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| 1 | Evaluating and Improving Wind Forecasts over South China: The Role of Orographic Parameterization in the GRAPES Model显示文摘Unresolved small-scale orographic(SSO) drags are parameterized in a regional model based on the Global/Regional Assimilation and Prediction System for the Tropical Mesoscale Model(GRAPES TMM). The SSO drags are represented by adding a sink term in the momentum equations. The maximum height of the mountain within the grid box is adopted in the SSO parameterization(SSOP) scheme as compensation for the drag. The effects of the unresolved topography are parameterized as the feedbacks to the momentum tendencies on the first model level in planetary boundary layer(PBL)parameterization. The SSOP scheme has been implemented and coupled with the PBL parameterization scheme within the model physics package. A monthly simulation is designed to examine the performance of the SSOP scheme over the complex terrain areas located in the southwest of Guangdong. The verification results show that the surface wind speed bias has been much alleviated by adopting the SSOP scheme, in addition to reduction of the wind bias in the lower troposphere. The target verification over Xinyi shows that the simulations with the SSOP scheme provide improved wind estimation over the complex regions in the southwest of Guangdong. | Shuixin ZHONG Zitong CHEN Daosheng XU Yanxia ZHANG | 2018 | Advances in Atmospheric Sciences2018，35，6： | 12 |
| 2 | An Arctic sea ice thickness variability revealed from satellite altimetric measurements显示文摘A modified algorithm taking into account the first year(FY) and multiyear(MY) ice densities is used to derive a sea ice thickness from freeboard measurements acquired by satellite altimetry ICESat(2003–2008). Estimates agree with various independent in situ measurements within 0.21 m. Both the fall and winter campaigns see a dramatic extent retreat of thicker MY ice that survives at least one summer melting season. There were strong seasonal and interannual variabilities with regard to the mean thickness. Seasonal increases of 0.53 m for FY the ice and 0.29 m for the MY ice between the autumn and the winter ICESat campaigns, roughly 4–5 month separation, were found. Interannually, the significant MY ice thickness declines over the consecutive four ICESat winter campaigns(2005–2008) leads to a pronounced thickness drop of 0.8 m in MY sea ice zones. No clear trend was identified from the averaged thickness of thinner, FY ice that emerges in autumn and winter and melts in summer. Uncertainty estimates for our calculated thickness, caused by the standard deviations of multiple input parameters including freeboard, ice density, snow density, snow depth, show large errors more than 0.5 m in thicker MY ice zones and relatively small standard deviations under 0.5 m elsewhere. Moreover, a sensitivity analysis is implemented to determine the separate impact on the thickness estimate in the dependence of an individual input variable as mentioned above. The results show systematic bias of the estimated ice thickness appears to be mainly caused by the variations of freeboard as well as the ice density whereas the snow density and depth brings about relatively insignificant errors. | BI Haibo HUANG Haijun SU Qiao YAN Liwen LIU Yanxia XU Xiuli | 2014 | Acta Oceanologica Sinica2014，33，11： | 8 |
| 3 | Extraction of hydrogen chloride by a coupled reaction-solvent extraction process显示文摘A coupled 反应溶剂抽取过程被用来把 HCl 从模仿的蒸馏器浪费移开。各种各样的提炼之物和 diluents 的抽取表演被比较,在各种各样的 diluents 的 N235 (第三级的胺的混合物) 的明显的盐基度是坚定的。最好的结果作为提炼之物用 N235 和 isoamyl 酒精被获得并且稀释分别地。从联合抽取的 HCl 的收益与这个抽取系统是 75% 。为在两个的 HCl 的移动的机制直接、联合的抽取被调查。为联合抽取, R 3 NHCl 离子对建筑群涉及 HCl 移动。为直接抽取,机制在 HCl 的高集中包含了氢契约的形成。 | Yunzhao Li Xingfu Song Guilan Chen Shuying Sun Yanxia Xu Jianguo Yu | 2015 | Frontiers of Chemical Science and Engineering2015，9，4： | 6 |
| 4 | An electrochemical impedance spectroscopic study of the electronic and ionic transport properties of LiCoO_2 cathode显示文摘The storage behavior and process of the first delithiation-lithiation of LiCoO2 cathode were investigated by electrochemical impedance spectroscopy(EIS). The electronic and ionic transport properties of LiCoO2 cathode along with variation of electrode potential were obtained in 1 mol·L?1 LiPF6-EC:DMC:DEC electrolyte solution. It was found that after 9 h storage of the LiCoO2 cathode in electrolyte solu-tions,a new arc appears in the medium frequency range in Nyquist plots of EIS,which increases with increasing the storage time. In the charge/discharge processes,the diameter of the new arc is reversi-bly changed with electrode potential. Such variation coincides well with the electrode potential de-pendence of electronic conductivity of the LiCoO2. Thus this new EIS feature is attributed to the change of electronic conductivity of LixCoO2 during storage of the LiCoO2 cathode in electrolyte solutions,as well as in processes of intercalation-deintercalationtion of lithium ions. It has been revealed that the reversible increase and decrease of the resistance of SEI film in charge-discharge processes can be also ascribed to the variation of electronic conductance of active materials of the LiCoO2 cathode. | ZHUANG QuanChao XU JinMei FAN XiaoYong DONG QuanFeng JIANG YanXia HUANG Ling SUN ShiGang | 2007 | Chinese Science Bulletin2007，52，9： | 5 |
| 5 | Defect engineering of molybdenum disulfide through ion irradiation to boost hydrogen evolution reaction performance显示文摘The inert basal plane of molybdenum disulfide (MoS2) restrains its further hydrogen evolution reaction (HER) performance.This work attempts ion irradiation to activate inert basal plane of MoS2 nanosheet to improve its electrocatalytic performance.Experimental results demonstrate the sulphur vacancies generated by ion irradiation on the basal plane of MoS2 mainly boost the efficiency of HER performance.The moderate fluence of carbon ion irradiation gains the optimum HER performance with an onset potential of 77 mV and Tafel slope of 66 mV/dec. | Cheng Sun Peipei Wang Hao Wang Chuan Xu Juntong Zhu Yanxia Liang Ying Su Yining Jiang Wenqi Wu Engang Fu Guifu Zou | 2019 | Nano Research2019，12，7： | 3 |
| 6 | Safety,tolerability,and pharmacokinetics of BAT8001 in patients with HER2-positive breast cancer:An open-label,dose-escalation,phase I study显示文摘Background:The introductions of anti-human epidermal growth factor receptor-2(HER2)agents have significantly improved the treatment outcome of patients with HER2-positive breast cancer.BAT8001 is a novel antibodydrug conjugate targeting human epidermal growth factor receptor-2(HER2)-expressing cells composed of a trastuzumab biosimilar linked to the drug-linker Batansine.This dose-escalation,phase I study was designed to assess the safety,tolerability,pharmacokinetics,and preliminary anti-tumor activity of BAT8001 in patients with HER2-positive locally advanced or metastatic breast cancer.Methods:This trial was conducted in subjects with histologically confirmed HER2-positive breast cancer(having evaluable lesions and an Eastern Cooperative Oncology Group performance status of 0 or 1)using a 3+3 design of escalating BAT8001 doses.Patients received BAT8001 intravenously in a 21-day cycle,with dose escalation in 5 cohorts:1.2,2.4,3.6,4.8,and 6.0 mg/kg.The primary objective was to evaluate the safety and tolerability of BAT8001.Preliminary activity of BAT8001 was also assessed as a secondary objective.Results:Between March 2017 to May 2018,29 HER2-positive breast cancer patients were enrolled.The observed dose-limiting toxicities were grade 4 thrombocytopenia and grade 3 elevated transaminase.The maximum tolerated dose was determined to be 3.6 mg/kg.Grade 3 or greater adverse events(AEs)occurred in 14(48.3%)of 29 patients,including thrombocytopenia in 12(41.4%)patients,aspartate aminotransferase increased in 4(13.8%)patients,γ-glutamyl transferase increased in 2(6.9%)patients,alanine aminotransferase increased in 2(6.9%)patients,diarrhea in 2(6.9%)patients.Objective response was observed in 12(41.4%,95%confidence interval[CI]=23.5%-61.1%)and disease control(including patients achieving objective response and stable disease)was observed in 24(82.8%,95%CI=64.2%-94.2%)patients.Conclusions:BAT8001 demonstrated favorable safety profiles,with promising anti-tumor activity in patients with HER2-positive locally advanced or metastatic breast cancer.BAT8001 has the potential to provide a new therapeutic option in patients with metastatic HER2-positive breast cancer. | Ruoxi Hong Wen Xia Liye Wang Kaping Lee Qianyi Lu Kuikui Jiang Shengfeng Li Jinquan Yu Jin Wei Weijia Tang Danyang Zhou Xin An Jiajia Huang Cong Xue Xiwen Bi Yanxia Shi Zhongyu Yuan Fei Xu Shusen Wang | 2021 | Cancer Communications2021，41，2： | 2 |
| 7 | Integration of QTL detection and marker assisted selection for improving resistance to Fusarium head blight and important agronomic traits in wheat显示文摘Fusarium head blight(FHB), caused by Fusarium graminearum, is one of the most destructive wheat(Triticum aestivum L.) diseases worldwide. Identification of quantitative trait loci(QTL) conferring FHB resistance followed by marker assisted selection(MAS) is an efficient approach to breed FHB-resistant varieties. In this study, 38 additive QTL and 18 pairs of epistatic QTL for FHB resistance were detected in four environments using a population of recombinant inbred lines(RILs) derived from varieties Neixiang 188 and Yanzhan 1. Six QTL clusters were located on chromosomes 2D, 4B, 4D, 5A, 5D and 7B, suggesting possible polytrophic functions. Six elite lines with good FHB resistance and agronomic traits were selected from the same population using the associated markers. Our results suggest that MAS of multiple QTL will be effective and efficient in wheat breeding. | Chao Lv Yanxia Song Lifeng Gao Qin Yao Ronghua Zhou Rugen Xu Jizeng Jia | 2014 | The Crop Journal2014，2，1： | 2 |
| 8 | High-Resolution Mesoscale Analysis Data from the South China Heavy Rainfall Experiment (SCHeREX): Data Generation and Quality Evaluation显示文摘In this study, the observational data acquired in the South China Heavy Rainfall Experiment (SCHeREX) from May to July 2008 and 2009 were integrated and assimilated with the US National Oceanic and Atmospheric Administration's (NOAA) Local Analysis and Prediction System (LAPS; information available online at http://gffzzc2aa3fc9434744efhfcpnnw0f96oc6o9v.ffgz.tsg.suse.edu.cn). A high-resolution mesoscale analysis dataset was then generated at a spatial resolution of 5 km and a temporal resolution of 3 h in four observational areas: South China, Central China, Jianghuai area, and Yangtze River Delta area. The quality of this dataset was evaluated as follows. First, the dataset was qualitatively compared with radar reflectivity and TBB image for specific heavy rainfall events so as to examine its capability in reproduction of mesoscale systems. The results show that the SCHeREX analysis dataset has a strong capability in capturing severe mesoscale convective systems. Second, the mean deviation and root mean square error of the SCHeREX mesoscale analysis fields were analyzed and compared with radiosonde data. The results reveal that the errors of geopotential height, temperature, relative humidity, and wind of the SCHeREX analysis were within the acceptable range of observation errors. In particular, the average error was 45 m for geopotential height between 700 and 925 hPa, 1.0-1.1°C for temperature, less than 20% for relative humidity, 1.5-2.0 m s-1 for wind speed, and 20-25° for wind direction. The above results clearly indicate that the SCHeREX mesoscale analysis dataset is of high quality and sufficient reliability, and it is applicable to refined mesoscale weather studies. | NI Yunqi CUI Chunguang LI Hongli PENG Juxiang QIU Xuexing ZHANG Yanxia XU Xiaolin GAO Mei JIE Lianshu ZHANG Wenhua | 2011 | Acta meteorologica Sinica2011，25，4： | 2 |
| 9 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 10 | Sex-specific responses of tree-ring growth to climate in the dioecious tree Populus cathayana显示文摘Aims Radial growth in response to climate has been reported in many trees,but the sex-specific responses of tree-ring growth associated with altitude in dioecious trees are still poorly known.This study aims to examine whether(i)there are sex-related responses of tree-ring growth to climate in dioecious trees;(ii)these responses could be changed with altitude elevation.Methods The tree-ring width and basal area increment(BAI)were measured over the past 30 years(1982-2011),and the sexual differences in relationship between BAI and time span and correlations between ring width and climatic factors were investigated in Populus cathayana trees at two altitude sites(1,450 m and 1,750 m a.s.l.)in Xiaowutai Mountain,Hebei,north China.Important Findings The BAI was increased over the past 30 years.Trees at high-altitude sites had significantly lower mean ring width and mean BAI than those trees at low-altitude sites(P<0.001).In addition,sexual dif-ferences in tree-ring growth and its response to climate were more pronounced by altitude elevation.Male trees had a significantly larger mean ring width and mean BAI than did females at high-alti-tude sites,whereas no significant sexual differences in these traits were detected at low-altitude sites.Female trees were sensitive to previous October-November temperatures at high altitude but to current February and April precipitation at low altitude(P<0.05),whereas male trees were sensitive to current June temperature at high altitude but to January precipitation at low altitude(P<0.05).Our results indicated that the responses of tree-ring growth to cli-mate are sex dependent and can be changed with altitude elevation. | Kechao Huang Yongmei Liao Tingfa Dong Yanxia Yang Jundong He Huihui Huan Qibing Zhang Xiao Xu | 2018 | Journal of Plant Ecology2018，11，5： | 2 |
| 11 | Comparative Osteology and Phylogenetic Relationship of Edmontosaurus and Shantungosaurus (Dinosauria:Hadrosauridae) from the Upper Cretaceous of North America and East Asia显示文摘The close affinity between Edmontosaurus and Shantungosaurus is corroborated on the basis of the following shared features:an occipital condyle deflected strongly posteroventrally; a posterodorsally reflected, lip-shaped oral margin of the premaxilla, with a deep, oval concavity at the anteromedial corner of the bone; a well-demarcated posterodorsal margin of the deeply excavated circumnarial fossa formed by a prominent arched ridge along the entire posterior half of the lateroventral border of the nasal; an anteroposteriorly broad jugal process of the postorbital; a strongly concave dorsal surface of the paired frontals; seven teeth per alveolus in the middle of the dentary tooth row; and a circular distal blade of the pubis that is much more expanded ventrally than dorsally. A revised phylogenetic analysis of Hadrosauroidea recovers a sister taxon relationship between Edmontosaurus and Shantungosaurus. Kerberosaurus is recovered as the sister taxon to the clade formed exclusively by these two genera. The clade Edmontosaurini could be defined as the least inclusive clade containing Kerberosaurus and Edmontosaurus, which is currently composed of the genera Kerberosaurus, Edmontosaurus, and Shantungosaurus. Zhuchengosaurus and Huaxiaosaurus,both from the Upper Cretaceous Wangshi Group in Zhucheng, are interpreted as junior synonyms of Shantungosaurus. Kundurosaurus is likewise considered a junior synonym of Kerberosaurus. The strict consensus tree together with biogeographic information indicates that the clade Edmontosaurini originated in Asia and subsequently dispersed into North America. | XING Hai ZHAO Xijin WANG Kebai LI Dunjing CHEN Shuqing Jordan C.MALLON ZHANG Yanxia XU Xing | 2014 | Acta Geologica Sinica(English Edition)2014，88，6： | 2 |
| 12 | Oxaliplatin,Fluorouracil and Leucovorin (FOLFOX) as First-line Chemotherapy for Metastatic or Recurrent Colorectal Cancer Patients显示文摘OBJECTIVE To investigate the efficiency and safety of the oxaliplatin, fluorouracil(5-FU)and leucovorin regimen(FOLFOX)in previously untreated patients with metastatic or recurrent colorectal cancer. METHODS Previously untreated patients with metastatic or recurrent colorectal cancer received 100 mg/m2 of oxaliplatin intravenously(IV)over 2 h on day 1,and IV 400 mg/m2 of leucovorin over 2 h followed by a bolus of 400 mg/m2 of 5-FU.Then 2,600~3,000 mg/m2 of 5-FU was administered by continuous infusion over 46 h. RESULTS An evaluated response rate was determined for 97 of 105 treated patients.The overal response rate was 35.1%,9 patients(9.3%) had a complete response and 25 patients(25.8%)a partial response.Thirty-two patients(33.0%)developed stable disease and 32.0%of the patients progressed.The median time to progression(TTP)was 7.7 months and the median overal survival 20.5 months.One and 2-year survival rates were 68%and 32%.Toxic effects based on the National Cancer Institute-Common Toxicity Criteria(NCI-CTC),reaching grade 3/4 were:neutropenia 12.3%, anemia 11.3%,vomiting 4.1%and diarrhea 7.2%.Grade 3 neuropathy was 5.1%.The overall survival rate of patients who had received a radical resection was superior to the patients who had not received a operation,or had received a pal iative resection(P=0.0658).The serum levels of CEA,ALP and LDH had no relationship with survival(P>0.05). CONCLUSION The FOLFOX regimen containing oxaliplatin,5-FU plus leucovorin was an efficacious regimen with good tolerability in previously untreated metastatic or recurrent colorectal cancer patients. | Bing Han Ruihua Xu Yanxia Shi Huiyan Luo Xiaojuan Xiang Yuhong Li Li Zhang Tongyu Lin Youjian He | 2007 | Chinese Journal of Clinical Oncology2007，4，6： | 2 |
| 13 | Preparation of highly dispersed Pt-SnO x nanoparticles supported on multi-walled carbon nanotubes for methanol oxidation显示文摘 | Chuangang Hu Yanxia Cao Lin Yang Zhengyu Bai Yuming Guo Kui Wang Pengle Xu Jianguo zhou | 2011 | Applied Surface Science2011，，18： | 1 |
| 14 | Tryptase promotes human monocyte-derived macrophage foam cell formation by suppressing LXRα activation显示文摘 | Pohsheng Yeong Yanxia Ning Yali Xu Xiaobo Li Lianhua Yin | 2010 | BBA - Molecular and Cell Biology of Lipids2010，，： | 1 |
| 15 | Effects of metal ions on crystal morphology and size of calcium sulfate whiskers in aqueous HCl solutions 显示文摘 | Mao Xiulong Song Xingfu Lu Guimin Sun Yuzhu Xu Yanxia Yu Jianguo | 2014 | Industrial & Engineering Chemistry Research2014，53，17： | 1 |
| 16 | Preparation of calcium carbonate and hydrogen chloride from distiller waste based on reactive extraction-crystallization process 显示文摘 | Li Yunzhao Song Xingfu Chen Guilan Sun Ze Xu Yanxia Yu Jianguo | 2015 | Chemical Engineering Journal2015，278，： | 1 |
| 17 | HZSM-5 Sup- ported Silica-Zirconia and Its Application in One-Step Synthesis of Methyl Isobutyl Ketone 显示文摘 | Liu Yanxia Sun Kunpeng Xu Xianlun | 2010 | Ca tal Commun2010，11，5： | 1 |
| 18 | Discrimination of the seeds of Notopterygium incisum and Notopterygium franchetii by validated HPLC-DAD–ESI-MS method and principal component analysis显示文摘 | Kaijie Xu Shunyuan Jiang Yan Zhou Yanxia Zhang Bing Xia Xuemin Xu Yi Zhou Yufei Li Mingkui Wang Lisheng Ding | 2011 | Journal of Pharmaceutical and Biomedical Analysis2011，，5： | 1 |
| 19 | Dye-templating nonsurfactant synthesis of mesoporous silica显示文摘 | Xu Yao Cui Yanxia Yang Dongjiang | 2008 | Microporous and Mesoporous Materials2008，109，： | 1 |
| 20 | Tanshinone IIA-Induced Attenuation of Lung Injury in Endotoxemic Mice Is Associated with Reduction of Hypoxia-Inducible Factor 1[alpha] Expression显示文摘 | Xu Min Cao Fale Liu Lili Zhang Bo Wang Yanxia Dong Haiying Cui Yan Dong Mingqing Xu Dunquan Liu Yi Zhao Pengtao Niu Wen Li Zhichao | 2011 | American Journal of Respiratory Cell and Molecular Biology2011，，5： | 1 |
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