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| 1 | Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis显示文摘Gouty arthritis is a very familiar inflammatory arthritis.Controlling inflammation is the key to preventing gouty arthritis.However,colchicine,the most highly represented drug used in clinical practice,has strict contraindications owing to some severe side effects.Curcumin(Cur),a natural anti-inflammatory drug,has demonstrated good safety and efficacy.However,the rapid degradation,poor aqueous solubility,and low bioavailability of Cur limit its therapeutic effect.To strengthen the effectiveness and bioavailability of Cur.Cur loaded tetrahedral framework nucleic acids(Cur-TFNAs)were synthesized to deliver Cur.Compared with free Cur,Cur-TFNAs exhibit a preferable drug stability,good biocompatibility(CCK-8 assay),ease of uptake(immunofluorescence),and higher tissue utilization(in vivo biodistribution).Most importantly,Cur-TFNAs present better anti-inflammatory effect than free Cur both in vivo and in vitro experiments through the determination of inflammation-related cytokines expression.Therefore,we believe that Cur-TFNAs have great prospects for the prevention of gout and similar inflammatory diseases. | Mei Zhang Xiaolin Zhang Taoran Tian Qi Zhang Yuting Wen Junyao Zhu Dexuan Xiao Weitong Cui Yunfeng Lin | 2022 | Bioactive Materials2022，7，2： | 10 |
| 2 | Integrated Energy System Planning at Modular Regional-user Level Based on a Two-layer Bus Structure显示文摘An integrated energy system(IES)planning method with modular simulation and optimization models is proposed in this paper.A two-layer bus structure is adopted in the simulation model,where the external bus structure is used for power balance while the internal bus structure simulates the fast dynamics of electricity and slow dynamics of heat network in detail.In addition,an improved self-adaptive genetic algorithm(GA)is adopted in the optimization model to solve the multi-dimension and multi-time-scales optimization problem for the regional-user level IEPS.The proposed method can improve the extension flexibility of the system optimal planning model with expected accuracy.A case study is used to verify the effectiveness of the proposed planning method. | Bowen Hong Jian Chen Weitong Zhang Zhiyong Shi Junjie Li Weiwei Miao | 2018 | CSEE Journal of Power and Energy Systems2018，4，2： | 8 |
| 3 | A Simulation System and Speed Guidance Algorithms for Intersection Traffic Control Using Connected Vehicle Technology显示文摘In the connected vehicle environment, real-time vehicle-state data can be obtained through vehicle-toinfrastructure communication, and the prediction accuracy of urban traffic conditions can significantly increase.This study uses the C++/Qt programming language and framework to build a simulation platform. A two-way six-lane intersection is set up on the simulation platform. In addition, two speed guidance algorithms based on optimizing the travel time of a single vehicle or multiple vehicles are proposed. The goal of optimization is to minimize the travel time, with common indicators such as average delay of vehicles, average number of stops, and average stop time chosen as indexes of traffic efficiency. When the traffic flow is not saturated, compared with the case of no speed guidance, single-vehicle speed guidance can improve the traffic efficiency by 20%, whereas multi-vehicle speed guidance can improve the traffic efficiency by 50%. When the traffic flow is saturated, the speed guidance algorithms show outstanding performance. The effect of speed guidance gradually enhances with increasing penetration rate, and the most obvious gains are obtained when the penetration rate increases from 10% to 40%. Thus, this study has shown that speed guidance in the connected vehicle environment can significantly improve the traffic efficiency of intersections, and the multi-vehicle speed guidance strategy is more effective than the single-vehicle speed guidance strategy. | Shuai Liu Weitong Zhang Xiaojun Wu Shuo Feng Xin Pei Danya Yao | 2019 | Tsinghua Science and Technology2019，24，2： | 6 |
| 4 | MII:A Novel Text Classification Model Combining Deep Active Learning with BERT显示文摘Active learning has been widely utilized to reduce the labeling cost of supervised learning.By selecting specific instances to train the model,the performance of the model was improved within limited steps.However,rare work paid attention to the effectiveness of active learning on it.In this paper,we proposed a deep active learning model with bidirectional encoder representations from transformers(BERT)for text classification.BERT takes advantage of the self-attention mechanism to integrate contextual information,which is beneficial to accelerate the convergence of training.As for the process of active learning,we design an instance selection strategy based on posterior probabilities Margin,Intra-correlation and Inter-correlation(MII).Selected instances are characterized by small margin,low intra-cohesion and high inter-cohesion.We conduct extensive experiments and analytics with our methods.The effect of learner is compared while the effect of sampling strategy and text classification is assessed from three real datasets.The results show that our method outperforms the baselines in terms of accuracy. | Anman Zhang Bohan Li Wenhuan Wang Shuo Wan Weitong Chen | 2020 | Computers, Materials & Continua2020，，6： | 4 |
| 5 | A novel approach for the field calibration of line structured - light sensors 显示文摘 | XIE Zexiao ZI-IU Weitong Zhang Zhiwei | 2010 | Measurement2010，43，2： | 1 |
| 6 | Perovskite quantum dot microarrays:In situ fabrication via direct print photopolymerization显示文摘Quantum dots color conversion(QDCC)is considered as a facial and versatile way to achieve full-color organic light emitting diode(OLED)and micro-LED display due to the wide color gamut performance and easy integration.However,the aggregation of QDs and coffee-ring effects after solvent evaporation lowers the light conversion efficiency and emission uniformity in QDs microarrays,raising blue-light leakage or optical crosstalk.Here,we report the fabrication of perovskite quantum dots(PQDs)microarrays by combining the inkjet printing and in situ fabrication of PQDs during the photopolymerization of precursor ink.The resulting PQDs microarrays exhibit three-dimensional(3D)morphology with hemisphere shape as well as strong photoluminescence,which is desirable for QDCC applications.We demonstrate the dominant role of ultraviolet(UV)curable precursors and surface functionalized substrate in controlling the shape of microarrays,where significantly increased contact angle(100°)and large height to diameter ratio(0.42)can be achieved.We further demonstrate the potential use of the in situ direct print photopolymerization method for fabricating large-area multicolor patterned pixel microarrays with a wide color gamut and high resolution.The fabrication of 3D PQDs microarrays opens up new opportunities in a variety of applications including photonics integration,micro-LED,and near-field display. | Xiu Liu Jianjun Li Pingping Zhang Weitong Lu Gaoling Yang Haizheng Zhong Yuejin Zhao | 2022 | Nano Research2022，15，8： | 1 |
| 7 | Effect of tetrahedral DNA nanostructures on LPS-induced neuroinflammation in mice显示文摘Neuroinflammation plays a significant role in inducing depression-like behavior. Tetrahedral DNA nanostructures(TDNs) are molecules that exhibit anti-inflammatory properties and can effectively penetrate the blood-brain barrier. Thus, researchers have hypothesized that TDNs regulate the secretion of proinflammatory cytokines and consequently alleviate depression-like behavior. To test this hypothesis, we investigated the effect of TDNs on the depression-like behavior of C57 mice induced by lipopolysaccharide(LPS). We performed open-field, tail suspension, and sucrose preference tests on LPS-and LPS/TDNtreated mice. The results indicated that the injection of TDNs into LPS-treated mice resulted in increased velocity, center zone duration, frequency to the center zone, and sucrose preference, and decreased immobility time. Immunofluorescence results indicated that peripheral administration of LPS in the mice activated inflammation, which culminated in distinct depression-like behavior. However, TDNs effectively alleviated the inflammation and depression-like behavior through the reduction of the expression levels of proinflammatory cytokines, such as interleukin-1β and tumor necrosis factor-α in the brain. Additionally, TDNs normalized the expression level of microglia cell activation markers, such as ionized calcium binding adaptor molecule 1, in the hippocampus of mice. These results indicated that TDNs attenuated the LPS-induced secretion of inflammatory factors and consequently alleviated depression-like behavior. | Xiao Yang Fan Zhang Yue Du Weitong Cui Yikai Dou Yunfeng Lin Zhihe Zhao Xiaohong Ma | 2022 | Chinese Chemical Letters2022，33，4： | 1 |
| 8 | Tetrahedral framework nucleic acids promote scarless healing of cutaneous wounds via the AKT-signaling pathway显示文摘While the skin is considered the first line of defense in the human body,there are some vulnerabilities that render it susceptible to certain threats,which is an issue that is recognized by both patients and doctors.Cutaneous wound healing is a series of complex processes that involve many types of cells,such as fibroblasts and keratinocytes.This study showed that tetrahedral framework nucleic acids(tFNAs),a type of self-assembled nucleic-acid material,have the ability to promote keratinocyte(HaCaT cell line)and fibroblast(HSF cell line)proliferation and migration in vitro.In addition,tFNAs increased the secretion of vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)in HSF cells and reduced the production of tumor necrosis factor-alpha(TNF-α)and interleukin-1 beta(IL-1β)in HaCaT cells by activating the AKT-signaling pathway.During in vivo experiments,tFNA treatments accelerated the healing process in skin wounds and decreased the development of scars,compared with the control treatment that did not use tFNAs.This is the first study to demonstrate that nanophase materials with the biological features of nucleic acids accelerate the healing of cutaneous wounds and reduce scarring,which indicates the potential application of tFNAs in skin tissue regeneration. | Junyao Zhu Mei Zhang Yang Gao Xin Qin Tianxu Zhang Weitong Cui Chenchen Mao Dexuan Xiao Yunfeng Lin | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 9 | miR-146a impedes the anti-aging effect of AMPK via NAMPT suppression and NAD^(+)/SIRT inactivation显示文摘Nicotinamide adenine dinucleotide(NAD^(+))is indispensable for the anti-aging activity of the sirtuin(SIRT)family enzymes.AMPactivated protein kinase(AMPK)upregulates NAD^(+)synthesis and SIRT activity in a nicotinamide phosphoribosyltransferase(NAMPT)-dependent manner.However,the molecular mechanisms that affect AMPK-driven NAMPT expression and NAD^(+)/SIRT activation remain unclear.In this study,we tried to identify senescence-associated microRNAs(miRNAs)that negatively regulate the cascade linking AMPK and NAMPT expression.miRNA-screening experiments showed that the expression of miR-146a increased in senescent cells but decreased following AMPK activation.Additionally,miR-146a overexpression weakened the metforminmediated upregulation of NAMPT expression,NAD^(+)synthesis,SIRT activity,and senescence protection,whereas treatment with the miR-146a inhibitor reversed this effect.Importantly,these findings were observed both in vitro and in vivo.Mechanistically,miR146a directly targeted the 3′-UTR of Nampt mRNA to reduce the expression of NAMPT.AMPK activators metformin and 5-aminoimidazole-4-carboxamide(AICAR)hindered miR-146a expression at the transcriptional level by promoting IκB kinase(IKK)phosphorylation to attenuate nuclear factor-kappaB(NF-κB)activity.These findings identified a novel cascade that negatively regulates the NAD^(+)/SIRT pathway by suppressing miR-146a-mediated NAMPT downregulation.Furthermore,our results showed that miR-146a impedes the anti-aging effect of AMPK.This mutual inhibitory relationship between miR-146a and AMPK enriches our understanding of the molecular connections between AMPK and SIRT and provides new insight into miRNA-mediated NAD^(+)/SIRT regulation and an intervention point for the prevention of aging and age-related diseases. | Hui Gong Honghan Chen Peng Xiao Ning Huang Xiaojuan Han Jian Zhang Yu Yang Tiepeng Li Tingting Zhao Haoran Tai Weitong Xu Gongchang Zhang Chuhui Gong Ming Yang Xiaoqiang Tang Hengyi Xiao | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 1 |
| 10 | A brain structural connectivity biomarker for autism spectrum disorder diagnosis in early childhood显示文摘Background:Autism spectrum disorder(ASD)is associated with altered brain development,but it is unclear which specific structural changes may serve as potential diagnostic markers,particularly in young children at the age when symptoms become fully estab-lished.Furthermore,such brain markers need to meet the requirements of precision medicine and be accurate in aiding diagnosis at an individual rather than only a group level.Objective:This study aimed to identify and model brain-wide differences in structural connectivity using diffusion tensor imaging(DTI)in young ASD and typically developing(TD)children.Methods:A discovery cohort including 93 ASD and 26 TD children and two independent validation cohorts including 12 ASD and 9 TD children from three different cities in China were included.Brain-wide(294 regions)structural connectivity was measured using DTI(fractional anisotropy,FA)together with symptom severity and cognitive development.A connection matrix was constructed for each child for comparisons between ASD and TD groups.Pattern classification was performed on the discovery dataset and the resulting model was tested on the two independent validation datasets.Results:Thirty-three structural connections showed increased FA in ASD compared to TD children and associated with both autistic symptom severity and impaired general cognitive development.The majority(29/33)involved the frontal lobe and comprised five different networks with functional relevance to default mode,motor control,social recognition,language and reward.Overall,clas-sification achieved very high accuracy of 96.77%in the discovery dataset,and 91.67%and 88.89%in the two independent validation datasets.Conclusions:Identified structural connectivity differences primarily involving the frontal cortex can very accurately distinguish novel individual ASD from TD children and may therefore represent a robust early brain biomarker which can address the requirements of precision medicine. | Xi Jiang Xiao-Jing Shou Zhongbo Zhao Yuzhong Chen Fan-Chao Meng Jiao Le Tian-Jia Song Xin-Jie Xu Weitong Guo Xiaoyan Ke Xiao-E Cai Weihua Zhao Juan Kou Ran Huo Ying Liu Hui-Shu Yuan Yan Xing Ji-Sheng Han Song-Ping Han Yun Li Hua Lai Lan Zhang Mei-Xiang Jia Jing Liu Xuan Liu Keith M.Kendrick Rong Zhang | 2023 | Psychoradiology2023，3，1： | 0 |
| 11 | Enhanced tensile ductility of tungsten microwires via high-density dislocations and reduced grain boundaries显示文摘Despite being strong with many outstanding physical properties,tungsten is inherently brittle at room temperature,restricting its structural and functional applications at small scales.Here,a facile strategy has been adopted,to introduce high-density dislocations while reducing grain boundaries,through electron backscatter diffraction(EBSD)-guided microfabrication of cold-drawn bulk tungsten wires.The designed tungsten microwire attains an ultralarge uniform tensile elongation of~10.6%,while retains a high yield strength of~2.4 GPa.in situ TEM tensile testing reveals that the large uniform elongation of tungsten microwires originates from the motion of pre-existing high-density dislocations,while the subsequent ductile fracture is attributed to crack-tip plasticity and the inhibition of grain boundary cracking.This work demonstrates the application potential of tungsten microcomponents with superior ductility and workability for micro/nanoscale mechanical,electronic,and energy systems. | Chaoqun Dang Weitong Lin Fanling Meng Hongti Zhang Sufeng Fan Xiaocui Li Ke Cao Haokun Yang Wenzhao Zhou Zhengjie Fan Ji-jung Kai Yang Lu | 2021 | Journal of Materials Science & Technology2021，，36： | 0 |
| 12 | Effect of crystal morphology of ultrahigh-nickel cathode materials on high temperature electrochemical stability of lithium ion batteries显示文摘Higher nickel content endows Ni-rich cathode materials LiNi_(x)Co_yMn_(1-x-y)O_(2)(x>0.6)with higher specific capacity and high energy density,which is regarded as the most promising cathode materials for Li-ion batteries.However,the deterioration of structural stability hinders its practical application,especially under harsh working conditions such as high-temperature cycling.Given these circumstances,it becomes particularly critical to clarify the impact of the crystal morphology on the structure and high-temperature performance as for the ultrahigh-nickel cathodes.Herein,we conducted a comprehensive comparison in terms of microstructure,high-temperature long-cycle phase evolution,and high-temperature electrochemical stability,revealing the differences and the working mechanisms among polycrystalline(PC),single-crystalline(SC)and Al doped SC ultrahigh-nickel materials.The results show that the PC sample suffers a severe irreversible phase transition along with the appearance of microcracks,resulting a serious decay of both average voltage and the energy density.While the Al doped SC sample exhibits superior cycling stability with intact layered structure.In-situ XRD and intraparticle structural evolution characterization reveal that Al doping can significantly alleviate the irreversible phase transition,thus inhibiting microcracks generation and enabling enhanced structure.Specifically,it exhibits excellent cycling performance in pouch-type full-cell with a high capacity retention of 91.8%after 500 cycles at 55℃.This work promotes the fundamental understanding on the correlation between the crystalline morphology and high-temperature electrochemical stability and provides a guide for optimization the Ni-rich cathode materials. | Bi Luo Hui Li Haoyu Qi Yun Liu Chuanbo Zheng Weitong Du Jiafeng Zhang Lai Chen | 2024 | Journal of Energy Chemistry2024，88，1： | 0 |
| 13 | Experimental study on the key factors of low-loss threshing of high-moisture maize显示文摘The rates of maize breakage and entrainment loss are high in the harvest of high-moisture maize,which remains an issue with the development of agricultural mechanization.In order to reduce the maize breakage and entrainment loss rates,the correlations among key factors,such as the threshing cylinder speed,concave clearance and feeding rate,and the rates of breakage and entrainment loss during high-moisture maize harvesting were studied in this paper.A single-factor experiment was carried out using a single-longitudinal-axial flow maize harvester,and an orthogonal experiment was carried out using single-and double-longitudinal-axial flow maize harvesters with the Taguchi experimental design method.The single-factor experiment revealed that when the cylinder speed increased,the breakage rate of maize decreased first and then increased,while the entrainment loss rate decreased.The breakage rate of maize decreased as the concave clearance increased,while the entrainment loss rate decreased first and then increased.The optimum value of the concave clearance was positively correlated with the ear diameter of maize;Additionally,the minimum breakage rate of maize occurred when the feeding rate was at the rated value,and the entrainment loss rate increased as the feeding rate increased.The orthogonal experiments revealed that the importance of cylinder speed,feeding rate,concave clearance on the maize breakage and entrainment loss rates were in descending order.The optimum values of parameters for the single-longitudinal-axial flow maize harvester were 370 r/min cylinder speed,40 mm concave clearance and 10 kg/s feeding rate.The optimum values of parameters the double-longitudinal-axial flow maize harvester were 550 r/min cylinder speed,35 mm concave clearance and 10 kg/s feeding rate.The research can provide a reference for parameter configuration and control strategy for the longitudinal-axial flow maize harvester with high-moisture maize. | Xiaolong Zhu Ruijuan Chi Yuefeng Du Jiahao Qin Zexin Xiong Weitong Zhang Xiaoyu Li | 2020 | International Journal of Agricultural and Biological Engineering2020，13，5： | 0 |
| 14 | Enhancing thermodynamic stability of single-crystal Ni-rich cathode material via a synergistic dual-substitution strategy显示文摘Nickel(Ni)-rich cathode materials have become promising candidates for the next-generation electrical vehicles due to their high specific capacity.However,the poor thermodynamic stability(including cyclic performance and safety performance or thermal stability)will restrain their wide commercial application.Herein,a single-crystal Ni-rich Li Ni_(0.83)Co_(0.12)Mn_(0.05)O_(2) cathode material is synthesized and modified by a dual-substitution strategy in which the high-valence doping element improves the structural stability by forming strong metal–oxygen binding forces,while the low-valence doping element eliminates high Li^(+)/Ni^(2+)mixing.As a result,this synergistic dual substitution can effectively suppress H2-H3 phase transition and generation of microcracks,thereby ultimately improving the thermodynamic stability of Ni-rich cathode material.Notably,the dual-doped Ni-rich cathode delivers an extremely high capacity retention of 81%after 250 cycles(vs.Li/Li+)in coin-type half cells and 87%after 1000 cycles(vs.graphite/Li^(+))in pouch-type full cells at a high temperature of 55℃.More impressively,the dual-doped sample exhibits excellent thermal stability,which demonstrates a higher thermal runaway temperature and a lower calorific value.The synergetic effects of this dual-substitution strategy pave a new pathway for addressing the critical challenges of Ni-rich cathode at high temperatures,which will significantly advance the high-energy-density and high-safety cathodes to the subsequent commercialization. | Jixue Shen Hui Li Haoyu Qi Zhan Lin Zeheng Li Chuanbo Zheng Weitong Du Hao Chen Shanqing Zhang | 2024 | Journal of Energy Chemistry2024，88，1： | 0 |
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