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| 1 | Jiangtang Xiaoke granule attenuates glucose metabolism disorder via regulating endoplasmic reticulum stress in the liver of type 2 diabetes mellitus mice显示文摘OBJECTIVE:To observe the effect of Jiangtang Xiaoke(JTXK) granule on endoplasmic reticulum(ER)stress in high fat diet(HFD)-induced type 2 diabetes mellitus(T2 DM) KK-Ay mice.METHODS:KK-Ay mice were fed with HFD to induce the T2 DM model,while normal control C57 BL/6 J mice were given standard feed.Fasting blood glucose(FBG) in all mice was measured weekly and oral glucose tolerance tests(OGTTs) were performed at 4 and 10 weeks after start of treatment to determine glucose metabolism.Serum fasting insulin(FINS) and insulin sensitivity index(ISI) were measured to determine insulin sensitivity.m RNA expressions of eukaryotic initiation factor-2 alpha(e IF2α),glucose regulated protein 78(GRP78),activating transcription factor 4(ATF4),and C/EBP homology protein(CHOP) were assessed by reverse transcription polymerase chain reaction and the protein expressions of p-e IF2α,GRP78,and CHOP were assessed by Western blotting.RESULTS:JTXK granule significantly reduced FBG and free fatty acid levels and improved OGTT at the120 min of the 10-week treatment in T2 DM KK-Ay mice.FINS and Hb Alc levels were reduced and insulin sensitivities were increased in KK-Ay diabetic mice,which were improved with the treatment of JTXK granule,especially at the 7 and 3.5 g/kg doses.JTXK granule at the 3.5 g/kg dose was most effective in reducing both gene and protein expressions of e IF2α,GRP78,and CHOP.CONCLUSION:ER stress response is increased in T2 DM KK-Ay mice.Treatment with JTXK granule attenuates glucose disorders,improves insulin sensitivity,and reduces serum FFA in T2 DM KK-Ay mice.The mechanisms may be attributed to regulation of the signaling ER stress pathway via decreasing e IF2α phosphorylation and suppressing e IF2α-ATF4-CHOP activation. | Zhang Yi Mo Fangfang Zhang Dongwei Gao Sihua Zhao Dandan Yu Na Mu Qianqian Zuo Jiacheng Ma Yue | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 3 |
| 2 | Theoretical screening of the transition metal heteronuclear dimer anchored graphdiyne for electrocatalytic nitrogen reduction显示文摘Developing efficient electrocatalysts for nitrogen reduction reaction(NRR)is crucial to replace the both energy-intensive and environment-malignant Haber-Bosch process.Here using density functional theory calculations,we systematically studied the potential of the heteronuclear 3 d transition metal dimers anchored graphdiyne monolayers(FeM@and NiM@GDY,M=Ti,V,Cr,Mn,Fe,Co,Ni,and Cu)as efficient NRR catalysts.Among all the studied double-atom catalysts(DACs),FeCo@and NiCo@GDY are the most promising with excellent NRR catalytic activity,high ability to suppress the competing hydrogen evolution reaction(HER),and good stability.For both FeCo@and NiCo@GDY,NRR prefers to the distal pathway with the calculated onset potentials of -0.44 and -0.36 V,respectively,which are comparable and even better than their homonuclear counterparts.Moreover,FeCo@and NiCo@GDY have higher ability to suppress HER than Fe_(2)@ and Co_(2)@GDY,which may result from the modulated d state electronic structure due to the synergy effect of the heteronuclear atoms in the DACs.Our work not only suggests that FeCo@and NiCo@GDY hold great promises as efficient,low-cost,and stable DACs for NRR,but also further provides a strategy,i.e.alloying the atomic metal catalysts,to improve the NRR catalytic activity and/or selectivity. | Dongwei Ma Zaiping Zeng Liangliang Liu Yu Jia | 2021 | Journal of Energy Chemistry2021，30，3： | 3 |
| 3 | Advance in the Studies on Small Cell Neuroendocrine Carcinoma of the Paranasal Sinuses显示文摘Small cell neuroendocrine carcinoma (SCNEC) of the paranasal sinuses is extremely rare,with an unclear pathogenesis.The presence of neuroendocrine granules is suggestive of neuroendocrine differentiation.It was reported that this disease relates to the presence of accessory salivary glands,and some basic research has shown that it might originate from the multi-potent stem cells.There are no specific clinical symptoms but rhinal and ophthalmological symptoms are found in most cases.Diagnosis mainly depends on histopathological manifestations,immunohistochemical results and features of the electron microscopic ultra-structure.Pathological differentiation from poorly differentiated squamous carcinoma,melanoma,esthesioneuroblastoma and neuroglioma etc.is needed.No unified regimen has been employed in treating the disease.At present,combined therapy has a manifest therapeutic effect,such as success with the 2003 French regimen.Tumor relapse is common and prognosis is poor.A complete combined treatment plan will be helpful to improve the prognosis. | Changsheng Cong Yonghua Yu Shuanghu Yuan Dongwei Gao | 2008 | Chinese Journal of Clinical Oncology2008，5，3： | 2 |
| 4 | The choice between bankruptcy liquidation and bankruptcy reorganization: a model and evidence显示文摘This paper proposes a two-period model to examine which bankruptcy procedure is better for both the debtor and creditor when insolvency happens.Our theoretical model depicts how firm size,industry characteristics,equity structure,and debt structure determine firms’bankruptcy resolutions.Using a comprehensive sample of bankrupt firms in the United States,we verify the predictions of a theoretical model.In our study,we deploy Probit and Logit models to address the predictions in the theoretical framework and conduct a series of robustness checks with econometric methods like Propensity Score Matching to confirm the empirical results.This paper finds that firms with larger size have more chance to file for Chapter 11 reorganization when insolvency happens.We also find that firms in asset-heavy(asset-light)industries are more likely to be reorganized(liquidated)under U.S.bankruptcy code. | Kai Yu Dongwei He | 2018 | Journal of Management Analytics2018，5，3： | 1 |
| 5 | Integration of high-throughput phenotyping,GWAS,and predictive models reveals the genetic architecture of plant height in maize显示文摘Plant height(PH)is an essential trait in maize(Zea mays)that is tightly associated with planting density,biomass,lodging resistance,and grain yield in the field.Dissecting the dynamics of maize plant architecture will be beneficial for ideotype-based maize breeding and prediction,as the genetic basis controlling PH in maize remains largely unknown.In this study,we developed an automated high-throughput phenotyping platform(HTP)to systematically and noninvasively quantify 77 image-based traits(i-traits)and 20 field traits(f-traits)for 228 maize inbred lines across all developmental stages.Time-resolved i-traits with novel digital phenotypes and complex correlations with agronomic traits were characterized to reveal the dynamics of maize growth.An i-trait-based genome-wide association study identified 4945 traitassociated SNPs,2603 genetic loci,and 1974 corresponding candidate genes.We found that rapid growth of maize plants occurs mainly at two developmental stages,stage 2(S2)to S3 and S5 to S6,accounting for the final PH indicators.By integrating the PH-association network with the transcriptome profiles of specific internodes,we revealed 13 hub genes that may play vital roles during rapid growth.The candidate genes and novel i-traits identified at multiple growth stages may be used as potential indicators for final PH in maize.One candidate gene,ZmVATE,was functionally validated and shown to regulate PH-related traits in maize using genetic mutation.Furthermore,machine learning was used to build predictive models for final PH based on i-traits,and their performancewas assessed across developmental stages.Moderate,strong,and very strong correlations between predictions and experimental datasets were achieved from the early S4(tenth-leaf)stage.Colletively,our study provides a valuable tool for dissecting the spatiotemporal formation of specific internodes and the genetic architecture of PH,as well as resources and predictive models that are useful for molecular design breeding and predicting maize varieties with ideal plant architectures. | Weixuan Wang Weijun Guo Liang Le Jia Yu Yue Wu Dongwei Li Yifan Wang Huan Wang Xiaoduo Lu Hong Qiao Xiaofeng Gu Jian Tian Chunyi Zhang Li Pu | 2023 | Molecular Plant2023，16，2： | 1 |
| 6 | A future laminted bamboo structure residetial building prototype in China:Life cycle assess- ment of energy use and carbon emission 显示文摘 | Yu Dongwei Tan Hongwei Yan Yingjun | 2011 | Energy and Building''2011，43，10： | 1 |
| 7 | Design and applicability analysis of independent double acquisition circuit of all-fiber optical current transformer显示文摘The advantages of the all-fiber optical current transformer include but are not limited to being small in size,having no magnetic saturation,exhibiting high measurement accuracy,and boasting strong electromagnetic interference resistance.However,the high cost of the all-fiber optical transformer limits its promotion and application in engineering.This paper proposes a design scheme of an independent double acquisition loop for the all-fiber optical current transformer based on the single optical path.Firstly,based on the closed-loop control mode and open-loop control mode,the twochannel sampling signal demand for relay protection,and the independent dual-acquisition loop design scheme of the all-fiber optical current transformer are proposed.Secondly,the reliability and economic feasibility of the scheme are demonstrated by an analysis of system failure and cost.The results show that the scheme can actualize the acquisition function of two independent all-fiber optical current transformer products on a single all-fiber current transformer in an integrated manner,which greatly reduces the cost of the all-fiber optical current transformer in engineering applications. | Songlin Gu Liu Han Dongwei Liu Wenbin Yu Zhihong Xiao Teng Feng | 2019 | Global Energy Interconnection2019，2，6： | 1 |
| 8 | Identification of TM9SF2 as a Candidate of the Cell Surface Marker Common to Breast Carcinoma Cells显示文摘OBJECTIVE We aimed identification of cell surface molecules,which might serve as diagnostic biomarkers or useful targets fortherapies, in breast cancer.METHODS We developed unique DNA microarray coupledwith spherical self-organizing map (sSOM) analysis to characterizecells and tissues by the cell surface markers. In the microarray 1,797probes for human genes coding membrane bound proteins werespotted. With this microarray the gene expression profiles of eightbreast carcinoma cell lines were compared to identify the genesthat were commonly expressed in breast carcinomas but not innormal cells.RESULTS The gene expression profiles of sSOM from the eightbreast carcinoma cell lines were successfully distinguished fromthat of normal breast tissue derived cells suggesting the presenceof genes of interest. sSOM on the data extensively filtered revealedseveral candidate genes, of which expression was significant incarcinoma cells but low in normal cells. Finally, TM9SF2 wasnominated through validations of PCR procedures together withCD24 and ErbB3, which are known breast carcinoma markers.TM9SF2 expression was further confirmed by immunologicalstaining. Interestingly, TM9SF2 was found to be expressed in allthe cell lines evaluated while CD24 and ErbB3 were not in allof the carcinoma cells, supporting their relationship in sSOM.Although physiological significance of TM9SF2 is unknown yet,siRNA treatment significantly inhibited the growth of MDA-MB-231 cells.CONCLUSION We propose TM9SF2 as a novel and usefuldiagnostic marker as well as a potential molecular target specificto breast carcinoma cells covering wide range of breast cancer. | Samah Abou-Sharieha Yuh Sugii Tuoya Dongwei Yu Ling Chen Heizou Tokutaka Masaharu Seno | 2009 | Chinese Journal of Clinical Oncology2009，6，1： | 1 |
| 9 | Advances in emission control of diesel vehicles in China显示文摘Diesel vehicles have caused serious environmental problems in China.Hence,the Chinese government has launched serious actions against air pollution and imposed more stringent regulations on diesel vehicle emissions in the latest China VI standard.To fulfill this stringent legislation,two major technical routes,including the exhaust gas recirculation(EGR)and high-efficiency selective catalytic reduction(SCR)routes,have been developed for diesel engines.Moreover,complicated aftertreatment technologies have also been developed,including use of a diesel oxidation catalyst(DOC)for controlling carbon monoxide(CO)and hydrocarbon(HC)emissions,diesel particulate filter(DPF)for particle mass(PM)emission control,SCR for the control of NOx emission,and an ammonia slip catalyst(ASC)for the control of unreacted NH3.Due to the stringent requirements of the China VI standard,the aftertreatment system needs to be more deeply integrated with the engine system.In the future,aftertreatment technologies will need further upgrades to fulfill the requirements of the near-zero emission target for diesel vehicles. | Guangyan Xu Wenpo Shan Yunbo Yu Yulong Shan Xiaodong Wu Ye Wu Shaojun Zhang Liqiang He Shijin Shuai Hailong Pang Xuefeng Jiang Heng Zhang Lei Guo Shufen Wang Feng-Shou Xiao Xiangju Meng Feng Wu Dongwei Yao Yan Ding Hang Yin Hong He | 2023 | Journal of Environmental Sciences2023，，1： | 1 |
| 10 | A future bamboo-structure residential building prototype in China:Life cycle assessment of energy use and carbon emission显示文摘 | Dongwei Yu Hongwei Tan Yingjun Ruan | 2011 | Energy and Buildings2011，43，2011： | 1 |
| 11 | Elevated nuclear PIGL disrupts the cMyc/BRD4 axis and improves PD-1 blockade therapy by dampening tumor immune evasion显示文摘To improve the efficacy of lenvatinib in combination with programmed death-1(PD-1)blockade therapy for hepatocellular carcinoma(HCC),we screened the suppressive metabolic enzymes that sensitize HCC to lenvatinib and PD-1 blockade,thus impeding HCC progression.After analysis of the CRISPR‒Cas9 screen,phosphatidylinositol-glycan biosynthesis class L(PIGL)ranked first in the positive selection list.PIGL depletion had no effect on tumor cell growth in vitro but reprogrammed the tumor microenvironment(TME)in vivo to support tumor cell survival.Specifically,nuclear PIGL disrupted the interaction between cMyc/BRD4 on the distant promoter of target genes and thus decreased the expression of CCL2 and CCL20,which are involved in shaping the immunosuppressive TME by recruiting macrophages and regulatory T cells.PIGL phosphorylation at Y81 by FGFR2 abolished the interaction of PIGL with importinα/β1,thus retaining PIGL in the cytosol and facilitating tumor evasion by releasing CCL2 and CCL20.Clinically,elevated nuclear PIGL predicts a better prognosis for HCC patients and presents a positive correlation with CD8+T-cell enrichment in tumors.Clinically,our findings highlight that the nuclear PIGL intensity or the change in PIGL-Y81 phosphorylation should be used as a biomarker to guide lenvatinib with PD-1 blockade therapy. | Hua Yu Tiezhu Shi Linli Yao Dongwei Xu Yufeng Ding Qiang Xia Wei Liu Xiongjun Wang | 2023 | Cellular & Molecular Immunology2023，20，8： | 1 |
| 12 | Salvia miltiorrhiza : An ancient Chinese herbal medicine as a source for anti-osteoporotic drugs显示文摘 | Yubo Guo Yu Li Liming Xue Richele P. Severino Sihua Gao Jianzhao Niu Lu-Ping Qin Dongwei Zhang Dieter Br?mme | 2014 | Journal of Ethnopharmacology2014，，3： | 1 |
| 13 | A future bamboo-structure residential building prototype in China: Life cycle assessment of energy use and carbon emission显示文摘 | Dongwei Yu Hongwei Tan Yingjun Ruan | 2011 | Energy & Buildings2011，，10： | 1 |
| 14 | A futurebamboo-structure residential building prototype in China: Lifecycle assessment of energy use and carbon emission显示文摘 | YU Dongwei TAN Hongwei RUAN Yingjun | 2011 | Energyand Buildings2011，43，10： | 1 |
| 15 | A future bamboo-struc- ture residential building prototype in China: life cycle assessment of energy use and carbon emission显示文摘 | YU Dongwei TAN Hongwei RUAN Yingjun | 2011 | Energy and Buildings2011，43，10： | 1 |
| 16 | A future bamboo-structure residential building prototype in China:Life cycle assessment of energy use and carbon emission显示文摘 | Yu Dongwei | 2011 | Energy and Buildings2011，，43： | 1 |
| 17 | A future bamboo-structure residential building prototype in China: Life cycle assessment of energy use and carbon emission显示文摘 | Dongwei Yu Hongwei Tan Yingjun Ruan | 2011 | Energy & Buildings2011，，10： | 1 |
| 18 | Evaluating the Derivative Value of Smart Grid Investment under Dual Carbon Target: A Hybrid Multi-Criteria Decision-Making Analysis显示文摘With the goal of“carbon peaking and carbon neutralization”,it is an inevitable trend for investing smart grid to promote the large-scale grid connection of renewable energy.Smart grid investment has a significant driving effect(derivative value),and evaluating this value can help to more accurately grasp the external effects of smart grid investment and support the realization of industrial linkage value with power grid investment as the core.Therefore,by analyzing the characterization of the derivative value of smart grid driven by investment,this paper constructs the evaluation index system of the derivative value of smart grid investment including 11 indicators.Then,the hybrid evaluation model of the derivative value of smart grid investment is developed based on anti-entropy weight(AEW),level based weight assessment(LBWA),and measurement alternatives and ranking according to the compromise solution(MARCOS)techniques.The results of case analysis show that for SG investment,the value of sustainable development can better reflect its derivative value,and when smart grid performs poorly in promoting renewable energy consumption,improving primary energy efficiency,and improving its own fault resistance,the driving force of its investment for future sustainable development will decline significantly,making the grid investment lack derivative value.In addition,smart grid investment needs to pay attention to the economy of investment,which is an important guarantee to ensure that the power grid has sufficient and stable sources of investment funds.Finally,compared with three comparison models,the proposed hybrid multi-criteria decision-making(MCDM)model can better improve the decision-making efficiency on the premise of ensuring robustness. | Na Yu Changzheng Gao Xiuna Wang Dongwei Li Weiyang You | 2023 | Energy Engineering2023，120，12： | 0 |
| 19 | Standardized Cultivation Technology of Maize Jinhai 5显示文摘It is very important to adopt standardized production technology in the process of maize cultivation,which is conducive to giving full play to the high-yield,high-quality and multi-resistant characteristics of Jinhai 5.This paper standardized the cultivation technology of Jinhai 5 from the aspects of maize seed quality,fertilization before sowing,sowing,seedling management,mid-period management,later management,disease and pest control,and harvesting,so as to provide reference for the standardized production of maize Jinhai 5. | Lizhi YU Xiufeng DENG Shaopeng LIU Dongwei WANG Yunfei MA | 2020 | Agricultural Biotechnology2020，9，6： | 0 |
| 20 | Preparation of P(MBA-co-MAA)/Zr(OH)_(4)/P(EGDMA-co-MAA)/TiO_(2)Tetra-layer Hybrid Microspheres and the Corresponding ZrO_(2)/TiO_(2)Double-shelled Hollow Microspheres显示文摘Double-shelled zirconia/titania(ZrO_(2)/TiO_(2))hollow microspheres were prepared by the selective removal of the polymer components via the calcination of the corresponding tetra-layer poly(N,N'-methylenebisacryl amide-comethacrylic acid)(P(MBA-co-MAA))/Zr(OH)_(4)/poly(ethyleneglycol dimethacrylate-co-methacrylic acid)(P(EGDMAco-MAA))/TiO_(2)hybrid microspheres.These tetra-layer microspheres were synthesized by the combination of the distillation copolymerization of N,N′-methylenebisacryl amide-co-methacrylic acid(MBA)or ethyleneglycol dimethacrylate(EGDMA)crosslinker and methacrylic acid(MAA)for the preparation of polymer core and thirdlayer as well as the controlled sol-gel hydrolysis of inorganic precursors for the construction of zirconium hydroxide(Zr(OH)_(4))and titania(TiO_(2))layers.The thicknesses of zirconia and titania shell-layers were conveniently controlled via varying the feed of zirconium n-butoxide(Zr(OBu)_(4))and titanium tetrabutoxide(TBOT)during the sol-gel hydrolysis,while the sizes of polymer layers were tuned through a multi-stage distillation precipitation copolymerization.The structure and morphology of the resultant microspheres were characterized by transmission electron microscopy(TEM),X-ray diffractometer(XRD),X-ray photoelectronic spectroscopy(XPS),and thermogrametric analysis(TGA). | Dianbin Qin Jinhui Yu Guomin Bian Yonglin Qi Dongwei Zhang Xinlin Yang | 2014 | Chinese Journal of Chemistry2014，32，2： | 0 |
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