|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nucleic acids and analogs for bone regeneration显示文摘With the incidence of different bone diseases increasing, effective therapies are needed that coordinate a combination of various technologies and biological materials. Bone tissue engineering has also been considered as a promising strategy to repair various bone defects. Therefore, different biological materials that can promote stem cell proliferation, migration, and osteoblastic differentiation to accelerate bone tissue regeneration and repair have also become the focus of research in multiple fields. Stem cell therapy, biomaterial scaffolds, and biological growth factors have shown potential for bone tissue engineering; however, off-target effects and cytotoxicity have limited their clinical use. The application of nucleic acids(deoxyribonucleic acid or ribonucleic acid)and nucleic acid analogs(peptide nucleic acids or locked nucleic acids), which are designed based on foreign genes or with special structures, can be taken up by target cells to exert different effects such as modulating protein expression, replacing a missing gene, or targeting specific gens or proteins. Due to some drawbacks, nucleic acids and nucleic acid analogs are combined with various delivery systems to exert enhanced effects, but current studies of these molecules have not yet satisfied clinical requirements. In-depth studies of nucleic acid or nucleic acid analog delivery systems have been performed, with a particular focus on bone tissue regeneration and repair. In this review, we mainly introduce delivery systems for nucleic acids and nucleic acid analogs and their applications in bone repair and regeneration. At the same time, the application of conventional scaffold materials for the delivery of nucleic acids and nucleic acid analogs is also discussed. | Yuxin Zhang Wenjuan Ma Yuxi Zhan Chenchen Mao Xiaoru Shao Xueping Xie Xiawei Wei Yunfeng Lin | 2018 | Bone Research2018，6，4： | 3 |
| 2 | Multi?targeted Antisense Oligonucleotide Delivery by a Framework Nucleic Acid for Inhibiting Biofilm Formation and Virulence显示文摘Biofilm formation is responsible for numerous chronic infections and represents a serious health challenge.Bacteria and the extracellular polysaccharides(EPS)cause biofilms to become adherent,toxic,resistant to antibiotics,and ultimately difficult to remove.Inhibition of EPS synthesis can prevent the formation of bacterial biofilms,reduce their robustness,and promote removal.Here,we have developed a framework nucleic acid delivery system with a tetrahedral configuration.It can easily access bacterial cells and functions by delivering antisense oligonucleotides that target specific genes.We designed antisense oligonucleotide sequences with multiple targets based on conserved regions of the VicK protein-binding site.Once delivered to bacterial cells,they significantly decreased EPS synthesis and biofilm thickness.Compared to existing approaches,this system is highly efficacious because it simultaneously reduces the expression of all targeted genes(gtfBCD,gbpB,ftf).We demonstrate a novel nucleic acid-based nanomaterial with multi-targeted inhibition that has great potential for the treatment of chronic infections caused by biofilms. | Yuxin Zhang Xueping Xie Wenjuan Ma Yuxi Zhan Chenchen Mao Xiaoru Shao Yunfeng Lin | 2020 | Nano-Micro Letters2020，12，6： | 3 |
| 3 | The biological applications of DNA nanomaterials:current challenges and future directions显示文摘DNA,a genetic material,has been employed in different scientific directions for various biological applications as driven by DNA nanotechnology in the past decades,including tissue regeneration,disease prevention,inflammation inhibition,bioimaging,biosensing,diagnosis,antitumor drug delivery,and therapeutics.With the rapid progress in DNA nanotechnology,multitudinous DNA nanomaterials have been designed with different shape and size based on the classic Watson–Crick base-pairing for molecular self-assembly.Some DNA materials could functionally change cell biological behaviors,such as cell migration,cell proliferation,cell differentiation,autophagy,and anti-inflammatory effects.Some single-stranded DNAs(ssDNAs)or RNAs with secondary structures via self-pairing,named aptamer,possess the ability of targeting,which are selected by systematic evolution of ligands by exponential enrichment(SELEX)and applied for tumor targeted diagnosis and treatment.Some DNA nanomaterials with three-dimensional(3D)nanostructures and stable structures are investigated as drug carrier systems to delivery multiple antitumor medicine or gene therapeutic agents.While the functional DNA nanostructures have promoted the development of the DNA nanotechnology with innovative designs and preparation strategies,and also proved with great potential in the biological and medical use,there is still a long way to go for the eventual application of DNA materials in real life.Here in this review,we conducted a comprehensive survey of the structural development history of various DNA nanomaterials,introduced the principles of different DNA nanomaterials,summarized their biological applications in different fields,and discussed the current challenges and further directions that could help to achieve their applications in the future. | Wenjuan Ma Yuxi Zhan Yuxin Zhang Chenchen Mao Xueping Xie Yunfeng Lin | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 2 |
| 4 | Fraction and chemical analysis of antioxidant active polysaccharide isolated from flue-cured tobacco leaves显示文摘 | XU Chunping YANG Chenchen MAO Duobin | 2014 | Pharmacogn Mag2014，10，37： | 1 |
| 5 | Fraction and Chemical Analysis of Antioxidant Active Polysaccharide Isolated from Fluecured Tobacco Leaves显示文摘 | Xu Chunping Yang Chenchen Mao Duobin | 2014 | Pharmacognosy Magazine2014，10，1： | 1 |
| 6 | Tetrahedral framework nucleic acids promote scarless healing of cutaneous wounds via the AKT-signaling pathway显示文摘While the skin is considered the first line of defense in the human body,there are some vulnerabilities that render it susceptible to certain threats,which is an issue that is recognized by both patients and doctors.Cutaneous wound healing is a series of complex processes that involve many types of cells,such as fibroblasts and keratinocytes.This study showed that tetrahedral framework nucleic acids(tFNAs),a type of self-assembled nucleic-acid material,have the ability to promote keratinocyte(HaCaT cell line)and fibroblast(HSF cell line)proliferation and migration in vitro.In addition,tFNAs increased the secretion of vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)in HSF cells and reduced the production of tumor necrosis factor-alpha(TNF-α)and interleukin-1 beta(IL-1β)in HaCaT cells by activating the AKT-signaling pathway.During in vivo experiments,tFNA treatments accelerated the healing process in skin wounds and decreased the development of scars,compared with the control treatment that did not use tFNAs.This is the first study to demonstrate that nanophase materials with the biological features of nucleic acids accelerate the healing of cutaneous wounds and reduce scarring,which indicates the potential application of tFNAs in skin tissue regeneration. | Junyao Zhu Mei Zhang Yang Gao Xin Qin Tianxu Zhang Weitong Cui Chenchen Mao Dexuan Xiao Yunfeng Lin | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 7 | Fraction and chemical analysis of antioxidant active polysaccharide isolated from flue-cured tobacco leaves显示文摘 | XU Chunping YANG Chenchen MAO Duobin | 2014 | Pharmacogn Mag2014，37，10： | 1 |
| 8 | Fraction and chemical analysis of antioxidant active polysaccharide isolated from flue-cured tobac- co leaves显示文摘 | Chunping Xu Chenchen Yang Duobin Mao | 2014 | Pharmacognosy Magazine2014，10，： | 1 |
| 9 | Timing and Single-pulse Study of Pulsar J1909+0122 Discovered by CRAFTS显示文摘We report the discovery of PSR J1909+0122 by the Five-hundred-meter Aperture Spherical Radio Telescope(FAST)as part of the Commensal Radio Astronomy FAST Survey.PSR J1909+0122 has a spin period of 1.257 s and a dispersion measure of 186.2 pc cm^(-3).The averaged pulse profile shows two distinct components.We performed a single-pulse study based on a one-hour observation at 1.25 GHz on 2021 August 23.We used a threshold of 5σ_(ep) to measure the nulling fraction(NF)as 63%±1.5%.The longitude-resolved fluctuation spectra and fast Fourier transform spectra of the binary sequences revealed the quasi-periodicity of nulling with a period of 30 rotation periods.We examined the reliability of the periodicity by comparing it to random noise injection.The NF,E,and modulation periodicity P_(M) of PSR J1909+0122 were compared with other periodic nulling pulsars,showing that the source of J1909+0122 has the second largest NF in the population.Long-term timing observations over six months were used to derive the phase-connected ephemeris of this pulsar.The measured P and P values disfavor dipolar geometry for polar gap models,and the prediction for a space-charge-limited flow model in the case of inverse Compton scattering is only just above the death line.In this work,PSR J1909+0122 has revealed possible correlations between nulling behavior and pulsar properties,which will help to shed light on the pulsar emission mechanism and its temporal evolution in future observations. | Yutong Chen Pei Wang Di Li Erbil Gügercinoğlu Rushuang Zhao Lingqi Meng Jianping Yuan Jiarui Niu Weiwei Zhu Yi Feng Chenchen Miao Chenhui Niu Qingdong Wu Na Wang Shen Wang Xiaoyao Xie Mengyao Xue Jumei Yao Mao Yuan Shanping You Xuhong Yu Youling Yue Jie Zhang Junshuo Zhang Lei Zhang Yabiao Wang Zhenye Gan Yuxi Li Zhongyi Sun Chengjie Wang | 2023 | Research in Astronomy and Astrophysics2023，23，8： | 0 |
| 10 | Modulating microenvironments to enhance CO_(2) electroreduction performance显示文摘Microenvironments of the catalytic center,which play a vital role in adjusting electrocatalytic CO_(2) reduction reaction(ECO_(2) RR)activity,have received increasing attention during the past few years.However,controllable microenvironment construction and the effects of multi-microenvironment variations for improving ECO_(2) RR performance remain unclear.Herein,we summarize the representative strategies for tuning the catalyst and local microenvironments to enhance ECO_(2) RR selectivity and activity.The multifactor synergetic effects of microen-vironment regulation for enhancing CO_(2) accessibility,stabilizing key intermediates,and improving the performance of ECO_(2) RR catalysts are discussed in detail,as well as perspectives on the challenges when investigating ECO_(2) RR microenvironments.We anticipate that the discussions in this review will inspire further research in microenvironment engineering to accelerate the development of the ECO 2 RR for practical application. | Dan Wang Junjun Mao Chenchen Zhang Jiawei Zhang Junshan Li Ying Zhang Yongfa Zhu | 2023 | eScience2023，3，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员