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21篇 您的检索式:作者名="Xiuli Zeng"
    题名 作者 年代 出处 被引量
1Adaptive Walking of a Quadrupedal Robot Based on Layered Biological Reflexes显示文摘A multiple-legged robot is traditionally controlled by using its dynamic model.But the dynamic-model-based approach fails to acquire satisfactory performances when the robot faces rough terrains and unknown environments.Referring animals' neural control mechanisms,a control model is built for a quadruped robot walking adaptively.The basic rhythmic motion of the robot is controlled by a well-designed rhythmic motion controller(RMC) comprising a central pattern generator(CPG) for hip joints and a rhythmic coupler(RC) for knee joints.CPG and RC have relationships of motion-mapping and rhythmic couple.Multiple sensory-motor models,abstracted from the neural reflexes of a cat,are employed.These reflex models are organized and thus interact with the CPG in three layers,to meet different requirements of complexity and response time to the tasks.On the basis of the RMC and layered biological reflexes,a quadruped robot is constructed,which can clear obstacles and walk uphill and downhill autonomously,and make a turn voluntarily in uncertain environments,interacting with the environment in a way similar to that of an animal.The paper provides a biologically inspired architecture,with which a robot can walk adaptively in uncertain environments in a simple and effective way,and achieve better performances.ZHANG Xiuli E Mingcheng ZENG Xiangyu ZHENG Haojun 2012Chinese Journal of Mechanical Engineering2012,25,4:10
2Monitor and control of neuronal activities with femtosecond pulse laser显示文摘Combined with the fluorescence labeling technique, two-photon microscopy excited with femtosecond pulse laser has become an important tool for neuroscience research. In this research, the calcium signals from neurons in rat cortex slice were monitored by a custom-built two-photon microscopy, and the spontaneous calcium signals and the pharmacological responses as well as the responses to femtosecond pulse laser stimulation were recorded. The results showed that the amplitude of the cal-cium signals increased in direct proportion to the corresponding electrical activities. Glutamate induced a calcium transient, but continuous application resulted in smaller response. Simultaneous monitoring of neuronal populations distinguished the neurons of different microcircuits. The femtosecond pulse laser induced local or global calcium signals in the pyramidal neurons. The approach of interrogation and control of neural activities using femtosecond pulse laser is non-contact, nondestructive, repeatable, and without any additional substrates, which will contribute to the development of neuroscience.ZHOU Wei LIU XiuLi LU XiaoHua LI JiaSong LUO QingMing ZENG ShaoQun 2008Chinese Science Bulletin2008,53,5:5
3The Mesenchymal Stem Cells Derived from Transgenic Mice Carrying Human Coagulation Factor Ⅷ Can Correct Phenotype in Hemophilia A Mice显示文摘Hemophilia A(HA)is an inherited X-linked recessive bleeding disorder caused by coagulant factor Ⅷ(FⅧ)deficiency.Previous studies showed that introduction of mesenchymal stem cells(MSCs)modified by FⅧ-expressing retrovirus may result in phenotypic correction of HA animals.This study aimed at the investigation of an alternative gene therapy strategy that may lead to sustained FⅧ transgene expression in HA mice.B-domain-deleted human FⅧ(hFⅧBD)vector was microinjected into single-cell embryos of wild-type mice to generate a transgenic mouse line,from which hFⅧBD-MSCs were isolated,followed by transplantation into HA mice.RT-PCR and real-time PCR analysis demonstrated the expression of hFⅧBD in multi-organs of recipient HA mice.Immunohistochemistry showed the presence of hFⅧBD positive staining in multi-organs of recipient HA mice.ELISA indicated that plasma hFⅧBD level in recipient mice reached its peak(77 ng/mL)at the 3rd week after implantation,and achieved sustained expression during the 5-week observation period.Plasma FⅧ activities of recipient HA mice increased from 0%to 32%after hFⅧBD-MSCs transplantation.APTT(activated partial thromboplastin time)value decreased in hFⅧBD-MSCs transplanted HA mice compared with untreated HA mice(45.5 s vs.91.3 s).Our study demonstrated an effective phenotypic correction in HA mice using genetically modified MSCs from hFⅧBD transgenic mice.Qing Wang Xiuli Gong Zhijuan Gong Xiaoyie Ren Zhaorui Ren Shuzhen Huang Yitao Zeng 2013Journal of Genetics and Genomics2013,40,12:2
4Buckling-delamination and cracking of thin titanium films under compression: Experimental and numerical studies显示文摘Xiuli Xue Shibin Wang Chaofeng Zeng Haili Bai Linan Li Zhiyong Wang 2014Surface & Coatings Technology2014,,:1
5Randomized trial of autologous bone marrow mesenchymal stem cells transplantation for hepatitis B virus cirrhosis: Regulation of T reg/ T h17 cells显示文摘Lanman Xu Yuewen Gong Benfu Wang Keqing Shi Yijun Hou Liping Wang Zuo Lin Yixiang Han Lu Lu Dazhi Chen Xiuli Lin Qiqiang Zeng Wenke Feng Yongping Chen 2014J Gastroenterol Hepatol2014,,8:1
6Dl-3-n butylphthalide attenuates brain injury caused by cortical infarction accompanied by cranial venous drainage disturbance显示文摘Background Cerebral venous disorder may have a harmful effect on ischaemic stroke;however,the underlying mechanism remains to be elucidated.Although Dl-3-n butylphthalide is a multitarget agent for antiischaemic stroke,its neuroprotective role in brain ischaemia accompanied by brain venous disturbance remains unclear.In this study,we induced cerebral venous disturbance by the occlusion of bilateral external jugular veins(EJVs)to explore the potential mechanism of the adverse effects of cerebrovenous disorders in cerebral infarction and explore the protective effect of Dl-3-n butylphthalide on cerebral infarction accompanied through cerebral venous disturbance.Methods Cerebral venous disturbance was induced in Sprague-Dawley rats through the permanent occlusion of bilateral EJVs,and cerebral ischaemic stroke was induced through the permanent occlusion of the right cortical branches of the middle cerebral artery.2,3,5-triphenyltetrazolium chloride staining,MRI,Evans blue extravasation and behavioural test were performed to evaluate infarction volume,cerebral blood flow(CBF),blood-brain barrier(BBB)integrity and neurological function.Immunofluorescence staining and western blot analysis were performed to detect loss of neuron,endothelial cells,pericytes and tight junctions.Results Bilateral EJVs occlusion did not cause cerebral infarction;however,it increased the infarction volume compared with the simple middle cerebral artery occlusion(MCAO)group,accompanied by severe neuron loss,worse neurological function,lower CBF,increased EJVs pressure,exacerbated Evans blue extravasation and brain oedema,as well as attenuated angiogenesis.Dl-3-n butylphthalide displayed a neuroprotective effect in rats with MCAO accompanied by EJVs occlusion by reducing neuron loss,accelerating CBF restoration,promoting angiogenesis and relieving BBB damage.Conclusion Bilateral EJVs occlusion did not significantly affect normal rats but aggravated brain damage in the case of ischaemic stroke.Dl-3-n butylphthalide treatment plays a neuroprotective role in rats with MCAO accompanied by EJVs occlusion,mainly due to the promotion of CBF restoration and BBB protection.Kangping Song Xiuli Zeng Xiaomei Xie Rongxuan Zhu Jianye Liang Guobing Chen Li’an Huang 2022Stroke & Vascular Neurology2022,7,3:1
7Neural spike train reconstruction from calcium imaging via a signal-shape composition model显示文摘Dear Editor,Since calcium imaging can simultaneously record the calcium signals of several hundred neurons, it has been a powerful tool in measuring the functional activity of neural populations. However, calcium imaging is an indirect measurement of neuronal firing activity, and this technique requires reconstructing the AP trains from the corresponding calcium fluorescence signals of the recorded neurons.Yu Shen Tingwei Quan Meng Wang Xiuli Liu Xiaohua Lv Xiaowei Chen Shaoqun Zeng 2020Science China(Life Sciences)2020,63,12:1
8Modulation of synchronous calcium oscillations in hippocampal neurons by photostimulation of astrocytes with femtosecond laser显示文摘A large body of evidence indicates that astrocytes play an important role in a range of brain functions through calcium (Ca2+) signaling. Experimentally evoking Ca2+ signaling is a useful technique for investigating the functions of astrocytes. However,conventional stimulation methods typically have poor spatio-temporal precision,and some are invasive. Our group has developed a technique to overcome these problems,in which astrocytes are photostimulated with a femtosecond laser. In the current study,we applied this method to a hippocampal neural network to explore astrocytic functions in detail. The results revealed that applying photostimulation to astrocytes in a cultured hippocampal astrocyte-neuron network caused the following changes:(i) Syn-chronous Ca2+ oscillations in neurons were induced; (ii) spontaneous Ca2+ synchrony instantaneously emerged; and (iii) high-frequency spontaneous Ca2+ synchrony was regulated. Thus,astrocytic Ca2+ signaling evoked by photostimulation was found to modulate synchronous Ca2+ oscillations in hippocampal neurons. We propose that photostimulation with a femtosecond laser will serve as a powerful tool in investigating astrocytic functions at the network level.ZHAO Yuan LIU XiuLi ZHANG Yuan ZHOU Wei ZENG ShaoQun 2010Chinese Science Bulletin2010,55,30:1
9The control of Aspergillus flavus with Cinnamomum jensenianum Hand.-Mazz essential oil and its potential use as a food preservative显示文摘Jun Tian Bo Huang Xiuli Luo Hong Zeng Xiaoquan Ban Jingsheng He Youwei Wang 2011Food Chemistry2011,,3:1
10OBSERVING NEURONAL ACTIVITIES WITH RANDOM ACCESS TWO-PHOTON MICROSCOPE显示文摘As a second messenger in signal transduction,calcium ion plays a very important role in neuronal information processing and integrating.Limited by the imaging technique,it is difficult to simultaneously perform deep tissue imaging and measure intracellular free calcium concentration([Ca^(2+)]i)in different compartments of neurons in brain slice noncollinearly.By means of random access two-photon microscopy,which provides high optical penetration into tissues and low photo damage,we successfully measured[Ca^(2+)]i of different parts of pyramidal neurons in neocortical layer V in rat brain slices with high spatial and temporal resolution.Combining the patch clamp technique,we stimulated the soma with depolarizing current and explored the dynamics of calcium in pyramidal neurons.YUXIANG WU XIULI LIU WEI ZHOU XIAOHUA LV SHAOQUN ZENG 2009Journal of Innovative Optical Health Sciences2009,2,1:0
11Constraining self-interacting dark matter with the full dataset of PandaX-II显示文摘Self-interacting dark matter(SIDM)is a leading candidate proposed to solve discrepancies between predictions of the prevailing cold dark matter theory and observations of galaxies.Many SIDM models predict the existence of a light force carrier that mediates strong dark matter self-interactions.If the mediator couples to the standard model particles,it could produce characteristic signals in dark matter direct detection experiments.We report searches for signals of SIDM models with a light mediator using the full dataset of the PandaX-II experiment,basing on a total exposure of 132 tonne-days.No significant excess over background is found,and our likelihood analysis leads to a strong upper limit on the dark matter-nucleon coupling strength.We further combine the PandaX-II constraints and those from observations of the light element abundances in the early universe,and show that direct detection and cosmological probes can provide complementary constraints on dark matter models with a light mediator.Jijun Yang Abdusalam Abdukerim Wei Chen Xun Chen Yunhua Chen Chen Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Shengming He Di Huang Yan Huang Ran Huo Yanlin Huang Zhou Huang Xiangdong Ji Yonglin Ju Shuaijie Li Qing Lin Huaxuan Liu Jianglai Liu Xiaoying Lu Wenbo Ma Yugang Ma Yajun Mao Yue Meng Nasir Shaheed Kaixiang Ni Jinhua Ning Xuyang Ning Xiangxiang Ren Changsong Shang Guofang Shen Lin Si Andi Tan Anqing Wang Hongwei Wang Meng Wang QiuHong Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Shiyong Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Yong Yang Chunxu Yu Hai-Bo Yu Jumin Yuan Ying Yuan Xinning Zeng Dan Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou 2021Science China(Physics,Mechanics & Astronomy)2021,64,11:0
12High-quality assembly and methylome of a Tibetan wild tree peony genome(Paeonia ludlowii)reveal the evolution of giant genome architecture显示文摘Tree peony belongs to one of the Saxifragales families,Paeoniaceae.It is one of the most famous ornamental plants,and is also a promising woody oil plant.Although two Paeoniaceae genomes have been released,their assembly qualities are still to be improved.Additionally,more genomes from wild peonies are needed to accelerate genomic-assisted breeding.Here we assemble a high-quality and chromosome-scale 10.3-Gb genome of a wild Tibetan tree peony,Paeonia ludlowii,which features substantial sequence divergence,including around 75%specific sequences and gene-level differentials compared with other peony genomes.Our phylogenetic analyses suggest that Saxifragales and Vitales are sister taxa and,together with rosids,they are the sister taxon to asterids.The P.ludlowii genome is characterized by frequent chromosome reductions,centromere rearrangements,broadly distributed heterochromatin,and recent continuous bursts of transposable element(TE)movement in peony,although it lacks recent whole-genome duplication.These recent TE bursts appeared during the uplift and glacial period of the Qinghai-Tibet Plateau,perhaps contributing to adaptation to rapid climate changes.Further integrated analyses with methylome data revealed that genome expansion in peony might be dynamically affected by complex interactions among TE proliferation,TE removal,and DNA methylation silencing.Such interactions also impact numerous recently duplicated genes,particularly those related to oil biosynthesis and flower traits.This genome resource will not only provide the genomic basis for tree peony breeding but also shed light on the study of the evolution of huge genome structures as well as their protein-coding genes.Pei-Xuan Xiao Yuanrong Li Jin Lu Hao Zuo Gesang Pingcuo Hong Ying Fan Zhao Qiang Xu Xiuli Zeng Wen-Biao Jiao 2023Horticulture Research2023,10,12:0
13PI4Kb, PIPs and BK_(Ca) channel function显示文摘Large conductance calcium-activated potassium(BKCa)channels are broadly expressed in vascular smooth muscle cells(VSMCs)and play a crucial role in the regulation of vascular tone[1].Activation of BKCachannel by elevation of the[Ca^(2+)]idue to membrane depolarization increases the K^+ conductance of the membrane,and drives the VSMC membrane potential to hyperpolarization,whichXiuli Cheng Xiaoqiu Tan Weixia Liu Hui Li Li Yan Yan Yang Xiaorong Zeng Jimin Cao 2016Science Bulletin2016,61,23:0
14Ultrasmall pH-responsive silicon phthalocyanine micelle for selective photodynamic therapy against tumo显示文摘Targeted photodynamic therapy(TPDT)based on the photosensitizers responsive for tumor micr oenvironment is promising because of the better anti-tumor effect and less phototoxicity against normal tissue than the traditional PDT.Nanoparticle based stimuli responsive photo-sensitizers have been widely explored for TPDT.Based on the acidic microenvironments in solid tumors,an ultrasmall pH-responsive silicon phthalocyanine nanomicelle(PSN)(smaller than 10 nm)was designed for selective PDT of tumor.PSN had high drug loading efficacy(more than 28%)and exhibited morphological transitions,enhanced fuorescence and improved singlet∞x-ygen yield under acidic environments.PSN was renal dlearable and could rapidly accumulate and be retained at tumor sites,achieving a tumor-inhibiting ffect better than phthalocyanine micelle without pH response.Tumors of mice treated with PSN for PDT were completely ablated without recurrence.Thus,we have developed a phthalocyanine-based pH responsive micelle with excellent tumor targeting ability,which is expected to realize the selective PDT of tumor.Yiming Zhou Wenlong Zeng Mengxuan Wang Rui Li Xiuli Yue Zhifei Dai 2022Journal of Innovative Optical Health Sciences2022,15,6:0
15Mapping the Brain-Wide Cholinergic Neurons Projecting to Skeletal Muscle in Mice by High-Throughput Light Sheet Tomography显示文摘Dear Editor,The cholinergic system plays an important role in regulating locomotion and motor functions by modulating neuronal activity[1].However,the anatomical relationships between the brain-wide cholinergic system and skeletal muscles remain unclear.To understand how this system modulates the activity of skeletal muscles,details of the pattern of cholinergic innervation and differences in the innervation of skeletal muscles are necessary.However,classical immunohistochemical methods are unable to test unequivocally whether a mapping exists in the connections from the brain to skeletal muscles.Dayu Chen Xiaofeng Cheng Xiong Yang Yongsheng Zhang Zhigang He Qian Wang Guojie Yao Xiuli Liu Shaoqun Zeng Jincao Chen Hongbing Xiang 2021Neuroscience Bulletin2021,37,2:0
16Transcriptome Analysis of Pacific White Shrimp(Litopenaeus vannamei)Hepatopancreas in Response to Taura Syndrome Virus(TSV)Experimental Infection显示文摘Digang Zeng Xiuli Chen Daxiang Xie Yongzhen Zhao Chunling Yang Yongmei Li Ning Ma Min Peng Qiong Yang Zhenping Liao Hui Wang Xiaohan Chen 2014广西水产科技2014,,1:0
17How the development of barren land into orchards affects soil ecosystem in Tibet,China显示文摘Fruit production is an important strategy for alleviating poverty on the Tibetan Plateau and leads to the conversion of natural barren land into orchards.This study aimed to understand how the conversion of barren land to peach(Prunus persica)orchards affects soil nutrients,heavy metals,and fungal communities in the 0–40 cm profile(at 20 cm intervals)in an experiment including three treatments,barren land(BL),peach orchards planting for 4 years(Y4),and peach orchards planting for 10 years(Y10).Results of the experiment showed that compared with BL,Y4 reduced the availability of some macronutrients(N and K)and micronutrients(Fe and Mn)due to the exclusive application of chemical fertilizer at the seedling stage.Conversely,Y10,which included six years of green cultivation management,using a combination of sheep manure and chemical fertilizer as well as alfalfa(Medicago sativa Linn)intercropping,effectively improved soil macronutrients,but did not enhance the availability of Fe and Mn.Although the investigated heavy metals(As,Hg,Pb,Cr,and Cd)in both the Y4 and Y10 soils were found to pose a low risk to food safety and soil environment,Hg,Cr,and As tended to accumulate in the subsoil(20–40 cm).Furthermore,the variations in the fungal community composition and functional groups were mainly driven by the interaction effects of macronutrients,micronutrients,and heavy metals,but their independent contribution to specific key functional groups cannot be overlooked.For example,Y4 and Y10 decreased the relative abundance of soil saprotrophic and lichenized fungi,mainly due to the loss of micronutrients(Fe and Mn).However,as a result of macronutrient input and dung saprotrophic fungi enrichment,orchard soils promoted the growth of pathogens that play critical roles in fungal co-occurrence networks.These findings indicate that supplementation with N or K fertilizer or manure at the seedling stage and fertilizers rich in Fe and Mn throughout the growth period would be beneficial to the balance of soil nutrients and provide insights into linking the variations in soil nutrients and heavy metals to the function of the fungal community during the conversion of barren land to orchards in alpine soil ecosystems.The risks posed by heavy metal accumulation and fungal pathogen enrichment should be actively prevented.Shuailin LI Shuo WANG Xiuli ZENG Yongxing CUI Wantai YU Qiang MA 2022Pedosphere2022,32,4:0
18Discovery and development of tricyclic matrinic derivatives as anti-diabetic candidates by AMPKαactivation显示文摘We found compound 12N-p-trifluoromethylbenzenesulfonyl matrinane(1)was a potent anti-diabetic agent.Thirty-five tricyclic matrinic derivatives were synthesized and determined for their stimulatory effects on glucose consumption in L6 myotubes,taking 1 as the lead.In high-fat diet(HFD)and STZ induced diabetic mice,9a significantly lowers blood glucose,improves glucose tolerance,and especially alleviates diabetic nephropathy and islet damage.Mechanism study indicates that 9a simultaneously targets mitochondrial complex I to increase AMP/ATP ratio,as well as liver kinase B1(LKB1)and calcium/calmodulindependent protein kinase(Ca MKK),which synergistically activates AMPKαand then stimulates glucose transporter 4(GLUT4)membrane translocation and 2-deoxyglucose(2-DG)uptake to exert anti-diabetic efficacy.Therefore,compound 9a with a novel structure is a promising anti-diabetic candidate with the advantage of multiple-target mechanism,worthy of further investigation.Yinghong Li Yuanhui Zhang Tianyu Niu Yudong Pang Yulong Shi Qingxuan Zeng Jingpu Zhang Jingyang Zhu Xiuli Zhong Yanxiang Wang Yan Wang Sheng Tang Weijia Kong Danqing Song Jiandong Jiang 2023Chinese Chemical Letters2023,34,1:0
19Day-ahead Network-constrained Unit Commitment Considering Distributional Robustness and Intraday Discreteness:A Sparse Solution Approach显示文摘Quick-start generation units are critical devices and flexible resources to ensure a high penetration level of renewable energy in power systems.By considering the wind uncertainty and both binary and continuous decisions of quickstart generation units within the intraday dispatch,we develop a Wasserstein-metric-based distributionally robust optimization model for the day-ahead network-constrained unit commitment(NCUC)problem with mixed-integer recourse.We propose two feasible frameworks for solving the optimization problem.One approximates the continuous support of random wind power with a finite number of events,and the other leverages the extremal distributions instead.Both solution frameworks rely on the classic nested column-and-constraint generation(C&CG)method.It is shown that due to the sparsity of L_(1)-norm Wasserstein metric,the continuous support of wind power generation could be represented by a discrete one with a small number of events,and the rendered extremal distributions are sparse as well.With this reduction,the distributionally robust NCUC model with complicated mixed-integer recourse problems can be efficiently handled by both solution frameworks.Numerical studies are carried out,demonstrating that the model considering quick-start generation units ensures unit commitment(UC)schedules to be more robust and cost-effective,and the distributionally robust optimization method captures the wind uncertainty well in terms of out-of-sample tests.Xiaodong Zheng Baorong Zhou Xiuli Wang Bo Zeng Jizhong Zhu Haoyong Chen Waisheng Zheng 2023Journal of Modern Power Systems and Clean Energy2023,11,2:0
20Rational design of interfacial bonds within dual carbon-protected manganese oxide towards durable aqueous zinc ion battery显示文摘Manganese-based cathode materials are promising candidates for aqueous zinc ion batteries(AZIBs)by reason of their low cost and high energy density.However,their practical applicability is hampered by the intrinsic defects of poor electrical conductivity,sluggish reaction kinetics,and severe structural deterioration.Herein,we constructed a hierarchically porous structure composed of carbon-encapsulated Mn O nanoparticles(MOC)and three-dimensional(3D)nitrogen-doped graphene aerogel(NGA)(denoted as MOC@NGA).The hybrid was synthesized by a facile in-situ coprecipitation and annealing of manganesebased metal-organic framework(Mn-MOF74)and NGA composite(Mn-MOF74@NGA).Specifically,the carbon shells inherited from organic ligand of Mn-MOF74 could restrain the volume changes of Mn O,and the porous NGA prevented the agglomeration of MOC nanoparticles and enriched the types of interfacial chemical bonds.Profiting from the synergistic effect of rich interface chemical bonds and dual-carbon protection,the MOC@NGA hybrids exhibit fast interfacial electron/charge transfer and transport,and outstanding structural stability.Therefore,MOC@NGA cathode delivers an excellent rate performance(270 and 99.8 m Ah g^(-1)at 0.1 and 2.0 A g^(-1))and maintains an excellent specific capacity of 151.6 m Ah g^(-1)after 2,000cycles at 1.0 A g^(-1).Moreover,the fabricated MOC@NGA-based quasi-solid-state battery not only achieves outstanding flexibility but also displays impressive cycling stability,demonstrating a promising potential for portable and flexible equipment.This work provides a feasible strategy for the fabrication of the bridging structure of manganese-based oxides and porous carbon matrix for high-specific capacity and durable AZIBs cathodes.Xiuli Guo Chunguang Li Xiyang Wang Zhenhua Li Hui Zeng Pan Hou Minggang Xie Yuxin Li Zhan Shi Shouhua Feng 2023Science China Chemistry2023,66,5:0
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