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| 1 | Pretreatment with scutellaria baicalensis stem-leaf total flavonoid prevents cerebral ischemia-reperfusion injury显示文摘Pretreatment with scutellaria baicalensis stem-leaf total flavonoid has protective effects against ischemia and attenuates myocardial ischemia-reperfusion injury.In this study,rats were given scutellaria baicalensis stem-leaf total flavonoid intragastrically at 50,100,and 200 mg/kg per day for7 days before focal cerebral ischemia-reperfusion injury models were established using the suture method.We then determined the protective effects of scutellaria baicalensis stem-leaf tota flavonoid pretreatment on focal cerebral ischemia-reperfusion injury.Results showed that neurological deficit scores increased,infarct volumes enlarged,apoptosis increased and Bcl-2 and Bax protein expression were upregulated at 24 hours after reperfusion.Pretreatment with scutellaria baicalensis stem-leaf total flavonoid at any dose lowered the neurological deficit scores reduced the infarct volume,prevented apoptosis in hippocampal cells,attenuated neuronal and blood-brain barrier damage and upregulated Bcl-2 protein expression but inhibited Bax protein expression.Doses of 100 and 200 mg/kg were the most efficacious.Our findings indicate that pretreatment with scutellaria baicalensis stem-leaf total flavonoid at 100 and 200 mg/kg can improve the neurological functions and have preventive and protective roles after focal cerebra ischemia-reperfusion injury. | Shumin Zhao Wei Kong Shufeng Zhang Meng Chen Xiaoying Zheng Xiangyu Kong | 2013 | Neural Regeneration Research2013，8，34： | 11 |
| 2 | Transcriptional Regulation of miR528 by OsSPL9 Orchestrates Antiviral Response in Rice显示文摘Many microRNAs (miRNAs) are critical regulators of plant antiviral defense.However,little is known about how these miRNAs respond to virus invasion at the transcriptional level.We previously show that defense against Rice stripe virus (RSV) invasion entailed a reduction of miR528 accumulation in rice,alleviating miR528-mediated degradation of L-Ascorbate Oxidase (AO) mRNA and bolstering the antiviral activity of AO.Here we show that the miR528-A0 defense module is regulated by the transcription factor SPL9.SPL9 displayed high-affinity binding to specific motifs within the promoter region of miR528 and activated the expression of miR528 gene in vivo.Loss-of-function mutations in SPL9 caused a significant reduction in miR528 accumulation but a substantial increase of AO mRNA,resulting in enhanced plant resistance to RSV.Conversely,transgenic overexpression of SPL9 stimulated the expression of miR528 gene,hence lowering the level of AO mRNA and compromising rice defense against RSV.Importantly,gain in RSV susceptibility did not occur when SPL9 was overexpressed in mir528 loss-of-function mutants,or in transgenic rice expressing a miR528-resistant AO.Taken together,the finding of SPL9-mediated transcriptional activation of miR528 expression adds a new regulatory layer to the miR528-A0 antiviral defense pathway. | Shengze Yao Zhirui Yang Rongxin Yang Yu Huang Ge Guo Xiangyue Kong Ying Lan Tong Zhou He Wang Wenming Wang Xiaofeng Cao Jianguo Wu Yi Li | 2019 | Molecular Plant2019，12，8： | 10 |
| 3 | Pretreatment with scutellaria baicalensis stem-leaf total flavonoid protects against cerebral ischemia/reperfusion injury in hippocampal neurons显示文摘Previous experimental studies have shown that cerebral infarction can be effectively reduced following treatment with scutellaria baicalensis stem-leaf total flavonoid(SSTF). However, the mechanism of action of SSTF as a preventive drug to treat cerebral infarction remains unclear. In this study, Sprague-Dawley rats were pretreated with 50, 100, 200 mg/kg SSTF via intragastric administration for 1 week prior to the establishment of focal cerebral ischemia/reperfusion injury. The results showed that pretreatment with SSTF effectively improved neurological function, reduced brain water content and the permeability of blood vessels, ameliorated ischemia-induced morphology changes in hippocampal microvessels, down-regulated Fas and Fas L protein expression, elevated the activity of superoxide dismutase and glutathione peroxidase, and decreased malondialdehyde content. In contrast to low-dose SSTF pretreatment, the above changes were most obvious after pretreatment with moderate- and high-doses of SSTF. Experimental findings indicate that SSTF pretreatment can exert protective effects on the brain against cerebral ischemia/reperfusion injury. The underlying mechanisms may involve reducing brain water content, increasing microvascular recanalization, inhibiting the apoptosis of hippocampal neurons, and attenuating free radical damage. | Xiangyu Kong Wei Kong Guangxin Miao Shumin Zhao Meng Chen Xiaoying Zheng Jiangtao Bai | 2014 | Neural Regeneration Research2014，9，23： | 7 |
| 4 | Design and immunogenicity assessment of HIV-1 virus-like particles as a candidate vaccine显示文摘The rapid growth of the global HIV/AIDS epidemic makes it a high priority to develop an effective vaccine.Since a live attenuated or inactivated HIV vaccine is not likely to be approved for clinical application due to safety concerns,HIV virus like particles(VLPs) offer an attractive alternative because they are considered safer since they lack viral genome.We got a stable eukaryotic cell line by G418 resistance selection,engineered to express the HIV-1 structure protein Gag and Env efficiently and stably.We confirmed the presence of Gag and Env proteins in the cell culture supernatant and that they could self-assemble into VLPs.These VLPs were found to be able to elicit specific humoral and cellular immune response after immunization without any adjuvant. | ZHANG XiZhen WANG XiaoDan ZHAO DongHai MENG XiangYu ZHAO XingHong YU XiangHui KONG Wei | 2011 | Science China(Life Sciences)2011，54，11： | 4 |
| 5 | Molecular Epidemiological Characteristics of Gastroenteritis Outbreaks Caused by Norovirus GII.4 Sydney[P31]Strains—China,October 2016–December 2020显示文摘Introduction:Human noroviruses are the leading cause of acute viral gastroenteritis(AGE)worldwide in all age groups.GII.4 strains have been the predominant genotype circulating globally over the last 2 decades and since 2012.GII.4 Sydney viruses have emerged and caused the majority of AGE outbreaks worldwide.Methods:Data from norovirus outbreaks from the laboratory-based surveillance of norovirus outbreaks in China(CaliciNet China)between October 2016–December 2020 were analyzed.Results:During October 2016–December 2020,1,954 norovirus outbreaks were reported,and positive fecal samples from 1,352(69.19%)outbreaks were genotyped.GII.4 Sydney[P31]viruses accounted for 2.1%(October 2016–August 2017),5.5%(September 2017–August 2018),3.3%(September 2018–August 2018),26.6%(September 2019–August 2020),and and 1.1%(September 2020–December 2020)of GII outbreaks,respectively.Compared to reference strains of GII.4 Sydney[P31]from 2012 to 2013,7 amino acid mutations in epitopes[A(297,372 and 373),B(333),E(414),and H(309 and 310)]and 1 in human histo-blood group antigens binding site at site II 372 were found by analyzing 9 GII.4 Sydney[P31]complete genomic sequences.Conclusions:This report identified the genomic variation of GII.4 Sydney[P31]from CaliciNet China.Continued surveillance with prompt genotyping and genetic analysis is necessary to monitor the emergence of novel GII.4 variants. | Xi Zhu Yaqing He Xingyan Wei Xiangyu Kong Qing Zhang Jingxin Li Miao Jin Zhaojun Duan | 2021 | China CDC weekly2021，3，53： | 3 |
| 6 | Coupled Cross-correlation Neural Network Algorithm for Principal Singular Triplet Extraction of a Cross-covariance Matrix显示文摘This paper proposes a novel coupled neural network learning algorithm to extract the principal singular triplet(PST)of a cross-correlation matrix between two high-dimensional data streams. We firstly introduce a novel information criterion(NIC),in which the stationary points are singular triplet of the crosscorrelation matrix. Then, based on Newton's method, we obtain a coupled system of ordinary differential equations(ODEs) from the NIC. The ODEs have the same equilibria as the gradient of NIC, however, only the first PST of the system is stable(which is also the desired solution), and all others are(unstable)saddle points. Based on the system, we finally obtain a fast and stable algorithm for PST extraction. The proposed algorithm can solve the speed-stability problem that plagues most noncoupled learning rules. Moreover, the proposed algorithm can also be used to extract multiple PSTs effectively by using sequential method. | Xiaowei Feng Xiangyu Kong Hongguang Ma | 2016 | IEEE/CAA Journal of Automatica Sinica2016，3，2： | 2 |
| 7 | Calibration of Mars Energetic Particle Analyzer (MEPA)显示文摘The first Mars exploration mission of China(Tianwen-1)is scheduled to be launched in 2020;a charged particle telescope,the Mars Energetic Particle Analyzer(MEPA),is carried as one of the payloads on the orbiter.The MEPA is designed to measure solar energetic particles(SEPs)and galactic cosmic rays(GCRs)in the near-Mars space and in the transfer orbit from Earth to Mars.Before the launch,the MEPA was calibrated in ground experiments with radioactive sources,electronic pulses,and accelerator beams.The calibration parameters,such as energy conversion constants,threshold values for the triggers,and particle identification criteria,were determined and have been stored for onboard use.The validity of the calibration parameters has been verified with radioactive sources and beams.The calibration results indicate that the MEPA can measure charged particles reliably,as designed,and that it can satisfy the requirements of the Tianwen-1 mission. | ShuWen Tang Yi Wang HongYun Zhao Fang Fang Yi Qian YongJie Zhang HaiBo Yang CunHui Li Qiang Fu Jie Kong XiangYu Hu Hong Su ZhiYu Sun YuHong Yu BaoMing Zhang Yu Sun ZhiPeng Sun | 2020 | Earth and Planetary Physics2020，4，4： | 2 |
| 8 | Modified gradient algorithm for total least square filtering显示文摘 | Xiangyu Kong Chongzhao Han Ruixuan Wei | 2006 | Neu- rocomputing2006，70，： | 1 |
| 9 | Multi-agent Simulation for Strategic Bidding in Electricity Markets Using Reinforcement Learning显示文摘In this paper,a theoretical framework of Multiagent Simulation(MAS)is proposed for strategic bidding in electricity markets using reinforcement learning,which consists of two parts:one is a MAS system used to simulate the competitive bidding of the actual electricity market;the other is an adaptive learning strategy bidding system used to provide agents with more intelligent bidding strategies.An ExperienceWeighted Attraction(EWA)reinforcement learning algorithm(RLA)is applied to the MAS model and a new MAS method is presented for strategic bidding in electricity markets using a new Improved EWA(IEWA).From both qualitative and quantitative perspectives,it is compared with three other MAS methods using the Roth-Erev(RE),Q-learning and EWA.The results show that the performance of the MAS method using IEWA is proved to be better than the others.The four MAS models using four RLAs are built for strategic bidding in electricity markets.Through running the four MAS models,the rationality and correctness of the four MAS methods are verified for strategic bidding in electricity markets using reinforcement learning. | Jidong Wang Jiahui Wu Xiangyu Kong | 2023 | CSEE Journal of Power and Energy Systems2023，9，3： | 1 |
| 10 | Monitoring of Gene Expression Profiles and Isolation of Candidate Genes Involved in Pollination and Fertilization in Rice (Oryza Sativa L.) with a 10K cDNA Microarray显示文摘 | Lefu Lan Wei Chen Ying Lai Jinfeng Suo Zhaosheng Kong Can Li Ying Lu Yujun Zhang Xiangyu Zhao Xiansheng Zhang Yansheng Zhang Bin Han Jing Cheng Yongbiao Xue | 2004 | Plant Molecular Biology2004，，4： | 1 |
| 11 | Disruption of Klf4 in Villin-Positive Gastric Progenitor Cells Promotes Formation and Progression of Tumors of the Antrum in Mice显示文摘 | Qiang Li Zhiliang Jia Li Wang Xiangyu Kong Qi Li Kun Guo Dongfeng Tan Xiangdong Le Daoyan Wei Suyun Huang Lopa Mishra Keping Xie | 2012 | Gastroenterology2012，，3： | 1 |
| 12 | Convergence analysis of mller algorithm for estimating minor component显示文摘 | GAO Yingbin KONG Xiangyu HU Changhua | 2015 | Neural Processing Letters2015，42，2： | 1 |
| 13 | Trajectory Tracking Control for Under-Actuated Hovercraft Using Differential Flatness and Reinforcement Learning-Based Active Disturbance Rejection Control显示文摘This paper proposes a scheme of trajectory tracking control for the hovercraft.Since the model of the hovercraft is under-actuated,nonlinear,and strongly coupled,it is a great challenge for the controller design.To solve this problem,the control scheme is divided into two parts.Firstly,we employ differential flatness method to find a set of flat outputs and consider part of the nonlinear terms as uncertainties.Consequently,we convert the under-actuated system into a full-actuated one.Secondly,a reinforcement learning-based active disturbance rejection controller(RL-ADRC)is designed.In this method,an extended state observer(ESO)is designed to estimate the uncertainties of the system,and an actorcritic-based reinforcement learning(RL)algorithm is used to approximate the optimal control strategy.Based on the output of the ESO,the RL-ADRC compensates for the total uncertainties in real-time,and simultaneously,generates the optimal control strategy by RL algorithm.Simulation results show that,compared with the traditional ADRC method,RL-ADRC does not need to manually tune the controller parameters,and the control strategy is more robust. | KONG Xiangyu XIA Yuanqing HU Rui LIN Min SUN Zhongqi DAI Li | 2022 | Journal of Systems Science & Complexity2022，35，2： | 1 |
| 14 | Monitoring of Gene Expression Profiles and Isolation of Candidate Genes Involved in Pollination and Fertilization in Rice (Oryza Sativa L.) with a 10K cDNA Microarray显示文摘 | Lefu Lan Wei Chen Ying Lai Jinfeng Suo Zhaosheng Kong Can Li Ying Lu Yujun Zhang Xiangyu Zhao Xiansheng Zhang Yansheng Zhang Bin Han Jing Cheng Yongbiao Xue | 2004 | Plant Molecular Biology2004，，4： | 1 |
| 15 | Monitoring of Gene Expression Profiles and Isolation of Candidate Genes Involved in Pollination and Fertilization in Rice (Oryza Sativa L.) with a 10K cDNA Microarray显示文摘 | Lefu Lan Wei Chen Ying Lai Jinfeng Suo Zhaosheng Kong Can Li Ying Lu Yujun Zhang Xiangyu Zhao Xiansheng Zhang Yansheng Zhang Bin Han Jing Cheng Yongbiao Xue | 2004 | Plant Molecular Biology2004，，4： | 1 |
| 16 | One-step method for preparing the experimental pure state in nuclear magnetic resonance显示文摘Quantum computing is an emerging and promising research field in modern quantum physics and is committed to accelerating traditional calculation processes using the principle of quantum mechanics[1,2].Several computation models have been proposed,including the circuit model[3],topologic quantum computation[4],adiabatic quantum computing[5],and duality quantum computing[6-8].Universal quantum computation generally includes a system initialization,evolutionary control,and a final-state readout[9],where the preparation of the initial state is a key step in the entire process. | JingWei Wen XiaoCong Qiu XiangYu Kong XinYu Chen Fan Yang GuiLu Long | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，3： | 0 |
| 17 | Sub-nanotesla sensitivity at the nanoscale with a single spin显示文摘High-sensitivity detection of the microscopic magnetic field is essential in many fields.Good sensitivity and high spatial resolution are mutually contradictory in measurement,which is quantified by the energy resolution limit.Here we report that a sensitivity of 0.5 nT/(Hz)(1/2)at the nanoscale is achieved experimentally by using nitrogen-vacancy defects in diamond with depths of tens of nanometers.The achieved sensitivity is substantially enhanced by integrating with multiple quantum techniques,including real-time-feedback initialization,dynamical decoupling with shaped pulses and repetitive readout via quantum logic.Our magnetic sensors will shed new light on searching new physics beyond the standard model,investigating microscopic magnetic phenomena in condensed matters,and detection of life activities at the sub-cellular scale. | Zhiyuan Zhao Xiangyu Ye Shaoyi Xu Pei Yu Zhiping Yang Xi Kong Ya Wang Tianyu Xie Fazhan Shi Jiangfeng Du | 2023 | National Science Review2023，10，12： | 0 |
| 18 | A telomere-to-telomere genome assembly of Zhonghuang 13,a widely-grown soybean variety from the original center of Glycine max显示文摘Soybean(Glycine max)stands as a globally significant agricultural crop,and the comprehensive assembly of its genome is of paramount importance for unraveling its biological characteristics and evolutionary history.Nevertheless,previous soybean genome assemblies have harbored gaps and incompleteness,which have constrained in-depth investigations into soybean.Here,we present Telomere-to-Telomere(T2T)assembly of the Chinese soybean cultivar Zhonghuang 13(ZH13)genome,termed ZH13-T2T,utilizing PacBio Hifi and ONT ultralong reads.We employed a multi-assembler approach,integrating Hifiasm,NextDenovo,and Canu,to minimize biases and enhance assembly accuracy.The assembly spans 1,015,024,879 bp,effectively resolving all 393 gaps that previously plagued the reference genome.Our annotation efforts identified 50,564 high-confidence protein-coding genes,707 of which are novel.ZH13-T2T revealed longer chromosomes,421 not-aligned regions(NARs),112 structure variations(SVs),and a substantial expansion of repetitive element compared to earlier assemblies.Specifically,we identified 25.67 Mb of tandem repeats,an enrichment of 5S and 48S rDNAs,and characterized their genotypic diversity.In summary,we deliver the first complete Chinese soybean cultivar T2T genome.The comprehensive annotation,along with precise centromere and telomere characterization,as well as insights into structural variations,further enhance our understanding of soybean genetics and evolution. | Anqi Zhang Tangchao Kong Baiquan Sun Shizheng Qiu Jiahe Guo Shuyong Ruan Yu Guo Jirui Guo Zhishuai Zhang Yue Liu Zheng Hu Tao Jiang Yadong Liu Shuqi Cao Shi Sun Tingting Wu Huilong Hong Bingjun Jiang Maoxiang Yang Xiangyu Yao Yang Hu Bo Liu Tianfu Han Yadong Wang | 2024 | The Crop Journal2024，12，1： | 0 |
| 19 | Framework of Decentralized Multi-chain Data Management for Power Systems显示文摘With the wide application of advanced information and communication technology(ICT),power systems are becoming more reliable,more efficient and self-healing.Meanwhile more sophisticated cyber-attacks have appeared,e.g.false data injection(FDI)attacks,which deeply affect the state estimation of power systems and can lead to destructive consequences.To better manage and protect measurement data in power systems,we propose a blockchain-based multi-chain framework,taking advantage of the existing infrastructure.In this framework,measurements from sensors are mined into blocks by base stations using Practical Byzantine Fault Tolerance(PBFT)as the consensus protocol.We analyze the security of the proposed framework and carry out simulations to show its superiority compared to existing systems.The result of the simulations further provides guidance for how to structure the networking in the proposed framework. | Xiangyue Kong Jiyuan Zhang Hao Wang Jie Shu | 2020 | CSEE Journal of Power and Energy Systems2020，6，2： | 0 |
| 20 | Investigation of Movement and Deposition Behaviors of Solid Particles in Hydraulic Water Reservoir via the CFD‑DEM Coupling Method显示文摘Solid contamination existing as solid particles in power fluid transmission systems may lead to transmission performance reduction,system failures,and component damage.The hydraulic reservoir will deposit the contamination and store hydraulic fluid.To investigate its purification ability for solid contamination,experiments and simulations for the motion and deposition status of the typical hydraulic system particles are carried out to reveal the interaction of particles and fluid in hydraulic water reservoirs.The results show that the CFD-DEM coupling method could predict the accurate deposition position of iron particles and sand particles when ignoring the small-scale turbulence effect in the flow field.Besides,the particle motion traces and deposition patterns in the reservoir illustrate that the flow development on the bottom surface results in the particles turning,and particles tend to settle in the low flow energy position.The motion of particles is also linked to particles Stokes number,and the same-size sand particles are easily driven by the fluid.The contribution of this paper could provide a guide for predicting the particle motion and deposition pattern in the hydraulic reservoir. | Mandi Li Decai Kong Qi Guo Xiangyu Liu Jing Yao Jianjun Hu Lijuan Chen | 2022 | Chinese Journal of Mechanical Engineering2022，35，6： | 0 |
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