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| 1 | Association between Bmi1 and clinicopathological status of esophageal squamous cell carcinoma显示文摘AIM:To investigate the clinicopathological roles of Bmi1 in esophageal squamous cell carcinoma(ESCC) .METHODS:Quantitative real-time polymerase chain reaction and immunohistochemical staining for Bmi1 were performed in cancerous and adjacent non-cancerous paraffi n-embedded esophageal specimens.RESULTS:The Bmi1 expression level was unaffected by gender and age.The level of Bmi1 mRNA in ESCC was signif icantly higher than that in the adjacent non-cancerous tissues(2.181 ± 2.158 vs 0.931 ± 0.894,P = 0.0152) ,and its over-expression was aggressively associated with lymph node metastasis(3.580 ± 2.487 vs 1.703 ± 0.758,P = 0.0003) ,poorer cell differentiation(P = 0.0000) and advanced pathological stage(3.827 ± 2.673 vs 1.590 ± 0.735,P = 0.0001) .The patients were divided into high-expression and low-expression groups based on the median expression level of Bmi1 mRNA,and a shorter overall survival time in the former group was observed.Immunohistochemistry for Bmi1 oncoprotein showed diffusely positive,focally positive and negative expression in 44,16 and 10 of 70 ESCC cases,respectively,compared with three,two and five of 10 adjacent non-cancerous cases(P=0.027) .The positive rate of the oncoprotein in samples of histological grade was higher than that of grade(P=0.031) ,but its expression had no relation to the lymph node metastasis and pathological staging.In 70 ESCC samples,Bmi1 showed high intense expression in the cytoplasm and less or even no expression in the nucleus.CONCLUSION:Bmi1 was over-expressed in ESCC.Increased Bmi1 mRNA expression was significantly associated with ESCC progression,and the oncoprotein was largely distributed in the cytoplasm of tumor cells. | Xiao-Ting He Xiu-Feng Cao Lv Ji Bin Zhu Jin Lv Dong-Dong Wang Pei-Hua Lu Heng-Guan Cui | 2009 | World Journal of Gastroenterology2009，15，19： | 15 |
| 2 | Preparation of a Crosslinked Chitosan Coated Calcium Sulfate Whisker and Its Reinforcement in Polyvinyl Chloride显示文摘A calcium sulfate whisker(CSW) coated with glutaraldehyde crosslinked chitosan(GACS) was prepared to reinforce polyvinyl chloride(PVC) in this study. The results show that the optimum concentration of both chitosan(CS) and glutaraldehyde(GA) is 0.05 wt%. The tensile strength, impact strength, flexural modulus and vicat softening temperature of the PVC composite with 12 wt% of modified CSW are increased by 17.5%, 40.4%, 0.8% and 3.8% compared with those of the PVC composite with 12 wt% of unmodified CSW, and by 2.9%, 42.4%, 27.1% and 6.8% compared with those of pure PVC, respectively. The dynamic mechanical analysis results indicate that the modified CSW/PVC composite exhibits much higher storage modulus and glass transition temperature than those of unmodified CSW/PVC composite and pure PVC.In addition, the modified CSW/PVC composite also demonstrates good thermal properties with a high rapidest decomposition temperature(Trpd) and char residue. The scanning electron microscopy images of tensile-fractured surfaces show that the modified CSW has a strong interfacial adhesion with PVC matrix. | Jiayang Cui Yangben Cai Wenjin Yuan Zhongfei Lv Shiai Xu | 2016 | Journal of Materials Science & Technology2016，32，8： | 12 |
| 3 | Science Letters:IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis with its expression associated with DNA hypomethylation of exon 1显示文摘Insulin-like growth factor binding-protein-7 (IGFBP7) was obtained from our previous colonic adenocarcinoma (CRC) and normal mucosa suppression subtraction hybridization (SSH) cDNA libraries. By RT-PCR and immunohistochemistry, we found that IGFBP7 was overexpressed in CRC tissue compared to normal tissue. However, our in vitro experiments performed in 10 CRC cell lines showed that IGFBP7 expressed only in SW480 and Caco2 cell lines, which implied an underlying reversible regulatory mechanism. Using methylation-specific PCR (MSP) and bisulfite sodium PCR (BSP), we found that its expression was associated with DNA hypomethylation of exon1. This was further supported by the in vitro study which showed restored IGFBP7 expression after demethylation agent 5-aza-2’-deoxycytidine treatment. Correlation analysis between IGFBP7 expression and prognosis indicated that overexpression of IGFBP7 in CRC tissue correlated with favourable survival. Investigation of the func-tional role of IGFBP7 through transfection studies showed that IGFBP7 protein could inhibit growth rate, decrease colony for-mation activity, and induce apoptosis in RKO and SW620 cells, suggesting it a potential tumor suppressor protein in colorectal carcinogenesis. In conclusion, our study clearly demonstrated that IGFBP7 plays a potential tumor suppressor role against colo-rectal carcinogenesis and its expression is associated with DNA hypomethylation of exon 1. | RUAN Wen-jing LIN Jie XU En-ping XU Fang-ying MA Yu DENG Hong HUANG Qiong LV Bing-jian HU Hu CUI Jing DI Mei-juan DONG Jian-kang LAI Mao-de | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，11： | 11 |
| 4 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 5 | 1,25-Dihydroxyvitamin D3 protects obese rats from metabolic syndrome via promoting regulatory T cell-mediated resolution of inflammation显示文摘Vitamin D_3 has been found to produce therapeutic effects on obesity-associated insulin resistance and dyslipidemia through its potent anti-inflammatory activity, but the precise immunomodulatory mechanism remains poorly understood. In the present study we found that 1,25-dihydroxyvitamin D_3[1,25(OH)_2D_3], the biologically active form of vitamin D_3, significantly attenuated monosodium glutamate(MSG)-induced obesity and insulin resistance as indicated by body weight reduction, oral glucose tolerance improvement, and a glucose infusion rate increase as detected with hyperinsulinemiceuglycemic clamp. Moreover, 1,25(OH)_2D_3 not only restored pancreatic islet functions but also improved lipid metabolism in insulin-targeted tissues. The protective effects of 1,25(OH)_2D_3 on glycolipid metabolism were attributed to its ability to inhibit an obesity-activated inflammatory response in insulin secretory and targeted tissues, as indicated by reduced infiltration of macrophages in pancreas islets and adipose tissue while enhancing the expression of Tgf-β1 in liver tissue, which was accompanied byincreased infiltration of Treg cells in immune organs such as spleen and lymph node as well as in insulintargeted tissues such as liver, adipose, and muscle. Together, our findings suggest that 1,25(OH)_2D_3 serves as a beneficial immunomodulator for the prevention and treatment of obesity or metabolic syndrome through its anti-inflammatory effects. | Wen Jin Bing Cui Pingping Li Fang Hua Xiaoxi Lv Jichao Zhou Zhuowei Hu Xiaowei Zhang | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 9 |
| 6 | Prevention and control of HIV/AIDS in China:lessons from the past three decades显示文摘In the past 37 years,human immunodeficiency virus/acquired immunodeficiency syndrome(HIV/AIDS)has undergone various major transmission routes in China,with the world most complex co-circulating HIV-1 subtypes,even the prevalence is still low.In response to the first epidemic outbreak of HIV in injecting drug users and the second one by illegal commercial blood collection,China issued the Anti-Drug Law and launched the Blood Donation Act and nationwide nucleic acid testing,which has avoided 98,232 to 211,200 estimated infections and almost ended the blood product-related infection.China has been providing free antiretroviral therapy(ART)since 2003,which covered>80%of the identified patients and achieved a viral suppression rate of 91%.To bend the curve of increasing the disease burden of HIV and finally end the epidemic,China should consider constraining HIV spread through sexual transmission,narrowing the gaps in identifying HIV cases,and the long-term effectiveness and safety of ART in the future. | Jun-Jie Xu Meng-Jie Han Yong-Jun Jiang Hai-Bo Ding Xi Li Xiao-Xu Han Fan Lv Qing-Feng Chen Zi-Ning Zhang Hua-Lu Cui Wen-Qing Geng Jing Zhang Qi Wang Jing Kang Xiao-Lin Li Hong Sun Ya-Jing Fu Ming-Hui An Qing-Hai Hu Zhen-Xing Chu Ying-Jie Liu Hong Shang | 2021 | Chinese Medical Journal2021，，23： | 9 |
| 7 | Efficacy of capecitabine-based combination therapy and singleagent capecitabine maintenance therapy in patients with metastatic breast cancer显示文摘Objective: The purpose of this study was to observe the efficacy and toxicities of capecitabine-based chemotherapy and capecitabine monotherapy as maintenance therapy in the treatment of metastatic breast cancer(MBC).Patients and methods: A total of 98 MBC patients were treated with capecitabine combined with vinorelbine(NX). Results: The median number of treatment was 6 cycles(1-7 cycles). There were two cases of complete remission(CR), 58 partial remission, 27 stable disease(SD), 11 progression disease. The overall response rate(ORR)(CR + PR) was 61.2%. The clinical benefit rate(CBR) was 75.5%. Fifty of effective patients received with capecitabine monotherapy as maintenance therapy. The ORR(CR + PR) was 4%. The CBR was 48%. The median progression-free survival(PFS) was 12 months. In maintenance therapy or not, the median post metastasis survival rate(MSR) was 63 and 28 months, respectively. In the combination therapy group, the major grade 3/4 toxicities included hand-foot syndrome(3.1%), skin pigmentation(2.0%), diarrhoea and abdominal distension(5.1%), stomatitis(1.0%), and leukopenia(20.4%).Conclusions: Capecitabine-based combination therapy and single-agent capecitabine maintenance therapy were well tolerated and effective to MBC. | Huimin Lv Min Yan Mengwei Zhang Limin Niu Huiai Zeng Shude Cui | 2014 | Chinese Journal of Cancer Research2014，26，6： | 8 |
| 8 | Salvianolic acid B stimulates osteogenesis in dexamethasone-treated zebrafish larvae显示文摘瞄准:我们的以前的研究证明 salvianolic 酸 B (柳安 B ) 支持造骨细胞区别和矩阵矿化作用。在这研究,我们在对待的 dexamethasone (Dex ) 在成骨上评估了柳安 B 的保护的效果幼虫的 zebrafish,和阐明的位于 \O 下面 mechanisms.Methods:在 3 d 柱子授精,野类型的 AB zebrafish 幼虫或骨头,转基因的 tg (sp7:egfp ) zebrafish 幼虫为 6 d 暴露于 Dex+Sal B 的柳安 B, Dex,或混合物。在 AB 紧张的骨头矿化作用幼虫的 zebrafish 与茜素红在 tg (sp7:egfp ) 染色,和造骨细胞区别被估计幼虫的 zebrafish 与荧光扫描被检验。在幼虫的造骨细胞特定的基因的表示用 qRT-PCR 试金被检测。在幼虫的氧化压力标记(ROS 和 MDA ) 的层次也是 measured.Results:暴露到 Dex (5-20 μ mol/L ) dose-dependently 减少了在 tg (sp7:egfp ) 的在野类型的 AB zebrafish 幼虫的骨头矿化作用区域和造骨细胞荧光区域和 IOD zebrafish 幼虫。暴露到 Dex (10 μ mol/L ) 显著地减少了造骨细胞特定的基因,包括的 runx2a, osteocalcin (OC ) ,碱的磷酸酶(高山) 和 osterix (sp7 ) 的表示,并且在幼虫增加了 ROS 和 MDA 的累积。合作暴露到柳安 B (0.2-2 μ mol/L ) dose-dependently 在 tg (sp7:egfp ) 在 AB zebafish 幼虫和造骨细胞荧光增加了骨头矿化作用区域和 IOD zebrafish 幼虫。合作暴露到柳安 B (2 μ mol/L ) 在多骨的织物的显著地稀释的有害改变和在两个对待 Dex 的 AB zebafish 幼虫和 tg (sp7:egfp ) 的氧化应力 zebrafish larvae.Conclusion:柳安 B 刺激骨头形成并且由抵抗氧化应力并且增加造骨细胞特定的基因的表示在幼虫的 zebrafish 在成骨上救引起 GC 的抑制。因此,柳安 B 可以由 GC 在骨头损失 trigged 上有保护的效果。 | Shi-ying LUO Jing-feng CHEN Zhi-guo ZHONG Xiao-hua LV Ya-jun YANG Jing-jing ZHANG Liao CUI | 2016 | Acta Pharmacologica Sinica2016，37，10： | 8 |
| 9 | Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors显示文摘Achievement of immunocompetent and therapeutic T lymphopoiesis from pluripotent stem cells(PSCs)is a central aim in T cell regenerative medicine.To date,preferentially reconstituting T lymphopoiesis in vivo from PSCs remains a practical challenge.Here we documented that synergistic and transient expression of Runx1 and Hoxa9 restricted in the time window of endothelial-to-hematopoietic transition and hematopoietic maturation stages in a PSC differentiation scheme(iR9-PSC)in vitro induced preferential generation of engraftable hematopoietic progenitors capable of homing to thymus and developing into mature T cells in primary and secondary immunodeficient recipients.Single-cell transcriptome and functional analyses illustrated the cellular trajectory of T lineage induction from PSCs,unveiling the T-lineage specification determined at as early as hemogenic endothelial cell stage and identifying the bona fide pre-thymic progenitors.The induced T cells distributed normally in central and peripheral lymphoid organs and exhibited abundant TCRαβrepertoire.The regenerative T lymphopoiesis restored immune surveillance in immunodeficient mice.Furthermore,gene-edited iR9-PSCs produced tumor-specific T cells in vivo that effectively eradicated tumor cells.This study provides insight into universal generation of functional and therapeutic T cells from the unlimited and editable PSC source. | Rongqun Guo Fangxiao Hu Qitong Weng Cui Lv Hongling Wu Lijuan Liu Zongcheng Li Yang Zeng Zhijie Bai Mengyun Zhang Yuting Liu Xiaofei Liu Chengxiang Xia Tongjie Wang Peiqing Zhou Kaitao Wang Yong Dong Yuxuan Luo Xiangzhong Zhang Yuxian Guan Yang Geng Juan Du Yangqiu Li Yu Lan Jiekai Chen Bing Liu Jinyong Wang | 2020 | Cell Research2020，30，1： | 7 |
| 10 | In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model显示文摘The urokinase-type plasminogen activator(uPA)loaded hollow nanogels(nUK)were synthesized by a one-step reaction of glycol chitosan and aldehyde capped poly(ethylene oxide).The resultant formulation is sensitive to diagnostic ultrasound(US)of 2 MHz.Herein,we evaluated the in vivo sonothrombolysis performance of the nUK on acute ischemic stroke rat model which was established by suture embolization of middle cerebral artery(MCA).Via intravenous(i.v.)administration,the experimental data prove a controlled release of the therapeutic protein around the clots under ultrasound stimulation,leading to enhanced thrombolysis efficiency of the nUK,evidenced from smaller infarct volume and better clinical scores when compared to the i.v.dose of free uPA no matter with or without US intervention.Meanwhile,the preservation ability of the nanogels not only prolonged the circulation duration of the protein,but also resulted in the better blood-brain barrier protection of the nUK formulation,showing no increased risk on the hemorrhagic transformation than the controls.This work suggests that the nUK is a safe sonothrombolytic formulation for the treatment of acute ischemic stroke. | Yuming Teng Haiqiang Jin Ding Nan Mengnan Li Chenghe Fan Yuanyuan Liu Pu Lv Wei Cui Yongan Sun Hongjun Hao Xiaozhong Qu Zhenzhong Yang Yining Huang | 2018 | Bioactive Materials2018，3，1： | 7 |
| 11 | A constitutive model coupling damage and material anisotropy for wide stress triaxiality显示文摘A constitutive model that can describe the damage evolution of anisotropic metal sheets during the complex forming processes which experience wide stress triaxiality history is essential to accurately predict the deformation and rupture behaviors of the processes.In this study,a modified Lemaitre damage criterion which couples with the anisotropic Barlat 89 yield function is established.The effects of stress triaxiality,Lode parameter and shear stress on damage accumulation are considered in the constitutive model.The model is numerically implemented and applied to fracture prediction in tensile tests with different stress triaxialities and a complex deformation process with wide stress triaxiality history.The good consistency of predictions and experiments indicates that the modified Lemaitre damage model has excellent fracture prediction ability.Finally,the accuracy of the model is analyzed and discussed. | Rui LI Mei ZHAN Zebang ZHENG Hongrui ZHANG Xiaolei CUI Wei LV Yudong LEI | 2020 | Chinese Journal of Aeronautics2020，33，12： | 7 |
| 12 | Characterization of the effective cellulose degrading strain CTL-6显示文摘An efficient cellulose degrading bacteria exists in the thermophilic wheat straw-degrading community, WDC2. However, this strain cannot be isolated and cultured using conventional separation techniques under strict anaerobic conditions. We successfully isolated a strain of effective cellulose degrading bacteria CTL-6 using a wash, heat shock, and solid-liquid alternating process. Analysis of its properties revealed that, although the community containing the strain CTL-6 grew under aerobic conditions, the purified strain CTL-6 only grew under anaerobic culture conditions. The strain CTL-6 had a striking capability of degrading cellulose (80.9% weight loss after 9 days of culture). The highest efficiency value of the endocellulase (CMCase activity) was 0.404 μmol/(min·mL), cellulose degradation efficiency by CTL-6 was remarkably high at 50-65°C with the highest degradation efficiency observed at 60°C. The 16S rRNA gene sequence analysis indicated that the closest relative to strain CTL-6 belonged to the genus Clostridium thermocellum. Strain CTL-6 was capable of utilizing cellulose, cellobiose, and glucose. Strain CTL-6 also grew with Sorbitol as the sole carbon source, whereas C. thermocellum is unable to do so. | Yucai Lv Xiaofen Wang Ning Li Xiaojuan Wang Masaharu Ishii Yasuo Igarashi Zongjun Cui | 2011 | Journal of Environmental Sciences2011，23，4： | 6 |
| 13 | miR-124 suppresses multiple steps of breast cancer metastasis by targeting a cohort of pro-metastatic genes in vitro显示文摘Metastasis is a multistep process involving modification of morphology to suit migration, reduction of tumor cell adhesion to the extracellular matrix, increase of cell mobility, tumor cell resistance to anoikis, and other steps. MicroRNAs are well-suited to regulate tumor metastasis due to their capacity to repress numerous target genes in a coordinated manner, thereby enabling their intervention at multiple steps of the invasion-metastasis cascade. In this study, we identified a microRNA exemplifying these attributes, miR-124, whose expression was reduced in aggressive MDA-MB-231 and SK-3rd breast cancer cells. Down-regulation of miR-124 expression in highly aggressive breast cancer cells contributed in part to DNA hypermethylation around the promoters of the three genes encoding miR-124. Ectopic expression of miR-124 in MDA-MB-231 cells suppressed metastasis-related traits including formation of spindle-like morphology, migratory capacity, adhesion to fibronectin, and anoikis. These findings indicate that miR-124 suppresses multiple steps of metastasis by diverse mechanisms in breast cancer cells and suggest a potential application of miR-124 in breast cancer treatment. | Xiao-Bin Lv Yu Jiao Yanwei Qing Haiyan Hu Xiuying Cui Tianxin Lin Erwei Song Fengyan Yu | 2011 | Chinese Journal of Cancer2011，30，12： | 6 |
| 14 | A critical epitope in CD147 facilitates memory CD4^(+) T-cell hyper-activation in rheumatoid arthritis显示文摘The abnormal activation of CD4^(+)CD45RO+memory T(Tm)cells plays an important role in the pathogenesis of rheumatoid arthritis(RA).Previous studies have shown that CD147 participates in T-cell activation.However,it remains unclear whether CD147 is involved in abnormal Tm-cell activation in RA patients.In this study,we demonstrated that CD147 was predominantly upregulated in Tm cells derived from RA patients.The anti-CD147 mAb 5A12 specifically inhibited Tm-cell activation and proliferation and further restrained osteoclastogenesis.Using a structural–functional approach,we depicted the interface between 5A12 and CD147.This allowed us to identify two critical residues,Lys63 and Asp65,as potential targets for RA treatment,as the double mutation K63A/D65A inhibited Tm-cell activation,mimicking the neutralization by 5A12.This study provides not only a theoretical basis for a“CD147-Tm/Osteoclast-RA chain”for the potential prevention and treatment of RA or other T-cell-mediated autoimmune diseases but also a new target for related drug design and development. | Na Guo Sheng Ye Kui Zhang Xiaoling Yu Hongyong Cui Xiangmin Yang Peng lin Minghua Lv Jinlin Miao Yang Zhang Qing Han Rongguang Zhang Zhinan Chen Ping Zhu | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 15 | Gastroesophageal reflux in cirrhotic patients without esophageal varices显示文摘AIM: To evaluate the esophageal motility and abnormal acid and bile reflux incidence in cirrhotic patients without esophageal varices (EV). METHODS: Seventy-eight patients with liver cirrhosis without EV confirmed by upper gastroesophageal endoscopy and 30 healthy control volunteers were prospectively enrolled in this study. All the patients were evaluated using a modified protocol including Child-Pugh score, upper gastrointestinal endoscopy, esophageal manometry, simultaneous ambulatory 24-h esophageal pH and bilirubin monitoring. All the patients and volunteers accepted the manometric study. RESULTS: In the liver cirrhosis group, lower esophageal sphincter pressure (LESP, 15.32 ± 2.91 mmHg), peristaltic amplitude (PA, 61.41 ± 10.52 mmHg), peristaltic duration (PD, 5.32 ± 1.22 s), and peristaltic velocity (PV, 5.22 ± 1.11 cm/s) were all significantly abnormal in comparison with those in the control group (P < 0.05), and LESP was negatively correlated with Child-Pugh score. The incidence of reflux esophagitis (RE) and pathologic reflux was 37.18% and 55.13%, respectively(vs control, P < 0.05). And the incidence of isolated abnormal acid reflux, bile reflux and mixed reflux was 12.82%, 14.10% and 28.21% in patients with liver cirrhosis without EV. CONCLUSION: Cirrhotic patients without EV presented esophageal motor disorders and mixed acid and bile reflux was the main pattern; the cirrhosis itself was an important causative factor. | Jun Zhang Pei-Lin Cui Dong Lv Shi-Wei Yao You-Qing Xu Zhao-Xu Yang | 2011 | World Journal of Gastroenterology2011，17，13： | 5 |
| 16 | A study on dynamic shear strength on frozen soil-concrete interface显示文摘Using newly developed dynamic shearing devices, the dynamic shearing strength of frozen soil-concrete interface was studied experimentally. By placing concrete blocks in the lower half of the shear box and frozen soil sample in the upper part, a series of dynamic shear tests on their interfaces were carried out. The obtained results are summarized and the main influencing factors are revealed. | Peng Lv JianKun Liu YingHui Cui | 2013 | Research in Cold and Arid Regions2013，5，4： | 5 |
| 17 | Enhancement of BMP-2 and VEGF carried by mineralized collagen for mandibular bone regeneration显示文摘Repairing damage in the craniofacial skeleton is challenging.Craniofacial bones require intramembranous ossification to generate tissue-engineered bone grafts via angiogenesis and osteogenesis.Here,we designed a mineralized collagen delivery system for BMP-2 and vascular endothelial growth factor(VEGF)for implantation into animal models of mandibular defects.BMP-2/VEGF were mixed with mineralized collagen which was implanted into the rabbit mandibular.Animals were divided into(i)controls with no growth factors;(ii)BMP-2 alone;or(iii)BMP-2 and VEGF combined.CT and hisomputed tomography and histological staining were performed to assess bone repair.New bone formation was higher in BMP-2 and BMP-2-VEGF groups in which angiogenesis and osteogenesis were enhanced.This highlights the use of mineralized collagen with BMP-2/VEGF as an effective alternative for bone regeneration. | Kun Liu Chun-Xiu Meng Zhao-Yong Lv Yu-Jue Zhang Jun Li Ke-Yi Li Feng-Zhen Liu Bin Zhang Fu-Zhai Cui | 2020 | Regenerative Biomaterials2020，7，4： | 5 |
| 18 | In-situ structural evolution analysis of Zr-doped Na_(3)V_(2)(PO_(4))_(2)F_(3) coated by N-doped carbon layer as high-performance cathode for sodium-ion batteries显示文摘With great superiorities in energy density,rate capability and structural stability,Na_(3)V_(2)(PO_(4))_(2) F_(3)(NVPF)has attracted much attentions as cathode of sodium ion battery(SIB),but it also faces challenges on its poor intrinsic electronic conductivity and the controversial de/sodiation mechanism.Herein,a series of Zr-doped NVPF coated by N-doped carbon layer(~5 nm in thickness,homogenously)materials are fabricated by a sol-gel method,and the optimized heteroatom-doping amounts of Zr and N doping improve intrinsic properties on enlarging lattice distance and enhancing electronic conductivity,respectively.Specifically,among all samples of Na_(3) V_(2-x)Zr_(x)(PO_(4))_(2) F_(3)/NC(NVPF-Zr-x/NC,x=0,0.01,0.02,0.05,and 0.1),the optimized electrode of NVPF-Zr-0.02/NC delivers high reversible capacities(119.2 mAh g^(-1) at0.5 C),superior rate capability(98.1 mA h g^(-1) at 20 C)and excellent cycling performance.The structural evolution of NVPF-Zr-0.02/NC electrode,in-situ monitored by X-ray diffractometer,follows a step-wise Na-extraction/intercalation mechanism with reversible multi-phase changes,not just a solid-solutionreaction one.Full cells of NVPF-Zr-0.02/NC//hard carbon demonstrate high capacity(99.8 mA h g^(-1) at 0.5 C),high out-put voltage(3.5 V)and good cycling stability.This work is favorable to accelerate the development of high-performance cathode materials and explore possible redox reaction mechanisms of SIBs. | Chuan Guo Jianwei Yang Zhiyuan Cui Shuo Qi Qianqian Peng Weiwei Sun Li-Ping Lv Yi Xu Yong Wang Shuangqiang Chen | 2022 | Journal of Energy Chemistry2022，31，2： | 5 |
| 19 | Maintenance treatment of trastuzumab for patients with advanced breast cancer to achieve long term survival: two case reports and literature review显示文摘Molecular subtyping of breast cancer may provide additional prognostic information regarding patient outcome. The epidermal growth factor receptor(HER2) overexpressing breast cancers are designated as HER2-postive(HER2+) breast cancer and carry a particularly unfavorable prognosis. We present two cases of HER2-postive metastatic breast cancer(MBC) who are found to be a challenge to treat, especially due to the occurrence of brain metastasis. Trastuzumab-based therapy improves clinical outcomes, even if the patient has undergone multi-line treatment. These case reports also emphasize the importance of retesting HER2 status because it can be discordance in receptor status between primary and recurrent breast cancer. | Min Yan Hui-Min Lv Meng-Wei Zhang Shu-De Cui | 2014 | Chinese Journal of Cancer Research2014，26，4： | 5 |
| 20 | Detection of Atrazine Residue in Food Samples by a Monoclonal Antibody-based Enzyme-linked Immunosorbent Assay显示文摘Atrazine(AT,2-chloro-4-ethylamino-6-isopropyl-amino-s-triazine)has been detected in ground water in several areas of the United States for many years,as well as in China,wherein the growth rate of its | LV Zhi Qiang WANG Cai Hong WANG Ting Ting CHEN Cui Cui WANG Ying NING Bao An LIU Ming LIU Jian Qing BAI Jia Lei PENG Yuan GAO Zhi Xian | 2013 | Biomedical and Environmental Sciences2013，26，5： | 5 |
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