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| 1 | Parameterizing soil organic carbon's impacts on soil porosity and thermal parameters for Eastern Tibet grasslands显示文摘This study investigates the stratification of soil thermal properties induced by soil organic carbon (SOC) and its impacts on the parameterization of the thermal properties. Soil parameters were measured for alpine grassland stations and North China flux stations, with a total of 34 stations and 77 soil profiles. Measured data indicate that the topsoils of alpine grasslands contain high SOC contents than underlying soil layers, which leads to higher soil porosity values and lower thermal conductivity and bulk density values in the topsoils. However, this stratification is not evident at the lowland stations due to low SOC contents. Evaluations against measured data show that three thermal conductivity schemes used in land surface models severely overestimate the values for soils with high SOC content (i.e. topsoils of alpine grassland), but they are better for soils with low SOC content. A new parameterization is then developed to take the impacts of SOC into account. The new one can well estimate the soil thermal conductivity values in both low and high SOC content cases, and therefore, it is a potential candidate of thermal conductivity scheme to be used in land surface models. | CHEN YingYing YANG Kun TANG WenJun QIN Jun ZHAO Long | 2012 | Science China Earth Sciences2012，55，6： | 31 |
| 2 | Toward Wisdom-Evolutionary and Primitive-Concise 6G:A New Paradigm of Semantic Communication Networks显示文摘The sixth generation(6G)mobile networks will reshape the world by offering instant,efficient,and intelligent hyper-connectivity,as envisioned by the previously proposed Ubiquitous-X 6G networks.Such hyper-massive and global connectivity will introduce tremendous challenges into the operation and management of 6G networks,calling for revolutionary theories and technological innovations.To this end,we propose a new route to boost network capabilities toward a wisdom-evolutionary and primitive-concise network(WePCN)vision for the Ubiquitous-X 6G network.In particular,we aim to concretize the evolution path toward the WePCN by first conceiving a new semantic representation framework,namely semantic base,and then establishing an intelligent and efficient semantic communication(IE-SC)network architecture.In the IE-SC architecture,a semantic intelligence plane is employed to interconnect the semantic-empowered physical-bearing layer,network protocol layer,and application-intent layer via semantic information flows.The proposed architecture integrates artificial intelligence and network technologies to enable intelligent interactions among various communication objects in 6G.It features a lower bandwidth requirement,less redundancy,and more accurate intent identification.We also present a brief review of recent advances in semantic communications and highlight potential use cases,complemented by a range of open challenges for 6G. | Ping Zhang Wenjun Xu Hui Gao Kai Niu Xiaodong Xu Xiaoqi Qin Caixia Yuan Zhijin Qin Haitao Zhao Jibo Wei Fangwei Zhang | 2022 | Engineering2022，8，1： | 28 |
| 3 | Review on photocatalytic and electrocatalytic artificial nitrogen fixation for ammonia synthesis at mild conditions: Advances,challenges and perspectives显示文摘The ammonia synthesis from nitrogen and water under ambient conditions is one of the most inviting but challenging reaction routes.Although nitrogen is abundant in the atmosphere and the ammonia synthesis reaction is exothermic on the thermodynamics,the conversion of N2 to ammonia is actually hard to proceed owing to the chemical inertness and stability of N2 molecules.In industry,ammonia synthesis is carried out by the Haber-Bosch process under harsh conditions (300-500 ℃,20-30 MPa) associated with the requirement of substantial energy input and the enormous emission of greenhouse gases (e.g.,CO2).Recently,a growing number of studies on photo(electro)catalytic and electrocatalytic nitrogen reduction reaction (NRR) in aqueous solution have attracted extensive attention,which holds great promise for nitrogen fixation under room temperature and atmospheric pressure.However,the very low efficiency and ambiguous mechanism still remain as the major hurdles for the development of photochemical and electrochemical NRR systems.Here we provide an overview of the latest progresses,remaining challenges and future prospects in photocatalytic and electrocatalytic nitrogen fixation.Moreover,this review offers a helpful guidance for the reasonable design of photocatalysts and electrocatalysts towards NRR by combining theory predictions and experiment results.We hope this review can stimulate more research interests in the relatively understudied but highly promising research field of NRR. | Xiaolan Xue Renpeng Chen Changzeng Yan Peiyang Zhao Yi Hu Wenjun Zhang Songyuan Yang Zhong Jin | 2019 | Nano Research2019，12，6： | 20 |
| 4 | A review of ecological restoration techniques in fluvial rivers显示文摘Rivers play an important role in people's living and agricultural production,however,intense human activities have broken the original ecological balance,and affected structures and functions of the river ecosystem.To restore the damaged river ecosystem back to a healthy status,effective ecological restoration measures need to be implemented.The main problems that the damaged rivers face are either the locally altered hydrological processes affected by construction of hydraulic facilities,or the deterioration of water quality resulted from pollution emissions,or both.In this study,ecological restoration techniques of the rivers affected by engineering control or pollution are reviewed respectively.In addition,three kinds of methods,i.e.physical,chemical and biological-ecological methods are introduced in details for the rivers affected by water pollution.At present,the development of river restoration techniques shows the following trends:1) the scale of ecological restoration is becoming larger;2) ecological restoration measures are required to meet multiple objectives;and 3) the management of water environment is changing from water quality management to aquatic ecosystem management. | Baozhu Pan Jianping Yuan Xinhua Zhang Zhaoyin Wang Jiao Chen Jinyou Lu Wenjun Yang Zhiwei Li Na Zhao Mengzhen Xu | 2016 | International Journal of Sediment Research2016，31，2： | 18 |
| 5 | Discovery and preliminary study of the high tungsten and lithium contents in the Dazhuyuan bauxite deposit, Guizhou, China显示文摘Bauxite in China remains an urgently needed resource largely dependent on imports. Based on the study of the newly-discovered Dazhuyuan bauxite deposit in northeastern Guizhou, we have found new enrichment of tungsten and lithium in bauxite, with the highest WO 3 content up to 0.33% and the highest Li 2 O content up to 0.58%. The present paper reports the initial result, and the spatial distribution feature of W and Li in the ore body (with Li enriched mostly in the north part of the west limb of the Liyuan syncline, whereas W enriched mostly in the central part of the east limb). The results suggest that it is necessary to delineate lithium and tungsten ore body independently, discuss the feasibility of its industrial utilization, and point out the new direction of synthetic appraisal for such kinds of traditional mineral resources, in order to forecast and assess bauxite resources in the region. | WANG DengHong LI PeiGang QU WenJun YIN LiJuan ZHAO Zhi LEI ZhiYuan WEN ShenFu | 2013 | Science China Earth Sciences2013，56，1： | 16 |
| 6 | Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty显示文摘在维生素 D 缺乏和自发的中央早熟的发身(ICPP ) 之间的关系最近被记录了。在这研究, 280 个女孩与 ICPP 诊断了,类似的年龄的 188 个正常发身控制女孩被注册并且回顾地学习了。有的 ICPP 组显著地降低浆液 25-hydroxyvitamin D (25 [哦] D ) 层次比控制组。而且,一种非线性的关系在浆液 25 之间被发现[哦] D 和 ICPP,和为浆液 25 的一个截止的点[哦] D 有或没有调整不同惊讶因素为 ICPP 在 31.8 ng/ml 被发现。有浆液 25 的女孩[哦] D31.8 ng/ml 有更低的机会比率(unadjusted:或 0.36, 95% CI 0.15 到 0.83, P < 0.05;调整的高度和重量:或 0.44, 95% CI 0.18 到 1.08, P = 0.072;BMI 调整了:或 0.36, 95% CI 0.16 到 0.84, P < 0.05 ) 。有 25 的 ICPP 题目[哦] D 缺乏从二另外的亚群比这些题目有一个更高的身体团索引(BMI ) 。关联分析证明那维生素 D 水平在 ICPP 组与 BMI 和一些新陈代谢的参数被相关。我们的学习建议那维生素 D 地位可以与 ICPP 风险被联系并且可以在 ICPP 上有阀值效果。 | Yue Zhao Wenjun Long Caiqi Du Huanhuan Yang Shimin Wu Qin Ning Xiaoping Luo | 2018 | Frontiers of Medicine2018，12，2： | 16 |
| 7 | Bioconjugated Silica Nanoparticles: Development and Applications显示文摘Advanced bioanalysis,including accurate quantitation,has driven the need to understand biology and medicine at the molecular level.Bioconjugated silica nanoparticles have the potential to address this emerging challenge.Particularly intriguing diagnostic and therapeutic applications in cancer and infectious disease as well as uses in gene and drug delivery,have also been found for silica nanoparticles.In this review,we describe the synthesis,bioconjugation,and applications of silica nanoparticles in different bioanalysis formats,such as selective tagging,barcoding,and separation of a wide range of biomedically important targets.Overall,we envisage that further development of these nanoparticles will provide a variety of advanced tools for molecular biology,genomics,proteomics and medicine. | Lin Wang Wenjun Zhao Weihong Tan | 2008 | Nano Research2008，1，2： | 15 |
| 8 | Highly Stretchable,Elastic,and Sensitive MXene-Based Hydrogel for Flexible Strain and Pressure Sensors显示文摘Electronic skin is driving the next generation of cutting-edge wearable electronic products due to its good wearability and high accuracy of information acquisition.However,it remains a challenge to fulfill the requirements on detecting full-range human activities with existing flexible strain sensors.Herein,highly stretchable,sensitive,and multifunctional flexible strain sensors based on MXene-(Ti_(3)C_(2)T_(x)-)composited poly(vinyl alcohol)/polyvinyl pyrrolidone double-network hydrogels were prepared.The uniformly distributed hydrophilic MXene nanosheets formed a three-dimensional conductive network throughout the hydrogel,endowing the flexible sensor with high sensitivity.The strong interaction between the double-network hydrogel matrix and MXene greatly improved the mechanical properties of the hydrogels.The resulting nanocomposited hydrogels featured great tensile performance(2400%),toughness,and resilience.Particularly,the as-prepared flexible pressure sensor revealed ultrahigh sensitivity(10.75 kPa^(-1))with a wide response range(0-61.5 kPa),fast response(33.5 ms),and low limit of detection(0.87 Pa).Moreover,the hydrogel-based flexible sensors,with high sensitivity and durability,could be employed to monitor fullrange human motions and assembled into some aligned devices for subtle pressure detection,providing enormous potential in facial expression and phonation recognition,handwriting verification,healthy diagnosis,and wearable electronics. | Yao Lu Xinyu Qu Wen Zhao Yanfang Ren Weili Si Wenjun Wang Qian Wang Wei Huang Xiaochen Dong | 2020 | Research2020，，1： | 14 |
| 9 | BiVO_(4),Bi_(2)WO_(6) and Bi_(2)MoO_(6) photocatalysis:A brief review显示文摘In recent years,photocatalytic technologies have been extensively studied and diffusely used in water splitting,decomposition of organic pollutants,reduction of carbon dioxide,etc.As a type of eye-catching semiconductors,BiVO_(4),Bi_(2)WO_(6),and Bi_(2)MoO_(6) (denoted as BiaAOb)have become a hotspot in photocatalytic researches due to their crystal structure stability,high light quantum and electronic transmission efficiency,and outstanding energy utilization capacity.However,pristine BiaAOb(A=V,W,and Mo)possesses several drawbacks,such as low separation efficiency of photo-excited electron-hole pairs,low specific surface area,as well as the poor quantum utilization,which restrict their photocatalytic performance.Considerable efforts,such as nanostructure modification,surface engineering,and heterojunction/homojunction fabrication,have been conducted to solve these problems.This integrated review aims to sum up recent advances in current studies on fabrication of high efficiency BiaAOb photocatalysts to accelerate the developments of BiaAOb-based materials in the photocatalysis(PC)field.The current challenges and prospects of BiaAOb are emphasized which stretches the existing fundamental theories of PC as well as provide a promising strategy to fabricate high efficiency BiaAOb catalysts to control environmental pollution and assist the sustainable development of energy. | Xintong Liu Shaonan Gu Yanjun Zhao Guowei Zhou Wenjun Li | 2020 | Journal of Materials Science & Technology2020，56，21： | 13 |
| 10 | Cardiac autonomic nerve fiber regeneration in chronic heart failure Do Akt gene-transduced mesenchymal stem cells promote repair?显示文摘BACKGROUND: Transplantation of Akt-over-expressing mesenchymal stem cells (Akt-MSCs) has been shown to repair infarcted myocardium and improve cardiac function. However, little is known about the therapeutic effects of Akt-MSCs on cardiac autonomic neuropathy in chronic heart failure (CHF). OBJECTIVE: The present study used adriamycin-induced CHF rat models to observe the effect of Akt-MSCs on cardiac autonomic nervous regeneration and the factors mediating this effect. DESIGN, TIME AND SETTING: A randomized, controlled animal experiment was performed at the Central Laboratory of Basic Medical College, China Medical University, between September 2008 and April 2009. MATERIALS: Rabbit anti-choline acetyltransferase (ChAT), growth associated protein-43 (GAP-43), synaptophysin (SYN) polyclonal antibodies and the secondary antibody (goat anti-rabbit IgG) were purchased from Boster, China. Cat-A-Kit assay system was provided by Amersham, USA. METHODS: (1) Adult rat MSCs were isolated and cultured for the preparation of Akt-MSCs. (2) Forty male Wistar rats were intramyocardially administered adriamycin at 2 mg/kg over 3 days for a total of five times and once a week for additional five times thereafter to establish CHF models. At 2 weeks after final adriamycin treatment, 34 successful CHF rat models were randomized to three groups: Akt-MSCs (n = 11), simple MSCs (s-MSCs, n =11), and control (n = 12). Each group was intravenously administered Akt-MSCs (2×106 cells in 100 μL PBS), s-MSCs (2×106 cells in 100 μL PBS) or equal volume of phosphate buffered saline, once a day for a total of three times. MAIN OUTCOME MEASURES: At 4 weeks after final adriamycin treatment, myocardial norepi- nephrine (NE) content was detected using a Cat-A-Kit assay system. Myocardial ChAT, SYN and GAP-43 were performed by immunohistochemistry and Western blot analysis. Prior to, 2 and 4 weeks after adriamycin treatment, echocardiographic examination was performed and left ventricular ejection fraction (LVEF) was determined. RESULTS: Myocardial NE content, as well as SYN-positive and GAP-43-positive nerve fiber density and expression, and LVEF, was the greatest in the Akt-MSCs group, followed by the s-MSCs group, and lastly the control group (P < 0.05 or P < 0.01). ChAT expression was similar between Akt-MSCs and s-MSCs groups, but it was higher compared with the control group (P < 0.05). NE contents were negatively correlated to LVEF (r = -0.64, P = 0.015). CONCLUSION: Transplantation of MSCs, in particular Akt-MSCs, promotes cardiac nervous regeneration in failing heart, which might be mediated by GAP-43. | Hongliang Kong Zhanquan Li Shumei Zhao Li Zhu Yingjun Zhao Weiwei Zhang GuipingXu Wenjun Hao Huijun Li Guoxian Qi | 2010 | Neural Regeneration Research2010，5，1： | 13 |
| 11 | Membrane fouling in ultrafiltration of natural water after pretreatment to different extents显示文摘The combined fouling during ultrafiltration(UF) of surface water pretreated to different extents was investigated to disclose the roles of polysaccharides, proteins, and inorganic particles in UF membrane fouling. Both reversible and irreversible fouling decreased with enhanced pretreatment(biologically active carbon(BAC) treatment and sand filtration). The sand filter effluent fouled the membrane very slowly. The UF membrane removed turbidity to less than 0.1 nephelometric turbidity unit(NTU), reduced polysaccharides by 25.4%–29.9%, but rejected few proteins. Both polysaccharides and inorganic particles were detected on the fouled membranes, but inorganic particles could be effectively removed by backwashing. The increase of turbidity in the sand filter effluent to 3.05 NTU did not significantly increase the fouling rate, but an increase in the turbidity in the BAC effluent to6.11 NTU increased the fouling rate by more than 100%. The results demonstrated that the polysaccharide, not the protein, constituents of biopolymers were responsible for membrane fouling. Membrane fouling was closely associated with a small fraction of polysaccharides in the feed water. Inorganic particles exacerbated membrane fouling only when the concentration of fouling–inducing polysaccharides in the feed water was relatively high. The combined fouling was largely reversible, and polysaccharides were the predominant substances responsible for irreversible fouling. | Lu Ao Wenjun Liu Lin Zhao Xiaomao Wang | 2016 | Journal of Environmental Sciences2016，28，5： | 12 |
| 12 | Early evaluation of growth traits of Larix kaempferi clones显示文摘Early selection is an important method to shorten the breeding cycle for tree species, which may differ in the time for early selection.To evaluate the early selected time for Larix kaempferi, tree height and diameter at breast height of 57 L.kaempferi clones were measured over many different growth years.The results indicated that, except for age × clone interaction for diameter at breast height(P = 0.741), there were significant differences among all variation sources(P < 0.01).The coefficient of phenotypic variation ranged from 14.89 to 35.65%for height and from 19.17 to 23.86% for diameter at breast height in different growth years.The repeatability of height and of diameter at breast height among clones was high,ranging from 0.6181 to 0.8531(height) and from 0.8443 to0.8497(diameter at breast height), in different growth years.There were significant positive correlations between all pairs of growth traits except between height in the 2 nd growth year and height in the 30 th growth year; and between height in the 2 nd growth year × diameter at breast height in the 30 th growth year.With a comprehensive evaluation method and a selection ratio of 10%, L65,L1, L62, L9, L15, and L78 were selected as excellent clones in the 30 th growth year.Their average values of height and diameter at breast height were 9.81 and 16.57%higher than the overall average, representing genetic gains of 6.46 and 13.99%, respectively.This study provides a theoretical foundation for the genetic improvement of L.kaempferi. | Yanyan Pan Shuchun Li Chenglu Wang Wenjun Ma Guiyou Xu Lili Shao Kailong Li Xiyang Zhao Tingbo Jiang | 2018 | Journal of Forestry Research2018，29，4： | 10 |
| 13 | Two-photon-excited near-infrared emissive carbon dotsas multifunctional agents for fluorescence imaging andphotothermal therapy显示文摘C dots (CDs) have shown great potential in bioimaging and phototherapy.However, it is challenging to manipulate their fluorescent properties andtherapeutic efficacy to satisfy the requirements for clinic applications. In thisstudy, we prepared S, Se-codoped CDs via a hydrothermal method anddemonstrated that the doping resulted in excitation wavelength-independentnear-infrared (NIR) emissions of the CDs, with peaks at 731 and 820 nm.Significantly, the CDs exhibited a photothermal conversion efficiency of -58.2%,which is the highest reported value for C nanostructures and is comparable tothat of Au nanostructures. Moreover, the CDs had a large two-photon absorptioncross section (-30,045 GM), which allowed NIR emissions and the photothermalconversion of the CDs through the two-photon excitation (TPE) mechanism. Invitro and in vivo tests suggested that CDs can function as new multi functionalphototheranostic agents for the TPE fluorescence imaging and photothermaltheraov of cancer cells. | Minhuan Lan Shaojing Zhao Zhenyu Zhang Li Yan Liang Guo Guangle Niu Jinfeng Zhang Junfang Zhao Hongyan Zhang Pengfei Wang Guangyu Zhu Chun-Sing Lee Wenjun Zhang | 2017 | Nano Research2017，10，9： | 9 |
| 14 | Land Use-Related Changes in Soils of Hainan Island During the Past Half Century显示文摘During the past half century, the land utilization of Hainan Island has undergone a rapid development,but in the meanwhile, soil degradation occurs. Analysis on some basic data of the soil series collected frommore than 100 soil profiles at the end of the 1990s and beginning of this century, in combination with dataavailable, showed that soils there suffered significant decline in organic matter, experienced P and K deficiencywith soil K going on losing and undergone acidification with continuing trend. The current situation calls forstrategies to build up Hainan into an important province of sound ecology by restoring forests, to improvefood quality by implementing K supplement projects, to combat soil acidification by ameliorating the soils andgrowing leguminous crops and to ensure health of the people by developing dairy production and increasingthe daily Ca uptake by the people. | GONG ZITONG, ZHANG GANLIN, ZHAO WENJUN, ZHAO YUGUO and CHEN ZHICHENGInstitute of Soil Science, the Chinese Academy of Sciences, Nanjing 210008 (China) | 2003 | Pedosphere2003，13，1： | 9 |
| 15 | Overexpression of lysine specific demethylase 1 predicts worse prognosis in primary hepatocellular carcinoma patients显示文摘AIM:To investigate the clinicopathological features and prognostic value of lysine specific demethylase 1(LSD1) in hepatocellular carcinoma(HCC).METHODS:We examined LSD1 expression in 60 paired liver cancer tissues and adjacent noncancerous tissues by quantitative real time polymerase chain reaction(qRT-PCR) and Western blotting.In addition,we analyzed LSD1 expression in 198 HCC samples by immunohistochemistry.The relationship between LSD1 expression,clinicopathological features and patient survival was investigated.RESULTS:Immunohistochemistry,Western blotting,and qRT-PCR consistently confirmed LSD1 overexpression in HCC tissues compared to adjacent non-neoplastic tissues(P < 0.01).Additionally,immunostaining showed more LSD1-positive cells in the higher tumor stage(T3-4) and tumor grade(G3) than in the lower tumor stage(T1-2,P < 0.001) and tumor grade(G1-2,P < 0.001),respectively.Moreover,HCC patients with high LSD1 expression had significantly lower 5-year overall survival rates(P < 0.001) and lower 5-year disease-free survival rates(P < 0.001),respectively.A Cox proportional hazards model further demonstrated that LSD1 over-expression was an independent predictor of poor prognosis for both 5-year disease-free survival [hazards ratio(HR) = 1.426,95%CI:0.672-2.146,P < 0.001] and 5-year overall survival(HR = 2.456,95%CI:1.234-3.932,P < 0.001) in HCC.CONCLUSION:Our data suggest for the first time that the overexpression of LSD1 protein in HCC tissues indicates tumor progression and predicts poor prognosis. | Ze-Kun Zhao Hai-Feng Yu Dao-Rong Wang Ping Dong Lei Chen Wen-Guang Wu WenJun Ding Ying-Bin Liu | 2012 | World Journal of Gastroenterology2012，18，45： | 8 |
| 16 | Fabrication of ZnO nanorods in ionic liquids and their photoluminescent properties显示文摘A novel and simple approach is reported to fabricate uniform single-crystal ZnO nanorods in ionic liq-uids. The as-obtained ZnO nanorods have been characterized by XRD,TEM,HRTEM,SAED,XPS,EDXA,PL and UV-vis absorption spectra. The rod diameters of the nanostructures can be controlled by tuning the amount of sodium hydroxide in the synthesis. Photoluminescence results show that the nanos-tructural ZnO exhibits better optical properties than bulk ZnO does and interestingly,the smaller the rod diameters are,the better optical property 1D nanostructural ZnO exhibits. The possible growth mechanism of ZnO nanorods is also investigated. | WANG Li ZHAO Bin CHANG LiXian ZHENG WenJun | 2007 | Science China Chemistry2007，50，2： | 8 |
| 17 | Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics显示文摘Background and purpose Stroke is the second leading cause of death worldwide and the leading cause of mortality and long-term disability in China,but its underlying risk genes and pathways are far from being comprehensively understood.We here describe the design and methods of whole genome sequencing(WGS)for 10914 patients with acute ischaemic stroke or transient ischaemic attack from the Third China National Stroke Registry(CNSR-III).Methods Baseline clinical characteristics of the included patients in this study were reported.DNA was extracted from white blood cells of participants.Libraries are constructed using qualified DNA,and WGS is conducted on BGISEQ-500 platform.The average depth is intended to be greater than 30×for each subject.Afterwards,Sentieon software is applied to process the sequencing data under the Genome Analysis Toolkit best practice guidance to call genotypes of single nucleotide variants(SNVs)and insertion-deletions.For each included subject,21 fingerprint SNVs are genotyped by MassARRAY assays to verify that DNA sample and sequencing data originate from the same individual.The copy number variations and structural variations are also called for each patient.All of the genetic variants are annotated and predicted by bioinformatics software or by reviewing public databases.Results The average age of the included 10914 patients was 62.2±11.3 years,and 31.4%patients were women.Most of the baseline clinical characteristics of the 10914 and the excluded patients were balanced.Conclusions The WGS data together with abundant clinical and imaging data of CNSR-III could provide opportunity to elucidate the molecular mechanisms and discover novel therapeutic targets for stroke. | Si Cheng Zhe Xu Yang Liu Jinxi Lin Yong Jiang Yilong Wang Xia Meng Anxin Wang Xinying Huang Zhimin Wang Guohua Chen Songdi Wu Zhengchang Jia Yongming Chen Xuerong Qiu Jun Wu Binbin Song Weizhong Ji Zhongping An Wenjun Xue Lili Zhao Yu Geng Hongyan Li Hao Li Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 8 |
| 18 | Effect of Gubenfangxiao decoction on respiratory syncytial virus-induced asthma and expression of asthma susceptibility gene orosomucoid 1-like protein 3 in mice显示文摘OBJECTIVE: To investigate the effect of Gubenfangxiao decoction(GBFXD) on respiratory-syncytial-virus(RSV)-induced asthma and the expression of asthma susceptibility gene, orosomucoid 1-like protein 3(ORMDL3) in mice.METHODS: Seventy-two female BALB/c mice were randomly assigned to normal, model, GBFXD high dose, GBFXD moderate dose, GBFXD low dose and montelukast groups. An asthma model was induced via intraperitoneal injection and aerosol inhalation of ovalbumin(OVA) and repeated intranasal instillation of RSV in all mice, except those in the normal group. All treatments were administered at the first onset of asthma(within 8 weeks of model establishment) and the mice were euthanized after 28 days of treatment. The levels of transforming growth factor-β(TGF-β) and interleukin-6(IL-6) in bronchoalveolar lavage fluid(BALF) of the mice were measured and the expression of asthma susceptibility gene ORMDL3 in lung tissue was determined using real-time polymerase chain reaction(RT-PCR) and western blotting.RESULTS: Expression of ORMDL3 and levels of TGF-β and IL-6 were significantly higher in the model group(P < 0.05, P < 0.01) compared with the normal mice. Levels of ORMDL3, TGF-β and IL-6 were significantly lower in all three GBFXD treated groups(P < 0.05) compared with the model group.However, the levels in the GBFXD treatment groups did not differ significantly from the montelukast group.CONCLUSION: GBFXD had a therapeutic effect in this experimental model. The functional mechanism of GBFXD may involve multiple factors, including alleviation of airway inflammation, down-regulation of asthma susceptibility gene ORMDL3 and inhibition of airway remodeling. | Huang Zhengguang Gao Lijuan Zhao Xia Ling Hao Chen Wenjun | 2016 | Journal of Traditional Chinese Medicine2016，36，1： | 7 |
| 19 | Mineral compositions in breast milk of healthy Chinese lactating women in urban areas and its associated factors显示文摘 | Zhao Ai Ning Yibing Zhang Yumei Yang Xiaoguang Wang Junkuan Li Wenjun Wang Peiyu | 2014 | Chinese Medical Journal2014，，14： | 7 |
| 20 | Changes in soil microbial community response to precipitation events in a semi-arid steppe of the Xilin River Basin, China显示文摘In the context of climate change, precipitation is predicted to become more intense at the global scale. Such change may alter soil microbial communities and the microbially mediated carbon and nitrogen dynamics. In this study, we experimentally repackaged precipitation patterns during the growing season(from June to September) of 2012 in a semi-arid temperate steppe of the Xilin River Basin in Inner Mongolia of China, based on the 60-year growing season precipitation data. Specifically, a total amount of 240 mm simulated precipitation was assigned to experimental plots by taking the following treatments:(1) P6(6 extreme precipitation events, near the 1^(st) percentile);(2) P10(10 extreme precipitation events, near the 5^(th) percentile);(3) P16(16 moderate precipitation events, near the 50^(th) percentile); and(4) P24(24 events, 60-year average precipitation, near the 50^(th) percentile). At the end of the growing season, we analyzed soil microbial community structure and biomass, bacterial abundance, fungal abundance and bacterial composition, by using phospholipid fatty acid(PLFA), real-time quantitative polymerase chain reaction(RT-qPCR) and 16S rRNA gene clone library methods. The extreme precipitation events did not change soil microbial community structure(represented by the ratio of PLFA concentration in fungi to PLFA concentration in bacteria, and the ratio of PLFA concentration in gram-positive bacterial biomass to PLFA concentration in gram-negative bacterial biomass). However, the extreme precipitation events significantly increased soil microbial activity(represented by soil microbial biomass nitrogen and soil bacterial 16S rRNA gene copy numbers). Soil fungal community showed no significant response to precipitation events. According to the redundancy analysis, both soil microbial biomass nitrogen and soil ammonium nitrogen(NH_4-N) were found to be significant in shaping soil microbial community. Acidobacteria, Actinobacteria and Proteobacteria were the dominant phyla in soil bacterial composition, and responded differently to the extreme precipitation events. Based on the results, we concluded that the extreme precipitation events altered the overall soil microbial activity, but did not impact how the processes would occur, since soil microbial community structure remained unchanged. | ZHANG Hui LIU Wenjun KANG Xiaoming CUI Xiaoyong WANG Yanfen ZHAO Haitao QIAN Xiaoqing HAO Yanbin | 2019 | Journal of Arid Land2019，11，1： | 5 |
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