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| 1 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 2 | Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors显示文摘Achievement of immunocompetent and therapeutic T lymphopoiesis from pluripotent stem cells(PSCs)is a central aim in T cell regenerative medicine.To date,preferentially reconstituting T lymphopoiesis in vivo from PSCs remains a practical challenge.Here we documented that synergistic and transient expression of Runx1 and Hoxa9 restricted in the time window of endothelial-to-hematopoietic transition and hematopoietic maturation stages in a PSC differentiation scheme(iR9-PSC)in vitro induced preferential generation of engraftable hematopoietic progenitors capable of homing to thymus and developing into mature T cells in primary and secondary immunodeficient recipients.Single-cell transcriptome and functional analyses illustrated the cellular trajectory of T lineage induction from PSCs,unveiling the T-lineage specification determined at as early as hemogenic endothelial cell stage and identifying the bona fide pre-thymic progenitors.The induced T cells distributed normally in central and peripheral lymphoid organs and exhibited abundant TCRαβrepertoire.The regenerative T lymphopoiesis restored immune surveillance in immunodeficient mice.Furthermore,gene-edited iR9-PSCs produced tumor-specific T cells in vivo that effectively eradicated tumor cells.This study provides insight into universal generation of functional and therapeutic T cells from the unlimited and editable PSC source. | Rongqun Guo Fangxiao Hu Qitong Weng Cui Lv Hongling Wu Lijuan Liu Zongcheng Li Yang Zeng Zhijie Bai Mengyun Zhang Yuting Liu Xiaofei Liu Chengxiang Xia Tongjie Wang Peiqing Zhou Kaitao Wang Yong Dong Yuxuan Luo Xiangzhong Zhang Yuxian Guan Yang Geng Juan Du Yangqiu Li Yu Lan Jiekai Chen Bing Liu Jinyong Wang | 2020 | Cell Research2020，30，1： | 7 |
| 3 | State of the climate over the Three Gorges Region of the Yangtze River in 2018显示文摘2018年长江三峡地区气温较常年偏高,降水量接近常年,暴雨日数少,风速偏大,相对湿度接近常年,酸雨弱。年内高温出现早,持续时间长,强度大;夏季出现阶段性伏旱;暴雨和强降水引发城市内涝。 | ZOU Xukai CHEN Xianyan ZENG Hongling CUI Tong ZHANG Qiang | 2020 | Atmospheric and Oceanic Science Letters2020，13，1： | 3 |
| 4 | MicroRNA-100 regulates osteogenic differentiation of human adipose-derived mesenchymal stem cells by targeting BMPR2显示文摘 | Yang Zeng Xuebin Qu Hongling Li Shan Huang Shihua Wang Qilin Xu Ruizhu Lin Qin Han Jing Li Robert Chunhua Zhao | 2012 | FEBS Letters2012，，16： | 2 |
| 5 | Climate observation of the Three Gorges Region of the Yangtze River in 2019显示文摘2019年,长江三峡地区年平均气温17.5℃,较常年偏高0.3℃;冬季偏冷,春,夏,秋三季气温均偏高;年高温日数偏多.2019年三峡地区年降水量1035.1毫米,较常年偏少13%;四季降水均偏少;年暴雨日数偏少.2019年,长江三峡地区年平均风速较常年偏大;年平均相对湿度接近常年;酸雨强度弱,为1999年以来的最弱年,近十余年酸雨强度呈现明显的减弱趋势.2019年,长江三峡地区高温过程多,持续时间长;三峡中东部地区出现伏秋连旱;华西秋雨开始早,三峡中西部雨量多. | Xianyan Chen Xukai Zou Qiang Zhang Hongling Zeng Tong Cui | 2021 | Atmospheric and Oceanic Science Letters2021，14，3： | 2 |
| 6 | XANES analysis of tribo-chemical and thermal films generating from some organic polysulfides显示文摘X 光检查吸收近的边结构(XANES ) 光谱学第一被用来描绘从烷基,本甲基和包含酰的器官的 polysulfides 产生的 triboehemical 和热电影的化学性质。从这些 polysulfides 产生的热电影主要由 FeSO4l 和烷基化二硫组成,这被发现了也存在在表面下并且从包含酰的 polysulfides 产生的热电影的体积。Undertriboehemical 条件,电影的作文依赖于添加剂的分子结构。也就是,从烷基 polysulfide 产生的 triboehemical 电影由烷基化二硫组成在外面表面, FeSO_4 的混合物, FeS_2 和亚在表面下,并且 FeSO_4in 体积;为本甲基 polysulfide 的 triboehemical 电影的作文由 FeSO4 组成在外面,出现作文在表面下并且体积与烷基 polysulfide.For 一样是包含酰的 polysulfides, triboehemical 电影由烷基化二硫组成在外面表面,和 FeS_2 在表面下并且体积。 | YI Hongling ZENG Xiangqiong CAO Yan RENTianhui M. Kasrai G. M. Bancroft | 2006 | Chinese Science Bulletin2006，51，22： | 2 |
| 7 | State of China’s climate in 2018显示文摘根据国家气候中心监测,2018年,全国平均气温10.09℃,较常年偏高0.54℃,春、夏季气温创历史新高;全国平均降水量673.8毫米,比常年偏多7%。2018年,生成和登陆台风多、登陆位置偏北、灾损重;低温冷冻害及雪灾频发,损失偏重;夏季暴雨过程频繁,但暴雨洪涝灾害总体偏轻;高温日数多,东北及中东部地区高温极端性突出;区域性和阶段性干旱明显,但影响偏轻;强对流天气少,经济损失偏轻;春季北方沙尘天气少,影响偏轻;阶段性雾霾影响大。与近5年相比,农作物受灾面积、死亡失踪人口以及直接经济损失均明显偏少。 | ZENG Hongling XIAO Chan CHEN Xianyan YE Dianxiu | 2019 | Atmospheric and Oceanic Science Letters2019，12，5： | 1 |
| 8 | State of the climate in the Three Gorges Region of the Yangtze River basin in 2020显示文摘2020年,长江三峡地区年平均气温17.2℃,接近常年;年平均降水量1530.8毫米,偏多29%,为1961年以来第二多,仅次于1998年.6月,7月降水量及年平均暴雨日数均为1961年以来第二多.平均风速较常年偏大;相对湿度略偏高;各月均无酸雨出现,近十余年酸雨强度呈现明显减弱趋势.2020年,三峡地区夏季暴雨洪涝灾害重.分析表明,冷空气频繁南下与西南暖湿水汽丰沛是造成三峡地区6–7月降水异常偏多的直接原因.2020年春季以来,印度洋海温持续偏暖导致西北太平洋副热带高压持续偏强偏南可能是造成6–7月长江流域气候异常的重要原因. | Tong Cui Xianyan Chen Xukai Zou Qiang Zhang Shuai Li Hongling Zeng | 2022 | Atmospheric and Oceanic Science Letters2022，15，2： | 1 |
| 9 | Cancer targeting Gene-Viro-Therapy specific for liver cancer by α-fetoproteincontrolled oncolytic adenovirus expression of SOCS3 and IL-24显示文摘为癌症治疗的基因治疗和 virotherapy 的联合收到了靠近的注意并且在癌症 biotherapy 的地里成为了一个趋势。称为指向 Gene-Viro-Therapy (CTGVT ) 或基因的癌症的策略武装了 Oncolytic 病毒的治疗(GAOVT ) 被建议了,在哪个 antitumor 基因被插入到 oncolytic 病毒的向量。在我们的以前的学习,有为正常房间和严格的肝的提高的安全的双调整 oncolytic 侵入人体气管粘膜的病菌指向癌症的能力,指明的 AdenAFPE1AE1B (55 )( 简短 AdenAFPD55 ) ,成功地被构造。在水流,工作, interleukin-24 (IL-24 ) 和表明 3 的 cytokine (SOCS3 ) 的 suppressor 基因被包装进 AdenAFPD55。新构造, AdenAFPD55-(IL-24 ) 和 AdenAFPD55-(SOCS3 ) ,在 hepatoma 房间的显示出的改进 tumoricidal 活动与 oncolytic 相比排队病毒的向量 AdenAFPD55。AdenAFPD55-(IL-24 ) 和 AdenAFPD55-(SOCS3 ) 的合作管理在 vitro 并且在一个裸体老鼠异种皮移植模特儿独自比 AdenAFPD55-(IL-24 ) 或 AdenAFPD55-(SOCS3 ) 显示出好一些的 antitumor 效果。而且,我们的结果也在 HuH-7 房间由 AdenAFPD55-(SOCS3 ) 感染显示出 Jak/Stat3 小径的那封锁能下面调整一些 anti-apoptosis 蛋白质例如 XIAP, Bcl-xL,和 survivin,它可能敏化房间到导致的 AdenAFPD55-(IL-24 ) apoptosis。这些结果显示 AdenAFPD55-(IL-24 ) 的那个合作管理, AdenAFPD55-(SOCS3 ) 可以为肝癌症的治疗作为一个候选人服务治疗学的途径。 | Xin Cao Ruicheng Wei Xinran Liu Yan Zeng Hongling Huang Miao Ding Kangjian Zhang Xin-Yuan Liu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，10： | 1 |
| 10 | Tribological Behavior of Three Novel Traiazine Derivatives as Additives in Rapeseed Oil显示文摘 | Xiangqiong Zeng Hua Wu Hongling Yi | 2007 | Wear2007，202，： | 1 |
| 11 | AlGaN/AlN/GaN/SiC HEMT structure with high mobility GaN thin layer as channel grown by MOCVD显示文摘 | Xiaoliang Wang Guoxin Hu Zhiyong Ma Junxue Ran Cuimei Wang Hongling Xiao Jian Tang Jianping Li Junxi Wang Yiping Zeng Jinmin Li Zhanguo Wang | 2006 | Journal of Crystal Growth2006，，： | 1 |
| 12 | Tribological behavior of three novel triazine derivatives as additives in rapeseed oil显示文摘 | Zeng Xiangqiong Wu Hua Yi Hongling | 2007 | Wear2007，262，： | 1 |
| 13 | Tribologieal behav ior of three novel triazine erivatives as additives in rapeseed oil显示文摘 | Zeng Xiangqiong Wu Hua Yi Hongling | 2007 | Wear2007，262，56： | 1 |
| 14 | Analysis of climatic features and major meteorological disasters over the Three Gorges Region of the Yangtze River Basin in 2021显示文摘本文分析了2021年长江三峡地区气候特征及主要天气气候事件.2021年,三峡地区年平均气温较常年偏高0.2℃,降水量偏多12.8%,年暴雨日数偏多,年平均风速偏大,年平均相对湿度偏高.2021年与2020年同为有记录以来酸雨强度最弱年.汛期区域强降水频发;春季多低温阴雨;秋冬寒潮过程降温幅度大影响广.9月中旬至10月初,三峡地区遭遇罕见“秋老虎”,分析表明该时段内异常高温与中高纬度大气环流及西太平洋副热带高压活动异常等因子密切相关. | Tong Cui Xianyan Chen Xukai Zou Qiang Zhang Hongling Zeng Linhai Sun | 2022 | Atmospheric and Oceanic Science Letters2022，15，6： | 0 |
| 15 | The complete and fully-phased diploid genome of a male Han Chinese显示文摘Since the release of the complete human genome,the priority of human genomic study has now been shifting towards closing gaps in ethnic diversity.Here,we present a fully phased and well-annotated diploid human genome from a Han Chinese male individual(CN1),in which the assemblies of both haploids achieve the telomere-to-telomere(T2T)level.Comparison of this diploid genome with the CHM13 haploid T2T genome revealed significant variations in the centromere.Outside the centromere,we discovered 11,413 structural variations,including numerous novel ones.We also detected thousands of CN1 alleles that have accumulated high substitution rates and a few that have been under positive selection in the East Asian population.Further,we found that CN1 outperforms CHM13 as a reference genome in mapping and variant calling for the East Asian population owing to the distinct structural variants of the two references.Comparison of SNP calling for a large cohort of 8869 Chinese genomes using CN1 and CHM13 as reference respectively showed that the reference bias profoundly impacts rare SNP calling,with nearly 2 million rare SNPs miss-called with different reference genomes.Finally,applying the CN1 as a reference,we discovered 5.80 Mb and 4.21 Mb putative introgression sequences from Neanderthal and Denisovan,respectively,including many East Asian specific ones undetected using CHM13 as the reference.Our analyses reveal the advances of using CN1 as a reference for population genomic studies and paleo-genomic studies.This complete genome will serve as an alternative reference for future genomic studies on the East Asian population. | Chentao Yang Yang Zhou Yanni Song Dongya Wu Yan Zeng Lei Nie Panhong Liu Shilong Zhang Guangji Chen Jinjin Xu Hongling Zhou Long Zhou Xiaobo Qian Chenlu Liu Shangjin Tan Chengran Zhou Wei Dai Mengyang Xu Yanwei Qi Xiaobo Wang Lidong Guo Guangyi Fan Aijun Wang Yuan Deng Yong Zhang Jiazheng Jin Yunqiu He Chunxue Guo Guoji Guo Qing Zhou Xun Xu Huanming Yang Jian Wang Shuhua Xu Yafei Mao Xin Jin Jue Ruan Guojie Zhang | 2023 | Cell Research2023，33，10： | 0 |
| 16 | 2019年中国气候概况显示文摘2019年,全国平均气温10.34°C,较常年偏高0.79°C,为1951年以来第5暖年四季气温均偏高,春秋明显偏暖。全国平均降水量645.5毫米,比常年偏多2.5%。2019年,台风生成多,登陆强度总体偏弱,仅‘利奇马’灾损重暴雨过程多,但暴雨洪涝灾害总体偏轻高温日数多,区域性特征明显区域性和阶段性干旱明显,但灾害损失偏轻强对流天气过程偏少,损失偏轻低温冷冻害和雪灾显著偏轻;春季北方沙尘天气少,影响偏轻。与近10年平均值相比,农作物受灾面积,死亡失踪人口以及直接经济损失均明显偏少。 | ZENG Hongling XIAO Chan CHEN Xianyan CHEN Yu YE Dianxiu | 2020 | Atmospheric and Oceanic Science Letters2020，13，4： | 0 |
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