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| 1 | The Sunway TaihuLight supercomputer: system and applications显示文摘The Sunway Taihu Light supercomputer is the world's first system with a peak performance greater than 100 PFlops. In this paper, we provide a detailed introduction to the Taihu Light system. In contrast with other existing heterogeneous supercomputers, which include both CPU processors and PCIe-connected many-core accelerators(NVIDIA GPU or Intel Xeon Phi), the computing power of Taihu Light is provided by a homegrown many-core SW26010 CPU that includes both the management processing elements(MPEs)and computing processing elements(CPEs) in one chip. With 260 processing elements in one CPU, a single SW26010 provides a peak performance of over three TFlops. To alleviate the memory bandwidth bottleneck in most applications, each CPE comes with a scratch pad memory, which serves as a user-controlled cache. To support the parallelization of programs on the new many-core architecture, in addition to the basic C/C++and Fortran compilers, the system provides a customized Sunway Open ACC tool that supports the Open ACC2.0 syntax. This paper also reports our preliminary efforts on developing and optimizing applications on the Taihu Light system, focusing on key application domains, such as earth system modeling, ocean surface wave modeling, atomistic simulation, and phase-field simulation. | Haohuan FU Junfeng LIAO Jinzhe YANG Lanning WANG Zhenya SONG Xiaomeng HUANG Chao YANG Wei XUE Fangfang LIU Fangli QIAO Wei ZHAO Xunqiang YIN Chaofeng HOU Chenglong ZHANG Wei GE Jian ZHANG Yangang WANG Chunbo ZHOU Guangwen YANG | 2016 | Science China(Information Sciences)2016，59，7： | 45 |
| 2 | The Cretaceous Songliao Basin:Volcanogenic Succession,Sedimentary Sequence and Tectonic Evolution,NE China显示文摘Songliao 盆(SB ) 是有盆的二种不同类型的迭加的盆充满。更低的被一座围住差错的火山描绘包括的遗传因子的继任设置暴烈,碎屑状的焦性没食子酸和 epiclastic 岩石。暴烈的岩石,从 110 妈标明日期到 130 妈,具有 geochemically 活跃的大陆人边缘类型。快,向北方, SB 块的移植发生在从他们的 paleomagnetic 信息推断的火山作用的主要事件期间。上面盆之一充满被非海洋的下垂风格统治 siliciclastics 和次要的碳酸盐的沉积顺序。盆中心向西变了从对在盆进化建议动态变化的 GGT 地震速度结构揭示的迟了的白垩纪早。因此,一个迭加的盆模型被建议。SB 的进化包含包括的三个时期(1 ) Alptian 和 pre-Aptian:制动火箭弧盆和安第斯山脉的范围系统与蒙古鄂霍次克海 collisional 带(MOCB ) 有关打字;(2 ) Albian 到 Companian:在与沿着欧亚的板的东方边缘的和平的板的倾斜的 subduction 有关的 transtension 下面的象下垂一样罢工滑倒盆;(3 ) 自从 Maastrichtian:在与在欧亚的板下面的和平的板的正常 subduction 有关的压缩下面的构造的反的盆,由掩冲断层描绘了,向西 depocenter 的移植并且盆边缘的东方高举。 | WANG Pujun XIE Xiao'an Mattem FRANK REN Yanguang ZHU Defeng SUN Xiaomeng | 2007 | Acta Geologica Sinica(English Edition)2007，81，6： | 38 |
| 3 | SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2显示文摘 | Huize Pan Di Guan Xiaomeng Liu Jingyi Li Lixia Wang Jun Wu Junzhi Zhou Weizhou Zhang Ruotong Ren Weiqi Zhang Ying Li Jiping Yang Ying Hao Tingting Yuan Guohong Yuan Hu Wang Zhenyu Ju Zhiyong Mao Jian Li Jing Qu FuchouTang Guang-Hui Liu | 2016 | Cell Research2016，26，2： | 32 |
| 4 | Danshenchuanxiongqin injection in the treatment of unstable angina pectoris: a systematic review and Meta-analysis显示文摘OBJECTIVE:To evaluate systematically the efficacy and safety of Danshenchuanxiongqin Injection(DCI)in the treatment of unstable angina pectoris(UAP).METHODS:Randomized controlled trials(RCTs)regarding DCI used for treating UAP were searched in English and Chinese electronic databases from inception to January 2014.Two reviewers independently retrieved RCTs and extracted relevant information.The Cochrane risk of bias method was used to assess the quality of included studies,and a Meta-analysis was conducted with Review Manager5.2 software.RESULTS:Eleven RCTs involving 1034 participants were included.The methodological quality was relatively passable.The Meta-analysis indicated that the combined use of DCI and conventional treatment with Western Medicine(WM)was more efficacious in the outcomes of total effective rate[Relative Risk(RR)=1.27,95%CI(confidence interval;1.18,1.35),P<0.000 01],the total effective rate of ECG[RR=1.40,95%CI(1.18,1.66),P<0.000 01],total cholesterol[Mean difference(MD)=-0.58,95%CI(-0.83,-0.33),P<0.000 01],total triglycerides[MD=-0.36,95%CI(-0.54,-0.17),P=0.0001],and the number of ST-segment depression[MD=-0.36,95%CI(-0.54,-0.17),P=0.0001].There were two adverse drug reactions reported in one study.CONCLUSION:Based on the systematic review,DCI combined with WM appeared to be efficacious in the treatment UAP.However,the evidence of DCI for treating UAP requires large-scale and double-blind RCTs to substantiate these findings. | Zhang Xiaomeng Wu Jiarui Zhang Bing Zhou Wei | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 24 |
| 5 | Efficacy and safety of puerarin injection in treatment of diabetic peripheral neuropathy: a systematic review and Meta-analysis of randomized controlled trials显示文摘OBJECTIVE: To systematically evaluate the clinical efficacy and safety of puerarin injection in the treatment of diabeticperi pheral neuropathy(DPN).METHODS: Randomized controlled trials investigating the efficacy of puerarin injection on DPN were searched for in China National Knowledge Infrastructure Database, Chinese Scientific Journals Database, Wanfang Database, Chinese Biomedical Literature Database, PubMed, and Cochrane Library from establishment to April 30.Two reviewers independently retrieved and extracted the information.The included studies were assessed by the Cochrane risk of bias and analyzed by Review Manager 5.2 software.RESULTS: Twenty-two studies involving 1664 participants were included. The quality of the studies was found to be relatively low. Meta-analysis showed that puerarin injection combined with western medication was more effective than conventional therapy for rate, nerve conduction velocity(NCV), and hemorheology index. Six adverse drug reactions(ADRs) from puerarin injection were reported in two studies. Reactions included facial flushing, palpitations, and pain at infusion locations. However,noserious ADRs were reported.CONCLUSION: Puerarin injection was effective for the treatment of DPN. Puerarin can improve the total effective rate, correct NCV that was decreased by diabetes, and improve the hemorheology index.Puerarin was also relatively safe clinically. However,since the articles included in the study were not high-quality, more studies should be conducted to strengthen their findings. | Jiarui Wu Xiaomeng Zhang Bing Zhang | 2014 | Journal of Traditional Chinese Medicine2014，34，4： | 23 |
| 6 | Stability of roof structure and its control in steeply inclined coal seams显示文摘To improve the effectiveness of control of surrounding rock and the stability of supports on longwall topcoal caving faces in steeply inclined coal seams, the stability of the roof structure and hydraulic supports was studied with physical simulation and theoretical analysis. The results show that roof strata in the vicinity of the tail gate subside extensively with small cutting height, while roof subsidence near the main gate is relatively assuasive. With increase of the mining space, the caving angle of the roof strata above the main gate increases. The characteristics of the vertical and horizontal displacement of the roof strata demonstrate that caved blocks rotate around the lower hinged point of the roof structure, which may lead to sliding instability. Large dip angle of the coal seam makes sliding instability of the roof structure easier.A three-hinged arch can be easily formed above both the tail and main gates in steeply inclined coal seams. With the growth in the dip angle, subsidence of the arch foot formed above the main gate decreases significantly, which reduces the probability of the roof structure becoming unstable as a result of large deformation, while the potential of the roof structure's sliding instability above the tail gate increases dramatically. | Li Xiaomeng Wang Zhaohui Zhang Jinwang | 2017 | International Journal of Mining Science and Technology2017，27，2： | 21 |
| 7 | Advances in the study of uncertainty quantification of large-scale hydrological modeling system显示文摘因为它不仅被物理因素而且由人的尺寸影响,地区性的水文学系统是极其复杂的。并且水文学模型在模仿复杂系统起一个很重要的作用。然而,由于它的复杂性和困难为模型可靠性和无常分析没有有效方法。在水文学建模的无常来自四个重要方面:在输入数据和参数的无常,在模型结构的无常,在分析方法的无常并且起始并且边界条件。这份报纸系统地在分析根据无常来源在大规模复杂水文学模型接近的无常的学习考察了最近的进展。另外,在为复杂水文学模型的无常分析的缺点和不足被指出。然后新无常 quantification 站台 PSUADE 和它的无常 quantification 方法被介绍,它将为大规模复杂水文学模型的无常分析是一个强大的工具和平台。最后,无常 quantification 上的一些未来观点被提出。 | SONG Xiaomeng ZHAN Chesheng KONG Fanzhe XIA Jun | 2011 | Journal of Geographical Sciences2011，21，5： | 21 |
| 8 | Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients显示文摘 | Lu Wen Jingyi Li Huahu Guo Xiaomeng Liu Shengmin Zheng Dafang Zhang Weihua Zhu Jianhui Qu Limin Guo Dexiao Du Xiao Jin Yuhao Zhang Yun Gao Jie Shen Hao Ge Fuchou Tang Yanyi Huang Jirun Peng | 2015 | Cell Research2015，25，11： | 19 |
| 9 | Interactive effects of wind speed,vegetation coverage and soil moisture in controlling wind erosion in a temperate desert steppe,Inner Mongolia of China显示文摘The rapid desertification of grasslands in Inner Mongolia of China poses a significant ecological threaten to northern China. The combined effects of anthropogenic disturbances(e.g., overgrazing) and biophysical processes(e.g., soil erosion) have led to vegetation degradation and the consequent acceleration of regional desertification. Thus, mitigating the accelerated wind erosion, a cause and effect of grassland desertification, is critical for the sustainable management of grasslands. Here, a combination of mobile wind tunnel experiments and wind erosion model was used to explore the effects of different levels of vegetation coverage, soil moisture and wind speed on wind erosion at different positions of a slope inside an enclosed desert steppe in the Xilamuren grassland of Inner Mongolia. The results indicated a significant spatial difference in wind erosion intensities depending on the vegetation coverage, with a strong decreasing trend from the top to the base of the slope. Increasing vegetation coverage resulted in a rapid decrease in wind erosion as explained by a power function correlation. Vegetation coverage was found to be a dominant control on wind erosion by increasing the surface roughness and by lowering the threshold wind velocity for erosion. The critical vegetation coverage required for effectively controlling wind erosion was found to be higher than 60%. Further, the wind erosion rates were negatively correlated with surface soil moisture and the mass flux in aeolian sand transport increased with increasing wind speed. We developed a mathematical model of wind erosion based on the results of an orthogonal array design. The results from the model simulation indicated that the standardized regression coefficients of the main effects of the three factors(vegetation coverage, soil moisture and wind speed) on the mass flux in aeolian sand transport were in the following order: wind speed>vegetation coverage>soil moisture. These three factors had different levels of interactive effects on the mass flux in aeolian sand transport. Our results will improve the understanding of the interactive effects of wind speed, vegetation coverage and soil moisture in controlling wind erosion in desert steppes, and will be helpful for the design of desertification control programs in future. | MENG Zhongju DANG Xiaohong GAO Yong REN Xiaomeng DING Yanlong WANG Meng | 2018 | Journal of Arid Land2018，10，4： | 19 |
| 10 | Texture and tectonic attribute of Cenozoic basin basement in the northern South China Sea显示文摘Based on the drilling data,the geological characteristics of the coast in South China,and the interpretation of the long seismic profiles covering the Pearl River Mouth Basin and southeastern Hainan Basin,the basin basement in the northern South China Sea is divided into four structural layers,namely,Pre-Sinian crystalline basement,Sinian-lower Paleozoic,upper Paleozoic,and Mesozoic structural layers.This paper discusses the distribution range and law and reveals the tectonic attribute of each structural layer.The Pre-Sinian crystalline basement is distributed in the northern South China Sea,which is linked to the Pre-Sinian crystalline basement of the Cathaysian Block and together they constitute a larger-scale continental block—the Cathaysian-northern South China Sea continental block.The Sinian-lower Paleozoic structural layer is distributed in the northern South China Sea,which is the natural extension of the Caledonian fold belt in South China to the sea area.The sediments are derived from southern East China Sea-Taiwan,Zhongsha-Xisha islands and Yunkai ancient uplifts,and some small basement uplifts.The Caledonian fold belt in the northern South China Sea is linked with that in South China and they constitute the wider fold belt.The upper Paleozoic structural layer is unevenly distributed in the northern South China.In the basement of Beibu Gulf Basin and southwestern Taiwan Basin,the structural layer is composed of the stable epicontinental sea deposit.The distribution areas in the Pearl River Mouth Basin and the southeastern Hainan Basin belong to ancient uplifts in the late Paleozoic,lacking the upper Paleozoic structural layers.The stratigraphic distribution and sedimentary environment in Middle-Late Jurassic to Cretaceous are characteristic of differentiation in the east and the west.The marine,paralic deposit is well developed in the basin basement of southwestern Taiwan but the volcanic activity is not obvious.The marine and paralic facies deposit is distributed in the eastern Pearl River Mouth Basin basement and the volcanic activity is stronger.The continental facies volcano-sediment in the Early Cretaceous is distributed in the basement of the western Pearl River Mouth Basin and Southeastern Hainan Basin.The Upper Cretaceous red continental facies clastic rocks are distributed in the Beibu Gulf Basin and Yinggehai Basin.The NE direction granitic volcanic-intrusive complex,volcano-sedimentary basin,fold and fault in Mesozoic basement have the similar temporal and spatial distribution,geological feature,and tectonic attribute with the coastal land in South China,and they belong to the same magma-deposition-tectonic system,which demonstrates that the late Mesozoic structural layer was formed in the background of active continental margin.Based on the analysis of basement structure and the study on tectonic attribute,the paleogeographic map of the basin basement in different periods in the northern South China Sea is compiled. | SUN XiaoMeng ZHANG XuQing ZHANG GongCheng LU BaoLiang YUE JunPei ZHANG Bin | 2014 | Science China Earth Sciences2014，57，6： | 18 |
| 11 | TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy显示文摘 | Chengyan Wang Xuming Tang Xiaomeng Sun Zhenchuan Miao Yaxin Lv Yanlei Yang Huidan Zhang Pengbo Zhang Yang Liu LiyingDu Yang Gao Ming Yin Mingxiao Ding Hongkui Deng | 2012 | Cell Research2012，22，1： | 17 |
| 12 | Kinetics and corrosion products of aqueous nitrate reduction by iron powder without reaction conditions control显示文摘Although considerable research has been conducted on nitrate reduction by zero-valent iron powder (Fe0), these studies were mostly operated under anaerobic conditions with invariable pH that was unsuitable for practical application. Without reaction conditions (dissolved oxygen or reaction pH) control, this work aimed at subjecting the kinetics of denitrification by microscale Fe0 (160–200 mesh) to analysis the factors affecting the denitrification of nitrate and the composition of iron reductive products coating upon the iron surface. Results of the kinetics study have indicated that a higher initial concentration of nitrate would yield a greater reaction rate constant. The reduction rate of nitrate increased with increasing Fe0 dosage. The reaction can be described as a pseudo-first order reaction with respect to nitrate concentration or Fe0 dosage. Experimental results also suggested that nitrate reduction by microscale Fe0 without reaction condition control primarily was an acid-driven surface-mediated process, and the reaction order was 0.65 with respect to hydrogen ion concentration. The analyses of X-ray diffractometry and X-ray photoelectron spectroscopy indicated that a black coating, consisted of Fe2O3, Fe3O4 and FeO(OH), was formed on the surface of iron grains as an iron corrosion product when the system initial pH was lower than 5. The proportion of FeO(OH) increased as reaction time went on, whereas the proportion of Fe3O4 decreased. | FAN Xiaomeng GUAN Xiaohong MA Jun AI Hengyu | 2009 | Journal of Environmental Sciences2009，21，8： | 17 |
| 13 | Potassium dehydroandrographolide succinate injection for treatment of infantile pneumonia:a systematic review and Meta-analysis显示文摘OBJECTIVE:To evaluate systematically the clinical efficacy and safety of potassium dehydroandrographolide succinate injection(PDS) in treatment of infantile pneumonia.METHODS:Randomized controlled trials(RCTs) of infantile pneumonia treated by PDS were searched in China National Knowledge Infrastructure Database,China Science and Technology Journal Database,Wanfang Database,Chinese Biomedical Literature Database,PubMed,and Cochrane Library,from January 1979 to July 2013.Two reviewers independently retrieved the RCTs and extracted the information.The quality of included studies was assessed by the Cochrane risk of bias,and a Meta-analysis was conducted with Review Manager 5.2 software.RESULTS:A total of 9 studies with 1056 participants were included.The quality of the studies was generally no high,only one study mentioned the random method.The Meta-analysis indicated that PDS was significantly superior to the conventional therapy in the total effective rate[relative risk(RR)=1.21,95%CI(1.14,1.27),P<0.000 01],the time of temperature recovery[mean difference(MD)=-1.43,95%CI(-1.75,-1.11),P<0.000 01],rale disappeared and cough relieving[MD=-1.44,95%CI(-1.93,-0.90),P<0.000 01].Six adverse drug reactions from five studies mainly represented rash and diarrhea,and no serious ADRs were reported.CONCLUSION:Based on this systematic review,PDS was proved effective and relatively safe in treatment of infantile pneumonia.However the articles enrolled in the study were not high in quality,studies with higher quality should be conducted for assessment of efficacy and safety of PDS in treatment of infantile pneumonia. | Zhang Xiaomeng Wu Jiarui Zhang Bing Dong Ling | 2015 | Journal of Traditional Chinese Medicine2015，35，2： | 17 |
| 14 | Analysis of miR-205 and miR-155 expression in the blood of breast cancer patients显示文摘The purpose of this study was to identify and validate circulating microRNAs (miRNAs) in human plasma for use as breast cancer (BC) biomarkers and to analyze their relationship to clinicopathologic features and its preliminary biological function. Genome-wide expression profiling of miRNAs in BC was investigated by microarray analysis. miR-155 was up-regulated greater than two-fold in BC compared with Normal Adjacent Tissue (NAT), whereas let-7b, miR-381, miR-10b, miR-125a-5p, miR-335, miR-205 and miR-145 were down- regulated greater than two-fold. Our hypothesis was that circulating miRNAs are also present and differentially expressed in the serum of BC patients compared to controls. Using real-time PCR (RT-PCR), we analyzed miR-205 and miR-155 in archived serum from 30 participants, 20 with breast cancer and 10 healthy people. miR-205 was down-regulated in BC patient serum while miR-155 was up-regulated. Furthermore, we analyzed the relationship between the expression levels of these two miRNAs and the clinicopathologic parameters of BC patients. High expression of miR155 was associated with clinical stage, molecular type, Ki-67 and p53 in BC patients (P<0.05). By contrast, we found no significant correlation between miR-205 and BC patient clinicopathologic parameters. Functional analysis showed that ectopic expression of miR-205 significantly inhibits cell proliferation and promotes apoptosis. miR-205 was down-regulated and miR-155 was up-regulated in BC patient serum. miR-155 was positive correlated with clinical stage and ki-67 and negatively correlated with p53 status. | Jingjing Liu Qixin Mao Yan Liu Xiaomeng Hao Sheng Zhang Jin Zhang | 2013 | Chinese Journal of Cancer Research2013，25，1： | 14 |
| 15 | Integration of a statistical emulator approach with the SCE-UA method for parameter optimization of a hydrological model显示文摘Parameter optimization of a hydrological model is an indispensable process within model development and application.The lack of knowledge regarding the efficient optimization of model parameters often results in a bottle-neck within the modeling process,resulting in the effective calibration and validation of distributed hydrological models being more difficult to achieve.The classical approaches to global parameter optimization are usually characterized by being time consuming,and having a high computation cost.For this reason,an integrated approach coupling a meta-modeling approach with the SCE-UA method was proposed,and applied within this study to optimize hydrological model parameter estimation.Meta-modeling was used to determine the optimization range for all parameters,following which the SCE-UA method was applied to achieve global parameter optimization.The multivariate regression adaptive splines method was used to construct the response surface as a surrogate model to a complex hydrological model.In this study,the daily distributed time-variant gain model(DTVGM) applied to the Huaihe River Basin,China,was chosen as a case study.The integrated objective function based on the water balance coefficient and the Nash-Sutcliffe coefficient was used to evaluate the model performance.The case study shows that the integrated method can efficiently complete the multi-parameter optimization process,and also demonstrates that the method is a powerful tool for efficient parameter optimization. | SONG XiaoMeng ZHAN CheSheng XIA Jun | 2012 | Chinese Science Bulletin2012，57，26： | 13 |
| 16 | Spatial and temporal analysis of tuberculosis in Zhejiang Province, China, 2009-2012显示文摘Background:Tuberculosis(TB)is an infectious disease of major public health concern.The disease has demonstrated large space-time variations.This study aims to explore the space-time dynamics of TB cases in an economically and geographically dynamic province in China with specific references of TB control for policy makers.Methods:Data on all reported TB cases from 2009 to 2012 were collected from the TB program at the Zhejiang Provincial Center for Disease Control and Prevention.We employed time series and exploratory spatial data analyses,including Moran’s I,Local Getis’s G_(i)^(*),and Kulldorff’s space-time scan statistics,to identify the temporal trends and spatial patterns of TB at a county level.Results:A total of 147,941 TB cases were reported during 2009–2012 in Zhejiang.A higher proportion of TB cases were younger,male,and registered permanent residents among all TB cases notified in the province.TB cases were reported most frequently in April with small peaks in June,July,and October.This disease was spatially clustering with Moran’s I values ranged from 0.29 to 0.32(p<0.001).A most likely cluster and ten secondary clusters were identified,mainly concentrated in the southeast and west counties of the province.Conclusions:This study identified seasonal patterns and significant space-time clusters of TB cases in Zhejiang,China.Poverty,migration,and seasonal effects may play important roles in potential clusters. | Erjia Ge Xin Zhang Xiaomeng Wang Xiaolin Wei | 2016 | Infectious Diseases of Poverty2016，5，1： | 13 |
| 17 | Effect of Protein Kinase C on Proliferation and Apoptosis of T Lymphocytes in Idiopathic Thrombocytopenic Purpura Children显示文摘It is well-documented that T lymphocyte proliferation and apoptosis are abnormal in idiopathic thrombocytopenic purpura (ITP) children. However, the underlying regulation mechanisms especially in terms of signal transduction remain unknown. In this paper, we reported the changes of protein kinase C (PKC) activity in peripheral blood T lymphocytes and the effect of PKC on T lymphocyte proliferation and apoptosis. We demonstrated that in ITP children, the activator (PMA) and inhibitor (H-7) of PKC affected on T lymphocyte proliferation and apoptosis dramatically, but they altered little in healthy children. PKC activity was significantly enhanced in ITP children together with an increased expression of FasL on CD3+ T, CD4+ T and CD8+T cells, resulting in a positive correlation between PKC activity and the expression of FasL on T cells. While the PKC activity and the platelet count were negatively correlated. Taken together, our findings suggest that the PKC activation may enhance T lymphocytes activity, suppress T cell apoptosis and be involve in thrombocytes damage as a mechanism related to immune pathogenesis of ITP. | Changlin Wu~(1,2) Fang Liu~1 Xuemin Zhou~1 Zhengwei Cheng~1 Xiaomeng Yang~1 Hong Xiao~1 Qun Chen~1 Kangrong Cai~1 ~1Department of Microbiology and Immunology,Guangdong Medical College,Zhanjiang,Guangdong,524023,China ~2Corresponding to:Dr.Changlin Wu,Department of Microbiology and Immunology,Guangdong Medical College,2 Wen-Ming East Road,Zhanjiang,Guangdong,524023,China. | 2005 | Cellular & Molecular Immunology2005，2，3： | 12 |
| 18 | An efficient global sensitivity analysis approach for distributed hydrological model显示文摘水文学模型的敏感分析是为模型无常 quantification 的钥匙。然而,怎么有效地验证模型并且为分布式的水文学模型识别主导的参数是一个瓶颈完成参数优化。为这个原因,一条新途径在这份报纸,支持向量机器在被用来起初构造反应表面被建议。然后,它与 Sobol 方法集成基于 SVM 的反应表面,即 RSMSobol 方法,确定参数敏感。在这个工作,分布式的时间变体获得模型(DTVGM ) 被用于 Huaihe 河盆,它被用作一个盒子验证它的有效性和可行性。我们选择了三个客观函数(即水平衡系数 WB, Nash-Sutcliffe 效率系数 NS,和关联系数 RC ) 为敏感分析作为输出回答估计模型性能。参数 g1 和 g2 为所有目的是很重要的结果表演工作,并且他们是几乎对古典途径的一样。而且, RSMSobol 方法不能仅仅完成敏感的 quantification,并且也减少计算费用,与与古典途径相比的好精确性。并且这条途径将在为一个复杂建模系统的全球敏感分析有效、可靠。 | SONG Xiaomeng ZHAN Chesheng XIA Jun KONG Fanzhe | 2012 | Journal of Geographical Sciences2012，22，2： | 12 |
| 19 | Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding显示文摘 | Jiping Yang Jingyi Li Keiichiro Suzuki Xiaomeng Liu Jun Wu Weiqi Zhang Ruotong Ren Weizhou Zhang Piu Chan Juan Carlos Izpisua Belmonte Jing Qu Fuchou Tang Guang-Hui Liu | 2017 | Cell Research2017，27，9： | 12 |
| 20 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders:executive summary and 2019 update of the management of high-risk population显示文摘Aim Cerebrovascular disease is the leading cause of death and disability in China,causing a huge burden among patients and their families.Hence,stroke prevention is critical,especially in the high-risk population.Here,we present the evidence-based guideline suitable for the Chinese population.Methods Literature search of PubMed and Cochrane library(from January 1964 to June 2019)was done.After thorough discussion among the writing group members,recommendations were listed and summarised.This guideline was reviewed and discussed by the fellow writing committees of the Chinese Stroke Association’s Stroke.Results This evidence-based guideline was written in three parts:controlling the risk factors of stroke,utilisation of antiplatelet agents and assessing the risks of first-ever stroke.All recommendations were listed along with the recommending classes and levels of evidence.Conclusions This guideline provides recommendations for primary prevention of cerebrovascular disease among high-risk population in China.Controlling related risk factors,appropriately using antiplatelet agents,assessing the risk of developing first-ever stroke should help reduce the rate of cerebrovascular disease in China. | Yilong Wang Shangrong Han Haiqiang Qin Huaguang Zheng Bin Jiang Yong Cao Yuan Gao Ling Guan Qian Jia Yong Jiang Yuming Jiao Shuya Li Yapeng Li Zixiao Li Wei Liu Xiaojuan Ru Dongling Sun Haixin Sun Penglian Wang Tingting Wang Lixia Zong Lei Guo Xuewei Xie Yuming Xu Yuyuan Xu Xiaomeng Yang Yingying Yang Mengyuan Zhou Wenzhi Wang Chinese Stroke Association Stroke Council Guideline Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，3： | 11 |
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