|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Differential mucin phenotypes and their significance in a variation of colorectal carcinoma显示文摘AIM: To investigate mucin expression profiles in colorectal carcinoma (CRC) histological subtypes with regard to clinicopathologic variables and prognosis. METHODS: Mucin (MUC)2 and MUC5AC expressions were assessed by immunohistochemistry for a total of 250 CRC cases that underwent surgical resection. CRCs included 63 well-to-moderately differentiated adenocar-cinomas (WMDAs), 91 poorly differentiated adenocarcinomas (PDAs), 81 mucinous adenocarcinoma (MUAs), and 15 signet-ring cell carcinomas (SRCCs). MUC2 and MUC5AC were scored as positive when ≥ 25% and ≥ 1% of cancer cells were stained positive, respectively. The human mutL homolog 1 and human mutS homolog 2 expressions were assessed by immunohistochemistry in PDAs to investigate mismatch-repair (MMR) status.Tumors that did not express either of these two were considered MMR-deficient. Results were analyzed for associations with clinicopathologic variables and the prognosis in individual histological CRC subtypes. RESULTS: MUC2-positive and MUC5AC-positive WMDA percentages were 49.2% and 30.2%, respectively. In contrast, MUC2-positive and MUC5AC-positive PDA percentages were 9.5% and 51.6%, respectively. MUC2 levels tended to decrease and MUC5AC levels tended to increase from WMDA to PDA. In 21 tumors comprising both adenoma and adenocarcinoma components in a single tumor (4 WMDAs, 7 PDAs, and 10 MUAs), MUC2 was significantly downregulated in PDA and MUC5AC was downregulated in PDA and MUA in the adenoma-carcinoma sequence. These results suggested that MUC2 levels might be associated with malignant potential and that MUC5AC expression was an early event in tumorigenesis. Despite worse prognoses than WMDA, high MUC2 expression levels were maintained in MUA (95.1%) and SRCC (71.5%), which suggested a pathogenesis for these subtypes distinct from that of WMDA. No significant associations were found between MUC2 expression and any clinicopathologic variables in any histological subtype. MUC5AC expression in PDA was closely associated with right-sided location (P = 0.017), absence of nodal metastasis (P = 0.010), low tumor node metastasis stage (P = 0.010), and MMR deficiency (P = 0.003). MUC2 expression in WMDA was a marginal prognostic factor for recurrence/metastasis-free survival (RFS) by univariate Cox analysis (P = 0.077) but not by multivariate Cox analysis (P = 0.161). MUC5AC expression in PDA was a significant prognostic factor for RFS by univariate Cox analysis (P = 0.007) but not by multivariate Cox analysis (P = 0.104). Kaplan-Meier curves and log-rank tests revealed that MUC2 expression was marginally associated with a better WMDA prognosis [P = 0.064 for RFS and P = 0.172 for overall survival (OS)] but not for PDA. In contrast, MUC5AC expression was significantly and marginally associated with a better PDA prognosis in terms of RFS and OS, respectively(P = 0.004 for RFS and P = 0.100 for OS), but not for WMDA and MUA. CONCLUSION: Mucin core protein expression profiles and clinical significance differ according to histological CRC subtypes. This may reflect different pathogeneses for these tumors. | Yasuo Imai Hidetsugu Yamagishi Kazunori Fukuda Yuko Ono Tohru Inoue Yoshihiko Ueda | 2013 | World Journal of Gastroenterology2013，19，25： | 14 |
| 2 | Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice显示文摘AIM:To investigate the causal relationship between hypoadiponectinemia and colorectal carcinogenesis in in vivo experimental model,and to determine the con-tribution of adiponectin defi ciency to colorectal cancer development and proliferation.METHODS:We examined the influence of adiponectin defi ciency on colorectal carcinogenesis induced by the administration of azoxymethane(AOM)(7.5 mg/kg,in-traperitoneal injection once a week for 8 wk),by using adiponectin-knockout(KO) mice.RESULTS:At 53 wk after the fi rst AOM treatment,KOmice developed larger and histologically more progres-sive colorectal tumors with greater frequency com-pared with wild-type(WT) mice,although the tumor incidence was not different between WT and KO mice.KO mice showed increased cell proliferation of colorec-tal tumor cells,which correlated with the expression levels of cyclooxygenase-2(COX-2) in the colorectal tumors.In addition,KO mice showed higher incidence and frequency of liver tumors after AOM treatment.Thirteen percent of WT mice developed liver tumors,and these WT mice had only a single tumor.In contrast,50% of KO mice developed liver tumors,and 58% of these KO mice had multiple tumors.CONCLUSION:Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by AOM in mice.This study strongly suggests that hypoadiponectinemia could be involved in the pathogenesis for colorectal cancer and liver tumor in human subjects. | Tamao Nishihara Miyako Baba Morihiro Matsuda Masahiro Inoue Yasuko Nishizawa Atsunori Fukuhara Hiroshi Araki Shinji Kihara Tohru Funahashi Shinji Tamura Norio Hayashi Hiroyasu Iishi Iichiro Shimomura | 2008 | World Journal of Gastroenterology2008，14，42： | 12 |
| 3 | Stratifying the risk of lymph node metastasis in undifferentiated-type early gastric cancer显示文摘AIM:To study how lymph node metastasis(LNM) risk is stratified in undifferentiated-type early gastric cancer(undiff-EGC) dependent on combinations of risk factors.METHODS:Five hundred and sixty-seven cases with undiff-EGC undergoing gastrectomy with lymphadenectomy were examined retrospectively.Using clinicopathological factors of patient age,location,size,an endoscopic macroscopic tumor form,ulceration,depth,histology,lymphatic involvement(LI) and venous involvement(VI),LNM risk was examined and stratified by conventional statistical analysis and datamining analysis.RESULTS:LNM was positive in 44 of 567 cases(7.8%).Univariate analysis revealed > 2 cm,protrusion,submucosal(sm),mixed type,LI and VI as significant prognostic factors and > 2 cm and LI-positive were independent factors by multivariate analysis.In preoperatively evaluable factors excluding LVI,sm and > 2 cm were independent factors.According to the depth and size,cases were categorized into the low-risk group [m and ≤ 2 cm,0%(LNM incidence)],the moderaterisk group(m and > 2 cm,5.6%; and sm and ≤ 2 cm,6.0%),and the high-risk group(sm and > 2 cm,19.3%).On the other hand,LNM occurred in 1.4% in all LI-negative cases,greatly lower than 28.2% in all LI-positive cases,and LNM incidence was low in LInegative cases even in the moderate- and high-risk groups.CONCLUSION:LNM-related factors in undiff-EGC were depth and size preoperatively while those were LI and size postoperatively.Among these factors,LI was the most significantly correlated factor. | Yukiko Asakawa Masahiko Ohtaka Shinya Maekawa Mitsuharu Fukasawa Yasuhiro Nakayama Tatsuya Yamaguchi Taisuke Inoue Tomoyoshi Uetake Minoru Sakamoto Tadashi Sato Yoshihiko Kawaguchi Hideki Fujii Kunio Mochizuki Masao Hada Toshio Oyama Tomotaka Yasumura Kosaku Omata Atsushi Nishiyama Keiichi Naito Hideo Hata Yoshiaki Haba Kazuyuki Miyata Haruhisa Saitoh Yoichi Yamadera Kazuo Miura Akira Kawaoi Tohru Abe Hajime Tsunoda Yuji Honda Masayuki Kurosaki Nobuyuki Enomoto | 2015 | World Journal of Gastroenterology2015，21，9： | 8 |
| 4 | Long-term prognostic impact of circulating tumour cells in gastric cancer patients显示文摘AIM To analyse the long-term prognostic impact of circulating tumour cells(CTCs) in gastric cancer patients who underwent surgery. METHODS A 7.5-m L peripheral vein blood sample was obtained from each patient with treatment-negative gastric adenocarcinoma before surgery. OBP-401, a telomerasespecific, replication-selective, oncolytic adenoviral agent carrying the green fluorescent protein gene, was used to label CTCs. Correlations between the number of CTCs and clinical end points were evaluated. RESULTS The median follow-up period of the surviving patients with gastric cancer was 60 mo. The CTC number tended to increase concomitantly with disease progression. The overall survival of patients with more than five CTCs in 7.5-m L of peripheral blood was lower than that of patients with five or less CTCs, although the difference was not significant(P = 0.183). A significant difference in relapse-free survival was found between patients with more than five and those with five or less CTCs(P = 0.034).CONCLUSION A lower number of CTCs was correlated with higher relapse-free survival rates in patients. Detection of CTCs using OBP-401 may be useful for predicting prognosis in gastric cancer. | Hiroaki Ito Jun Sato Yukio Tsujino Noriko Yamaguchi Satoshi Kimura Keigo Gohda Katsuhiro Murakami Manabu Onimaru Tohru Ohmori Fumihiro Ishikawa Haruhiro Inoue | 2016 | World Journal of Gastroenterology2016，22，46： | 8 |
| 5 | Protein induced by vitamin K absence or antagonist Ⅱ-producing gastric cancer显示文摘Protein induced by vitamin K absence or antagonist Ⅱ(PIVKA-Ⅱ) is a putative specific marker of hepatocellular carcinoma(HCC),but it may also be produced by asmall number of gastric cancers.To date,16 cases of PIVKA-Ⅱ-producing gastric cancer have been reported,2 of which were reported by us and all of which were identified in Japan.There are no symptoms specific to PIVKA-Ⅱ-producing gastric cancer,and the representative clinical symptoms are general fatigue,appetite loss,and upper abdominal pain.Serum alpha-feto-protein(AFP)levels are also increased in almost allcases.Liver metastasis is observed in approximately 80% of cases and portal vein tumor thrombus is ob-served in approximately 20% of cases.Differential diagnosis between metastatic liver tumor and HCC is often difficult.Grossly,almost all cases appear as advanced gastric cancer.Histologically,a hepatoid pattern is observed in many cases,in addition to a moderately to poorly differentiated adenocarcinoma component.The production of PIVKA-Ⅱ and AFP is usually confirmed using immunohistochemical staining.Treatment and prognosis largely depends on the existence of liver meta-stasis,and the prognosis of patients with liver metas-tasis is very poor.PIVKA-Ⅱ may be produced during the hepatocellular metaplasia of the tumor cells. | Yoshihisa Takahashi Tohru Inoue Toshio Fukusato | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，4： | 4 |
| 6 | Altered mucosal DNA methylation in parallel with highly active Helicobacter pylori -related gastritis显示文摘 | Takeichi Yoshida Jun Kato Takao Maekita Satoshi Yamashita Shotaro Enomoto Takayuki Ando Tohru Niwa Hisanobu Deguchi Kazuki Ueda Izumi Inoue Mikitaka Iguchi Hideyuki Tamai Toshikazu Ushijima Masao Ichinose | 2013 | Gastric Cancer2013，，4： | 3 |
| 7 | 改良热分解法制备新型钛酸钙涂层的实验研究显示文摘目的研究改良热分解法制备的钛金属表面钛酸钙复合涂层材料的特性。方法应用改良热分解法在钛金属表面制备钛酸钙复合涂层材料,该涂层由含有无定形碳的钛酸钙(CaTiO3-αC)与羟基磷灰石(HA)组成。实验中通过控制钙磷比(Ca/P)、钙钛比(Ca/Ti)、烧结温度和烧结速率,使CaTiO3颗粒的晶体结构中含有摩尔分数为4%的无定形碳。结果通过对HA中碳的检测,证实了存在碳酸磷灰石的结构。钛表面的黏附-分离实验显示,CaTiO3-αC/HA涂层的黏附强度是单纯HA涂层的2.5倍。结论改良热分解法制备的CaTiO3-αC层(0.6μm厚)和含有碳酸磷灰石的HA层(2.4μm厚)组成的双层生物活性材料能够作为钛表面理想的涂层材料。 | Noriyuki Nagai Bao-hong Zhao Mika Okauchi Andrea Rodriguez Mehmet Gunduz Hailong Hu Midori Kubota Noriyuki Nagaoka Miho Inoue Hitoshi Nagatsuka Tohru Takagi Masam Akao | 2010 | 中国实用口腔科杂志2010，3，6： | 1 |
| 8 | Useful DNA typing using AmpFeSTRR IdentifilerR Kit for formalde- hyde-fixed paraffin-embedded (FFPE) tissues in early gastric cancer patient with lymph node metastasis显示文摘 | Hisako Motani Saitoh Hiroyuki Inoue Tohru Tanizawa | 2009 | Histology and histopathology2009，24，79： | 1 |
| 9 | Age-related changes of p75 Neurotrophin receptor-positive adipose-derived stem cells显示文摘 | Takaaki Yamada Hirohiko Akamatsu Seiji Hasegawa Naoki Yamamoto Tomohisa Yoshimura Yuichi Hasebe Yu Inoue Hiroshi Mizutani Tohru Uzawa Kayoko Matsunaga Satoru Nakata | 2010 | Journal of Dermatological Science2010，，1： | 1 |
| 10 | Design of an optimal controller for a discrete time system subject to previewable demand显示文摘 | Tohru Katayama Takahira Ohki Toshio Inoue | 1985 | Int J of Control1985，41，3： | 1 |
| 11 | NF-κB Regulates B-Cell-Derived Nerve Growth Factor Expression显示文摘在哺乳动物的大脑,四 neurotrophins 被识别了:神经生长因素(NGF ) ,导出大脑的神经营养的因素(BDNF ) , neurotrophin-3 (NT-3 ) 和 neurotrophin-4/5 (NT-4/5 ) 。NGF 在中央、外部的神经系统的开发和函数施加一个重要角色。然而,有免疫力的房间的几种类型例如桅杆房间,淋巴细胞, basophils 和嗜曙红血球,生产,存储并且释放 NGF,这最近被记录了。积累现出症状之前的潜、临床的数据显示 NGF 和另外的 neurotrophins 的机能障碍可以贡献损害有免疫力的回答, NGF 的集中经常与疾病严厉相关。因此,这研究的目的是阐明贡献的 cytokineneurotrophins 相互作用的潜在的发信号机制增加了 NGF 层次。我们抄写 factorNF-B 玩的数据表演在调整 B-cell-derived NGF 的一个枢轴的角色表示。 | Klaus Heese Noriko Inoue Tohru Sawada | 2006 | Cellular & Molecular Immunology2006，3，1： | 1 |
| 12 | Effect of corticosteroids in addition to intravenous gamma globulin therapy on serum cytokine levels in the acute phase of Kawasaki disease in children显示文摘 | Yasunori Okada Makoto Shinohara Tomio Kobayashi Yoshinari Inoue Takeshi Tomomasa Tohru Kobayashi Akihiro Morikawa | 2003 | The Journal of Pediatrics2003，，3： | 1 |
| 13 | Linkage of Familial Moyamoya Disease (Spontaneous Occlusion of the Circle of Willis) to Chromosome 17q25显示文摘 | Tohru Yamauchi Mitsuhiro Tada Kiyohiro Houkin Toshihiro Tanaka Yusuke Nakamura Satoshi Kuroda Hiroshi Abe Takuya Inoue Kiyonobu Ikezaki Toshio Matsushima Masashi Fukui | 2000 | Stroke: Journal of the American Heart Association2000，，： | 1 |
| 14 | Prediction of Intravenous Immunoglobulin Unresponsiveness in Patients With Kawasaki Disease显示文摘 | Tohru Kobayashi Yoshinari Inoue Kazuo Takeuchi Yasunori Okada Kazushi Tamura Takeshi Tomomasa Tomio Kobayashi Akihiro Morikawa | 2006 | Circulation2006，，22： | 1 |
| 15 | A specific gene-expression signature quantifies the degree of hepatic fibrosis in patients with chronic liver disease显示文摘AIM: To study a more accurate quantification of hepatic fibrosis which would provide clinically useful information for monitoring the progression of chronic liver disease. METHODS: Using a cDNA microarray containing over 22 000 clones, we analyzed the gene-expression profiles of non-cancerous liver in 74 patients who underwent hepatic resection. We calculated the ratio of azan- stained: total area, and determined the morphologic fibrosis index (MFI), as a mean of 9 section-images. We used the MFI as a reference standard to evaluate our method for assessing liver fibrosis. RESULTS: We identified 39 genes that collectively showed a good correlation (r > 0.50) between gene-expression and the severity of liver fibrosis. Many of the identified genes were involved in immune responses and cell signaling. To quantify the extent of liver fibrosis, we developed a new genetic fibrosis index (GFI) based on gene-expression profiling of 4 clones using a linear support vector regression analysis. This technique, based on a supervised learning analysis, correctly quantified the various degrees of fibrosis in both 74 training samples (r = 0.76, 2.2% vs 2.8%, P < 0.0001) and 12 independent additional test samples (r = 0.75, 9.8% vs 8.6%, P < 0.005). It was far better in assessing liver fibrosis than blood markers such as prothrombin time (r = -0.53), type Ⅳ collagen 7s (r = 0.48), hyaluronic acid (r = 0.41), and aspartate aminotransferase to platelets ratio index (APRI) (r = 0.38). CONCLUSION: Our cDNA microarray-based strategy may help clinicians to precisely and objectively monitor the severity of liver fibrosis. | Tohru Utsunomiya Masahiro Okamoto Shigeki Wakiyama Masaji Hashimoto Kengo Fukuzawa Takahiro Ezaki Shinichi Aishima Yasuji Yoshikawa Taizo Hanai Hiroshi Inoue Graham F Barnard Masaki Mori | 2007 | World Journal of Gastroenterology2007，13，3： | 1 |
| 16 | Analysis of the gene-expression profile regarding the progression of human gastric carcinoma显示文摘 | Masaki Mori Koshi Mimori Yasuji Yoshikawa Kenji Shibuta Tohru Utsunomiya Noriaki Sadanaga Fumiaki Tanaka Ayumi Matsuyama Hiroshi Inoue Keizo Sugimachi | 2002 | Surgery2002，，1： | 1 |
| 17 | Prediction of Intravenous Immunoglobulin Unresponsiveness in Patients With Kawasaki Disease显示文摘 | Tohru Kobayashi Yoshinari Inoue Kazuo Takeuchi Yasunori Okada Kazushi Tamura Takeshi Tomomasa Tomio Kobayashi Akihiro Morikawa | 2006 | Circulation2006，，22： | 1 |
| 18 | Solid-liquid phase behavior of binary fatty acid mixtures显示文摘 | Tohru Inoue Yusuke Hisatsugu Ruri tshikawa | 2004 | Chemistry and Physics of Lipids2004，127，： | 1 |
| 19 | Prediction of intravenous immunoglobulin unresponsiveness in patients with Kawasaki disease显示文摘 | Tohru Kobayashi M D Yoshinari Inoue M D Kazuo Takeuchi M D | 2006 | Circulation2006，112，： | 1 |
| 20 | Analysis of gastric cancer with cDNA microarray显示文摘 | Naotsugu Haraguchi Hiroshi Inoue Koshi Mimori Fumiaki Tanaka Tohru Utsunomiya Kouji Yoshikawa Masaki Mori | 2004 | Cancer Chemotherapy and Pharmacology2004，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员