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| 1 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 2 | A Domestication-Associated Gene GmPRR3b Regulates the Circadian Clock and Flowering Time in Soybean显示文摘Improved soybean cultivars have been adapted to grow at a wide range of latitudes,enabling expansion of cultivation worldwide.However,the genetic basis of this broad adaptation is still not clear.Here,we report the identification of GmPRR3b as a major flowering time regulatory gene that has been selected during domestication and genetic improvement for geographic expansion.Through a genome-wide association study of a diverse soybean landrace panel consisting of 279 accessions,we identified 16 candidate quantitative loci associated with flowering time and maturity time.The strongest signal resides in the known flowering gene E2,verifying the effectiveness of our approach.We detected strong signals associated with both flowering and maturity time in a genomic region containing GmPRR3b.Haplotype analysis revealed that GmPRR3bH6 is the major form of GmPRR3b that has been utilized during recent breeding of modern cultivars.mRNA profiling analysis showed that GmPRR3bH6 displays rhythmic and photoperiod-dependent expression and is preferentially induced under long-day conditions.Overexpression of GmPRR3bH6 increased main stem node number and yield,while knockout of GmPRR3bH6 using CRISPR/Cas9 technology delayed growth and the floral transition.GmPRR3bH6 appears to act as a transcriptional repressor of multiple predicted circadian clock genes,including GmCCAIa,which directly upregulates J/GmELF3a to modulate flowering time.The causal SNP(Chr12:5520945)likely endows GmPRR3bH6 a moderate but appropriate level of activity,leading to early flowering and vigorous growth traits preferentially selected during broad adaptation of landraces and improvement of cultivars. | Cong Li Ying-hui Li Yanfei Li Hongfeng Lu Huilong Hong Yu Tian Hongyu Li Tao Zhao Xiaowei Zhou Jun Liu Xinan Zhou Scott A.Jackson Bin Liu Li-juan Qiu | 2020 | Molecular Plant2020，13，5： | 11 |
| 3 | Liquid crystal integrated metalens with tunable chromatic aberration显示文摘Overcoming chromatic aberrations is a vital concern in imaging systems in order to facilitate fullcolor and hyperspectral imaging.By contrast,large dispersion holds opportunities for spectroscopy and tomography.Combining both functions into a single component will significantly enhance its versatility.A strategy is proposed to delicately integrate two lenses with a static resonant phase and a switchable geometric phase separately.The former is a metasurface lens with a linear phase dispersion.The latter is composed of liquid crystals(LCs)with space-variant orientations with a phase profile that is frequency independent.By this means,a broadband achromatic focusing from 0.9 to 1.4 THz is revealed.When a saturated bias is applied on LCs,the geometric phase modulation vanishes,leaving only the resonant phase of the metalens.Correspondingly,the device changes from achromatic to dispersive.Furthermore,a metadeflector with tunable dispersion is demonstrated to verify the universality of the proposed method.Our work may pave a way toward active metaoptics,promoting various imaging applications. | Zhixiong Shen Shenghang Zhou Xinan Li Shijun Ge Peng Chen Wei Hu Yanqing Lu | 2020 | Advanced Photonics2020，2，3： | 7 |
| 4 | The combination of chidamide with the CHOEP regimen in previously untreated patients with peripheral T-cell lymphoma: a prospective, multicenter, single arm, phase 1b/2 study显示文摘Objective:To assess the efficacy and safety of the novel histone deacetylase inhibitor,chidamide,in combination with cyclophosphamide,doxorubicin,vincristine,etoposide,and prednisone(Chi-CHOEP)for untreated peripheral T-cell lymphoma(PTCL).Methods:A prospective,multicenter,single arm,phase 1 b/2 study was conducted.A total of 128 patients with untreated PTCL(18–70 years of age)were enrolled between March 2016 and November 2019,and treated with up to 6 cycles with the Chi-CHOEP regimen.In the phase 1 b study,3 dose levels of chidamide were evaluated and the primary endpoint was determination of the maximumtolerated dose and recommended phase 2 dose(RP2 D).The primary endpoint of the phase 2 study was 2-year progression-free survival(PFS).Results:Fifteen patients were enrolled in the phase 1 b study and the RP2 D for chidamide was determined to be 20 mg,twice a week.A total of 113 patients were treated at the RP2 D in the phase 2 study,and the overall response rate was 60.2%,with a complete response rate of 40.7%.At a median follow-up of 36 months,the median PFS was 10.7 months,with 1-,2-,and 3-year PFS rates of 49.9%,38.0%,and 32.8%,respectively.The Chi-CHOEP regimen was well-tolerated,with grade 3/4 neutropenia occurring in approximately two-thirds of the patients.No unexpected adverse events(AEs)were reported and the observed AEs were manageable.Conclusions:This large cohort phase 1 b/2 study showed that Chi-CHOEP was well-tolerated with modest efficacy in previously untreated PTCL patients. | Wei Zhang Liping Su Lihong Liu Yuhuan Gao Quanshun Wang Hang Su Yuhuan Song Huilai Zhang Jing Shen Hongmei Jing Shuye Wang Xinan Cen Hui Liu Aichun Liu Zengjun Li Jianmin Luo Jianxia He Jingwen Wang O.A.O’Connor Daobin Zhou | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 5 | A comparative study of magnetic properties between whole cells and isolated magnetosomes of Magnetospirillum magneticum AMB-1显示文摘The magnetic properties of magnetosome magnetite are of interdisciplinary interest because magnetosomes are potential carriers of natural remanent magnetization and paleoenvironment, as well as novel nano-biomaterials in biotechnological and biomedical applications. We carried out magnetic and electron transmission microscopy analyses of fresh Magnetospirillum magneticum AMB-1 whole cells and isolated magnetosomes. Results revealed that AMB-1 synthesized single-domain magnetite magneto-somes, which are arranged in the form of linear fragmental chain. The distinct differences of magnetic properties between these two samples can be faithfully interpreted in terms of spatial arrangement of magnetosomes and magnetostatic interaction. For the whole cells, the strong intra-chain interactions and weak inter-chain interactions generate behaviors of non-interacting uniaxial single-domain particles. Its δ-ratio is 3.0 and passes the Moskowitz test. In contrast, the isolated magnetosome sample has reduced values of coercivity and δ-ratio (1.5), due to increasing three-dimensional magnetostatic interactions and collapse of magneto-some chains. These observations provide useful insights into applications of the biogenic magnetite (magnetosomes) in magnetic nano-materials and magnetofossils in the paleomagnetic and environmental magnetism. | LI JinHua PAN YongXin LIU QingSong QIN HuaFeng DENG ChengLong CHE RenChao YANG XinAn | 2010 | Chinese Science Bulletin2010，55，1： | 3 |
| 6 | Large-Scale Synthesis of the Stable Co-Free Layered Oxide Cathode by the Synergetic Contribution of Multielement Chemical Substitution for Practical Sodium-Ion Battery显示文摘The O3-type layered oxide cathodes for sodium-ion batteries(SIBs)are considered as one of the most promising systems to fully meet the requirement for future practical application.However,fatal issues in several respects such as poor air stability,irreversible complex multiphase evolution,inferior cycling lifespan,and poor industrial feasibility are restricting their commercialization development.Here,a stable Co-free O3-type NaNi_(0.4)Cu_(0.05)Mg_(0.05)Mn_(0.4)Ti_(0.1O2) cathode material with large-scale production could solve these problems for practical SIBs.Owing to the synergetic contribution of the multielement chemical substitution strategy,this novel cathode not only shows excellent air stability and thermal stability as well as a simple phase-transition process but also delivers outstanding battery performance in half-cell and full-cell systems.Meanwhile,various advanced characterization techniques are utilized to accurately decipher the crystalline formation process,atomic arrangement,structural evolution,and inherent effect mechanisms.Surprisingly,apart from restraining the unfavorable multiphase transformation and enhancing air stability,the accurate multielement chemical substitution engineering also shows a pinning effect to alleviate the lattice strains for the high structural reversibility and enlarges the interlayer spacing reasonably to enhance Na^(+)diffusion,resulting in excellent comprehensive performance.Overall,this study explores the fundamental scientific understandings of multielement chemical substitution strategy and opens up a new field for increasing the practicality to commercialization. | Yao Xiao Tao Wang Yan-Fang Zhu Hai-Yan Hu Shuang-Jie Tan Shi Li Peng-Fei Wang Wei Zhang Yu-Bin Niu En-Hui Wang Yu-Jie Guo Xinan Yang Lin Liu Yu-Mei Liu Hongliang Li Xiao-Dong Guo Ya-Xia Yin Yu-Guo Guo | 2020 | Research2020，，1： | 3 |
| 7 | Preliminary experimental results by the prototype of Sanya Incoherent Scatter Radar显示文摘In the past decades,the Incoherent Scatter Radar(ISR)has been demonstrated to be one of the most powerful instruments for ionosphere monitoring.The Institute of Geology and Geophysics at the Chinese Academy of Sciences was founded to build a state-ofthe-art phased-array ISR at Sanya(18.3°N,109.6°E),a low-latitude station on Hainan Island,named the Sanya ISR(SYISR).As a first step,a prototype radar system consisting of eight subarrays(SYISR-8)was built to reduce the technical risk of producing the entire large array.In this work,we have summarized the preliminary experimental results based on the SYISR-8.The amplitude and phase among 256 channels were first calibrated through an embedded internal monitoring network.The mean oscillation of the amplitude and phase after calibration were about 1 dB and 5°,respectively,which met the basic requirements.The beam directivity was confirmed by crossing screen of the International Space Station.The SYISR-8 was further used to detect the tropospheric wind profile and meteors.The derived winds were evaluated by comparison with independent radiosonde and balloon-based GPS measurements.The SYISR-8 was able to observe several typical meteor echoes,such as the meteor head echo,range-spread trail echo,and specular trail echo.These results confirmed the validity and reliability of the SYISR-8 system,thereby reducing the technical risk of producing the entire large array of the SYISR to some extent. | XinAn Yue WeiXing Wan Han Xiao LingQi Zeng ChangHai Ke BaiQi Ning Feng Ding BiQiang Zhao Lin Jin Chen Li MingYuan Li JunYi Wang HongLian Hao Ning Zhang | 2020 | Earth and Planetary Physics2020，4，6： | 3 |
| 8 | High resolution multispectral spatial light modulators based on tunable Fabry-Perot nanocavities显示文摘Spatial light modulators(SLMs)are the most relevant technology for dynamic wavefront manipulation.They find diverse applications ranging from novel displays to optical and quantum communications.Among commercial SLMs for phase modulation,Liquid Crystal on Silicon(LCoS)offers the smallest pixel size and,thus,the most precise phase mapping and largest field of view(FOV).Further pixel miniaturization,however,is not possible in these devices due to inter-pixel cross-talks,which follow from the high driving voltages needed to modulate the thick liquid crystal(LC)cells that are necessary for full phase control.Newly introduced metasurface-based SLMs provide means for pixel miniaturization by modulating the phase via resonance tuning.These devices,however,are intrinsically monochromatic,limiting their use in applications requiring multi-wavelength operation.Here,we introduce a novel design allowing small pixel and multi-spectral operation.Based on LC-tunable Fabry-Perot nanocavities engineered to support multiple resonances across the visible range(including red,green and blue wavelengths),our design provides continuous 2π phase modulation with high reflectance at each of the operating wavelengths.Experimentally,we realize a device with 96 pixels(~1 μm pitch)that can be individually addressed by electrical biases.Using it,we first demonstrate multi-spectral programmable beam steering with FOV~18° and absolute efficiencies exceeding 40%.Then,we reprogram the device to achieve multi-spectral lensing with tunable focal distance and efficiencies~27%.Our design paves the way towards a new class of SLM for future applications in displays,optical computing and beyond. | Shampy Mansha Parikshit Moitra Xuewu Xu Tobias Wwmass Rasna Maruthiyodan Veetil Xinan Liang Shi-Qiang Li Ramon Paniagua-Dominguez Arseniy I.Kuznetsov | 2022 | Light(Science & Applications)2022，11，6： | 3 |
| 9 | Augmented renal clearance in Chinese intensive care unit patients after traumatic brain injury: a cross-sectional study显示文摘To the Editor:Augmented renal clearance(ARC)refers to an enhanced elimination of circulating solutes,including drugs,by the kidneys at a rate statistically higher than normal.On the first day of intensive care unit(ICU)admission,ARC occurrence may predict continued creatinine clearance(CrCl)elevation for 1 day to several weeks.[1]ARC has a substantial adverse effect on renally cleared antibiotics'pharmacokinetics/pharmacodynamics.Treatment failure or worse outcomes are more frequent in ARC patients.Thus,a'one size fits all'approach to drug dosing in ARC patients is inappropriate;dosing requires adjustment for some variables. | Zilong Dang Hong Guo Bin Li Maohua Zhen Jian Liu Yuhui Wei Hongyan Qin Zhimin Dou Lei Zhang Lei Zhu Yongqiang Cao Fengjiao Li Xinan Wu | 2022 | Chinese Medical Journal2022，，6： | 3 |
| 10 | QUALITATIVE ANALYSIS OF A STOCHASTIC PREDATOR-PREY SYSTEM WITH DISEASE IN THE PREDATOR显示文摘 | SHUANG LI XINAN ZHANG | 2013 | International Journal of Biomathematics2013，6，1： | 2 |
| 11 | Changes in the pharmacokinetics of glibenclamide in rats with streptozotocin-induced diabetes mellitus显示文摘The aim of this study was to investigate the pharmacokinetics of glibenclamide(Gli)administrated orally and intravenously to normal and diabetic rats.The AUC(0–720 min)of orally administered Gli in diabetic rats(321.24 mg min/L)was greater than that(57.752 mg min/L)in normal rats.CL(0.019 L/min/kg)was significantly slower than that(0.092 L/min/kg)of normal rats.The AUC(0–480min)of intravenous Gli in diabetic rats(1528.280 mg min/L)also was significantly greater than that(509.523 mg min/L)in normal rats,and CL was decreased approximately 3-fold.No significant difference in intestinal absorption of Gli was observed between normal and diabetic rats as determined by in situ single-pass intestinal perfusion.The clearance of Diclofenac(a substrate of CYP2C9)was determined to evaluate changes in hepatic drug-metabolizing enzyme activity in rats.The CL in diabetic rats was significantly lower(42.43%decrease)than that in normal rats.Hepatic protein expression of CYP2C9 was measured using Western blot analysis;compared with normal rats,the hepatic protein expression of CYP2A9 was decreased in diabetic rats.Therefore,the slower clearance of Gli in diabetic rats can be attributed primarily to the lower expression of hepatic CYP2C9. | Yuqing Li Yuhui Wei Fan Zhang Dan Wang Xinan Wu | 2012 | Acta Pharmaceutica Sinica B2012，2，2： | 1 |
| 12 | Chaos gray-coded genetic algorithm and its application for pollution source identifications in convection–diffusion equation显示文摘 | Xiaohua Yang Zhifeng Yang Xinan Yin Jianqiang Li | 2007 | Communications in Nonlinear Science and Numerical Simulation2007，，8： | 1 |
| 13 | Earliest Triassic microbialites in the South China block and other areas: controls on their growth and distribution显示文摘 | Steve Kershaw Yue Li Sylvie Crasquin-Soleau Qinglai Feng Xinan Mu Pierre-Yves Collin Alan Reynolds Li Guo | 2007 | Facies2007，，3： | 1 |
| 14 | Earliest Triassic microbialites in the South China block and other areas: controls on their growth and distribution显示文摘 | Steve Kershaw Yue Li Sylvie Crasquin-Soleau Qinglai Feng Xinan Mu Pierre-Yves Collin Alan Reynolds Li Guo | 2007 | Facies2007，，3： | 1 |
| 15 | Predictive model of Vibrio parahaemolyticus growth and survival on salmon meat as a function of temperature显示文摘 | YANG Zhenquan JIAO Xinan LI Ping | 2009 | Food microbiology2009，26，6： | 1 |
| 16 | A feed-through ACFM probe with sensor array for pipe string cracks inspection 显示文摘 | LI Wei YUAN Xinan CHEN Guoming | 2014 | NDT&E International2014，67，： | 1 |
| 17 | Design and performance of the LLRF control system for CSNS linac显示文摘Objective The China Spallation Neutron Source(CSNS)linac is designed with beam energy of 80 MeV and a peak current of 15 mA in the first phase.It consists of RFQ,two bunchers of medium-energy beam transmission line,four DTL tanks and one debuncher of linac-to-ring beam transmission line.Correspondingly,eight online RF power sources are used to power these accelerators.In order to stabilize the amplitude,phase and resonant frequency of the RF accelerating field,and minimize beam loss,we have established digital low-level RF(LLRF)control system.Methods The LLRF system includes RF reference line,analog module(AM),clock distribution module,digital control module(DCM),high-power protection module,timing and RF interlock module and so on.The DCM is mainly responsible for the stability of the RF field amplitude and phase,and RF interlock module can quickly cut off the RF drive in case of arc in the RF transmission system,VSWR over threshold or cavity vacuum fault and so on.Result During beam commissioning,all of eight online units of LLRF control system were operating stably and reliably.The amplitude and phase variations of the linac fields have been achieved about±0.4%and±0.15°with 10-mA beam loading,much better than the design requirements of±1%in amplitude and±1°in phase.Conclusion With the help of this system,we achieved stable operation under different beam loads.Also,many important progresses have been achieved in the LLRF control system for amore convenient operation and a higher stability performance.This article describes the design and implementation of the LLRF for CSNS linac. | Linyan Rong Zhencheng Mu Jian Li Zhexin Xie Wenzhong Zhou Bo Wang Maliang Wan Meifei Liu Xinan Xu | 2020 | Radiation Detection Technology and Methods2020，4，2： | 1 |
| 18 | Earliest Triassic microbialites in the South China block and other areas: controls on their growth and distribution显示文摘 | Steve Kershaw Yue Li Sylvie Crasquin-Soleau Qinglai Feng Xinan Mu Pierre-Yves Collin Alan Reynolds Li Guo | 2007 | Facies2007，，3： | 1 |
| 19 | LiMoO 3 (IO 3 ): A new molybdenyl iodate based on WO 3 -type sheets with large SHG response显示文摘 | Xuean Chen Li Zhang Xinan Chang Haiping Xue Hegui Zang Weiqiang Xiao Xuemei Song Hui Yan | 2006 | Journal of Alloys and Compounds2006，，： | 1 |
| 20 | International Meridian Circle Program显示文摘The Earth is buffered from the ferocious onslaught of the solar wind by a thin layer of matter known as the atmosphere and geospace.This layer absorbs energy from irradiance and outburst from the Sun,as well as from disasters,transient phenomena and anthropogenic emissions originated from Earth.Through complicated physics,the absorbed energy changes the atmospheric and geospace state and sometimes gets re-released to power extreme events such as space weather.Taking place globally,these complicated processes cannot be understood unless they are studied globally.The Chinese scientists have proposed the International Meridian Circle Program(IMCP)to meet this demand.By operating nearly 1000 instruments encompassing all latitudes along with the 120°E–60°W longitudes,IMCP aims,for the first time,to construct comprehensive 3D data representation of the atmosphere and geospace on a global scale and empower interdisciplinary research to tackle key questions related to Earth’s environment and climate change. | LIU William WANG Chi SHEN Xuhui WU Jian BLANC Michel YAN Yihua FU Suiyan YUE Xinan LEI Jiuhou GONG Wei ZHANG Shaodong ZHANG Qinghe WANG Xin YANG Jing ZHANG Xiaoxin GAO Jing XU Jiyao YANG Guotao LI Hui REN Liwen YANG Fang | 2020 | 空间科学学报2020，40，5： | 1 |
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