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| 1 | Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion显示文摘The recent outbreak of coronavirus disease(COVID-19)caused by SARS-CoV-2 infection in Wuhan,China has posed a serious threat to global public health.To develop specific anti-coronavirus therapeutics and prophylactics,the molecular mechanism that underlies viral infection must first be defined.Therefore,we herein established a SARS-CoV-2 spike(S)protein-mediated cell-cell fusion assay and found that SARS-CoV-2 showed a superior plasma membrane fusion capacity compared to that of SARS-CoV.We solved the X-ray crystal structure of six-helical bundle(6-HB)core of the HR1 and HR2 domains in the SARS-CoV-2 S protein S2 subunit revealing that several mutated amino acid residues in the HR1 domain may be associated with enhanced interactions with the HR2 domain.We previously developed a pan-coronavirus fusion inhibitor,EK1,which targeted the HR!domain and could inhibit infection by divergent human coronaviruses tested,including SARS-CoV and MERS-CoV.Here we generated a series of lipopeptides derived from EK1 and found that EK1C4 was the most potent fusion inhibitor against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection with IC50s of 1.3 and 15.8 nM,about 241-and 149-fold more potent than the original EK1 peptide,respectively.EK1C4 was also highly effective against membrane fusion and infection of other human coronavirus pseudoviruses tested,including SARS-CoV and MERS-CoV,as well as SARSr-CoVs,and potently inhibited the replication of 5 live human coronaviruses examined,including SARS-CoV-2.Intranasal application of EK1C4 before or after challenge with HCoV-OC43 protected mice from infection,suggesting that EK1C4 could be used for prevention and treatment of infection by the currently circulating SARS-CoV-2 and other emerging SARSr-CoVs. | Shuai Xia Meiqin Liu Chao Wang Wei Xu Qiaoshuai Lan Siliang Feng Feifei Qi Linlin Bao Lanying Du Shuwen Liu Chuan Qin Fei Sun Zhengli Shi Yun Zhu Shibo Jiang Lu Lu | 2020 | Cell Research2020，30，4： | 81 |
| 2 | Clinical characteristics, diagnosis and management of respiratory distress syndrome in full-term neonates显示文摘然而,背景呼吸悲痛症候群(RDS ) 是新生的呼吸失败和新生的死亡的最普通的原因之一它的临床的特征与早熟的 RDS,和这些特征很不同很好没迄今为止被记录。这研究是在完整术语的出生不满一月的婴儿调查致病,临床的特征和 RDS 的管理策略,与开发为改进在有 RDS.Methods 的完整术语的出生不满一月的婴儿的结果的一个工作协议的目的有 RDS 的 125 个完整术语的婴儿的一个总数在这研究被注册。他们的临床并且实验室数据为分析 125 个案例包括了的完整术语的新生的 RDS.Results (1 ) 的特征被收集 94 男性和 31 个女婴儿,阴道交货在 45 种情况中发生在 80 种情况和剖腹产中。(2 ) RDS 的发作时间是(3.11 牧潯敶吗? | LIU Jing SHI Yun DONG Jian-ying ZHENG Tian LI Jing-ya LU Li-li LIU Jing-jing LIANG Jing ZHANG Hao FENG Zhi-chun | 2010 | Chinese Medical Journal2010，，19： | 79 |
| 3 | 碳化硅颗粒增强铝基复合材料开发与应用的研究现状显示文摘从复合材料的制备工艺、微观组织与力学性能等方面综述了国内外碳化硅颗粒增强铝基复合材料开发与应用的研究现状,指出了开发与应用中存在的问题,并对今后的发展趋势作出了预测。 | 王文明 潘复生 Lu Yun 曾苏民 | 2004 | 兵器材料科学与工程2004，27，3： | 73 |
| 4 | Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients显示文摘Background:A patient’s infectivity is determined by the presence of the virus in different body fluids,secretions,and excreta.The persistence and clearance of viral RNA from different specimens of patients with 2019 novel coronavirus disease(COVID-19)remain unclear.This study analyzed the clearance time and factors influencing 2019 novel coronavirus(2019-nCoV)RNA in different samples from patients with COVID-19,providing further evidence to improve the management of patients during convalescence.Methods:The clinical data and laboratory test results of convalescent patients with COVID-19 who were admitted to from January 20,2020 to February 10,2020 were collected retrospectively.The reverse transcription polymerase chain reaction(RT-PCR)results for patients’oropharyngeal swab,stool,urine,and serum samples were collected and analyzed.Convalescent patients refer to recovered non-febrile patients without respiratory symptoms who had two successive(minimum 24 h sampling interval)negative RT-PCR results for viral RNA from oropharyngeal swabs.The effects of cluster of differentiation 4(CD4)+T lymphocytes,inflammatory indicators,and glucocorticoid treatment on viral nucleic acid clearance were analyzed.Results:In the 292 confirmed cases,66 patients recovered after treatment and were included in our study.In total,28(42.4%)women and 38 men(57.6%)with a median age of 44.0(34.0-62.0)years were analyzed.After in-hospital treatment,patients’inflammatory indicators decreased with improved clinical condition.The median time from the onset of symptoms to first negative RT-PCR results for oropharyngeal swabs in convalescent patients was 9.5(6.0-11.0)days.By February 10,2020,11 convalescent patients(16.7%)still tested positive for viral RNA from stool specimens and the other 55 patients’stool specimens were negative for 2019-nCoV following a median duration of 11.0(9.0-16.0)days after symptom onset.Among these 55 patients,43 had a longer duration until stool specimens were negative for viral RNA than for throat swabs,with a median delay of 2.0(1.0-4.0)days.Results for only four(6.9%)urine samples were positive for viral nucleic acid out of 58 cases;viral RNA was still present in three patients’urine specimens after throat swabs were negative.Using a multiple linear regression model(F=2.669,P=0.044,and adjusted R2=0.122),the analysis showed that the CD4+T lymphocyte count may help predict the duration of viral RNA detection in patients’stools(t=-2.699,P=0.010).The duration of viral RNA detection from oropharyngeal swabs and fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group(15 days vs.8.0 days,respectively;t=2.550,P=0.013)and the duration of viral RNA detection in fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group(20 days vs.11 days,respectively;t=4.631,P<0.001).There was no statistically significant difference in inflammatory indicators between patients with positive fecal viral RNA test results and those with negative results(P>0.05).Conclusions:In brief,as the clearance of viral RNA in patients’stools was delayed compared to that in oropharyngeal swabs,it is important to identify viral RNA in feces during convalescence.Because of the delayed clearance of viral RNA in the glucocorticoid treatment group,glucocorticoids are not recommended in the treatment of COVID-19,especially for mild disease.The duration of RNA detection may relate to host cell immunity. | Yun Ling Shui-Bao Xu Yi-Xiao Lin Di Tian Zhao-Qin Zhu Fa-Hui Dai Fan Wu Zhi-Gang Song Wei Huang Jun Chen Bi-Jie Hu Sheng Wang En-Qiang Mao Lei Zhu Wen-Hong Zhang Hong-Zhou Lu | 2020 | Chinese Medical Journal2020，，9： | 58 |
| 5 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 6 | 2000–2020年中国氮氧化物排放清单及排放趋势(英文)显示文摘研究目的:建立2000–2020年中国氮氧化物排放清单,了解中国主要行业和省份氮氧化物的排放情况,为评估氮氧化物的环境影响和制定相关减排政策提供依据。创新要点:分析了中国主要省份产业结构对氮氧化物排放量的影响;根据不同情景分析,预测2020年中国氮氧化物的排放量。研究方法:1.基于自底向上法,根据不同类型化石燃料的氮氧化物排放因子,结合化石燃料消耗量,建立中国2000–2010年氮氧化物排放清单;2.基于IPAT方程,并以中国2000–2010年的国内生产总值增长数据和氮氧化物排放量为依据,分三种情景,分析2011–2020年中国能源消耗和氮氧化物排放趋势。重要结论:2010年中国氮氧化物的排放量约是2000年的两倍;自2009年起,中国氮氧化物总排放量超过了二氧化硫总排放量;主要由于产业结构和地区生产总值的不同,中国东部和西部氮氧化物排放量有明显差异;制造业、电力行业和交通运输业是中国氮氧化物的主要排放源,其中交通运输业氮氧化物排放量呈现逐年增长趋势;预计2020年中国氮氧化物排放量为19.7 Mt。 | Yun SHI Yin-feng XIA Bi-hong LU Nan LIU Lei ZHANG Su-jing LI Wei LI | 2014 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2014，15，6： | 34 |
| 7 | SiCp/Al复合材料界面反应研究现状显示文摘界面反应研究是碳化硅颗粒增强的铝基复合材料研发中的重要研究方向。各国研究者分别从界面反应规律、影响因素、控制途径等方面展开研究。界面反应规律方面研究了Al合金液与SiC颗粒可能存在的界面化学反应、界面反应过程和界面反应模型、界面上的相等;界面反应影响因素方面研究了界面反应与制备工艺过程、参数的关系;界面反应有效控制途径方面研究了、基体合金化、SiC颗粒表面处理、工艺选择与工艺参数控制等。今后的界面反应研究方向为:界面精细结构的研究;界面反应的化学热力学及动力学研究等。 | 王文明 潘复生 孙旭炜 曾苏民 Lu Yun | 2004 | 重庆大学学报(自然科学版)2004，27，3： | 29 |
| 8 | The Chromosome-Level Reference Genome of Tea Tree Unveils Recent Bursts of Nonautonomous LTR Retrotransposons in Driving Genome Size Evolution显示文摘Dear Editor,The tea tree Camellia sinensis,a member of the genus Camellia in the Theaceae family,includes two major cultivated varieties,C.sinensis var.assamica(CSA\Assam type)and C.sinensis var.sinensis(CSS;Chinese type)(Ming and Bartholomew,2007).Due to the high economic importance of the tea tree,considerable efforts have been made to explore genetic basis of the biosynthesis of natural metabolites that determine health benefits and diverse tea flavors(Shi et al.,2011;Li et al.,2011;Li et al.,2015;Xia et aL,2017;Liu et al.,2019). | Qun-Jie Zhang Wei L i Kui Li Hong Nan Cong Shi Yun Zhang Zhang-Yan Dai Yang-Lei Lin Xiao-Lan Yang Yan Tong Dan Zhang Cui Lu Li-Ying Feng Chen-Feng Wang Xiao-Xin Liu Jian-An Huang Wen-Kai Jiang Xing-Hua Wang Xing-Cai Zhang Evan E.Eichler Zhong-Hua Liu and Li-Zhi Gao | 2020 | Molecular Plant2020，13，7： | 27 |
| 9 | Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein显示文摘Very recently,a novel coronavirus,2019-nCoV,emerged in Wuhan,China and then quickly spread worldwide,resulting in>17,388 confirmed cases and 361 deaths as of 3 February 2020,thus calling for the development of safe and effective therapeutics and prophylatics.1,2 Similar to severe acute respiratory syndrome(SARS)-CoV,2019-nCoV belongs to lineage B betacoronavirus,and it has the ability to utilize human angiotensin-converting enzyme 2(ACE2)as a receptor to infect human cells. | Shuai Xia Yun Zhu Meiqin Liu Qiaoshuai Lan Wei Xu Yanling Wu Tianlei Ying Shuwen Liu Zhengli Shi Shibo Jiang Lu Lu | 2020 | Cellular & Molecular Immunology2020，17，7： | 27 |
| 10 | Effects of arsenic on seed germination and physiological activities of wheat seedlings显示文摘The effects of arsenic(As)were investigated on seed germination,root and shoot length and their biomass and some other factorsto elucidate the toxicity of As.The results showed low concentrations of As(0-1 mg/kg)stimulated seed germination and thegrowth of root and shoot,however,these factors all decreased gradually at high concentrations of As(5-20 mg/kg).The contentsof O2.-,MDA,soluble protein and peroxidase(POD)activity all increased with increasing As concentrations.Soluble sugar content,ascorbate peroxidase(APX),and superoxide dismutase(SOD)activities decreased at low concentrations of As,and increased at highconcentrations of As.While acetylsalicylic acid(ASA)and chlorophyll contents,catalase(CAT)activity displayed increasing trendwhen the concentrations of As was lower than 1 mg/kg,and then decreasing trend.By polyacrylamide gel electrophoresis(PAGE),Asinduced the expression of POD isozymes of wheat seedlings.As induced the expression of CAT isozymes but inhibited the expressionof SOD isozymes of wheat seedlings at concentrations lower than 1 mg/kg.However,As inhibited the expression of CAT isozymes butinduced the expression of SOD isozymes at concentrations higher than 5 mg/kg.The results indicated As could exert harmfulness inthe early development stage of wheat at inappropriate concentrations. | LI Chun-xi FENG Shu-li SHAO Yun JIANG Li-na LU Xu-yang HOU Xiao-li | 2007 | Journal of Environmental Sciences2007，19，6： | 25 |
| 11 | Clinical evaluations of mineralized collagen in the extraction sites preservation显示文摘The purpose of this study was to explore the different effects between biomimetic mineralized collagen(MC)and ordinary physically blended hydroxyapatite/collagen(HA/Col)composite in evaluating new bone formation and regenerated bone height in human extraction sockets.Thirty-four patients who cannot retain teeth caused by trauma or decay were randomly selected from Department of Stomatology of Dongzhimen Hospital from December 2013 to December 2014.The patients were randomly divided into two groups.After the operation of tooth extraction,17 patients were implanted with biomimetic MC(MC group),and other 17 patients were implanted with ordinary physically blended nHA/Col composite(nHA/Col group).X-ray positioning projection by auto-photographing was taken to test the distance between the lowest position and the neighboring CEJm-CEJd immediately,1 month and 3 months after the operation.The height of new bone formation of the MC group was significantly higher than the nHA/Col group.Biomimetic MC showed better clinical outcomes in the bone formation for extraction site preservation and would have broad application prospect in the field of oral and maxillofacial surgeries. | Lu Feng Liang Zhang Yun Cui Tian-Xi Song Zhi-Ye Qiu Xiu-Mei Wang Bao-Sheng Tan | 2016 | Regenerative Biomaterials2016，3，1： | 26 |
| 12 | 搅拌铸造制备SiC_p/Al复合材料的研究现状显示文摘综述了搅拌铸造制备SiCp/Al复合材料的研究现状,指出了搅拌铸造法存在的问题,对搅拌铸造法在制备SiCp/Al复合材料中的地位和发展前景作了预测。 | 王文明 潘复生 LU Yun 曾苏民 | 2004 | 轻合金加工技术2004，32，4： | 25 |
| 13 | Carbon isotopic composition of modern soil and paleosol as a response to vegetation change on the Chinese Loess Plateau显示文摘The relationship between the carbon isotopic composition of paleosols and paleovegetation on the Loess Plateau is still unclear. One of the main reasons is that we are short of knowledge about the characteristics of the carbon isotopic composition of modern soil in this area. A preliminary investigation of the carbon isotopic compositions of the modern soil and the loess/paleosol sequence on the Loess Plateau shows that the carbon isotopic composition of modern soil is consistent with the distribution of modern plants on the Loess Plateau, where the ecosystem is dominated by a mixture of C4 and C3 plants. Comparing theδ13C values of modern soil and loess-paleosol sequences from the Xunyi profile, we conclude that C3 plants dominated the landscape during loess sediment stages, while C4 plants expanded during paleosol stages. | LIU Weiguo NING Youfeng AN Zhisheng WU Zhenghai LU Huayu CAO Yunning | 2005 | Science China Earth Sciences2005，48，1： | 24 |
| 14 | Experimental study on the effect of Kang-Lai-Te induced apoptosis of human hepatoma carcinoma cell HepG2显示文摘BACKGROUND:Kang-Lai-Te(KLT)is extracted from the traditional Chinese herbal medicine Semen Coicis,which has been used in China as an effective clinical drug for over a thousand years.It contains numerous ingredients with anti-tumor effects.In our previous studies on transplanted hepatomas in rats,KLT could stop the cells in the G2+M stage of cell cycle and then reduce the number of cells entering the stage G0 and G1,but the mechanism of the anti-proliferative effect was unknown.In this experiment,we examined whether KLT inhibits HepG2 cell growth,if so,tried to explore its mechanism. METHODS:KLT at different concentrations was used for the treatment of hepatocellular carcinoma cells in vitro,respectively.The proliferation inhibitory rate was evaluated by MTT assay,induction of cell apoptosis rate and the protein levels of Fas and Fas ligand(FasL)were determined by flow cytometry(FCM),and the expression of Fas and FasL mRNA was detected by real-time fluorescent quantitative RT-PCR. RESULTS:KLT produced an obvious time and dose- dependent inhibitory effect on HepG2 cells,and marked apoptosis was detected by FCM.The protein of Fas increased by 11.01%,18.71%,28.71%and 37.15%;the protein of FasL increased by 1.49%,1.91%,3.27%and 3.38%in comparison with the control(P<0.05).Real-time fluorescent quantitative RT-PCR showed that treating HepG2 cells with KLT caused the upregulation of Fas and FasL mRNA.CONCLUSION:KLT inhibits HepG2 growth by inducing apoptosis,which may be mediated through activation of the Fas/FasL pathway. | Lu, Yun Wu, Li-Qun Dong, Qian Li, Chang-Sheng | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，3： | 24 |
| 15 | Predictive Value of Serum Creatinine, Blood Urea Nitrogen,Uric Acid, and β2-Microglobulin in the Evaluation of Acute Kidney Injury after Orthotopic Liver Transplantation显示文摘 | Hai-Yang Lu Xin-Yu Ning Ying-Qi Chen Shu-Jun Han Ping Chi Sai-Nan Zhu Yun Yue | 2018 | Chinese Medical Journal2018，，9： | 23 |
| 16 | Establishment and application of an artificial intelligence diagnosis system for pancreatic cancer with a faster region-based convolutional neural network显示文摘Background:Early diagnosis and accurate staging are important to improve the cure rate and prognosis for pancreatic cancer.This study was performed to develop an automatic and accurate imaging processing technique system,allowing this system to read computed tomography(CT)images correctly and make diagnosis of pancreatic cancer faster.Methods:The establishment of the artificial intelligence(AI)system for pancreatic cancer diagnosis based on sequential contrastenhanced CT images were composed of two processes:training and verification.During training process,our study used all 4385 CT images from 238 pancreatic cancer patients in the database as the training data set.Additionally,we used VGG16,which was pretrained in ImageNet and contained 13 convolutional layers and three fully connected layers,to initialize the feature extraction network.In the verification experiment,we used sequential clinical CT images from 238 pancreatic cancer patients as our experimental data and input these data into the faster region-based convolution network(Faster R-CNN)model that had completed training.Totally,1699 images from 100 pancreatic cancer patients were included for clinical verification.Results:A total of 338 patients with pancreatic cancer were included in the study.The clinical characteristics(sex,age,tumor location,differentiation grade,and tumor-node-metastasis stage)between the two training and verification groups were insignificant.The mean average precision was 0.7664,indicating a good training ejffect of the Faster R-CNN.Sequential contrastenhanced CT images of 100 pancreatic cancer patients were used for clinical verification.The area under the receiver operating characteristic curve calculated according to the trapezoidal rule was 0.9632.It took approximately 0.2 s for the Faster R-CNN AI to automatically process one CT image,which is much faster than the time required for diagnosis by an imaging specialist.Conclusions:Faster R-CNN AI is an effective and objective method with high accuracy for the diagnosis of pancreatic cancer. | Shang-Long Liu Shuo Li Yu-Ting Guo Yun-Peng Zhou Zheng-Dong Zhang Shuai Li Yun Lu | 2019 | Chinese Medical Journal2019，，23： | 23 |
| 17 | Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients显示文摘 | Lu Wen Jingyi Li Huahu Guo Xiaomeng Liu Shengmin Zheng Dafang Zhang Weihua Zhu Jianhui Qu Limin Guo Dexiao Du Xiao Jin Yuhao Zhang Yun Gao Jie Shen Hao Ge Fuchou Tang Yanyi Huang Jirun Peng | 2015 | Cell Research2015，25，11： | 19 |
| 18 | CYP2C19*2 and Other Allelic Variants Affecting Platelet Response to Clopidogrel Tested by Thrombelastography in Patients with Acute Coronary Syndrome显示文摘 | Jian Liu Xiao-Yan Nie Yong Zhang Yun Lu Lu-Wen Shi Wei-Min Wang | 2015 | Chinese Medical Journal2015，，16： | 19 |
| 19 | N6-Methyladenine DNA Methylation in Japonica and Indica Rice Genomes and Its Association with Gene Expression,Plant Development, and Stress Responses显示文摘N6-Methyladenine (6mA)DNA methylation has recently been implicated as a potential new epigenetic marker in eukaryotes,including the dioot modelArabidopsis thaliana.However,the conservation and divergence of 6mA distribution patterns and functions in plants remain elusive.Here we report high-quality 6mA methylomes at single-nucleotide resolution in rice based on substantially improved genome sequences of two rice cultivars,Nipponbare (Nip;Japonica)and 93-11 (Indica).Analysis of 6mA genomic distribution and its association with transcription suggest that 6mA distribution and function is rather conserved between rice and Arabidopsis.We found that 6mA levels are positively correlated with the expression of key stressrelated genes,which may be responsible for the difference in stress tolerance between Nip and 93-11. Moreover,we showed that mutations in DDM1 cause defects in plant growth and decreased 6mA level. Our results reveal that 6mA is a conserved DNA modification that is positively associated with gene expression and contributes to key agronomic traits in plants. | Qian Zhang Zhe Liang Xuean Cui Changmian Ji Yun Li Pingxian Zhang Jingrong Liu Adeel Riaz Pu Yao Min Liu Yunpeng Wang Tiegang Lu Hao Yu Donglei Yang Hongkun Zheng Xiaofeng Gu | 2018 | Molecular Plant2018，11，12： | 18 |
| 20 | Traditional Chinese medicine integrated with chemotherapy for stage Ⅳ non-surgical gastric cancer: a retrospective clinical analysis显示文摘OBJECTIVE: Traditional Chinese medicine(TCM) is regarded as an important treatment for gastric cancer patients, especially for those in advanced stage. To evaluate the effects of TCM treatment on gastric cancer patients, the authors performed a retrospective study to report the result of the integrated treatment of TCM with chemotherapy for stage IV non-surgical gastric cancer.METHODS: In this study, 182 patients with stage IV and non-surgical gastric cancer were retrospectively analyzed to evaluate the effects of TCM integrated with chemotherapy. Among the 182 cases, 88 cases received integrated therapy consisting of TCM and chemotherapy, while 94 cases received chemotherapy alone. The overall survival and Karnofsky performance status(KPS) score were measured as the main outcome.RESULTS: The median overall survival of the integrated therapy group and chemotherapy group were 16.9 and 10.5 months, respectively. The 1-, 3-and 5-year survival rates of integrated therapy group vs. chemotherapy group were 70% vs. 32%, 18% vs. 4%, and 11% vs. 0%, respectively. There was a significant difference between the two groups(χ2 = 42.244, P < 0.001). After six-month treatment, KPS scores of the integrated therapy group and the chemotherapy group were 75.00 ± 14.78 and 60.64 ± 21.39, respectively(P < 0.001). The Cox regression analysis showed that TCM treatment is a protective factor for patients' overall survival. CONCLUSION: This study demonstrated that TCM integrated with chemotherapy may prolong overall survival and improve survival rate and life quality of patients with stage IV non-surgical gastric cancer. | xuan liu li-juan xiu jian-peng jiao jing zhao ying zhao ye lu jun shi yong-jin li min ye yu-fang gu xiao-wei wang jing-yu xu ci-an zhang yong-ying liu yun luo xiao-qiang yue | 2017 | Journal of Integrative Medicine2017，15，6： | 18 |
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