CI=4%-15%),respectively.Patients with either no response to immunochemotherapy or relapse within 12 months after stem-cell transplantation had inferior survival with a median OS of 5.9 months(95%CI=5.5-7.1 months)and 2-year OS rate of 16%(95%CI=12%-20%).International prognostic index score 4-5(hazard ratio[HR]=2.22;95%CI=1.47-3.35),central nervous systemrelapse(HR=1.43;95%CI=1.04-1.97),and best response status(HR=2.68;95%CI=1.42-5.03 for partial remission.HR=5.97,95%CI=3.21-11.11 for stable disease/progressive disease)were independent unfavorable prognostic factors.Conclusions:This is the first large-scale Asian cohort study focusing on outcomes of refractory DLBCL.The definition of the SCHOLAR-1 study identifies patients with homogenously inferior survival,thus is appropriate to select refractory DLBCL.Due to poor clinical outcomes in the rituximab era,patients with refractory DLBCL may be potential candidates for novel treatment modalities. | Shuo Wang Li Wang Jianda Hu Wenbin Qian Xi Zhang Yu Hu Qi Zhu Bobin Chen Depei Wu Chung-Chou H.Chang Pengpeng Xu Xiaoyun Zheng Juying Wei Yao Liu Guohui Cui Yong Tang Yan Ma Haiwen Huang Hongmei Yi Weili Zhao | 2021 | Cancer Communications2021，41，3： | 10 |
| 5 | NIR-II ?uorescence in vivo confocal microscopy with aggregation-induced emission dots显示文摘Significantly reduced tissue scattering of fluorescence signals in the second near-infrared(NIR-Ⅱ,1,000–1,700 nm)spectral region offers opportunities for large-depth in vivo bioimaging.Nowadays,most reported works concerning NIR-II fluorescence in vivo bioimaging are realized by wide-field illumination and 2D-arrayed detection(e.g.,via InGaAs camera),which has high temporal resolution but limited spatial resolution due to out-of-focus signals.Combining NIR-II fluorescence imaging with confocal microscopy is a good approach to achieve high-spatial resolution visualization of biosamples even at deep tissues.In this presented work,a NIR-II fluorescence confocal microscopic system was setup.By using a kind of aggregation-induced emission(AIE)dots as NIR-II fluorescent probes,800 lm-deep 3D in vivo cerebrovascular imaging of a mouse was obtained,and the spatial resolution at 700 lm depth could reach 8.78 lm.Moreover,the time-correlated single photon counting(TCSPC)technique and femtosecond laser excitation were introduced into NIR-II fluorescence confocal microscopy,and in vivo confocal NIR-II fluorescence lifetime microscopic imaging(FLIM)of mouse cerebral vasculature was successfully realized. | Wenbin Yu Bing Guo Hequn Zhang Jing Zhou Xiaoming Yu Liang Zhu Dingwei Xue Wen Liu Xianhe Sun Jun Qian | 2019 | Science Bulletin2019，64，6： | 10 |
| 6 | Apatite fission track thermochronology in the Kuluketage and Aksu areas,NW China:Implication for tectonic evolution of the northern Tarim显示文摘Tarim Precambrian bedrocks are well exposed in the Kuluketage and Aksu areas,where twenty four samples were taken to reveal the denudation history of the northern Tarim Craton.Apatite fission track dating and thermal history modeling suggest that the northern Tarim experienced multi-stage cooling events which were assumed to be associated with the distant effects of the Cimmerian orogeny and India-Eurasia collision in the past.But the first episode of exhumation in the northern Tarim,occurring in the mid-Permian to Triassic,is here suggested to be induced by docking of the Tarim Craton and final amalgamation of the Central Asian Orogenic Belt.The cooling event at ca.170 Ma may be triggered by the Qiangtang-Eurasia collision.Widespread Cretaceous exhumation could be linked with docking of the Lhasa terrane in the late Jurassic.Cenozoic reheating and recooling likely occurred because of the northpropagating stress,however,this has not affected the northern Tarim much because the Tarim is characterized by rigid block-like motion. | Zhiyong Zhang Wenbin Zhu Dewen Zheng Bihai Zheng Wei Yang | 2016 | Geoscience Frontiers2016，7，2： | 8 |
| 7 | Analyzing and modeling the coverage of vegetation in the Qaidam Basin of China: The role of spatial autocorrelation显示文摘在植被和环境因素之间的关系总是是在生态学的一个主要话题,但是揭示植被也是一个重要方法对的动态反应和气候上的效果改变的反馈。为特殊地理地点和 Qaidam 盆的气候的特征,与支持传统并且遥感数据,在这份报纸,一个植被范围模型被建立。由五个环境因素的植被范围的量的预言开始通过多重逐步的回归(MSR ) 被认识到模型。然而,在这五个环境因素之中有重要 multicollinearity,它减少 MSR 模型的表演。然后通过 Moran 的介绍索引,反映植被分发,仅仅平均年度降雨的二个变量和本地 Moran 索引的空间自相关的指示物在植被范围模型的最后的建立被使用。结果证明在植被的分发有重要空间自相关。在植被范围模型的建立的空间自相关的角色让改进不仅从 0.608 ~ 0.656 的模型试穿 R2,而且在独立人士之中移开 multicollinearity。 | ZHU Wenbin JIA Shaofeng LU Aifeng YAN Tingting | 2012 | Journal of Geographical Sciences2012，22，2： | 8 |
| 8 | Phosphorylation of PLIN3 by AMPK promotes dispersion of lipid droplets during starvation显示文摘Dear Editor,Lipid droplets(LDs)are dynamic lipid-storage organelles of storage depots and sources of essential substrates for myriad cellular processes and protect cells from lipotoxicity(Ohsaki et al.,2006).Disrupted LD and fat storage homeostasis has been linked to metabolic diseases such as atherosclerosis,obesity,and type II diabetes(Levin et al.,2001).Structurally,the core of neutral lipids in LDs is surroun ded by a phospholipid mono layer and coated with specific proteins(Storey et al.,2011).Perilipin family of proteins are the predominant LD-associated proteins. | Jianxi Zhu Mingyang Xu Yi Liu Lisha Zhuang Kejun Ying Feng Liu Dan Liu Wenbin Ma Zhou Songyang | 2019 | Protein & Cell2019，10，5： | 7 |
| 9 | SERK Receptor-like Kinases Control Division Patterns of Vascular Precursors and Ground Tissue Stem Cells during Embryo Development in Arabidopsis显示文摘During embryo development, the vascular precursors and ground tissue stem cells divide to renew them-selves and produce the vascular tissue, endodermal cells, and cortical cells. However, the molecular mech-anisms regulating division of these stem cells have remained largely elusive. In this study, we show that loss of function of SOMATIC EMBRYOGENESIS RECEPTOR-UKE KINASE (SERK) genes results in aberrant em-bryo development. Fewer cortical, endodermal, and vascular cells are generated in the embryos of serk1 serk2bak1 triple mutants. WUSCHEL-RELATED HOMBOBOX5 (WOXS) is ectopically expressed in vascular cells of serkl serk2 bak1 embryos. The first transverse division of vascular precursors in mid-globular em-bryos and second asymmetric division of ground tissue stem cells in early-heart embryos are abnormally altered to a longitudinal division. The embryo defects can be partially rescued by constitutively activated mitogen-activated protein kinase (MAPK) kinase kinase YODA (YDA) and MAPK kinase MKK5. Taken together, our results reveal that SERK-mediated signals regulate division patterns of vascular precursors and ground tissue stem cells, likely via the YDA-MKK4/5 cascade, during embryo development. | Huiqiang Li Zeping Cai Xiaojuan Wang Meizhen Li Yanwei Cui Nan Cui Fei Yang Mingsong Zhu Junxiang Zhao Wenbin Du Kai He Jing Yi Frans E.Tax Suiwen Hou Jia Li Xiaoping Gou | 2019 | Molecular Plant2019，12，7： | 7 |
| 10 | Niobium alloying effect in high carbon equivalent grey cast iron显示文摘The effect of niobium on the formation of NbC phase and solidification structure in high carbon equivalent grey cast iron was investigated.The experimental results indicated that an increase in the niobium content is favorable to refining the graphite and eutectic cell;and the pearlite lamellar spacing is reduced.Based on the thermodynamic calculation the formation of NbC is prior to the eutectic reaction.The reduction in the pearlite lamellar spacing is mainly attributed to the decrease of eutectic temperature with the addition of niobium.Additionally,properties including hardness and wear resistance were improved after the addition of niobium. | Zhou Wenbin Zhu Hongbo Zheng Dengke Zheng Hongxing Hua Qin Zhai Qijie | 2011 | China Foundry2011，8，1： | 7 |
| 11 | Organobentonites as adsorbents for some organic pollutants and its application in wastewater treatment显示文摘Organobentonitesasadsorbentsforsomeorganicpollutantsanditsapplicationinwastewatertreatment￥ZhuLizhong;ZhangJianying;LiYimin;S... | Zhu Lizhong Zhang Jianying Li Yimin Shen Xueyou Qi Wenbin(Department of Environmental Science. Hangzhou University, Hangzhou 310028, China) | 1996 | Journal of Environmental Sciences1996，8，3： | 5 |
| 12 | Eocene Basins on the SE Tibetan Plateau: Markers of Minor Offset along the Xuelongshan–Diancangshan–Ailaoshan Structural System显示文摘The offset of geological bodies provides robust evidence of displacement along a fault or ductile shear zone. The amount of displacement along the Xuelongshan–Diancangshan–Ailaoshan structural system, southeastern Tibetan Plateau, is uncertain because of the lack of offset geological markers. This NNW–SSE-trending system is developed in three isolated metamorphic complexes and interjacent nonmetamorphosed rocks. They are expected to record similar post-Eocene strain, although their structural patterns should be distinct. Geological mapping in the area between the Xuelongshan and Diancangshan metamorphic complexes has revealed a small Eocene basin, the Madeng Basin, located to the west of the structural system. The sedimentary and volcanic successions of the Madeng Basin are comparable to those of the Jianchuan Basin, which is located to the east of the structural system. Zircon U–Pb geochronological and bulk geochemical data demonstrate that the volcanic rocks of both basins formed during 37–34 Ma and share the same geochemical features. These data suggest that the Madeng and Jianchuan basins previously constituted a single basin, with the distribution of high-K volcanic rocks in the basins defining an ENE–WSW-trending volcanic belt that shows a limited dextral offset of ≤20 km across the Xuelongshan–Diancangshan–Ailaoshan structural system. Therefore, the northern segment of the structural system records no evidence of large-scale lateral movement/displacement. The results suggest that the Indochina block, which is bounded by the Xuelongshan–Diancangshan–Ailaoshan structural system to the east and the Sagaing Fault to the west, has not extruded southward as a whole but rather has been deformed by pervasive crustal shortening. | LIAO Cheng YANG Tiannan XUE Chuandong LIANG Mingjuan XIN Di XIANG Kun JIANG Lili SHI Pengliang ZHU Wenbin WAN Liangchun TANG Jing YU Jing WU Pinglei | 2020 | Acta Geologica Sinica(English Edition)2020，94，4： | 5 |
| 13 | Spatial distribution of vegetation and the influencing factors in Qaidam Basin based on NDVI显示文摘The spatial distribution of vegetation in Qaidam Basin was analyzed using GIMMS(Global Inventory Modeling and Mapping Studies) /NDVI(Normalized Difference Vegetation Index) data set from January 1982 to December 2006.Based on the data of precipitation,terrain,stream systems,land use and the map of vegetation distribution in Qaidam Basin,we studied the factors influencing the spatial distribution of vegetation.The results showed that the vegetation was generally low in Qaidam Basin and there was a clear semi-ring structure from southeast to northwest.In some areas,the existence of rivers,lakes and spring belts turned this semi-ring structure into a non-continuous state and formed distinct bright spots and continuous linear features.There were four main factors that affected the spatial distribution of vegetation coverage in Qaidam Basin,i.e.,precipitation,hydrological conditions,altitude and human activities.Precipitation and altitude have a correlation and determine the basic pattern of vegetation distribution in Qaidam Basin.The impacts of hydrological conditions and human activities were mainly embodied in partial areas,and often broke the pattern of vegetation distribution dominated by precipitation and altitude. | WenBin ZHU AiFeng LV ShaoFeng JIA | 2011 | Journal of Arid Land2011，3，2： | 4 |
| 14 | Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair显示文摘There are intense interests in discovering pro regenerative medicine leads that can promote cardiac differentiation and regeneration,as well as repair damaged heart tissues.We have combined zebrafish embryo-based screens with cardiomyogenesis assays to discover selective small molecules that modulate heart development and regeneration with minimal adverse effects.Two related compounds with novel structures,named as Cardiomogen 1 and 2(CDMG1 and CDMG2),were identified for their capacity to promote myocardial hyperplasia through expansion of the cardiac progenitor cell population.We find that Cardiomogen acts as a Wnt inhibitor by targeting p-catenin and reducing Tcf/Lef-mediated transcription in cultured cells.CDMG treatment of amputated zebrafish hearts reduces nuclear p-catenin in injured heart tissue,increases cardiomyocyte(CM)proliferation,and expedites wound healing,thus accelerating cardiac muscle regeneration.Importantly,Cardiomogen can alleviate the functional deterioration of mammalian hearts after myocardial infarction.Injured hearts exposed to CDMG1 display increased newly formed CMs and reduced fibrotic scar tissue,which are in part attributable to the^-catenin reduction.Our findings indicate Cardiomogen as a Wnt inhibitor in enhancing injury-induced CM proliferation and heart regeneration,highlighting the values of embryo-based small molecule screens in discovery of effective and safe medicine leads. | Shuying Xie Wenbin Fu Guangju Yu Xueli Hu Kaa Seng Lai Xiangwen Peng Yating Zhou Xuejiao Zhu Ptamen Christov Leah Sawyer Terri T.Ni Gary A.Sulikowski Zhongzhou Yang Ethan Lee Chunyu Zeng Wei E.Wang Tao P.Zhong | 2020 | Journal of Molecular Cell Biology2020，12，1： | 4 |
| 15 | Involvement of long non-coding RNAs in the progression of esophageal cancer显示文摘Esophageal cancer(EC)is one of the most common malignant tumors of the digestive system with high incidence and mortality rate worldwide.Therefore,exploring the pathogenesis of ECand searching for new targeted therapies are the current research hotspot for EC treatment.Long non-coding RNAs(lncRNAs)are endogenous RNAs with more than 200 nucleotides,but without proteincoding function.In recent years,lncRNAs have gradually become the focuses in the field of non-coding RNA.Some lncRNAs have been proved to be closely related to the pathogenesis of EC.Many lncRNAs are abnormally expressed in EC and participate in many biological processes including cell proliferation,apoptosis,and metastasis by inhibiting or promoting target gene expression.LncRNAs can also regulate the progression of EC through epithelial-mesenchymal transformation(EMT),which is closely related to the occurrence,development,and prognosis of EC.In this article,we review and discuss the involvement of lncRNAs in the progression of EC. | Wenhua Xue Yuanyuan Zheng Zhibo Shen Lifeng Li Zhirui Fan Wenbin Wang Zijia Zhu Yunkai Zhai Jie Zhao Quancheng Kan | 2021 | Cancer Communications2021，41，5： | 4 |
| 16 | Late Mesozoic Thermotectonic Evolution of the Jueluotage Range,Eastern Xinjiang,Northwest China:Evidence from Apatite Fission Track Data显示文摘摘要:尽管许多作者强调了变丑的新生代历史,发掘并且在与印度亚洲碰撞有关的 Tianshan 区域冷却,几乎不对压缩的中生代历史被知道并且在 Tianshan 以内高举。以便关于中生代发掘历史和在东方 Tianshan 冷却的进程获得信息,磷灰石上的分裂磁道方法被使用。采样在 Jueluotage 范围被做。三件样品(Z001-Z003 ) 在 Yandong pluton 的地上凿穿 ZK6301 从花岗石被拿;从比是的 pluton 年龄年轻得多的 97.0 ~ 87.6 妈的年龄范围在 334 点由 U-Pb 锆石标明日期 ????????? Y ?? 霈吗?? | ZHU Wenbin WAN Jinglin SHU Liangshu ZHANG Zhiyong SU Jinbao SUN Yah GUO Jichun ZHANG Xueyun | 2008 | Acta Geologica Sinica(English Edition)2008，82，2： | 4 |
| 17 | Improving cognitive impairment by Tongxinluo via inhibiting expression of beta-secretase 1/beta-amyloid peptide in experimental vascular dementia显示文摘BACKGROUND: Tongxinluo has been clinically proven to be effective in improving memory and cognitive function in patients with post-stroke vascular dementia. Is the mechanism related to the deposition of beta-amyloid peptide (Aβ) in hippocampus? OBJECTIVE: To observe the effect of Tongxinluo on cognitive impairment in a mouse model with vascular dementia and the changes of Aβ deposition andβ-secretase 1 (BACE1) expression. DESIGN: Randomized controlled study. SETTING: State Key Laboratory of Pharmaceutical Biotechnology of Nanjing University and Affiliated Drum Tower Hospital of Nanjing University Medical School. MATERIALS: The experiment was carried out in the State Key Laboratory of Pharmaceutical Biotechnology of Nanjing University and Affiliated Drum Tower Hospital of Nanjing University Medical School from March 2006 to January 2007. A total of 36 healthy Kunming mice, 18 of each gender, were chosen. The study was conducted in accordance with the National Regulations of Experimental Animal Administration, and all animal experiments were approved by the Committee of Experimental Animal Administration of Nanjing University. Tongxinluo was provided by Shijiazhuang Yiling Pharmaceutical Co., Ltd. METHODS: All mice were randomly divided into 6 groups, including naive control (n=6), sham-operated control (n=6) and experimental groups treated with different doses of Tongxinluo (0.2, 0.4, and 0.6 g/kg/d; n=6 for each group) or vehicle (n=6). Five groups were subjected to bilateral common carotid arteries (2-VO) occlusion to produce a vascular dementia model (no occlusion was performed in sham-operated group). The mice in the Tongxinluo treatment groups were intragastricly administered daily with a Tongxinluo suspension (40 g/L in distilled water) at doses of 0.2, 0.4 or 0.6 g/kg/d from day 1 to day 30 post-surgery. The animals in vehicle, sham-operated and naive groups were administered an equal volume of distilled water. MAIN OUTCOME MEASURES: ①Escape latency time determined in all groups of mice before and after 2-VO occlusion by Morris water maze. ②Changes in BACE1 mRNA expression in the hippocampi of mice among the six groups by RT-PCR assay, and BACE1 and Aβ protein expression in the hippocampi of mice by Western blot. RESULTS: All 36 mice were involved in the final analysis. ① No difference was detected in escape latency time to a hidden platform among all groups in water maze test before surgery (P > 0.05) At 30 days after 2-VO occlusion, the vehicle animals exhibited a significantly longer latency in finding the hidden platform compared to that of sham-operated and naive animals (P < 0.01). The prolonged escape latency was significantly reduced by oral administration of 0.4 g or 0.6 kg/day (P < 0.01, P < 0.05). BACE1 mRNA and protein expression in vehicle animals were much higher than in sham-operated and naive animals (P < 0.01). The ischemia-induced increases in BACE1 mRNA and protein level were attenuated by all three doses of Tongxinluo treatment (P < 0.01), and the 0.4 g/kg/d treatment was the most effective. Aβ protein expression in vehicle animals after 2-VO occlusion were much higher than in sham-operated and na?ve animals (P < 0.01). 2-VO occlusion-induced Aβ generation was significantly attenuated by all doses of Tongxinluo treatment, with the most effective dose being 0.4 g/kg/d (P < 0.01). CONCLUSION: BACE1 mRNA levels and protein levels of BACE1 and Aβare reduced in the hippocampi of vascular dementia model mice by all three doses of Tongxinluo treatment, with the most effective dose being 0.4 g/kg/d. The results suggest that inhibition of post-ischemia BACE1 expression and Aβ generation in brain might underlie Tongxinluo’s effects in improving cognitive impairment. | Jia Jia Wenbin Zhu Lihui Wang Yun Xu | 2008 | Neural Regeneration Research2008，3，3： | 3 |
| 18 | Enhancing (de)hydrogenation kinetics properties of the Mg/MgH_(2) system by adding ANi_(5)(A=Ce,Nd,Pr,Sm,and Y) alloys via ball milling显示文摘Magnesium(Mg)-based alloys have already been widely studied as the hydrogen storage materials because of their high reversible hydrogen storage capacity,low cost,light weight,etc.However,the poor de/hydrogenation kinetic properties dramatically hinder the practical applications.In this work,the MgH_(2)-ANi_(5)(A=Ce,Nd,Pr,Sm,and Y) composites were prepared by a high-energy ball milling method.which can effectively refine the particle size thus improving the kinetic properties.Experimental results reveal that the MgH_(2)-ANi_(5) composites mainly consist of Mg_(2)NiH_(4),MgH_(2) and rare earth(RE) hydride,which will be dehydrogenated to form Mg_(2)Ni,Mg and stable RE hydride reversibly.Accordingly,the asmilled MgH_(2)-ANi_(5)(A=Ce,Nd,Pr,Sm,and Y) composites with various A-elements can respectively contribute to a reversible hydrogen storage capacity of 6.16 wt%,5.7 wt%,6.21 wt%,6.38 wt%,and 6.5 wt%at a temperature of 300℃,and show much better kinetic properties in comparison to the pure MgH_(2) without any additive.In-situ formed Mg_(2) Ni and stable RE hydride(such as CeH_(2.73) and YH_(2)) might act as effective catalysts to significantly improve the hydrogen storage properties of MgH_(2).The present work provides a guideline on improving the kinetic properties of the Mg-based hydrogen storage alloys. | Wenfang Liao Wenbin Jiang Xu-Sheng Yang Hui Wang Liuzhang Ouyang Min Zhu | 2021 | Journal of Rare Earths2021，39，8： | 3 |
| 19 | Structure Engineering in Biomass-Derived Carbon Materials for Electrochemical Energy Storage显示文摘Biomass-derived carbon materials(B-d-CMs)are considered as a group of very promising electrode materials for electrochemical energy storage(EES)by virtue of their naturally diverse and intricate microarchitectures,extensive and low-cost source,environmental friendliness,and feasibility to be produced in a large scale.However,the practical application of raw B-d-CMs in EES is limited by their relatively rare storage sites and low diffusion kinetics.In recent years,various strategies from structural design to material composite manipulation have been explored to overcome these problems.In this review,a controllable design of B-d-CM structures boosting their storage sites and diffusion kinetics for EES devices including SIBs,Li-S batteries,and supercapacitors is systematically summarized from the aspects of effects of pseudographic structure,hierarchical pore structure,surface functional groups,and heteroatom doping of B-d-CMs,as well as the composite structure of B-d-CMs,aiming to provide guidance for further rational design of the B-d-CMs for high-performance EES devices.Besides,the contemporary challenges and perspectives on B-d-CMs and their composites are also proposed for further practical application of B-d-CMs for EES devices. | Ruizi Li Yanping Zhou Wenbin Li Jixin Zhu Wei Huang | 2020 | Research2020，，1： | 3 |
| 20 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
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