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| 1 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 2 | Hepatic encephalopathy complicated with hyponatremia and acid-base disturbance and its prognosis显示文摘Objective:To improve the diagnosis and therapeutic effect of occurrence and development of hyponatremia and disorder of acid-base balance among patients with hepatic encephalopathy(HE) by elucidating the regularity and mechanism,as well as its influence on prognosis.Methods:327 HE patients admitted to our hospital from January 1990 to June 2010 were enrolled.Meanwhile 316 patients hospitalized in the medical department of the same hospital were chosen as the control group.Patients in both groups were given the same methods to measure arterial blood gas parameters(pH value,PaCO2,[HCO3-],TCO2,BE and SaO2),blood biochemistry([Na+],[K+],[Cl-]),liver function,kidney function and blood glucose,serum sodium,and thereupon tocalculate the anion gap(AG) and the potential [HCO3-],and acid-base balance disorder.Results:Among the 327 HE patients,hyponatremia was found in 188 cases(57.4%),of whom 132 patients died(70.2%).While among the 316 patients in control group,68 presented with hyponatremia(21.5%),and 19 died(27.9%).The incidence and mortality were significantly different between the two groups(P<0.001).All the 327 patients presented with different degrees of acid-base balance disorder and 178 died(54.4%),in whom 164(50.2%) belonged to simple acid-base balance disorder and 74(45.1%) died,136(41.6%) were dual acid-base balance disorder and 80(58.8%) died,27(8.2%) were triple acid-base disturbance and 24(88.9%) died.Whereas in the control group only 83 patients(26.2%) were recognized as simple and dual acid-base balance disorder,and 18(21.7%) died.There was higher incidence of acid-base balance disorder and mortality rate in HE group than control one(P<0.001).Conclusion:Hyponatremia is valuable to judge HE patients' prognosis.The key parameters in the judgment and evaluation on acid-base balance disorder among HE patients are the change of pH values and serum electrolyte values.When pH value ≤ 7.30 or > 7.55,it generally suggests a poor prognosis. | Ren Chengshan Wang Lei Zhao Xiaoyan Yang Shiming Zhang Yanqi Wang Xiwen Bo Jianying Zhang Pengbin Guo Hong Ling Xianlong Li Yihui Da Siping Xie Xia Ren Wei Li Chunhua Qian Guisheng | 2012 | Journal of Medical Colleges of PLA(China)2012，27，3： | 3 |
| 3 | Development of low-coherence high-power laser drivers for inertial confinement fusion显示文摘The use of low-coherence light is expected to be one of the effective ways to suppress or even eliminate the laser–plasma instabilities that arise in attempts to achieve inertial confinement fusion.In this paper,a review of low-coherence high-power laser drivers and related key techniques is first presented.Work at typical low-coherence laser facilities,including Gekko XII,PHEBUS,Pharos III,and Kanal-2 is described.The many key techniques that are used in the research and development of low-coherence laser drivers are described and analyzed,including low-coherence source generation,amplification,harmonic conversion,and beam smoothing of low-coherence light.Then,recent progress achieved by our group in research on a broadband low-coherence laser driver is presented.During the development of our low-coherence high-power laser facility,we have proposed and implemented many key techniques for working with low-coherence light,including source generation,efficient amplification and propagation,harmonic conversion,beam smoothing,and precise beam control.Based on a series of technological breakthroughs,a kilojoule low-coherence laser driver named Kunwu with a coherence time of only 300 fs has been built,and the first round of physical experiments has been completed.This high-power laser facility provides not only a demonstration and verification platform for key techniques and system integration of a low-coherence laser driver,but also a new type of experimental platform for research into,for example,high-energy-density physics and,in particular,laser–plasma interactions. | Yanqi Gao Yong Cui Lailin Ji Daxing Rao Xiaohui Zhao Fujian Li Dong Liu Wei Feng Lan Xia Jiani Liu Haitao Shi Pengyuan Du Jia Liu Xiaoli Li Tao Wang Tianxiong Zhang Chong Shan Yilin Hua Weixin Ma Xun Sun Xianfeng Chen Xiuguang Huang Jian Zhu Wenbing Pei Zhan Sui Sizu Fu | 2020 | Matter and Radiation at Extremes2020，5，6： | 1 |
| 4 | A novel blind dig- ital watermarking algorithm based on quantization for jiagu- wen rubbing image in contourlet domain 显示文摘 | Ma Xiaohu Wei Jingjing Tao Yanqi | 2010 | Audio language and processing2010，23，25： | 1 |
| 5 | Unexpected divergence in magnetoreceptor MagR from robin and pigeon linked to two sequence variations显示文摘Birds exhibit extraordinary mobility and remarkable navigational skills,obtaining guidance cues from the Earth’s magnetic field for orientation and long-distance movement.Bird species also show tremendous diversity in navigation strategies,with considerable differences even within the same taxa and among individuals from the same population.The highly conserved iron and iron-sulfur cluster binding magnetoreceptor(MagR)protein is suggested to enable animals,including birds,to detect the geomagnetic field and navigate accordingly.Notably,MagR is also implicated in other functions,such as electron transfer and biogenesis of iron-sulfur clusters,raising the question of whether variability exists in its biochemical and biophysical features among species,particularly birds.In the current study,we conducted a comparative analysis of MagR from two different bird species,including the migratory European robin(Erithacus rubecula)and the homing pigeon(Columba livia).Sequence alignment revealed an extremely high degree of similarity between the MagRs of these species,with only three sequence variations.Nevertheless,two of these variations underpinned significant differences in metal binding capacity,oligomeric state,and magnetic properties.These findings offer compelling evidence for the marked differences in MagR between the two avian species,potentially explaining how a highly conserved protein can mediate such diverse functions. | Shun Wang Peng Zhang Fan Fei Tianyang Tong Xiujuan Zhou Yajie Zhou Jing Zhang Mengke Wei Yanqi Zhang Lei Zhang Yulong Huang Lin Zhang Xin Zhang Tiantian Cai Can Xie | 2024 | Zoological Research2024，45，1： | 0 |
| 6 | Assessment of Agricultural Drought Vulnerability Based on Crop Growth Stages:A Case Study of Huaibei Plain,China显示文摘Climate change can lead to and intensify drought disasters.Quantifying the vulnerability of disaster-affected elements is significant for understanding the mechanisms that transform drought intensity into eventual loss.This study proposed a growth-stage-based drought vulnerability index(GDVI)of soybean using meteorological,groundwater,land use,and field experiment data and crop growth model simulation.The CROPGRO-Soybean model was used to simulate crop growth and water deficit.Four growth stages were considered since the sensitivity of soybean to drought is strictly related to the growth stage.The GDVI was applied to the Huaibei Plain,Anhui Province,China,with the goal of quantifying the spatiotemporal characteristics of soybean drought vulnerability in typical years and growth stages.The results show that:(1)The sensitivity of leaf-related parameters exceeded that of other parameters during the vegetative growth stage,whereas the top weight and grain yield showed a higher sensitivity in the reproductive growth stage;(2)A semi-logarithmic law can describe the relationship between the drought sensitivity indicators and the GDVI during the four growth stages.The pod-filling phase is the most vulnerable stage for water deficit and with the highest loss upper limit(over 70%);(3)The 2001 and 2002 seasons were the driest time during 1997-2006.Fuyang and Huainan Cities were more vulnerable to drought than other regions on the Huaibei Plain in 2001,while Huaibei and Suzhou Cities were the most susceptible areas in 2002.The results could provide effective decision support for the categorization of areas vulnerable to droughts. | Yanqi Wei Juliang Jin Haichao Li Yuliang Zhou Yi Cui Nii Amarquaye Commey Yuliang Zhang Shangming Jiang | 2023 | International Journal of Disaster Risk Science2023，14，2： | 0 |
| 7 | Coordination of EZH2 and SOX2 specifies human neural fate decision显示文摘Polycomb repressive complexes(PRCs)are essential in mouse gastrulation and specify neural ectoderm in human embryonic stem cells(hESCs),but the underlying molecular basis remains unclear.Here in this study,by employing an array of different approaches,such as gene knock-out,RNA-seq,ChIP-seq,et al.,we uncover that EZH2,an important PRC factor,specifies the normal neural fate decision through repressing the competing meso/endoderm program.EZH2^(−/−)hESCs show an aberrant re-activation of meso/endoderm genes during neural induction.At the molecular level,EZH2 represses meso/endoderm genes while SOX2 activates the neural genes to coordinately specify the normal neural fate.Moreover,EZH2 also supports the proliferation of human neural progenitor cells(NPCs)through repressing the aberrant expression of meso/endoderm program during culture.Together,our findings uncover the coordination of epigenetic regulators such as EZH2 and lineage factors like SOX2 in normal neural fate decision. | Yuan Zhao Tianyu Wang Yanqi Zhang Liang Shi Cong Zhang Jingyuan Zhang Jiao Yao Qianyu Chen Xiaofen Zhong Yanxing Wei Yongli Shan Guangjin Pan | 2021 | Cell Regeneration2021，10，1： | 0 |
| 8 | Genome-wide methylation profiling reveals differentially methylated genes in blood DNA of small-cell lung cancer patients显示文摘Dear Editor,Small-cell lung cancer(SCLC),one of the most-deadly malignant tumors,accounts for∼15%of all lung cancers.1,2 Although highly responsive to the standard chemoradiotherapy,the recurrence rate of SCLC is nearly unity,with median survival time ranging from 2–6 months.Almost all SCLC patients are inoperable,leading to the difficulty in obtaining adequate biopsy tissue for research.3 Consequently,there is an urgent need to find noninvasive biomarkers to predict the risk and provide early diagnosis of SCLC.We aimed to identify potential epigenomic markers for SCLC development in blood DNA and reveal differentially methylated genes through a multi-omics approach,from genome-wide DNA methylation profiling,followed by pathway enrichment analyses and target gene validation utilizing Gene Expression Omnibus(GEO)and Oncomine microarray databases,to TCGA PanCancer cohorts.It is known that virtually all patients with SCLC are victims of tobacco smoking,4 but it is unknown whether stopping smoking before SCLC diagnosis would influence the epigenetic biomarkers under investigation.We here report a study that identified aberrantly methylated genes between current and former smokers among SCLC patients,revealing a set of candidate biomarkers in peripheral blood DNA for better stratifying patients with high risk. | Yanqi He Calvin Wei Zhifu Sun Julie M.Cunningham Liang Wang Zong Wei Ping Yang | 2022 | Precision Clinical Medicine2022，5，3： | 0 |
| 9 | Tianwen-1 Mars entry vehicle trajectory and atmosphere reconstruction preliminary analysis显示文摘The Tianwen-1 Mars entry vehicle successfully landed on the surface of Mars in southern Utopia Planitia on May 15,2021,at 7:18(UTC+8).To acquire valuable Martian flight data,a scientific instrumentation package consisting of a flush air data system and a multilayer temperature-sensing system was installed aboard the entry vehicle.A combined approach was applied in the entry,descent,and landing trajectory reconstruction using all available data obtained by the inertial measurement unit and the flush air data system.An aerodynamic database covering the entire flight regime was generated using computational fluid dynamics methods to assist in the reconstruction process.A preliminary analysis of the trajectory reconstruction result,along with the atmosphere reconstruction and aerodynamic performance,was conducted.The results show that the trajectory agrees closely with the nominal trajectory and the wind-relative attitude.Suspected wind occurred at the end of the trajectory. | Haogong Wei Wei Rao Guangqiang Chen Guidong Wang Xin Zou Qi Li Yanqi Hu | 2022 | Astrodynamics2022，6，1： | 0 |
| 10 | Backward scattering of laser plasma interactions from hundreds-of-joules broadband laser on thick target显示文摘The use of broadband laser technology is a novel approach for inhibiting processes related to laser plasma interactions(LPIs).In this study,several preliminary experiments into broadband-laser-driven LPIs are carried out using a newly established hundreds-of-joules broadband second-harmonic-generation laser facility.Through direct comparison with LPI results for a traditional narrowband laser,the actual LPI-suppression effect of the broadband laser is shown.The broadband laser had a clear suppressive effect on both back-stimulated Raman scattering and back-stimulated Brillouin scattering at laser intensities below 1×10^(15) W cm^(−2).An abnormal hot-electron phenomenon is also investigated,using targets of different thicknesses. | Peipei Wang Honghai An Zhiheng Fang Jun Xiong Zhiyong Xie Chen Wang Zhiyu He Guo Jia Ruirong Wang Shu Zheng Lan Xia Wei Feng Haitao Shi Wei Wang Jinren Sun Yanqi Gao Sizu Fu | 2024 | Matter and Radiation at Extremes2024，9，1： | 0 |
| 11 | Mechanism Analysis of Additional Damping Control Strategies for the High-frequency Resonance of MMC Connected to AC Grid显示文摘High-frequency resonance can occur when a modular multilevel converter(MMC)is inserted into an AC grid.Additional damping control is a relatively low-cost resonance suppression strategy compared to passive damping strategies.This paper analyzes the influences of a feed-forward voltage filter and feedback current filter for the inner controller for the high-frequency impedance characteristics of the MMC based on a model.Moreover,the mechanism,influencing factors,and limitations of the existing strategy including an additional lowpass filter in the voltage feed-forward stage are investigated.Secondly,a resonance suppression strategy for the inclusion of additional cascaded notch filters in the voltage feed-forward stage is proposed,and its parameter design method and applicable scenarios are analyzed.In addition,this paper analyzes the effects of the inclusion of an additional control in other stages for the inner controller of the MMC.Finally,the correctness of the theoretical analysis and the proposed strategy is verified based on the simulation of an actual project on PSCAD/EMTDC. | Yanqi Hou Chongru Liu Yu Wang Wei Kong | 2023 | CSEE Journal of Power and Energy Systems2023，9，3： | 0 |
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