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| 1 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 2 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 3 | Preparation of special silicon steel grade MgO from hydromagnesite显示文摘A preparation technology of MgO powder used in special silicon steel from hydromagnesite mineral has been developed. The preparation technology includes the following steps: (1) calcining the hydromagnesite at 700-750°C for 1.5-2 h; (2) hydrating the calcined hydromagnesite to be slurry containing the solid-liquid ratio of 15-20 g?L?1; (3) acquiring Mg(HCO3)2 solution by carbonating the slurry, the carbonation temperature, CO2 pressure, and end point PH value of carbonation are less than 40°C, 0.4-0.6 MPa, and 7 respectively during the carbonation process; (4) preparing precipitated basic magnesium carbonate by thermally decomposing the Mg(HCO3)2 solution at 90-100°C; (5) obtaining the MgO product by calcining the precipitated basic magnesium carbonate at 850-950°C for 30-60 min, and adopting flowing nitrogen during the cooling process. By using this technology, more than 80wt% magnesium in hydromagnesite mineral can be extracted, and high-performance MgO products used in special silicon steel can be ob- tained. | Xiangyang Zhou Shanni Li Jie Li Hongzhuan Liu Shangyuan Wu | 2007 | Journal of University of Science and Technology Beijing2007，14，3： | 11 |
| 4 | Effect of Cyclocarya paliurus polysaccharides on streptozotocin-induced diabetic nephropathy in rats显示文摘OBJEVTIVE:To investigate the efficacy of Cyclocarya paliurus(C.paliurus)polysaccharides on streptozotocin-induced diabetic nephropathy in rats.METHODS:Rats were divided into 6 groups,including group of normal control,group of diabetic control,group of metformin treatment,low-dose group of C.paliurus polysaccharides treatment,middle-dose group of C.paliurus polysaccharides treatment and high-dose group of C.paliurus polysaccharides treatment.Histological analysis of kidney was analyzed using hematoxilin and eosin.Levels of blood glucose,creatinine,urea,uric acid were determined by spectrophotometry.Anti-oxidative enzymes were measured by real-time polymerase chain reaction(PCR)and enzyme-linked immunosorbent assay(ELISA).Advanced glycation end products(AGEs)and transforming growth factor-β1(TGF-β1)level was measured by ELISA.RESULTS:Abnormal changes were observed in the group of diabetic control characterized by atrophy of the renal glomeruli with hypercellularity,congestion of glomerular tufts,dilation of the renal spaces,and degeneration of renal tubule.Compared with that of normal group,blood glucose,creatinine,urea,uric acid level was significantly increased in the group of diabetic control.Superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase level was significantly decreased,but AGEs and TGF-β1 level was significantly increased.By contrast,administration of C.paliurus polysaccharides and metformin could reverse the above-mentioned results of the group of diabetic control,especially in the high-dose group of C.paliurus polysaccharides.CONCLUSION:Our findings suggest that C.paliurus polysaccharides may play a protecting role for nephropathy of diabetic rats by lowering glucose,creatinine,urea,uric acid level,enhancing the antioxidative ability,and reducing AGEs and TGF-β1 expression. | Xia Xichao Mao Dongxue Dai Hongmei Wu Xi Zhang Zuyuan Wang Huaying Zhou Wenwen Dong Yanmei Wang Mengqi Li Yuan Shao Xiangyang Ouyang Jingfeng | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 9 |
| 5 | Modulation of Gut Microbiota in Pathological States显示文摘人类微生态是寄居在人体中的微生物聚集体,且主要存在于胃肠道(GIT)中。肠道微生态随着人体发育而演化,并在人类健康和疾病中起着重要作用。近年来,由于微生态会影响宿主代谢、生理学和免疫系统发育,而且微生态紊乱可能导致许多疾病,其越来越受到人们的关注。肠道微生态可能与恶性肿瘤有一定联系,如胃癌和结直肠癌;也可能与其他一些疾病有关,如非酒精性脂肪肝(NAFLD)、被称为工业化世界'生活方式疾病'的肥胖和糖尿病、冠心病以及中枢神经系统紊乱。虽然分子技术革命为我们更准确地研究肠道微生态提供了必要的工具,但是我们需要更精确地阐明其与某些人类疾病病理变化的关系,明确微生态在不同疾病中的作用是新的治疗策略发展的基础。本文概述了肠道微生态对人类健康的重要影响以及调整肠道菌群结构的潜在用途,如菌群移植用于治疗耐药艰难梭菌(C.difficile)的感染。通过微生态干预调整肠道区域以改善人类健康的概念虽刚刚兴起,但其治疗意义显著。因此,抑制有害菌、促进有益菌可能会保护人类健康,并且这些努力将为探索发展更加合理的治疗方案打下基础。 | Yulan Wang BaohongWang Junfang wu xiangyang Jiang Huiru Tang Ole H. Nielsen | 2017 | Engineering2017，3，1： | 9 |
| 6 | Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2-ARE pathway显示文摘Lotus seed is well known as traditional food and medicine,but its skin is usually discarded.Recent studies have shown that lotus seed skin contains a high concentration of proanthocyanidins that have multi-functions,such as antioxidation,anti-inflammation,and anti-cancer effects.In the present study,we aimed to isolate and purify the proanthocyanidins from lotus seed skin by acetone extraction and rotary evaporation,identify their chemical structures by HPLC-MS-MS and NMR,and further investigate the antioxidant properties of the extract purified by macroporous resin (PMR) from lotus seed skin both in vitro and in vivo.The results showed that PMR mainly contained oligomeric proanthocyanidins,especially dimeric procyanidin B1 (PB1),procyanidin B2 and procyanidin B4.Although it had limited ability to directly scavenge radicals in vitro,PMR could significantly enhance the expressions of antioxidant proteins via activation of nuclear factory-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway in HepG2 cells.Molecular data revealed that PB1,a major component in PMR,stabilized Nrf2 by inhibiting the ubiquitination of Nrf2,which led to subsequent activation of the Nrf2-ARE pathway,including the enhancements of Nrf2 nuclear translocation,Nrf2-ARE binding and ARE transcriptional activity.Moreover,the in vivo results in high fat diet-induced mice further verified the powerful antioxidant property of PMR.These results revealed that lotus seed skin is a promising resource for functional food development. | Tao Li Qili Li Weiguo Wu Yong Li De-xing Hou Hua Xu Baodong Zheng Shaoxiao Zeng Yang Shan Xiangyang Lu Fangming Deng Si Qin | 2019 | Acta Biochimica et Biophysica Sinica2019，51，1： | 8 |
| 7 | STUDY ON MECHANISM OF ARC-EXCITED ULTRASONIC显示文摘0INTRODUCTIONAnelectricalarccanbeidentifiedasadynamicresistanceinanarcweldingcircuit.Itistriedsucesfulyintungsteninertgasarcw... | Wu Minsheng Wang Zhengxian Li Luming Sun Diqing Duan Xiangyang Department of Mechanical Engineering, Qinghua University | 1999 | Chinese Journal of Mechanical Engineering1999，12，1： | 8 |
| 8 | Gene editing and its applications in biomedicine显示文摘The steady progress in genome editing, especially genome editing based on the use of clustered regularly interspaced short palindromic repeats(CRISPR) and programmable nucleases to make precise modifications to genetic material, has provided enormous opportunities to advance biomedical research and promote human health. The application of these technologies in basic biomedical research has yielded significant advances in identifying and studying key molecular targets relevant to human diseases and their treatment. The clinical translation of genome editing techniques offers unprecedented biomedical engineering capabilities in the diagnosis, prevention, and treatment of disease or disability. Here, we provide a general summary of emerging biomedical applications of genome editing, including open challenges. We also summarize the tools of genome editing and the insights derived from their applications, hoping to accelerate new discoveries and therapies in biomedicine. | Guanglei Li Xiangyang Li Songkuan Zhuang Liren Wang Yifan Zhu Yangcan Chen Wen Sun Zeguang Wu Zhuo Zhou Jia Chen Xingxu Huang Jin Wang Dali Li Wei Li Haoyi Wang Wensheng Wei | 2022 | Science China(Life Sciences)2022，65，4： | 8 |
| 9 | Long-term effects of mowing on plasticity and allometry of Leymus chinensis in a temperate semi-arid grassland,China显示文摘Mowing is an important land management practice for natural semi-arid regions.A growing body of empirical evidence shows that different mowing regimes affect the functioning of grassland ecosystems.However,the responses of plant functional traits to long-term mowing and their allometric scaling under long-term mowing are poorly understood.For a better understanding of the effects of mowing on grassland ecosystems,we analyzed the allometric traits of leaves and stems of Leymus chinensis(Trin.) Tzvel.,a dominant grass species in eastern Eurasian temperate grassland,at different mowing intensities(no clipping,clipping once every two years,once a year and twice a year).Experiments were conducted on plots established over a decade ago in a typical steppe of Xilinhot,Inner Mongolia,China.Results showed that most of the functional traits of L.chinensis decreased with the increased mowing intensity.The responses of leaves and stems to long-term mowing were asymmetric,in which leaf traits were more stable than stem traits.Also significant allometric relationships were found among most of the plant functional traits under the four mowing treatments.Sensitive traits of L.chinensis(e.g.leaf length and stem length) were primary indicators associated with aboveground biomass decline under high mowing intensity.In conclusion,the allometric growth of different functional traits of L.chinensis varies with different long-term mowing practices,which is likely to be a strategy used by the plant to adapt to the mowing disturbances. | LI Xiliang HOU Xiangyang REN Weibo Taogetao BAOYIN LIU Zhiying Warwick BADGERY LI Yaqiong WU Xinhong XU Huimin | 2016 | Journal of Arid Land2016，8，6： | 7 |
| 10 | NEXT:a neural network framework for next POI recommendation显示文摘The task of next POI recommendations has been studied extensively in recent years.However,developing a unified recommendation framework to incorporate multiple factors associated with both POIs and users remains challenging,because of the heterogeneity nature of these information.Further,effective mechanisms to smoothly handle cold-start cases are also a difficult topic.Inspired by the recent success of neural networks in many areas,in this paper,we propose a simple yet effective neural network framework,named NEXT,for next POI recommendations.NEXT is a unified framework to learn the hidden intent regarding user's next move,by incorporating different factors in a unified manner.Specifically,in NEXT,we incorporate meta-data information,e.g.,user friendship and textual descriptions of POIs,and two kinds of temporal contexts(i.e.,time interval and visit time).To leverage sequential relations and geographical influence,we propose to adopt DeepWalk,a network representation learning technique,to encode such knowledge.We evaluate the effectiveness of NEXT against other state-of-the-art alternatives and neural networks based solutions.Experimental results on three publicly available datasets demonstrate that NEXT significantly outperforms baselines in real-time next POI recommendations.Further experiments show inherent ability of NEXT in handling cold-start. | Zhiqian ZHANG Chenliang LI Zhiyong WU Aixin SUN Dengpan YE Xiangyang LUO | 2020 | Frontiers of Computer Science2020，14，2： | 5 |
| 11 | Cancer-associated adipocyte-derived G-CSF promotes breast cancer malignancy via Stat3 signaling显示文摘Adipocyte is the most predominant cell type in the tumor microenvironment of breast cancer and plays a pivotal role in cancer progression,yet the underlying mechanisms and functional mediators remain elusive.We isolated primary preadipocytes from mammary fat pads of human breast cancer patients and generated mature adipocytes and cancer-associated adipocytes(CAAs)in vitro.The CAAs exhibited significantly different gene expression profiles as assessed by transcriptome sequencing.One of the highly expressed genes in CAAs is granulocyte colony-stimulating factor(G-CSF).Treatment with recombinant human G-CSF protein or stable expression of human G-CSF in triple-negative breast cancer(TNBC)cell lines enhanced epithelial–mesenchymal transition,migration,and invasion of cancer cells,by activating Stat3.Accordantly,targeting G-CSF/Stat3 signaling with G-CSF-neutralizing antibody,a chemical inhibitor,or siRNAs for Stat3 could all abrogate CAA-or G-CSF-induced migration and invasion of breast cancer cells.The pro-invasive genes MMP2 and MMP9 were identified as target genes of G-CSF in TNBC cells.Furthermore,in human breast cancer tissues,elevated G-CSF expression in adipocytes is well correlated with activated Stat3 signal in cancer cells.Together,our results suggest a novel strategy to intervene with invasive breast cancers by targeting CAA-derived G-CSF. | Li Liu Yudong Wu Cheng Zhang Chong Zhou Yining Li Yi Zeng Chunbo Zhang Rong Li Daya Luo Lieliang Wang Long Zhang Shuo Tu Huan Deng Shiwen Luo Ye-Guang Chen Xiangyang Xiong Xiaohua Yan | 2020 | Journal of Molecular Cell Biology2020，12，9： | 4 |
| 12 | TiO2/EDTA-rich carbon composites: Synthesis, characterization and visible-light-driven photocatalytic reduction of Cr(Ⅵ)显示文摘Ti02/EDTA-rich carbon composites(TiO_2/EDTA-RC) have been successfully synthesized via a low temperature carbonization process. TiO_2/EDTA-RC exhibits marked absorption of visible light and excellent photoreduction of Cr(Ⅵ) activity under visible light irradiation(λ>420 nm). Due to the high carboxyl group content and strong coordination ability of EDTA, TiO_2-EDTA complex can be easily fabricated between EDTA incorporated in carbon sheet and titanol group on the surface of TiO_2. TiO_2-EDTA complexes on the surface of TiO_2/EDTA-RC, the LMCT complex, are responsible for the prominent photoreduction of Cr(Ⅵ) properties of Ti02/EDTA-RC under visible light irradiation. In addition, the unique structure ofTiO_2/EDTA-RC is also propitious to the visible-light photocatalytic reduction of Cr(Ⅵ).Carbon sheet of TiO_2/EDTA-RC acts as a supporter. TiO_2 nanoparticles and EDTA homogeneously disperse into the carbon sheet supporter and form the TiO_2-EDTA complexes, which can avoid the aggregation of TiO_2 nanoparticles in the aqueous solution and provide more photocatalytic reaction points for the reduction of Cr(Ⅵ). | Zhijun Luo Lingling Qu Jianzhong Ji Jing wang Suying Jiang Zhiren WU Xiangyang Wu | 2018 | Chinese Chemical Letters2018，29，3： | 3 |
| 13 | Aging effect on the mobility and bioavailability of copper in soil显示文摘Aging effect on the mobility and bioavailability of copper(Cu) was investigated using a spiked soil with different incubation periods from 3 to 56 d.Wheat was planted and earthworms were cultured separately in the incubated soils.The mobility of Cu in soil was evaluated by a chemical fractionation scheme and the toxicity and bioavailability were assessed by measuring the biomass and Cu concentration in tissues.Results showed that aging had a significant effect on Cu fraction distribution,of which Cu tended to incorporate from the exchangeable into more stable fractions such as the reducible and oxidisable fractions.However,aging had little effect on Cu bioavailability to wheat and earthworm.Comparing the soil being incubated for 3 d and 56 d,Cu concentration in wheat roots decreased from 14.5 to 12.8 mg/kg,and no significant changes in Cu concentration were observed in both wheat shoots and earthworms.The Cu concentration was around 2.0 and 50 mg/kg for wheat shoots and earthworms,respectively,irrespective of soil incubation time.The CaCl2-extractable Cu had a linear relationship with Cu concentration in wheat roots(R2 = 0.65,P < 0.05),but no linear relationship can be found for wheat shoots and earthworms.Biological control may be more crucial for Cu accumulation in organism than the changes in soil Cu fraction caused by aging. | LU Anxiang ZHANG Shuzhen QIN Xiangyang WU Wenyong LIU Honglu | 2009 | Journal of Environmental Sciences2009，21，2： | 3 |
| 14 | The application of three-dimensional seismic spectral decomposition and semblance attribute to characterizing the deepwater channel depositional elements in the Taranaki Basin of New Zealand显示文摘In the past few years, three-dimensional(3-D) seismogram has become an essential tool for the interpretation of subsurface stratigraphy and depositional systems. Seismic stratigraphy in conjunction with seismic geomorphology has elevated the degree to which seismic data can facilitate geological interpretation, especially in a deepwater environment. Technologies such as time slicing and interval attribute analysis can enhance geomorphological interpretations, and, when integrated with stratigraphic analyses, can yield insights regarding distribution of seal and reservoir facies. Multiple attributes corendering can further bring out features of geological interest that other technologies may overlook. This method involves corender spectral decomposition components(SDC) with semblance attributes to describe the distribution of deepwater channel elements and the boundaries of deepwater sinuous channel. Applying this technology to four elements is observed:(1) point-bars,(2) migration of channel meander loops,(3) channel erosion/cut, and(4) avulsion. The planview expression of the deepwater channel ranges from low sinuosity to high sinuosity. Furthermore, this technology has enabled interpreters to visualize details of complex depositional elements and can be used to predict net-to-gross ratio in channel systems, which can be incorporated into borehole planning for exploration as well as development needs to improve risk management significantly. The technology is applied to the study area in an effort to illustrate the variety of interpretation technologies available to the geoscientist. | LI Quan WU Wei YU Shui KANG Hongquan TONG Liqing CAO Xiangyang LIU Xiaolong | 2017 | Acta Oceanologica Sinica2017，36，9： | 3 |
| 15 | Sustainable management of Chinese grasslands—issues and knowledge显示文摘China has almost 400 Mhm^2 of grasslands,90% of which is considered degraded to varying degrees,on which 16 million herders depend for their livelihoods and many more indirectly, along the value-adding chain.Since 1950, average stocking rates across China have increased 4-fold. National policies have focused over recent decades on finding ways to rehabilitate the degraded grasslands, to sustain livestock production from them, and to improve the livelihoods of herder households, who are among the poorest people in China. A large collaborative program commenced in the early 2000 s to help find solutions to the sustainable management of grasslands.This paper summarizes key findings of many research projects, identifies where knowledge is weak and argues that the successful rehabilitation of grasslands will also require policies that provide incentives and support for herders as they move from a focus on survival to a focus on production of higher quality products, for which consumers are increasingly willing to pay. A key focus is to emphasize the improvement of animal production per head. When this is done, it naturally leads to lower stocking rates, which in turn provides the opportunities for grasslands to recover. Across a range of experiments, farm demonstrations and analyses using models, in Inner Mongolia and Gansu, a consistent result has been that a 50% reduction in stocking rates, improves net household income and starts the process of grassland rehabilitation.Rather than focusing on stocking rates, better management of grasslands could be achieved by maintaining the grasslands above critical values for herbage mass, values that help optimize botanical composition, reduce soil erosion, optimize animal growth rates and aid ecosystem functions. Managing to critical values for herbage mass is likely to be more effective than efforts to calculate sustainable stocking rates. An early summer rest is valuable for aiding grassland rehabilitation and summer productivity, but a total grazing ban(typically for 5 years)may not achieve its aims as evidence shows it may take 10–15 years to achieve a better grassland state. Lessdesirable plant species often increase in degraded grasslands that are rested and grazing can help manage those species. Surveys of herders indicate they have very mixed views on the benefits of total grazing bans that are unlikely to rehabilitate grasslands to an ideal botanical composition.The current objective is to work with grasslands that herders now have and optimize the existing composition.Grazing grasslands in winter results primarily in weight loss by animals and there is now evidence of how winter grazing reduces grassland growth in the next summer. It is better to keep animals in well-built sheds and feed them better, improved feeding through the cold months is required. In addition to the application of results from national programs designed to improve grasslands, it will be important to train herders as they move from survival to production, to foster the development of better markets for their livestock products, to devise better financial support for herder businesses and to revise land tenure arrangements so that herders can expand the area of land they graze on better terms than apply at present. | David KEMP Guodong HAN Fujiang HOU Xiangyang HOU Zhiguo LI Yi SUN Zhongwu WANG Jianping WU Xiaoqing ZHANG Yingjun ZHANG Xuyin GONG | 2018 | Frontiers of Agricultural Science and Engineering2018，5，1： | 3 |
| 16 | Climatology and seasonal variability of satellite-derived chlorophyll a around the Shandong Peninsula显示文摘The chlorophyll a(Chl a)is an important indicator of marine ecosystems.The spatiotemporal variation of the Chl a greatly aff ects the mariculture and marine ranching in coastal waters of the Shandong Peninsula.In the current study,the climatology and seasonal variability of surface Chl-a concentration around the Shandong Peninsula are investigated based on 16 years(December 2002-November 2018)of satellite observations.The results indicate that the annual mean Chl-a concentration is greater in the Bohai Sea than in the Yellow Sea and decreases from coastal waters to off shore waters.The highest Chl-a concentrations are found in Laizhou Bay(4.2-8.0 mg/m^(3)),Haizhou Bay(4.2-5.9 mg/m^(3))and the northeast coast of the Shandong Peninsula(4.4-5.0 mg/m^(3)),resulting from the combined eff ects of the intense riverine input and long residence time caused by the concave shape of the coastline.The seasonal Chl-a concentration shows a significant spatial variation.The Chl-a concentrations in these three subregions generally exhibit an annual maximum in August/September,due to the combined eff ects of sea surface temperature,river discharge and sea surface wind.In the southeast coast region,however,the Chl-a concentration is lowest throughout the year and reaches a maximum in February with a minimum in July,forced by the seasonal evolution of the Yellow Sea Cold Water and monsoon winds.The interannual Chl-a concentration trends vary among regions and seasons.There are significant increasing trends over a large area around Haizhou Bay from winter to summer,which are mainly caused by the rising sea surface temperature and eutrophication.In other coastal areas,the Chl-a concentration shows decreasing trends,which are clearest in summer and induced by the weakening land rainfall.This study highlights the differences in the Chl-a dynamics among regions around the Shandong Peninsula and is helpful for further studies of coupled physical-ecological-human interactions at multiple scales. | Xiukai SONG Yanzhen GU Fangguo ZHAI Peiliang LI Pengxia LIU Zizhou LIU Wenfan WU Yaozu CHEN Xiangyang JIANG Jianlong HE | 2021 | Journal of Oceanology and Limnology2021，39，4： | 3 |
| 17 | Improving reflectance estimation by BRDF-consistent region clustering显示文摘在反射评价的以前的研究通常要求一幅图象的优先的分割进一致反射的区域。由于措施噪音和 BRDF (双向反射功能) 的有限采样方向,反射的如此的估计的结果不是精确的。在这篇论文,我们为由合并有一致反射观察的图象区域在反射估计减少不确定性建议一个新奇方法。每个图象区域充当一个反射潜水艇空格,因此图象区域合并能导致潜水艇空格减小。我们建议一个贝叶斯的分割框架减少由使用新奇合并标准的反射不确定性。最后,一个最大的可能性反射评价为每个产生图象区域被做。试验性的结果验证合并方法的这个面向反射的区域的可行性和优势。 | ZHANG Hongxin WU Xiangyang LIN Steve BAO Hujun | 2006 | Progress in Natural Science:Materials International2006，16，3： | 3 |
| 18 | Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders in mice显示文摘Both immunosuppressants and antibiotics (ABX) are indispensable for transplant patients. However, the former increases the risk of new-onset diabetes, whereas the latter impacts intestinal microbiota (IM). It is still unclear whether and how the interaction between immunosuppressants and ABX alters the IM and thus leads to glucose metabolism disorders. This study examined the alterations of glucose and lipid metabolism and IM in mice exposed to tacrolimus (TAC) with or without ABX. We found that ABX further aggravated TAC-induced glucose tolerance and increased insulin secretion. Combined treatment resulted in exacerbated lipid accumulation in the liver. TAC-altered microbial community was further amplified by ABX administration, as characterized by reductions in phylum Firmicutes, family Lachnospiraceae, and genus Copyococcus. Analyses based on the metagenomic profiles revealed that ABX augmented the effect of TAC on microbial metabolic function mostly related to lipid metabolism. The altered components of gut microbiome and predicted microbial functional profiles showed significant correlation with hepatic lipid accumulation and glucose disorders. In conclusion, ABX aggravated the effect of TAC on the microbiome and its metabolic capacities, which might contribute to hepatic lipid accumulation and glucose disorders. These findings suggest that the ABX-altered microbiome can amplify the diabetogenic effect of TAC and could be a novel therapeutic target for patients. | Yuqiu Han Xiangyang Jiang Qi Ling Li Wu Pin Wu Ruiqi Tang Xiaowei Xu Meifang Yang Lijiang Zhang Weiwei Zhu Baohong Wang Lanjuan Li | 2019 | Frontiers of Medicine2019，13，4： | 3 |
| 19 | Ultrasound-enhanced fluorescence imaging and chemotherapy of multidrugresistant tumors using multifunctional dendrimer/carbon dot nanohybrids显示文摘Development of innovative nanomedicine enabling enhanced theranostics of multidrug-resistant(MDR)tumors remains to be challenging.Herein,we report the development of a newly designed multifunctional yellowfluorescent carbon dot(y-CD)/dendrimer nanohybrids as a platform for ultrasound(US)-enhanced fluorescence imaging and chemotherapy of MDR tumors.Generation 5(G5)poly(amidoamine)dendrimers covalently modified with efflux inhibitor of D-α-tocopheryl polyethylene glycol 1000 succinate(G5-TPGS)were complexed with one-step hydrothermally synthesized y-CDs via electrostatic interaction.The formed G5-TPGS@y-CDs complexes were then physically loaded with anticancer drug doxorubicin(DOX)to generate(G5-TPGS@y-CDs)-DOX complexes.The developed nanohybrids display a high drug loading efficiency(40.7%),strong y-CD-induced fluorescence emission,and tumor microenvironment pH-preferred DOX release profile.Attributing to the DOX/TPGS dual drug design,the(G5-TPGS@y-CDs)-DOX complexes can overcome the multidrug resistance(MDR)of cancer cells and effectively inhibit the growth of cancer cells and tumors.Furthermore,the introduction of US-targeted microbubble destruction technology was proven to render the complexes with enhanced intracellular uptake and anticancer efficacy in vitro and improved chemotherapeutic efficacy and fluorescence imaging of tumors in vivo due to the produced sonoporation effect.The developed multifunctional dendrimer/CD nanohybrids may represent an advanced design of nanomedicine for US-enhanced theranostics of different types of MDR tumors. | Dan Li Lizhou Lin Yu Fan Long Liu Mingwu Shen Rong Wu Lianfang Du Xiangyang Shi | 2021 | Bioactive Materials2021，6，3： | 3 |
| 20 | Different Ablation Models for the Wall-plasma Interaction Process in Pulsed Plasma Thruster显示文摘Ablation excited by current pulses is a very critical physical process in pulse plasma thrusters(PPT).Its effects on wall-plasma interaction directly determine the PPT performances.In order to reveal the process of the ablated wall interaction with the discharge plasma in PPT,ablation models formulated by three different boundary conditions at the wall-plasma interface are studied.These are the two widely used high-speed evaporation models(Model-L and Model-M),and the recently developed Keida-Zaghloul model(Model-K)of the Knudsen layer that takes into account the internal degrees of freedom on the energy flux conservation.First,fundamental mechanisms of the three ablation models are clarified by comparative analysis in order to gain a comprehensive understanding of the wall-plasma interaction.Then,the applicability of different ablation models with the numerical solutions of LES-6 PPT is investigated in detail using magnetohydrodynamic(MHD)modeling.Results show that Model-L and Model-M are actually special cases of Model-K when a simplified jump conditions limited by high velocity at the vapor/plasma interface is used;A ratio of ablation rate in Model-L to that in Model-M is about 0.8at the same wall surface temperature,while it rises to 1 at different surface temperature determined by Model-L and Model-M in PPT.Even though Model-K solution requires significant computational time,it shows more accurate ablation feature for the wall-plasma interaction and possesses better computing precision of impulse bit during post-pulse which is useful for future studies of the late time ablation. | YANG Lei LIU Xiangyang WANG Siyu XIE Kan WU Zhiwen WANG Ningfei | 2013 | 高电压技术2013，39，9： | 3 |
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