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| 1 | High power all-fiberized and narrow-bandwidth MOPA system by tandem pumping strategy for thermally induced mode instability suppression显示文摘An all-fiberized and narrow-bandwidth master oscillator power amplification(MOPA) system with record output power of 4 kW level and slope efficiency of 78% is demonstrated. Tandem pumping strategy is tentatively introduced into the narrow-bandwidth MOPA system for thermally induced mode instability(TMI) suppression. The stimulated Brillouin scattering(SBS) effect is balanced by simply using one-stage phase modulation technique. With different phase modulation signals, SBS limited output powers of 336 W, 1.2 kW and 3.94 kW are respectively achieved with spectral bandwidths accounting for 90% power of ~0.025, 0.17 and ~0.89 nm. Compared with our previous 976 nm pumping system, TMI threshold is overall boosted to be >5 times in which tandem pumping increases the TMI threshold of >3times. The beam quality(M~2 factor) of the output laser is well within 1.5 below the TMI threshold while it is ultimately saturated to be 1.86 with the influence of TMI at maximal output power. Except for SBS and TMI, stimulated Raman scattering(SRS) effect will be another challenge for further power scaling. In such a high power MOPA system, multidetrimental effects(SBS, SRS and TMI) will coexist and may be mutual-coupled, which could provide a well platform for further comprehensively investigating and optimizing the high power, narrow-bandwidth fiber amplifiers. | Pengfei Ma Hu Xiao Daren Meng Wei Liu Rumao Tao Jinyong Leng Yanxing Ma Rongtao Su Pu Zhou Zejin Liu | 2018 | High Power Laser Science and Engineering2018，6，4： | 9 |
| 2 | A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases显示文摘The development of broad-spectrum antivirals against human coronaviruses(HCoVs)is critical to combat the current coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants,as well as future outbreaks of emerging CoVs.We have previously identified a polyethylene glycol-conjugated(PEGylated)lipopeptide,EK1C4,with potent pan-CoV fusion inhibitory activity.However,PEG linkers in peptide or protein drugs may reduce stability or induce anti-PEG antibodies in vivo.Therefore,we herein report the design and synthesis of a series of dePEGylated lipopeptide-based pan-CoV fusion inhibitors featuring the replacement of the PEG linker with amino acids in the heptad repeat 2 C-terminal fragment(HR2-CF)of HCoV-OC43.Among these lipopeptides,EKL1C showed the most potent inhibitory activity against infection by SARS-CoV-2 and its spike(S)mutants,as well as other HCoVs and some bat SARS-related coronaviruses(SARSr-CoVs)tested.The dePEGylated lipopeptide EKL1C exhibited significantly stronger resistance to proteolytic enzymes,better metabolic stability in mouse serum,higher thermostability than the PEGylated lipopeptide EK1C4,suggesting that EKL1C could be further developed as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. | Jie Zhou Wei Xu Zezhong Liu Chao Wang Shuai Xia Qiaoshuai Lan Yanxing Cai Shan Su Jing Pu Lixiao Xing Youhua Xie Lu Lu Shibo Jiang Qian Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 5 |
| 3 | Griffithsin with A Broad-Spectrum Antiviral Activity by Binding Glycans in Viral Glycoprotein Exhibits Strong Synergistic Effect in Combination with A Pan-Coronavirus Fusion Inhibitor Targeting SARS-CoV-2 Spike S2 Subunit显示文摘Dear Editor,The pandemic of coronavirus disease 2019(COVID-19)caused by SARS-Co V-2 has posed a significant threat to global public health and economy,thus calling for the rapid development of effective therapeutics and prophylactics.Repurposing existing medicines with clinical safety profiles offers a more rapid hope of combating COVID-19pandemic than developing a new therapeutic. | Yanxing Cai Wei Xu Chenjian Gu Xia Cai Di Qu Lu Lu Youhua Xie Shibo Jiang | 2020 | Virologica Sinica2020，35，6： | 4 |
| 4 | Review on key technologies and typical applications of multi-station integrated energy systems显示文摘To realize the low-carbon development of power systems,digital transformation,and power marketization reform,the substation,data center,energy storage,photovoltaic,and charging stations are important components for the construction of new infrastructure.The integration infrastructure represented by multi-station integrated energy systems(MSIESs)represents the development trend,and its connotation and denotation are not immutable.This study firstly analyzed the components of MSIESs and their sub-stations and overall characteristics,and proposed an overall architecture for MSIESs.Thereafter,this system was characterized in detail from three aspects:planning and design,operation control,and market operation.The planning and construction of MSIESs was analyzed from the aspects of planning and design process,typical fusion subsystems,supply and demand prediction,and capacity determination;the operational control of MSIESs was analyzed from the aspects of model construction,coordination control,and safety assessment.Moreover,the market operation of MSIESs was examined from the aspects of the business model and spot market.Furthermore,the technical development trend of MSIESs has been explored in this study. | Zhenlan Dou Chunyan Zhang Wei Wang Dan Wang Qiqi Zhang Yanxing Cai Ruitian Fan | 2022 | Global Energy Interconnection2022，5，3： | 2 |
| 5 | Early changes to the extracellular space in the hippocampus under simulated microgravity conditions显示文摘The smooth transportation of substances through the brain extracellular space(ECS)is crucial to maintaining brain function;however,the way this occurs under simulated microgravity remains unclear.In this study,tracer-based magnetic resonance imaging(MRI)and DECS-mapping techniques were used to image the drainage of brain interstitial fluid(ISF)from the ECS of the hippocampus in a tail-suspended hindlimb-unloading rat model at day 3(HU-3)and 7(HU-7).The results indicated that drainage of the ISF was accelerated in the HU-3 group but slowed markedly in the HU-7 group.The tortuosity of the ECS decreased in the HU-3 group but increased in the HU-7 group,while the volume fraction of the ECS increased in both groups.The diffusion rate within the ECS increased in the HU-3 group and decreased in the HU-7 group.The alterations to ISF drainage and diffusion in the ECS were recoverable in the HU-3 group,but neither parameter was restored in the HU-7 group.Our findings suggest that early changes to the hippocampal ECS and ISF drainage under simulated microgravity can be detected by tracer-based MRI,providing a new perspective for studying microgravity-induced nano-scale structure abnormities and developing neuroprotective approaches involving the brain ECS. | Yajuan Gao Hongbin Han Jichen Du Qingyuan He Yanxing Jia Junhao Yan Hui Dai Bin Cui Jing Yang Xunbin Wei Liu Yang Rui Wang Ren Long Qiushi Ren Xing Yang Jiabin Lu | 2022 | Science China(Life Sciences)2022，65，3： | 2 |
| 6 | AIM2 Facilitates the Apoptotic DNA-induced Systemic Lupus Erythematosus via Arbitrating Maerophage Functional Maturation 显示文摘 | Weijuan Zhang Yanxing Cai Wei Xu | 2013 | J Clin Immuno12013，33，： | 1 |
| 7 | C-reactive protein functions as a negative regulator of macrophage activation induced by apoptotic DNA显示文摘C-reactive protein(CRP),an acute-phase protein with an ability to bind to nuclear antigen,has been reported to regulate cytokine secretion and modulate immune responses.We previously reported that activated syngeneic lymphocyte-derived apoptotic DNA(apopDNA)could induce macrophage activation and contribute to the initiation and progression of lupus nephritis.It is reasonable to hypothesize that CRP might regulate apopDNA-induced macrophage activation.Herein,CRP was shown to promote macrophage-mediated apopDNA uptake by binding to apopDNA(CRP/apopDNA complex).Notably,CRP/apopDNA treatment inhibited the production of inflammatory cytokines and chemokines by macrophages which could be induced by apopDNA alone.Further coculture and transwell studies revealed that CRP/apopDNA-induced macrophages prohibited apopDNA-induced macrophage activation in an IL-10 dependent manner.These results provide insight into the potential mechanism of CRP regulatory activity in macrophage activation induced by apopDNA in the context of lupus nephritis and other autoimmune diseases. | Weijuan Zhang Yanxing Cai Wei Xu Sidong Xiong | 2011 | Protein & Cell2011，2，8： | 0 |
| 8 | Data Matching of Solar Images Super-Resolution Based on Deep Learning显示文摘The images captured by different observation station have different resolutions.The Helioseismic and Magnetic Imager(HMI:a part of the NASA Solar Dynamics Observatory SDO)has low-precision but wide coverage.And the Goode Solar Telescope(GST,formerly known as the New Solar Telescope)at Big Bear Solar Observatory(BBSO)solar images has high precision but small coverage.The super-resolution can make the captured images become clearer,so it is wildly used in solar image processing.The traditional super-resolution methods,such as interpolation,often use single image’s feature to improve the image’s quality.The methods based on deep learning-based super-resolution image reconstruction algorithms have better quality,but small-scale features often become ambiguous.To solve this problem,a transitional amplification network structure is proposed.The network can use the two types images relationship to make the images clear.By adding a transition image with almost no difference between the source image and the target image,the transitional amplification training procedure includes three parts:transition image acquisition,transition network training with source images and transition images,and amplification network training with transition images and target images.In addition,the traditional evaluation indicators based on structural similarity(SSIM)and peak signal-to-noise ratio(PSNR)calculate the difference in pixel values and perform poorly in cross-type image reconstruction.The method based on feature matching can effectively evaluate the similarity and clarity of features.The experimental results show that the quality index of the reconstructed image is consistent with the visual effect. | Liu Xiangchun Chen Zhan Song Wei Li Fenglei Yang Yanxing | 2021 | Computers, Materials & Continua2021，，9： | 0 |
| 9 | Coordination of EZH2 and SOX2 specifies human neural fate decision显示文摘Polycomb repressive complexes(PRCs)are essential in mouse gastrulation and specify neural ectoderm in human embryonic stem cells(hESCs),but the underlying molecular basis remains unclear.Here in this study,by employing an array of different approaches,such as gene knock-out,RNA-seq,ChIP-seq,et al.,we uncover that EZH2,an important PRC factor,specifies the normal neural fate decision through repressing the competing meso/endoderm program.EZH2^(−/−)hESCs show an aberrant re-activation of meso/endoderm genes during neural induction.At the molecular level,EZH2 represses meso/endoderm genes while SOX2 activates the neural genes to coordinately specify the normal neural fate.Moreover,EZH2 also supports the proliferation of human neural progenitor cells(NPCs)through repressing the aberrant expression of meso/endoderm program during culture.Together,our findings uncover the coordination of epigenetic regulators such as EZH2 and lineage factors like SOX2 in normal neural fate decision. | Yuan Zhao Tianyu Wang Yanqi Zhang Liang Shi Cong Zhang Jingyuan Zhang Jiao Yao Qianyu Chen Xiaofen Zhong Yanxing Wei Yongli Shan Guangjin Pan | 2021 | Cell Regeneration2021，10，1： | 0 |
| 10 | Unsupervised Graph-Based Tibetan Multi-Document Summarization显示文摘Text summarization creates subset that represents the most important or relevant information in the original content,which effectively reduce information redundancy.Recently neural network method has achieved good results in the task of text summarization both in Chinese and English,but the research of text summarization in low-resource languages is still in the exploratory stage,especially in Tibetan.What’s more,there is no large-scale annotated corpus for text summarization.The lack of dataset severely limits the development of low-resource text summarization.In this case,unsupervised learning approaches are more appealing in low-resource languages as they do not require labeled data.In this paper,we propose an unsupervised graph-based Tibetan multi-document summarization method,which divides a large number of Tibetan news documents into topics and extracts the summarization of each topic.Summarization obtained by using traditional graph-based methods have high redundancy and the division of documents topics are not detailed enough.In terms of topic division,we adopt two level clustering methods converting original document into document-level and sentence-level graph,next we take both linguistic and deep representation into account and integrate external corpus into graph to obtain the sentence semantic clustering.Improve the shortcomings of the traditional K-Means clustering method and perform more detailed clustering of documents.Then model sentence clusters into graphs,finally remeasure sentence nodes based on the topic semantic information and the impact of topic features on sentences,higher topic relevance summary is extracted.In order to promote the development of Tibetan text summarization,and to meet the needs of relevant researchers for high-quality Tibetan text summarization datasets,this paper manually constructs a Tibetan summarization dataset and carries out relevant experiments.The experiment results show that our method can effectively improve the quality of summarization and our method is competitive to previous unsupervised methods. | Xiaodong Yan Yiqin Wang Wei Song Xiaobing Zhao A.Run Yang Yanxing | 2022 | Computers, Materials & Continua2022，，10： | 0 |
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