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| 1 | Differential water use strategies among selected rare and endangered species in West Ordos Desert of China显示文摘Aims West Ordos Desert(WOD)in Inner Mongolia of China is charac-terized by unique geographical and ecological features to avoid the direct invasion of Quaternary Continental Glaciation,so it hosts many endangered relic species such as Tetraena mongol-ica,Ammopiptanthus mongolicus and Potaninia mongolica from Tertiary.However,how these plants utilize available water sources remains unknown.The objective of this study was to investigate the water utilization strategies of selected rare and endangered plant species in WOD by comparing hydrogen isotope ratios between their xylem water and possible water sources following four rainfall events of varying-intensities.Methods We measured the hydrogen isotope ratios of xylem water from T.mongolica,A.mongolicus and P.mongolica and an accom-panying species Sarcozygium xanthoxylum and potential water sources(including precipitation and soil water in different soil layers from 0 to 150 cm)over 9 days following each of four varying-intensity rainfall events during the summer of 2012.And then calculated the percentage utilization of potential water sources by each species after each rainfall events using the linear mixing model.We also made the measurements of soil moisture and root biomass in favor of interpretation of plant water use strategies.Important Findings Tetraena mongolica,A.mongolicus and S.xanthoxylum primarily relied on deep soil water,whereas P.mongolica depended predomi-nantly on rainwater.These rare and endangered desert plants had differential utilizations of available water sources,so some com-petition for limited water existed among some species.Tetraena mongolica had a competitive relationship in absorption of soil moisture with the same family species S.xanthoxylum,suggesting that T.mongolica and S.xanthoxylum should be restored separately at different areas in the WOD.Overall,this study provides a better understanding of water use strategies of these four plants and scien-tific evidence for protecting rare and endangered plants,maintain-ing regional species diversity,and developing effective vegetation restoration plans in the WOD. | Jie Chen Qing Xu Deqiang Gao Aiyun Song Yuguang Hao Yingbin Ma | 2017 | Journal of Plant Ecology2017，10，4： | 9 |
| 2 | Liensinine induces gallbladder cancer apoptosis and G2/M arrest by inhibiting ZFX-induced PI3K/AKT pathway显示文摘Gallbladder carcinoma (GBC) is the most comm on and aggressive can cer of the biliary tract. Liensinine has been proved to have hypotensive effect. However, the effect of liensinine on GBC is still unknown. The aim of this study is to investigate the effect and mechanism of liensinine in human GBC cells. Cell viability assay and colony formation assay were performed to assess cell growth and proliferation. Flow cytometry analysis was used to investigate cell cycle apoptosis in vitro. Hoechst 33342 staining was also used to evaluate cell apoptosis. Western blot analysis was used to determine the expression of proteins corresponding to the related cell cycle and apoptosis.The effect of liensinine treatment in vivo was experimented with xenografted tumors. We found that liensinine significantly inhibited the growth of GBC cells both in vivo and in vitro. In vitro, cell growth and proliferation were significantly suppressed by liensinine in a dose- and time-dependent manner. In vivo, liensinine inhibited tumor growth. Liensinine could induce GBC cells G2/M phase arrest by up-regulating the levels of Cyclin B1 and CDK1 proteins. Liensinine also affected GBC cell cycle progress!on and induced apoptosis by down-regulating phosphorylated protein kinase B (AKT), phosphorylated protein kinase B (p-AKT), phosphatidylinositol 3-kinase (PI3K), and Zinc finger X-chromosomal protein (ZFX) proteins. Liensinine induced G2/M arrest and apoptosis in gallbladder cancer, suggest!ng that liensinine might represent a novel and effective agent against gallbladder cancer. | Yitong Shen Rui Bian Yaxiong Li Yuan Gao Yingbin Liu Yuzhen Xu Xiaoling Song Yijian Zhang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 4 |
| 3 | Induction of metallothionein expression during monocyte to melanoma-associated macrophage differentiation显示文摘联系肿瘤的巨噬细胞(TAM ) 在黑瘤生长和转移起一个关键作用。TAM 的渗入与黑瘤的差的预后相关。TAM 响应肿瘤微型环境暗示被区分开来与单核白血球。然而,机制 TAM 怎么从单核白血球在区别以后适应肿瘤微型环境,充分没被理解。另外,因为大多数的表示通常使用了巨噬细胞标记,在黑瘤的 TAM 的特定的鉴定是困难的, CD68,也在黑瘤房间被表示。在更早的研究,我们由基因 microarray 分析发现家庭是的 metallothionein (MT ) 的七个成员在调节黑瘤的媒介的 upregulated 导致了巨噬细胞(MCIM-M ) 。MT 在锌新陈代谢和发炎被含有。在现在的学习,我们证实 metallothionein 的那表情在 M-CSF 被导致区分的巨噬细胞(M-CSF/M ) 和在用即时 PCR, immunofluorescence,和西方的污点分析的 mRNA 和蛋白质层次的 MCIM-M。而且,我们在 vivo 在黑瘤纸巾表明了 metallothionein 的存在,那 metallothionein 与 TAM 标记, CD68 和 CD163 是 co 局部性的。最后,我们在 M-CSF/M 和 MCIM-M 两个都表明了锌进口商基因 Zip8 的正式就职。我们的学习为 TAM 作为一个新奇标记识别 metallothionein 并且建议 metallothionein 可能在肿瘤微型环境在巨噬细胞改编和功能起重要作用。 | Yingbin GE Rikka AZUMA Bethsebah GEKONGE Alfonso LOPEZ-CORAL Min XIAO Gao ZHANG Xiaowei XU Luis J. MONTANER Zhi WEI Meenhard HERLYN Tao WANG Russel E. KAUFMAN | 2012 | Frontiers in Biology2012，7，4： | 2 |
| 4 | Convergence analysis of mller algorithm for estimating minor component显示文摘 | GAO Yingbin KONG Xiangyu HU Changhua | 2015 | Neural Processing Letters2015，42，2： | 1 |
| 5 | Regulation of BMP2K in AP2M1-mediated EGFR internalization during the development of gallbladder cancer显示文摘Dear Editor,Gallbladder cancer(GBC),the most common malignant tumor of the biliary tract,is a highly invasive form of cancer.Surgical resection is currently the first line approach to effectively treat GBC;however,very few patients have the opportunity to receive radical surgical treatment due to lack of obvious symptoms.1 The median survival of patients with GBC is only 12 months and 5-year survival rate is<5%,indicating GBC is extremely poor prognosis.Therefore,it is urgent to identify novel key molecules that can potentially serve as early diagnostic biomarkers and/or therapeutic targets.The current study focused on the potential role of bone morphogenetic protein 2 inducible kinase(BMP2K),a serine/threonine kinase,which was recently identified as clathrin-coated vesicle-associated protein in the development of GBC;the outcome may hold diagnostic and therapeutic promising for clinical practice. | Xiaoling Song Maolan Li Wenguang Wu Wei Dang Yuan Gao Rui Bian Runfa Bao Yunping Hu Defei Hong Jun Gu Yingbin Liu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 6 | A Novel mRNA Signature Related to Immunity to Predict Survival and Immunotherapy Response in Hepatocellular Carcinoma显示文摘Background and Aims:Hepatocellular carcinoma(HCC)is the most common primary liver cancer and the incidence and mortality rates are increasing.Given the limited treatments of HCC and promising application of immunotherapy for cancer,we aimed to identify an immune-related prognostic signature that can predict overall survival(OS)rates and immunotherapy response in HCC.Methods:The initial signature development was conducted using a training dataset from the Cancer Genome Atlas followed by independent internal and external validations from that resource and the Gene Expression Omnibus.A signature based nomogram was generated using multivariate Cox regression analysis.The associations of signature score with tumor immune phenotype and response to immunotherapy were analyzed using single-sample gene set enrichment analysis and tumor immune dysfunction and exclusion algorithm.A cohort from Zhongshan Hospital was employed to verify the pre dictive robustness of the signature regarding prognostic risk and immunotherapy response.Results:The prognostic signature,IGS_(HCC),consisting of 22 immune-related genes,had independent prognostic ability,with training and validation cohorts.Also,IGS_(HCC)stratified HCC patients with different outcomes in subgroups.The prognostic accuracy of IGS_(HCC)was better than three reported prognostic signatures.The IGS_(HCC)-based nomogram had high accuracy and significant clinical benefits in predicting 3-and 5-year OS.IGS_(HCC)reflected distinct immunosuppressive phenotypes in low-and high-score groups.Patients with low IGS_(HCC)scores were more likely than those with high scores to benefit from immunotherapy.Conclusions:IGS_(HCC)predicted HCC prognosis and response to immunotherapy,and contributed to individualized clinical management. | Chenhao Zhou Jialei Weng Yuan Gao Chunxiao Liu Xiaoqiang Zhu Qiang Zhou Chia-Wei Li Jialei Sun Manar Atyah Yong Yi Qinghai Ye Yi Shi Qiongzhu Dong Yingbin Liu Mien-Chie Hung Ning Ren | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 1 |
| 7 | Downregulated expression of hepatoma-derived growth factor (HDGF) reduces gallbladder cancer cell proliferation and invasion显示文摘 | Maolan Li Jun Shen Xiangsong Wu Bingtai Zhang Rui Zhang Hao Weng Qian Ding Zhujun Tan Guofeng Gao Jiasheng Mu Jiahua Yang Yijun Shu Runfa Bao Qichen Ding Wenguang Wu Yang Cao Yingbin Liu | 2013 | Medical Oncology2013，，2： | 1 |
| 8 | Influences of environmental factors on the spawning stock-recruitment relationship of Portunus trituberculatus in the northern East China Sea显示文摘Based on the Ricker-type models,the spawning stock-recruitment(S-R)relationship of Portunus trituberculatus was analysed under the impacts of environmental factors(including red tide area(AORT),sea level height(SLH),sea surface salinity(SSS)and typhoon landing times(TYP))in the northern East China Sea in 2001 and 2014.Besides the traditional Ricker model,two other Ricker-type S-R models were built:Ricker model with ln-linear environmental impact(Ricker-type 2)and Ricker model with ln-quadratic polynomial environmental impact(Ricker-type 3).Results showed that AORT,SLH,SSS and TYP had great influences on the recruitment of P.trituberculatus.When SSS reached 29 and 31,recruitment decreased from 20.7×10^(3) million to 8.3×10^(3) million individuals.In this case,recruitment declined,whereas AORT and TYP increased.Analysis of the S-R model showed that the Akaike information criterion(AIC)value of the traditional Ricker model was 14.619,which remarkably decreased after addition of the environmental factors.Different numbers of environmental factors were added to the Ricker model,and the best result was obtained when four factors were added to the model together.Moreover,Ricker-type 2 model,with the AIC value of-5.307,was better than Ricker-type 3 model(add above four environmental factors at the same time).The findings indicated that the mechanisms by which various environmental factors affect the S-R relationship are different. | Li Gao Yingbin Wang | 2021 | Acta Oceanologica Sinica2021，40，8： | 1 |
| 9 | Convergence Analysis of a Self-Stabilizing Algorithm for Minor Component Analysis显示文摘The M?ller algorithm is a self-stabilizing minor component analysis algorithm.This research document involves the study of the convergence and dynamic characteristics of the M?ller algorithm using the deterministic discrete time(DDT)methodology.Unlike other analysis methodologies,the DDT methodology is capable of serving the distinct time characteristic and having no constraint conditions.Through analyzing the dynamic characteristics of the weight vector,several convergence conditions are drawn,which are beneficial for its application.The performing computer simulations and real applications demonstrate the correctness of the analysis’s conclusions. | Haidi Dong Yingbin Gao Gang Liu | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，6： | 0 |
| 10 | Adaptive Generalized Eigenvector Estimating Algorithm for Hermitian Matrix Pencil显示文摘Generalized eigenvector plays an essential role in the signal processing field.In this paper,we present a novel neural network learning algorithm for estimating the generalized eigenvector of a Hermitian matrix pencil.Differently from some traditional algorithms,which need to select the proper values of learning rates before using,the proposed algorithm does not need a learning rate and is very suitable for real applications.Through analyzing all of the equilibrium points,it is proven that if and only if the weight vector of the neural network is equal to the generalized eigenvector corresponding to the largest generalized eigenvalue of a Hermitian matrix pencil,the proposed algorithm reaches to convergence status.By using the deterministic discretetime(DDT)method,some convergence conditions,which can be satisfied with probability 1,are also obtained to guarantee its convergence.Simulation results show that the proposed algorithm has a fast convergence speed and good numerical stability.The real application demonstrates its effectiveness in tracking the optimal vector of beamforming. | Yingbin Gao | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，11： | 0 |
| 11 | Scalable synthesized high-performance TiO_(2)-Si-C hybrid anode for lithium batteries显示文摘At present,developing a simple strategy to effectively solve the shackles of volume expansion,poor conductivity and interface compatibility faced by Si-C anode in lithium batteries(LIBs)is the key to its commercialization.Here,low-cost nano-Si powders were prepared from Si-waste of solar-cells by sanding treatment,which can effectively reduce the commercialization cost for Si-C anode.Furthermore,micro-nano structured Gr@Si/C/TiO_(2) anode materials with graphite(Gr)as the inner core,TiO_(2)-doped and carbon-coated Si as the outer coating-layer,were synthesized at kilogram-scale per milling batch.Comprehensive characterization results indicate that TiO_(2)-doped carbon layer can improve the interface compatibility with the electrolyte,further promote the reduction of electrode polarization,and finally enhance the battery performance for the Gr@Si/C/TiO_(2) anodes.Accordingly,Gr@Si/C/TiO_(2) composites can output excellent LIB performance,especially with high initial coulombic efficiency(ICE)of 82.51%and large average reversible capacity of~810 mA h g^(-1) at 0.8 A g^(-1) after 1000 cycles.Moreover,Gr@Si/C/TiO_(2)‖NCM811 pouch full cells deliver impressive performance especially with high energy density of~489.3 W h kg^(-1) based on the total weight of active materials,suggesting its promising application in the high performance LIBs. | Liao Shen Chengjie Xu Jingguo Gao Jianming Tao Qiaobao Zhang Yue Chen Yingbin Lin Zhigao Huang Jiaxin Li | 2023 | Journal of Energy Chemistry2023，，2： | 0 |
| 12 | Easily Obtaining Excellent Performance High-voltage LiCoO_(2)via Pr_(6)O_(11)Modification显示文摘Developing an effective method to synthesize high-performance high-voltage LiCoO_(2) is essential for its industrialization in lithium batteries(LIBs).This work proposes a simple mass-produced strategy for the first time,that is,negative temperature coefficient thermosensitive Pr_(6)O_(11) nanoparticles are uniformly modified on LiCoO_(2) to prepare LiCoO_(2)@Pr_(6)O_(11)(LCO@PrO)via a liquid-phase mixing combined with annealing method.Tested at 274 mA g−1,the modified LCO@PrO electrodes deliver excellent 4.5 V high-voltage cycling performance with capacity retention ratios of 90.8%and 80.5%at 25 and 60℃,being much larger than those of 22.8%and 63.2%for bare LCO electrodes.Several effective strategies were used to clearly unveil the performance enhancement mechanism induced by Pr_(6)O_(11) modification.It is discovered that Pr_(6)O_(11) can improve interface compatibility,exhibit improved conductivity at elevated temperature,thus enhance the Li^(+)diffusion kinetics,and suppress the phase transformation of LCO and its resulting mechanical stresses.The 450 mAh LCO@PrO‖graphite pouch cells show excellent LIB performance and improved thermal safety characteristics.Importantly,the energy density of such pouch cell was increased even by~42%at 5 C.This extremely convenient technology is feasible for producing high-energy density LIBs with negligible cost increase,undoubtedly providing important academic inspiration for industrialization. | Yongcong Huang Chenjie Xu Jingguo Gao Liao Shen Qian Liu Guiying Zhao Qingshui Xie Yingbin Lin Jiaxin Li Zhigao Huang | 2023 | Energy & Environmental Materials2023，6，2： | 0 |
| 13 | Preliminary Study of Oxidative Stress in Human Hepatocellular Carcinoma and Adjacent Normal Liver Tissues显示文摘OBJECTIVE The antioxidative system in human hepatocellular carcinoma was investigated. METHODS The activities of cytosolic catalase (CAT), superoxide dismu-tase, glutathione peroxidase (GSH-Px), glutathione S-tranferase and levels of reduced glutathione, total protein thiols and malondialdehyde were assayed in 10 cases of hepatocellular carcinoma and adjacent normal liver. RESULTS Hepatoma tissues showed higher activities of CAT, GSH -Px and lower content of total antioxidative capacity compared to adjacent normal liver tissue (P<0.05). CONCLUSION These findings suggest that the antioxidative defense-related enzymes and antioxidants are largely regulated in hepatoma cells. However, the mechanism which is not clear requires further investigation. | Hongwei Yu Chunying Chen Jiangxue Wang Yuxi Gao Guilong Deng Yingbin Liu Shuyou Peng Zhifang Chai | 2006 | Chinese Journal of Clinical Oncology2006，3，1： | 0 |
| 14 | Functional prediction of tomato PLATZ family members and functional verification of Sl PLATZ17显示文摘PLATZ is a novel zinc finger DNA-binding protein that plays an important role in regulating plant growth and development and resisting abiotic stress.However,there has been very little research on the function of this family gene in tomatoes,which limits its application in germplasm resource improvement.Therefore,the PLATZ gene family was identified and analyzed in tomato,and its roles were predicted and verified to provide a basis for in-depth research on SlPLATZ gene function.In this study,the PLATZ family members of tomato were identified in the whole genome,and 19 SlPLATZ genes were obtained.Functional prediction was conducted based on gene and promoter structure analysis and RNA-seq-based expression pattern analysis.SlPLATZ genes that responded significantly under different abiotic stresses or were significantly differentially expressed among multiple tissues were screened as functional gene resources.SlPLATZ17 was selected for functional verification by experiment-based analysis.The results showed that the downregulation of SlPLATZ17 gene expression reduced the drought and salt tolerance of tomato plants.Tomato plants overexpressing SlPLATZ17 had larger flower sizes and long,thin petals,adjacent petals were not connected at the base,and the stamen circumference was smaller.This study contributes to understanding the functions of the SlPLATZ family in tomato and provides a reference for functional gene screening. | Min Xu Zhao Gao Dalong Li Chen Zhang Yuqi Zhang Qian He Yingbin Qi He Zhang Jingbin Jiang Xiangyang Xu Tingting Zhao | 2024 | Journal of Integrative Agriculture2024，23，1： | 0 |
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