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| 1 | Role of ROS/Kv/HIF Axis in the Development of Hypoxia-Induced Pulmonary Hypertension显示文摘Hypoxic pulmonary hypertension (HPH) is a common complication in patients with chronic obstructive pulmonary disease (COPD), sleep-disordered breathing, or dwellers in high altitude. The exact mechanisms underlying the development of HPH still remain unclear. Reactive oxygen species (ROS),hypoxia inducible factors (HIF), and potassium channels (KV) are believed as the main factors during the development of HPH. We propose that the “ROS/Kv/HIF axis” may play an important initiating role in the development of HPH. Being formed under a hypoxic condition, ROS affects the expression and function of HIFs or KV, and consequently triggers multiple downstream signaling pathways and genes expression that participate in promoting pulmonary vasoconstriction and arterial remodeling. Thus, further study determining the initiating role of “ROS/Kv/HIF axis” in the development of HPH could provide theoretic evidences to better understand the underlying mechanisms of HPH, and help identify new potential targets in the treatment of HPH. | Wen Wu Yan Li Dunquan Xu | 2017 | Chinese Medical Sciences Journal2017，32，4： | 5 |
| 2 | Tanshinone IIA-Induced Attenuation of Lung Injury in Endotoxemic Mice Is Associated with Reduction of Hypoxia-Inducible Factor 1[alpha] Expression显示文摘 | Xu Min Cao Fale Liu Lili Zhang Bo Wang Yanxia Dong Haiying Cui Yan Dong Mingqing Xu Dunquan Liu Yi Zhao Pengtao Niu Wen Li Zhichao | 2011 | American Journal of Respiratory Cell and Molecular Biology2011，，5： | 1 |
| 3 | 结核分枝杆菌PknI激酶通过胞外传感器结构域二聚化被激活的结构研究显示文摘文章简介蛋白激酶对于宿主内结核分枝杆菌的存活起中心作用。课题组解析了丝氨酸/苏氨酸蛋白激酶(STPKs)家族里的跨膜蛋白成员Pkn I的传感器域(单体和二聚体形式)以及激酶域的高分辨率晶体结构。 | Qiaoling Yan Dunquan Jiang Lanfang Qian Qingqing Zhang Wei Zhang Weihong Zhou Kaixia Mi Luke Guddat Haitao Yang 饶子和 | 2018 | 科学新闻2018，0，4： | 0 |
| 4 | Multiple rapid-responsive probes for hypochlorite detection based on dioxetane luminophore derivatives显示文摘In recent years,various methods for detecting exogenous and endogenous hypochlorite have been studied,considering its essential role as a biomolecule.However,the existing technologies still pose obstacles such as their invasiveness,high costs,and complicated operation.In the current study,we developed a glow-type chemiluminescent probe,hypochlorite chemiluminescence probe(HCCL)-1,based on the scaffold of Schaap's 1,2-dioxetane luminophores.To better explore the physiological and pathological functions of hypochlorite,we modified the luminophore scaffold of HCCL-1 to develop several probes,including HCCL-2,HCCL-3,and HCCL-4,which amplify the response signal of hypochlorite.By comparing the luminescent intensities of the four probes using the IVIS®system,we determined that HCCL-2 with a limit of detection of 0.166 mM has enhanced sensitivity and selectivity for tracking hypochlorite both in vitro and in vivo. | Yingai Sun Yuqi Gao Chunchao Tang Gaopan Dong Pei Zhao Dunquan Peng Tiantian Wang Lupei Du Minyong Li | 2022 | Journal of Pharmaceutical Analysis2022，12，3： | 0 |
| 5 | Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target显示文摘 | Qingqing Zhang Huijuan Liu Xiang Liu Dunquan Jiang Bingjie Zhang Hongliang Tian Cheng Yang Luke W. Guddat Haitao Yang Kaixia Mi Zihe Rao | 2018 | Protein & Cell2018，9，11： | 0 |
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