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1Uniform,Highly Conductive,and Patterned Transparent Films of a Percolating Silver Nanowire Network on Rigid and Flexible Substrates Using a Dry Transfer Technique显示文摘Silver nanowire films are promising alternatives to tin-doped indium oxide(ITO)films as transparent conductive electrodes.In this paper,we report the use of vacuum filtration and a polydimethylsiloxane(PDMS)-assisted transfer printing technique to fabricate silver nanowire films on both rigid and flexible substrates,bringing advantages such as the capability of patterned transfer,the best performance among various ITO alternatives(10Ω/sq at 85%transparency),and good adhesion to the underlying substrate,thus eliminating the previously reported adhesion problem.In addition,our method also allows the preparation of high quality patterned films of silver nanowires with different line widths and shapes in a matter of few minutes,making it a scalable process.Furthermore,use of an anodized aluminum oxide(AAO)membrane in the transfer process allows annealing of nanowire films at moderately high temperature to obtain films with extremely high conductivity and good transparency.Using this transfer technique,we obtained silver nanowire films on a flexible polyethylene terephthalate(PET)substrate with a transparency of 85%,a sheet resistance of 10Ω/sq,with good mechanical flexibility.Detailed analysis revealed that the Ag nanowire network exhibits two-dimensional percolation behavior with good agreement between experimentally observed and theoretically predicted values of critical volume。Anuj R.Madaria Akshay Kumar Fumiaki N.Ishikawa Chongwu Zhou 2010Nano Research2010,3,8:39
2Diagnosis and Treatment of Keloids and Hypertrophic Scars—Japan Scar Workshop Consensus Document 2018显示文摘There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases.This is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these diseases.By contrast,Caucasians are less likely to develop keloids and hypertrophic scars,and if they do,the scars tend not to be severe.This ethnic disparity also means that countries vary in terms of their differential diagnostic algorithms.The lack of clear treatment guidelines also means that primary care physicians are currently applying a hotchpotch of treatments,with uneven outcomes.To overcome these issues,the Japan Scar Workshop(JSW)has created a tool that allows clinicians to objectively diagnose and distinguish between keloids,hypertrophic scars,and mature scars.This tool is called the JSW Scar Scale(JSS)and it involves scoring the risk factors of the individual patients and the affected areas.The tool is simple and easy to use.As a result,even physicians who are not accustomed to keloids and hypertrophic scars can easily diagnose them and judge their severity.The JSW has also established a committee that,in cooperation with outside experts in various fields,has prepared a Consensus Document on keloid and hypertrophic scar treatment guidelines.These guidelines are simple and will allow even inexperienced clinicians to choose the most appropriate treatment strategy.The Consensus Document is provided in this article.It describes(1)the diagnostic algorithm for pathological scars and how to differentiate them from clinically similar benign and malignant tumors,(2)the general treatment algorithms for keloids and hypertrophic scars at different medical facilities,(3)the rationale behind each treatment for keloids and hypertrophic scars,and(4)the body site-specific treatment protocols for these scars.We believe that this Consensus Document will be helpful for physicians from all over the world who treat keloids and hypertrophic scars.Rei Ogawa Sadanori Akita Satoshi Akaishi Noriko Aramaki-Hattori Teruyuki Dohi Toshihiko Hayashi Kazuo Kishi Taro Kono Hajime Matsumura Gan Muneuchi Naoki Murao Munetomo Nagao Keisuke Okabe Fumiaki Shimizu Mamiko Tosa Yasuyoshi Tosa Satoko Yamawaki Shinichi Ansai Norihisa Inazu Toshiko Kamo Reiko Kazki Shigehiko Kuribayashi 2019Burns & Trauma2019,7,1:31
3TIDAL FEATURES IN THE CHINA SEAS AND THEIR ADJACENT SEA AREAS AS DERIVED FROM TOPEX/POSEIDON ALTIMETER DATA显示文摘Some important tidal features of 8 major tidal constituents ( M 2, S 2, K 1, O 1, P 1, Sa, N 2 and K 2 ) in the China Seas and their adjacent sea areas were obtained using six years’ TOPEX/POSEIDON altimeter data. The results showed that the obtained co tidal and co range charts for these major tidal constituents agreed well with those of previous researches using observational data from coastal tidal gauge stations and numerical models.胡建宇 Hiroshi KAWAMURA 洪华生 Fumiaki KOBASⅢ 谢强 2001Chinese Journal of Oceanology and Limnology2001,19,4:9
4Age-dependent eradication of Helicobacter pylori in Japanese patients显示文摘AIM:To determine the general risk factors affecting the failure rate of first-line eradication therapy in Japanese patients with Helicobacter pylori(H.pylori)infection.METHODS:The present study enrolled 253 patients who had an H.pylori infection,underwent gastroendoscopy,and were treated with H.pylori eradication therapy.Eradication therapy consisted of 30 mg lansoprazole plus 750 mg amoxicillin and 400 mg clarithromycin twice daily for 7 d.All of the patients underwent a 13 C urea breath test at least 1 mo after the completion of eradication therapy.The current study investigated the independent factors associated with successful H.pylori eradication using a multiple logistic regression analysis.RESULTS:The overall success rate in the patients was 85.8%.Among the general factors examined in the multivariate analyses,only having an age less than 50 years was found to be significantly associated with a poor response to H.pylori eradication.Moreover,side effects were the only clinical factors in the patients who were under 50 years of age that significantly influenced the poor response to H.pylori eradication.CONCLUSION:H.pylori-positive elderly patients should undergo eradication therapy.In addition,it is necessary to improve H.pylori eradication therapy in younger patients.Satoshi Mamori Akihiro Higashida Fumiaki Kawara Katsuhiro Ohnishi Akihiko Takeda Eri Senda Cho Ashida Hajime Yamada 2010World Journal of Gastroenterology2010,16,33:7
5CD13 is a therapeutic target in human liver cancer stem cells显示文摘Haraguchi Naotsugu Ishii Hideshi Mimori Koshi Tanaka Fumiaki Ohkuma Masahisa Kim Ho Min Akita Hirofumi Takiuchi Daisuke Hatano Hisanori Nagano Hiroaki Barnard Graham F Doki Yuichiro Mori Masaki 2010Journal of Clinical Investigation2010,,9:7
6Feasibility and safety of endoscopic submucosal dissection for lower rectal tumors with hemorrhoids显示文摘AIM: To evaluate the feasibility and safety of endoscopic submucosal dissection(ESD) for lower rectal lesions with hemorrhoids.METHODS: The outcome of ESD for 23 lesions with hemorrhoids(hemorrhoid group) was compared with that of 48 lesions without hemorrhoids extending to the dentate line(non-hemorrhoid group) during the same study period. RESULTS: Median operation times(ranges) in the hemorrhoid and non-hemorrhoid groups were 121(51-390) and 130(28-540) min. The en bloc resection rate and the curative resection rate in the hemorrhoid group were 96% and 83%, and they were 100% and 90% in the non-hemorrhoid group, respectively. In terms of adverse events, perforation and postoperative bleeding did not occur in both groups. In terms of the clinical course of hemorrhoids after ESD, the rate of complete recovery of hemorrhoids after ESD in lesions with resection of more than 90% was significantly higher than that in lesions with resection of less than 90%.CONCLUSION: ESD on lower rectal lesions with hemorrhoids could be performed safely, similarly to that on rectal lesions extending to the dentate line without hemorrhoids. In addition, all hemorrhoids after ESD improved to various degrees, depending on the resection range.Shinwa Tanaka Takashi Toyonaga Yoshinori Morita Namiko Hoshi Tsukasa Ishida Yoshiko Ohara Tetsuya Yoshizaki Fumiaki Kawara Eiji Umegaki Takeshi Azuma 2016World Journal of Gastroenterology2016,22,27:6
7Factors associated with residual gastroesophageal reflux disease symptoms in patients receiving proton pump inhibitor maintenance therapy显示文摘AIM To elucidate the factors associated with residual gastroesophageal reflux disease(GERD) symptoms in patients receiving proton pump inhibitor(PPI) maintenance therapy in clinical practice.METHODS The study included 39 GERD patients receiving maintenance PPI therapy. Residual symptoms were assessed using the Frequency Scale for Symptoms of GERD(FSSG) questionnaire and the Gastrointestinal Symptom Rating Scale(GSRS). The relationships between the FSSG score and patient background factors, including the CYP2C19 genotype, were analyzed.RESULTS The FSSG scores ranged from 1 to 28 points(median score: 7.5 points), and 19 patients(48.7%) had a score of 8 points or more. The patients' GSRS scores were significantly correlated with their FSSG scores(correlation coefficient = 0.47, P < 0.005). In erosive esophagitis patients, the FSSG scores of the CYP2C19 rapid metabolizers(RMs) were significantly higher than the scores of the poor metabolizers and intermediate metabolizers(total scores: 16.7 ± 8.6 vs 7.8 ± 5.4, P < 0.05; acid reflux-related symptom scores: 12 ± 1.9 vs 2.5 ± 0.8, P < 0.005). In contrast, the FSSG scores of the CYP2C19 RMs in the non-erosive reflux disease patients were significantly lower than those of the other patients(total scores: 5.5 ± 1.0 vs 11.8 ± 6.3, P < 0.05; dysmotility symptom-related scores: 1.0 ± 0.4 vs 6.0 ± 0.8, P < 0.01). CONCLUSION Approximately half of the GERD patients receiving maintenance PPI therapy had residual symptoms associated with a lower quality of life, and the CYP2C19 genotype appeared to be associated with these residual symptoms.Fumiaki Kawara Tsuyoshi Fujita Yoshinori Morita Atsushi Uda Atsuhiro Masuda Masaya Saito Makoto Ooi Tsukasa Ishida Yasuyuki Kondo Shiei Yoshida Tatsuya Okuno Yoshihiko Yano Masaru Yoshida Hiromu Kutsumi Takanobu Hayakumo Kazuhiko Yamashita Takeshi Hirano Midori Hirai Takeshi Azuma 2017World Journal of Gastroenterology2017,23,11:5
8En bloc pancreaticoduodenectomy and right hemicolectomy for locally advanced right-sided colon cancer显示文摘AIM To assess the usefulness of en bloc right hemicolectomy with pancreaticoduodenectomy(RHCPD) for locally advanced right-sided colon cancer(LARCC).METHODS We retrospectively reviewed the database of Saitama Medical Center, Jichi Medical University, between January 2009 and December 2016. During this time, 299 patients underwent radical right hemicolectomy for right-sided colon cancer. Among them, 5 underwent RHCPD for LARCC with tumor infiltration to adjacent organs. Preoperative computed tomography(CT) was routinely performed to evaluate local tumor infiltration into adjacent organs. During the operation, we evaluated the resectability and the amount of infiltration into the adjacent organs without dissecting the adherent organs from the cancer. When we confirmed that radical resection was feasible and could lead to R0 resection, we performed RHCPD. The clinical data were carefully reviewed, and the demographic variables, intraoperative data, and postoperative parameters were recorded.RESULTS The median age of the 5 patients who underwent RHCPD for LARCC was 70 years. The tumors were located in the ascending colon(three patients) and transverse colon(two patients). Preoperative CT revealed infiltration of the tumor into the duodenum in all patients, the pancreas in four patients, the superior mesenteric vein(SMV) in two patients, and tumor thrombosis in the SMV in one patient. We performed RHCPD plus SMV resection in three patients. Major postoperative complications occurred in 3 patients(60%) as pancreatic fistula(grade B and grade C, according to International Study Group on Pancreatic Fistula Definition) and delayed gastric empty. None of the patients died during their hospital stay. A histological examination confirmed malignant infiltration into the duodenum and/or pancreas in 4 patients(80%), and no patients showed any malignant infiltration into the SMV. Two patients were histologically confirmed to have tumor thrombosis in the SMV. All of the tumors had clear resection margins(R0). The median follow-up time was 77 mo. During this period, two patients with tumor thrombosis died from liver metastasis. The overall survival rates were 80% at 1 year and 60% at 5 years. All patients with node-negative status(n = 2) survived for more than seven years.CONCLUSION This study showed that the long-term survival is possible for patients with LARCC if RHCPD is performed successfully, particularly in those with node-negative status.Yuji Kaneda Hiroshi Noda Yuhei Endo Nao Kakizawa Kosuke Ichida Fumiaki Watanabe Takaharu Kato Yasuyuki Miyakura Koichi Suzuki Toshiki Rikiyama 2017World Journal of Gastrointestinal Oncology2017,9,9:4
9人工全膝关节中多孔钽金属型和骨水泥型胫骨假体周围骨矿物质密度比较显示文摘背景:多孔钽金属近年来用作全膝关节置换的金属植入材料。其多孔性、低弹性模量和高摩擦性能可保证良好的生理负荷传导并保留假体周围的骨储备。但就我们所知,这种小梁金属(TrabecularMetal)胫骨假体对周围骨矿物质密度的影响未见文献报道。本文的目的是对使用非骨水泥的小梁金属胫骨假体和骨水泥型胫骨假体关节周围骨矿物质密度进行比较。方法:对使用小梁金属胫骨假体和使用骨水泥固定的钴铬钼合金胫骨假体各28个膝分别在术前2周、术后2周、术后6、12、18和24个月进行双能x线吸收光谱扫描,以评价假体周围骨矿物质密度。所有手术均由一名医师操作并采用髌旁内侧入路。结果:术前两组股骨颈、腕关节、腰椎椎体或膝关节的骨密度均无明显差异。术后两组的胫骨骨密度均下降。但术后24个月的胫骨侧位x线片显示小梁金属胫骨假体周围的骨密度减低明显小于骨水泥型胫骨假体组(平均值±标准差,-6.7%±22.9%与-36.8%+24.2%;p=0.002)。两组患者的膝关节学会(Knee Society)评分、膝关节活动度和腰椎椎体骨密度在术后24个月无明显差异。假体微动和假体周围骨折在两组膝关节中均未见到。结论:全膝关节置换术使用小梁金属胫骨假体的胫骨外侧平台的骨密度降低小于使用骨水泥型胫骨假体的膝关节。确定多孔钽金属胫骨假体用于全膝关节置换的长期临床疗效尚待进一步研究。Yukihide Minoda Akio Kobayashi Hiroyoshi Iwaki Mitsuhiko Ikebuchi Fumiaki Inori Kunio Takaoka 赵建宁(译) 包倪荣(译) 2010中华骨科杂志2010,30,6:4
10Gastric plexiform fibromyxoma resected by endoscopic submucosal dissection after observation of chronological changes:A case report显示文摘A 66-year-old man was diagnosed with a gastric submucosal tumor. Endoscopic ultrasound(EUS) revealed an iso/hypoechoic mass in the third layer. No malignant cells were detected in a histological examination. Yearly follow-up endoscopy and EUS showed the slow growth of the tumor. Endoscopic submucosal dissection(ESD) was performed and a glistening tumor was resected. The lesion showed a multinodular plexiform growth pattern consisting of spindle cells with an abundant fibromyxoid stroma that was rich in small vessels. The tumor was diagnosed as plexiform fibromyxoma(PF) by immunohistochemistry. Although difficulties are associated with reaching a diagnosis preoperatively, chronological changes on EUS may contribute to the diagnosis of PF. ESD may also be useful in the diagnosis and treatment of PF.Fumiaki Kawara Shinwa Tanaka Takashi Yamasaki Yoshinori Morita Yoshiko Ohara Yoshihiro Okabe Namiko Hoshi Takashi Toyonaga Eiji Umegaki Hiroshi Yokozaki Takanori Hirose Takeshi Azuma 2017World Journal of Gastrointestinal Oncology2017,9,6:3
11Spermatogenesis in aged rats after prenatal 3,3′,4,4′,5-pentachlorobiphenyl exposure显示文摘Shin Wakui Fumio Takagi Tomoko Muto Kiyofumi Yokoo Shyou Hirono Yasuko Kobayashi Kinji Shirota Fumiaki Akahori Yoshihiko Suzuki Hiroshi Hano Hitoshi Endou Yoshikatsu Kanai 2007Toxicology2007,,2:3
12Esophageal diverticulum exposed during endoscopic submucosal dissection of superficial cancer显示文摘Endoscopic submucosal dissection(ESD) is now widely accepted as a strategy to treat superficial esophageal neoplasms.The rate of adverse events,such as perforation,has been decreasing with the improvement of devices and techniques.In this paper,we report a case of esophageal cancer that had a diverticulum under cancerous epithelium.The diverticulum was not detected during preoperative examination,and led to perforation during the ESD procedure.Our case shows that,although rare,some diverticula can exist underneath the mucosal surface without obvious depression.If there is any sign of hidden diverticula during ESD,surgeons should proceed with caution or,depending on the case,the procedure should be discontinued to avoid adverse events.Shinwa Tanaka Takashi Toyonaga Yoshiko Ohara Tetsuya Yoshizaki Fumiaki Kawara Tsukasa Ishida Namiko Hoshi Yoshinori Morita Takeshi Azuma 2015World Journal of Gastroenterology2015,21,10:2
13Preliminary Study to Identify Criterion for Quench Crack Prevention by Computer Simulation显示文摘A criterion for preventing quench cracks has not been established although much research has been conducted in this field. A few predictions of cracking have been recently reported using simulated results of heat treatment processes. However, these results were insufficient to predict crack generation clearly because the mechanism relates not only to stress distributions in the parts but also to material characteristics. Systematic studies by the combination of experiment and simulation are therefore required to reliably identify a criterion for crack prevention by computer simulation. As a preliminary work before starting the full-scale research, a review of quench cracking research was conducted and existing test methods were classified. Several test results for cylindrical specimens were simulated for considering a cause of the crack generation. Lastly a tentative plan was made for the future research.Kyozo Arimoto Fumiaki Ikuta Takashi Horino Shigeyuki Tamura Michiharu Narazaki Yoshio Mikita 2004材料热处理学报2004,25,5:2
14Clinical practice guidelines for gastrointestinal stromal tumor (GIST) in Japan: English version显示文摘Toshirou Nishida Seiichi Hirota Akio Yanagisawa Yoshinori Sugino Manabu Minami Yoshitaka Yamamura Yoshihide Otani Yasuhiro Shimada Fumiaki Takahashi Tetsuro Kubota 2008International Journal of Clinical Oncology2008,,5:2
15The Representative Porcine Model for Human Cardiovascular Disease显示文摘Yoriyasu Suzuki Alan C. Yeung Fumiaki Ikeno Andrea Vecchione 2010Journal of Biomedicine and Biotechnology2010,,:2
16Over- and under-expressed microRNAs in human colorectal cancer显示文摘Kazuo Motoyama Hiroshi Inoue Yasushi Takatsuno Fumiaki Tanaka Koshi Mimori Hiroyuki Uetake Kenichi Sugihara Masaki Mori 2009International Journal of Oncology2009,,4:2
17Down-regulation of miR-125a-3p in human gastric cancer and its clinicopathologicalsignificance显示文摘Yojiro Hashiguchi Naohiro Nishida Koshi Mimori Tomoya Sudo Fumiaki Tanaka Kohei Shibata Hideshi Ishii Hidetaka Mochizuki Kazuo Hase Yuichiro Doki Masaki Mori 2012International Journal of Oncology2012,,5:2
18Relationship between clinicopathological features and mucin phenotypes of advanced gastric adenocarcinoma显示文摘AIM: To investigate a relationship between the clinicopathological features and mucin phenotypes in advanced gastric adenocarcinoma (AGA). METHODS: Immunohistochemical staining was performed to determine the mucin phenotypes in 38 patients with differentiated adenocarcinomas (DACs), 9 with signet-ring cell carcinomas (SIGs), and 48 with other diffuse-type adenocarcinomas (non-SIGs) of AGA. The mucin phenotypes were classified into 4 types: gastric (G), gastrointestinal (GI), intestinal, and unclassified. RESULTS: The G-related mucin phenotypes were highly expressed in all the histological subtypes of AGA. The expression of the GI phenotype in SIG patients was lower than that in DAC patients (P = 0.02), and this phenotype was observed in 56% of the non-SIG patients in the intramucosal layer. Among non-SIG cases, the expression of the GI phenotype was significantly higherin patients with extended adenocarcinomas and those with positive rates of lymph node metastasis. There was no difference between the expressions of the G and other GI phenotypes factors. Among DAC and non-SIG patients, there were no differences between the survival rates of the corresponding patient groups. CONCLUSION: The GI phenotype might possess more invasive characteristics than the G phenotype in nonSIG. Neither of the phenotypes indicated a poor prognosis of DAC and non-SIG.Fumiaki Toki Atsushi Takahashi Ryusuke Aihara Kyoichi Ogata Hiroyuki Ando Tetsuro Ohno Erito Mochiki Hiroyuki Kuwano 2010World Journal of Gastroenterology2010,16,22:2
19Fractional Flow Reserve Versus Angiography for Guiding Percutaneous Coronary Intervention in Patients With Multivessel Coronary Artery Disease显示文摘Nico H.J. Pijls William F. Fearon Pim A.L. Tonino Uwe Siebert Fumiaki Ikeno Bernhard Bornschein Marcel van't Veer Volker Klauss Ganesh Manoharan Thomas Engstr?m Keith G. Oldroyd Peter N. Ver Lee Philip A. MacCarthy Bernard De Bruyne 2010Journal of the American College of Cardiology2010,,3:2
20Endoscopic submucosal dissection for early gastric cancer in anastomosis site after distal gastrectomy显示文摘Shinwa Tanaka Takashi Toyonaga Yoshinori Morita Tsuyoshi Fujita Tetsuya Yoshizaki Fumiaki Kawara Chika Wakahara Daisuke Obata Aya Sakai Tsukasa Ishida Nobunao Ikehara Takeshi Azuma 2014Gastric Cancer2014,,2:2
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